• 3178 Citations
  • 29 Scopus h-Index
20012020
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Research Output 2001 2020

  • 3178 Citations
  • 29 Scopus h-Index
  • 134 Article
  • 1 Letter
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Article
2012
18 Citations (Scopus)

Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence

Karpyak, V. M., Geske, J. R., Colby, C. L., Mrazek, D. A. & Biernacka, J. M., Jul 2012, In : Addiction Biology. 17, 4, p. 798-806 9 p.

Research output: Contribution to journalArticle

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
N-Methylaspartate
Alcoholism
Single Nucleotide Polymorphism
Genes
16 Citations (Scopus)

Genomic determinants of motor and cognitive outcomes in Parkinson's disease

Chung, S. J., Armasu, S. M., Biernacka, J. M., Anderson, K. J., Lesnick, T. G., Rider, D. N., Cunningham, J. M., Eric Ahlskog, J., Frigerio, R. & Maraganore, D. M., Aug 2012, In : Parkinsonism and Related Disorders. 18, 7, p. 881-886 6 p.

Research output: Contribution to journalArticle

Parkinson Disease
Single Nucleotide Polymorphism
Genes
Genome-Wide Association Study
Proportional Hazards Models
42 Citations (Scopus)

Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: Selective serotonin reuptake inhibitor response pharmacogenomics

Abo, R., Hebbring, S., Ji, Y., Zhu, H., Zeng, Z. B., Batzler, A., Jenkins, G. D., Biernacka, J. M., Snyder, K., Drews, M., Fiehn, O., Fridley, B., Schaid, D. J., Kamatani, N., Nakamura, Y., Kubo, M., Mushiroda, T., Kaddurah-Daouk, R., Mrazek, D. A. & Weinshilboum, R. M., Apr 2012, In : Pharmacogenetics and Genomics. 22, 4, p. 247-253 7 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Serotonin Uptake Inhibitors
Single Nucleotide Polymorphism
Genome
Citalopram
20 Citations (Scopus)

Pharmacogenomics of antidepressant induced mania: A review and meta-analysis of the serotonin transporter gene (5HTTLPR) association

Biernacka, J. M., McElroy, S. L., Crow, S., Sharp, A., Benitez, J., Veldic, M. D., Kung, S., Cunningham, J. M., Post, R. M., Mrazek, D. & Frye, M. A., Jan 2012, In : Journal of Affective Disorders. 136, 1-2

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Pharmacogenetics
Bipolar Disorder
Antidepressive Agents
Meta-Analysis
7 Citations (Scopus)

Pretransplant Psychiatric and Substance Use Comorbidity in Patients with Cholangiocarcinoma Who Received a Liver Transplant

Schneekloth, T. D., Jowsey, S. G., Biernacka, J. M., Burton, M. C., Vasquez, A. R., Bergquist, T., Drews, M. S. & Gores, G. J., Mar 2012, In : Psychosomatics. 53, 2, p. 116-122 7 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Psychiatry
Comorbidity
Substance-Related Disorders
Transplants
54 Citations (Scopus)

SNP interaction detection with Random Forests in high-dimensional genetic data

Winham, S. J., Colby, C. L., Freimuth, R., Wang, X., De Andrade, M., Huebner, M. & Biernacka, J. M., Jul 15 2012, In : BMC Bioinformatics. 13, 1, 164.

Research output: Contribution to journalArticle

Single nucleotide Polymorphism
Random Forest
Nucleotides
Polymorphism
Single Nucleotide Polymorphism
19 Citations (Scopus)

Use of the gamma method for self-contained gene-set analysis of SNP data

Biernacka, J. M., Jenkins, G. D., Wang, L. M., Moyer, A. & Fridley, B. L., May 2012, In : European Journal of Human Genetics. 20, 5, p. 565-571 7 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Genes
Phenotype
Cisplatin
Glutathione
89 Citations (Scopus)

Using a pharmacogenomic algorithm to guide the treatment of depression.

