Jian Yuan, PhD

  • 1422 Citations
  • 20 Scopus h-Index
20052020

Research output per year

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Research Output

  • 1422 Citations
  • 20 Scopus h-Index
  • 44 Article
  • 1 Comment/debate
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Article
2020

CHK2-FOXK axis promotes transcriptional control of autophagy programs

Chen, Y., Wu, J., Liang, G., Geng, G., Zhao, F., Yin, P., Nowsheen, S., Wu, C., Li, Y., Li, L., Kim, W., Zhou, Q., Huang, J., Liu, J., Zhang, C., Guo, G., Deng, M., Tu, X., Gao, X., Liu, Z. & 4 others, Chen, Y., Lou, Z., Luo, K. & Yuan, J., Jan 1 2020, In : Science Advances. 6, 1, eaax5819.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair

Zhou, Q., Huang, J., Zhang, C., Zhao, F., Kim, W., Tu, X., Zhang, Y., Nowsheen, S., Zhu, Q., Deng, M., Chen, Y., Qin, B., Luo, K., Liu, B., Lou, Z., Mutter, R. W. & Yuan, J., Dec 1 2020, In : Nature communications. 11, 1, 2639.

Research output: Contribution to journalArticle

Open Access
2019

A novel UCHL 3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair

Song, Z., Tu, X., Zhou, Q., Huang, J., Chen, Y., Liu, J., Lee, S. B., Kim, W., Nowsheen, S., Luo, K., Yuan, J. & Lou, Z., Jun 1 2019, In : Cell Death and Disease. 10, 6, 398.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

DDX17 promotes hepatocellular carcinoma progression via inhibiting Klf4 transcriptional activity

Xue, Y., Jia, X., Li, C., Zhang, K., Li, L., Wu, J., Yuan, J. & Li, Q., Nov 1 2019, In : Cell Death and Disease. 10, 11, 814.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Tu, X., Qin, B., Zhang, Y., Zhang, C., Kahila, M., Nowsheen, S., Yin, P., Yuan, J., Pei, H., Li, H., Yu, J., Song, Z., Zhou, Q., Zhao, F., Liu, J., Zhang, C., Dong, H., Mutter, R. W. & Lou, Z., Jun 20 2019, In : Molecular Cell. 74, 6, p. 1215-1226.e4

Research output: Contribution to journalArticle

10 Scopus citations

USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2

Wu, J., Chen, Y., Geng, G., Li, L., Yin, P., Nowsheen, S., Li, Y., Wu, C., Liu, J., Zhao, F., Kim, W., Zhou, Q., Huang, J., Guo, G., Zhang, C., Tu, X., Gao, X., Lou, Z., Luo, K., Qiao, H. & 1 others, Yuan, J., May 1 2019, In : Cancer Letters. 449, p. 114-124 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex

Kim, W., Zhao, F., Wu, R., Qin, S., Nowsheen, S., Huang, J., Zhou, Q., Chen, Y., Deng, M., Guo, G., Luo, K., Lou, Z. & Yuan, J., Dec 1 2019, In : Nature communications. 10, 1, 5304.

Research output: Contribution to journalArticle

Open Access
2018

ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Tu, X., Kahila, M. M., Zhou, Q., Yu, J., Kalari, K. R., Wang, L. M., Harmsen, W. S., Yuan, J., Boughey, J. C., Goetz, M. P., Sarkaria, J. N., Lou, Z. & Mutter, R., Nov 1 2018, In : Molecular Cancer Therapeutics. 17, 11, p. 2462-2472 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Chk1 inhibitor SCH 900776 enhances the antitumor activity of MLN4924 on pancreatic cancer

Li, J. A., Song, C., Rong, Y., Kuang, T., Wang, D., Xu, X., Yuan, J., Luo, K., Qin, B., Nowsheen, S., Lou, Z. & Lou, W., Jan 1 2018, (Accepted/In press) In : Cell Cycle. p. 1-9 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway

Xue, Y., Jia, X., Li, L., Dong, X., Ling, J., Yuan, J. & Li, Q., Sep 18 2018, In : Biochemical and Biophysical Research Communications. 503, 4, p. 2885-2891 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Erratum to: Topoisomerase IIα controls the decatenation checkpoint (Nature Cell Biology, (2009), 11, 2, (204-210), 10.1038/ncb1828)

Luo, K., Yuan, J., Chen, J. & Lou, Z., Jan 1 2018, (Accepted/In press) In : Nature Cell Biology.