Hall-Flavin, D. K., Winner, J. G., Allen, J. D., Jordan, J. J., Nesheim, R. S., Snyder, K. A., Drews, M. S., Eisterhold, L. L., Biernacka, J. M. & Mrazek, D. A., 2012, In : Translational Psychiatry. 2

Research output: Contribution to journalArticle

Pharmacogenetics
Depression
Psychiatry
Therapeutics
Ambulatory Care Facilities
2011
24 Citations (Scopus)

Common variants in PARK loci and related genes and Parkinson's disease

Chung, S. J., Armasu, S. M., Biernacka, J. M., Lesnick, T. G., Rider, D. N., Lincoln, S. J., Ortolaza, A. I., Farrer, M. J., Cunningham, J. M., Rocca, W. A. & Maraganore, D. M., Feb 1 2011, In : Movement Disorders. 26, 2, p. 280-288 9 p.

Research output: Contribution to journalArticle

Parkinson Disease
Disease Susceptibility
Single Nucleotide Polymorphism
Genes
Age of Onset
84 Citations (Scopus)

CYP2C19 variation and citalopram response

Mrazek, D. A., Biernacka, J. M., O'Kane, D. J., Black, J. L., Cunningham, J. M., Drews, M. S., Snyder, K. A., Stevens, S. R., Rush, A. J. & Weinshilboum, R. M., Jan 2011, In : Pharmacogenetics and Genomics. 21, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Citalopram
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Genotype
Depression
19 Citations (Scopus)

Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility?

Biernacka, J. M., Armasu, S. M., Cunningham, J. M., Eric Ahlskog, J., Chung, S. J. & Maraganore, D. M., Dec 2011, In : Parkinsonism and Related Disorders. 17, 10, p. 730-736 7 p.

Research output: Contribution to journalArticle

Disease Susceptibility
Single Nucleotide Polymorphism
Parkinson Disease
Minisatellite Repeats
Genes
46 Citations (Scopus)

Effect of cytochrome P450 enzyme polymorphisms on pharmacokinetics of venlafaxine

McAlpine, D. E., Biernacka, J. M., Mrazek, D. A., O'Kane, D. J., Stevens, S. R., Langman, L. J., Courson, V. L., Bhagia, J. & Moyer, T. P., Feb 2011, In : Therapeutic Drug Monitoring. 33, 1, p. 14-20 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Pharmacokinetics
Cytochrome P-450 CYP2D6
Genotype
Venlafaxine Hydrochloride
28 Citations (Scopus)

Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures

Kim, J. H., Karpyak, V. M., Biernacka, J. M., Nam, H. W., Lee, M. R., Preuss, U. W., Zill, P., Yoon, G., Colby, C., Mrazek, D. A. & Choi, D. S., 2011, In : PLoS One. 6, 1, e16331.

Research output: Contribution to journalArticle

Alcohol Withdrawal Seizures
adenosine
alcohol abuse
seizures
Adenosine
96 Citations (Scopus)

Gene set analysis of SNP data: Benefits, challenges, and future directions

Fridley, B. L. & Biernacka, J. M., Aug 2011, In : European Journal of Human Genetics. 19, 8, p. 837-843 7 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Genes
Genome-Wide Association Study
Phenotype
Genetic Research
118 Citations (Scopus)

Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: Pharmacometabolomics-informed pharmacogenomics

Ji, Y., Hebbring, S., Zhu, H., Jenkins, G. D., Biernacka, J. M., Snyder, K., Drews, M., Fiehn, O., Zeng, Z., Schaid, D. J., Mrazek, D. A., Kaddurah-Daouk, R. & Weinshilboum, R. M., Jan 2011, In : Clinical Pharmacology and Therapeutics. 89, 1, p. 97-104 8 p.

Research output: Contribution to journalArticle

Glycine Dehydrogenase
Citalopram
Pharmacogenetics
Serotonin Uptake Inhibitors
Glycine
10 Citations (Scopus)

Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients

Shinozaki, G., Jowsey, S., Amer, H., Biernacka, J. M., Colby, C., Walker, D., Black, J., Rundell, J., Stegall, M. D. & Mrazek, D. A., Dec 21 2011, In : Depression and Anxiety. 28, 12, p. 1111-1118 8 p.