Research output: Contribution to journalArticle

L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage

Nowsheen, S., Aziz, K., Aziz, A., Deng, M., Qin, B., Luo, K., Jeganathan, K. B., Zhang, H., Liu, T., Yu, J., Deng, Y., Yuan, J., Ding, W., Van Deursen, J. M. & Lou, Z., Apr 1 2018, In : Nature Cell Biology. 20, 4, p. 455-464 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistance through YAP1 stabilization

Li, L., Liu, T., Li, Y., Wu, C., Luo, K., Yin, Y., Chen, Y., Nowsheen, S., Wu, J., Lou, Z. & Yuan, J., May 1 2018, In : Oncogene. 37, 18, p. 2422-2431 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization

Wu, C., Luo, K., Zhao, F., Yin, P., Song, Y., Deng, M., Huang, J., Chen, Y., Li, L., Lee, S. B., Kim, J. J., Zhou, Q., Tu, X., Nowsheen, S., Luo, Q., Gao, X., Lou, Z., Liu, Z. & Yuan, J., Nov 1 2018, In : Cell Death and Differentiation. 25, 10, p. 1855-1869 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Nowsheen, S., Aziz, K., Luo, K., Deng, M., Qin, B., Yuan, J., Jeganathan, K. B., Yu, J., Zhang, H., Ding, W., Van Deursen, J. M. & Lou, Z., Dec 1 2018, In : Nature communications. 9, 1, 2736.

Research output: Contribution to journalArticle

5 Scopus citations
2017

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

Liu, T., Yu, J., Deng, M., Yin, Y., Zhang, H., Luo, K., Qin, B., Li, Y., Wu, C., Ren, T., Han, Y., Yin, P., Kim, J. J., Lee, S. B., Lin, J., Zhang, L., Zhang, J., Nowsheen, S., Wang, L., Boughey, J. & 3 others, Goetz, M. P., Yuan, J. & Lou, Z., Jan 9 2017, In : Nature communications. 8, 13923.

Research output: Contribution to journalArticle

52 Scopus citations

USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response

Li, Y., Luo, K., Yin, Y., Wu, C., Deng, M., Li, L., Chen, Y., Nowsheen, S., Lou, Z. & Yuan, J., Jun 1 2017, In : Nature communications. 8, 15752.

Research output: Contribution to journalArticle

23 Scopus citations

USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling

Luo, K., Li, Y., Yin, Y., Li, L., Wu, C., Chen, Y., Nowsheen, S., Hu, Q., Zhang, L., Lou, Z. & Yuan, J., May 15 2017, In : EMBO Journal. 36, 10, p. 1434-1446 13 p.

Research output: Contribution to journalArticle

34 Scopus citations
2016

A phosphorylation–deubiquitination cascade regulates the BRCA2–RAD51 axis in homologous recombination

Luo, K., Li, L., Li, Y., Wu, C., Yin, Y., Chen, Y., Deng, M., Nowsheen, S., Yuan, J. & Lou, Z., Dec 1 2016, In : Genes and Development. 30, 23, p. 2581-2595 15 p.

Research output: Contribution to journalArticle

23 Scopus citations

Deubiquitination and Activation of AMPK by USP10

Deng, M., Yang, X., Qin, B., Liu, T., Zhang, H., Guo, W., Lee, S. B., Kim, J. J., Yuan, J., Pei, H., Wang, L. & Lou, Z., Feb 18 2016, In : Molecular Cell. 61, 4, p. 614-624 11 p.

Research output: Contribution to journalArticle

42 Scopus citations
2015

CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase

Luo, K., Deng, M., Li, Y., Wu, C., Xu, Z., Yuan, J. & Lou, Z., Apr 23 2015, In : Nucleic acids research. 43, 11, p. 5465-5475 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

KAP1 deacetylation by SIRT1 promotes non-homologous end-joining repair

Lin, Y. H., Yuan, J., Pei, H., Liu, T., Ann, D. K. & Lou, Z., Apr 23 2015, In : PloS one. 10, 4, e0123935.

Research output: Contribution to journalArticle

26 Scopus citations

Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1

Oi, N., Yuan, J., Malakhova, M., Luo, K., Li, Y., Ryu, J., Zhang, L., Bode, A. M., Xu, Z., Li, Y., Lou, Z. & Dong, Z., May 14 2015, In : Oncogene. 34, 20, p. 2660-2671 12 p.

Research output: Contribution to journalArticle

22 Scopus citations
2014

A Divergent Role of the SIRT1-TopBP1 Axis in Regulating Metabolic Checkpoint and DNA Damage Checkpoint

Liu, T., Lin, Y. H., Leng, W., Jung, S. Y., Zhang, H., Deng, M., Evans, D., Li, Y., Luo, K., Qin, B., Qin, J., Yuan, J. & Lou, Z., Dec 4 2014, In : Molecular Cell. 56, 5, p. 681-695 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

HERC2-USP20 axis regulates DNA damage checkpoint through Claspin

Yuan, J., Luo, K., Deng, M., Li, Y., Yin, P., Gao, B., Fang, Y., Wu, P., Liu, T. & Lou, Z., Dec 1 2014, In : Nucleic acids research. 42, 21, p. 13110-13121 12 p.