Research output: Contribution to journalArticle

Depression
Single Nucleotide Polymorphism
Kidney
Post-Traumatic Stress Disorders
Tacrolimus Binding Proteins
6 Citations (Scopus)

Trazodone and alcohol relapse: A retrospective study following residential treatment

Kolla, B. P., Schneekloth, T. D., Biernacka, J. M., Frye, M. A., Mansukhani, M., Hall-Flavin, D. K., Karpyak, V. M., Loukianova, L. L., Lesnick, T. G. & Mrazek, D., Nov 2011, In : American Journal on Addictions. 20, 6, p. 525-529 5 p.

Research output: Contribution to journalArticle

Trazodone
Residential Treatment
Retrospective Studies
Alcohols
Recurrence

Utilization of residential alcoholism treatment in bipolar disorder

Hall-Flavin, D. K., Schneekloth, T. D., Loukianova, L. L., Karpyak, V. M., Lesnick, T. G., Biernacka, J. M., Mrazek, D. A. & Frye, M. A., Jan 2011, In : American Journal on Addictions. 20, 1, p. 40-44 5 p.

Research output: Contribution to journalArticle

Residential Treatment
Bipolar Disorder
Alcoholism
Drinking
Retrospective Studies
16 Citations (Scopus)

Variants in estrogen-related genes and risk of Parkinson's disease

Chung, S. J., Armasu, S. M., Biernacka, J. M., Lesnick, T. G., Rider, D. N., Cunningham, J. M. & Maraganore, D. M., Jun 2011, In : Movement Disorders. 26, 7, p. 1234-1242 9 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Parkinson Disease
Estrogens
Genes
Disease Susceptibility
2010
24 Citations (Scopus)

Gender differences in the relationship between depressive symptoms and cravings in alcoholism

Boykoff, N., Schneekloth, T. D., Hall-Flavin, D., Loukianova, L., Karpyak, V. M., Stevens, S. R., Biernacka, J. M., Mrazek, D. A. & Frye, M. A., 2010, In : American Journal on Addictions. 19, 4, p. 352-356 5 p.

Research output: Contribution to journalArticle

Alcoholism
Alcohols
Depression
Dual (Psychiatry) Diagnosis
Prospective Studies
17 Citations (Scopus)

Interaction of SLC6A4 and DRD2 polymorphisms is associated with a history of delirium tremens

Karpyak, V. M., Biernacka, J. M., Weg, M. W. V., Stevens, S. R., Cunningham, J. M., Mrazek, D. A. & Black, J. L., Jan 2010, In : Addiction Biology. 15, 1, p. 23-34 12 p.

Research output: Contribution to journalArticle

Alcohol Withdrawal Delirium
Alcohol Withdrawal Seizures
Logistic Models
Genetic Polymorphisms
Alcoholics
45 Citations (Scopus)

Self-Contained gene-set analysis of expression data: An evaluation of existing and novel methods

Fridley, B. L., Jenkins, G. D. & Biernacka, J. M., 2010, In : PLoS One. 5, 9, p. 1-9 9 p., e12693.

Research output: Contribution to journalArticle

Genes
genes
gemcitabine
methodology
Phenotype
2009
3 Citations (Scopus)
Single Nucleotide Polymorphism
70 Citations (Scopus)

Machine learning in genome-wide association studies

Szymczak, S., Biernacka, J. M., Cordell, H. J., González-Recio, O., König, I. R., Zhang, H. & Sun, Y. V., 2009, In : Genetic Epidemiology. 33, SUPPL. 1

Research output: Contribution to journalArticle

Genome-Wide Association Study
Single Nucleotide Polymorphism
Genome
Machine Learning
Education
29 Citations (Scopus)

Sequence variations of the human MPDZ gene and association with alcoholism in subjects with european ancestry

Karpyak, V. M., Kim, J. H., Biernacka, J. M., Wieben, E. D., Mrazek, D. A., Black, J. L. & Choi, D. S., Apr 2009, In : Alcoholism: Clinical and Experimental Research. 33, 4, p. 712-721 10 p.