Research output: Contribution to journalArticle

40 Scopus citations
2013

Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein

Qin, B., Gao, B., Yu, J., Yuan, J. & Lou, Z., May 31 2013, In : Journal of Biological Chemistry. 288, 22, p. 16139-16144 6 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012

Regulation of SIRT1 activity by genotoxic stress

Yuan, J., Luo, K., Liu, T. & Lou, Z., Apr 23 2012, In : Genes and Development. 26, 8, p. 791-796 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Sumoylation of MDC1 is important for proper DNA damage response

Luo, K., Zhang, H., Wang, L., Yuan, J. & Lou, Z., Jul 4 2012, In : EMBO Journal. 31, 13, p. 3008-3019 12 p.

Research output: Contribution to journalArticle

99 Scopus citations
2010

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

Yuan, J., Luo, K., Zhang, L., Cheville, J. C. & Lou, Z., Feb 5 2010, In : Cell. 140, 3, p. 384-396 13 p.

Research output: Contribution to journalArticle

283 Scopus citations
2009

A c-Myc-SIRT1 feedback loop regulates cell growth and transformation

Yuan, J., Minter-Dykhouse, K. & Lou, Z., Apr 20 2009, In : Journal of Cell Biology. 185, 2, p. 203-211 9 p.

Research output: Contribution to journalArticle

155 Scopus citations

Histone H3-K56 acetylation is important for genomic stability in mammals

Yuan, J., Pu, M., Zhang, Z. & Lou, Z., Jun 1 2009, In : Cell Cycle. 8, 11, p. 1747-1753 7 p.

Research output: Contribution to journalArticle

Open Access
157 Scopus citations

Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA)

Chen, X., Gu, X., Shan, Y., Tang, W., Yuan, J., Zhong, Z., Wang, Y., Huang, W., Wan, B. & Yu, L., Apr 2009, In : Molecular Biology Reports. 36, 4, p. 669-676 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Topoisomerase IIα controls the decatenation checkpoint

Luo, K., Yuan, J., Chen, J. & Lou, Z., Jan 1 2009, In : Nature Cell Biology. 11, 2, p. 204-210 7 p.

Research output: Contribution to journalArticle

72 Scopus citations
2007

Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE

Guo, Z., Yuan, J., Tang, W., Chen, X., Gu, X., Luo, K., Wang, Y., Wan, B. & Yu, L., Sep 2007, In : Molecular Biology Reports. 34, 3, p. 137-144 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2006

Activation of transcriptional activities of AP1 and SRE by a novel zinc finger protein ZNF445

Luo, K., Yuan, J., Shan, Y., Li, J., Xu, M., Cui, Y., Tang, W., Wan, B., Zhang, N., Wu, Y. & Yu, L., Feb 15 2006, In : Gene. 367, 1-2, p. 89-100 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260

Guo, Z., Tang, W., Yuan, J., Chen, X., Wan, B., Gu, X., Luo, K., Wang, Y. & Yu, L., Sep 8 2006, In : Biochemical and Biophysical Research Communications. 347, 4, p. 867-871 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53

Yuan, J., Tang, W., Luo, K., Chen, X., Gu, X., Wan, B. & Yu, L., Sep 2006, In : Molecular Biology Reports. 33, 3, p. 151-158 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Identification and characterization of the human SCAN domain zinc-finger gene ZNF449

Luo, K., Li, J., Cui, Y., Xu, M., Yuan, J., Tang, W., Wan, B. & Yu, L., Mar 2006, In : Molecular Biology Reports. 33, 1, p. 51-57 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway

Tang, W., Yuan, J., Chen, X., Gu, X., Luo, K., Li, J., Wan, B., Wang, Y. & Yu, L., Sep 2006, In : Journal of Biochemistry and Molecular Biology. 39, 5, p. 626-635 10 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations
2005

Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis

Liu, L., Zhang, J., Yuan, J., Dang, Y., Yang, C., Chen, X., Xu, J. & Yu, L., Mar 1 2005, In : Molecular Biology Reports. 32, 1, p. 41-45 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Cloning, expression and characterization of the human NOB1 gene

Zhang, Y., Ni, J., Zhou, G., Yuan, J., Ren, W., Shan, Y., Tang, W., Yu, L. & Zhao, S., Sep 1 2005, In : Molecular Biology Reports. 32, 3, p. 185-189 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Cloning and characterization of the CDZFP gene which encodes a putative zinc finger protein

Tang, W., Yuan, J., Chen, X., Shan, Y., Luo, K., Guo, Z., Zhang, Y., Wan, B. & Yu, L., Oct 1 2005, In : DNA Sequence - Journal of DNA Sequencing and Mapping. 16, 5, p. 391-396 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B

Yuan, J., Shan, Y., Chen, X., Tang, W., Luo, K., Ni, J., Wan, B. & Yu, L., Dec 2005, In : Molecular Biology Reports. 32, 4, p. 205-214 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains

Liu, L., Yang, C., Yuan, J., Chen, X., Xu, J., Wei, Y., Yang, J., Lin, G. & Yu, L., Dec 1 2005, In : Molecules and Cells. 19, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

15 Scopus citations