Research output: Contribution to journalArticle

Alcohol Withdrawal Seizures
Alcoholism
Genes
Alcohols
Haplotypes
123 Citations (Scopus)

SLC6A4 variation and citalopram response

Mrazek, D. A., Rush, A. J., Biernacka, J. M., O'Kane, D. J., Cunningham, J. M., Wieben, E. D., Schaid, D. J., Drews, M. S., Courson, V. L., Snyder, K. A., Black, J. L. & Weinshilboum, R. M., Apr 5 2009, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 150, 3, p. 341-351 11 p.

Research output: Contribution to journalArticle

Citalopram
Single Nucleotide Polymorphism
Introns
Depression
Haplotypes
2007
10 Citations (Scopus)

Exploring causality via identification of SNPs or haplotypes responsible for a linkage signal

Biernacka, J. M. & Cordell, H. J., Nov 2007, In : Genetic Epidemiology. 31, 7, p. 727-740 14 p.

Research output: Contribution to journalArticle

Causality
Haplotypes
Single Nucleotide Polymorphism
Linkage Disequilibrium
Viverridae
2 Citations (Scopus)

Using linkage and association to identify and model genetic effects: Summary of GAW15 group 4

Yang, Q., Biernacka, J. M., Chen, M. H., Houwing-Duistermaat, J. J., Bergemann, T. L., Basu, S., Fan, R., Liu, L., Bourgey, M., Clerget-Darpoux, F., Lin, W. Y., Elston, R. C. & Cupples, L. A., 2007, In : Genetic Epidemiology. 31, SUPPL. 1

Research output: Contribution to journalArticle

Genetic Models
Pedigree
Single Nucleotide Polymorphism
Information Storage and Retrieval
Rheumatoid Arthritis
2006
133 Citations (Scopus)

Heterozygosity for a POMC-null mutation and increased obesity risk in humans

Farooqi, I. S., Drop, S., Clements, A., Keogh, J. M., Biernacka, J. M., Lowenbein, S., Challis, B. G. & O'Rahilly, S., Sep 2006, In : Diabetes. 55, 9, p. 2549-2553 5 p.

Research output: Contribution to journalArticle

Pro-Opiomelanocortin
Obesity
Mutation
Heterozygote
Adrenal Insufficiency
2 Citations (Scopus)

Perils and pitfalls of permutation tests for distinguishing the effects of neighbouring polymorphisms

Biernacka, J. M. & Cordell, H. J., Nov 2006, In : Genetic Epidemiology. 30, 7, p. 582-589 8 p.

Research output: Contribution to journalArticle

Viverridae
Logistic Models
Linkage Disequilibrium
Haplotypes
Alleles
2005
4 Citations (Scopus)

Comparison of family-based association tests in chromosome regions selected by linkage-based confidence intervals

Lewinger, J. P., Lee, S. S. F., Biernacka, J. M., Wu, L. Y., Shi, H. S. & Bull, S. B., Dec 30 2005, In : BMC Genetics. 6, SUPPL.1, S62.

Research output: Contribution to journalArticle

Chromosomes
Confidence Intervals
Single Nucleotide Polymorphism
Software
Genome
22 Citations (Scopus)

Simultaneous localization of two linked disease susceptibility genes

Biernacka, J. M., Sun, L. & Bull, S. B., Jan 2005, In : Genetic Epidemiology. 28, 1, p. 33-47 15 p.

Research output: Contribution to journalArticle

Disease Susceptibility
Genes
Alleles
Confidence Intervals
Viverridae
6 Citations (Scopus)

Tests for the presence of two linked disease susceptibility genes

Biernacka, J. M., Sun, L. & Bull, S. B., Dec 2005, In : Genetic Epidemiology. 29, 4, p. 389-401 13 p.

Research output: Contribution to journalArticle

Disease Susceptibility
Genes
Viverridae
Chromosomes, Human, Pair 6
Type 1 Diabetes Mellitus
2001
1 Citation (Scopus)

Does simultaneous consideration of multiple regions improve disease gene localization?

Biernacka, J. M., Lewinger, J. P., Chan, V. & Bull, S. B., 2001, In : Genetic Epidemiology. 21, SUPPL. 1

Research output: Contribution to journalArticle

Genes
Disease Susceptibility
Nuclear Family
Alleles
Weights and Measures