Jian Yuan, PhD

  • 1278 Citations
  • 18 Scopus h-Index
20052019
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  • 11 Similar Profiles
DNA Damage Medicine & Life Sciences
Proteins Medicine & Life Sciences
Homologous Recombination Medicine & Life Sciences
Zinc Fingers Medicine & Life Sciences
Genes Medicine & Life Sciences
Double-Stranded DNA Breaks Medicine & Life Sciences
Organism Cloning Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

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Projects

Research Output 2005 2019

  • 1278 Citations
  • 18 Scopus h-Index
  • 42 Article
  • 1 Comment/debate

A novel UCHL 3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair

Song, Z., Tu, X., Zhou, Q., Huang, J., Chen, Y., Liu, J., Lee, S. B., Kim, W., Nowsheen, S., Luo, K., Yuan, J. & Lou, Z., Jun 1 2019, In : Cell Death and Disease. 10, 6, 398.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Double-Stranded DNA Breaks
Homologous Recombination
DNA Damage
Ubiquitination

DDX17 promotes hepatocellular carcinoma progression via inhibiting Klf4 transcriptional activity

Xue, Y., Jia, X., Li, C., Zhang, K., Li, L., Wu, J., Yuan, J. & Li, Q., Nov 1 2019, In : Cell Death and Disease. 10, 11, 814.

Research output: Contribution to journalArticle

Open Access
Hepatocellular Carcinoma
DEAD-box RNA Helicases
Gene Expression
Atlases
Zinc Fingers
4 Citations (Scopus)

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Tu, X., Qin, B., Zhang, Y., Zhang, C., Kahila, M., Nowsheen, S., Yin, P., Yuan, J., Pei, H., Li, H., Yu, J., Song, Z., Zhou, Q., Zhao, F., Liu, J., Zhang, C., Dong, H. M., Mutter, R. & Lou, Z., Jun 20 2019, In : Molecular Cell. 74, 6, p. 1215-1226.e4

Research output: Contribution to journalArticle

Exosome Multienzyme Ribonuclease Complex
DNA Damage
Radiation
Drug Therapy
Genetic Therapy
2 Citations (Scopus)

USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2

Wu, J., Chen, Y., Geng, G., Li, L., Yin, P., Nowsheen, S., Li, Y., Wu, C., Liu, J., Zhao, F., Kim, W., Zhou, Q., Huang, J., Guo, G., Zhang, C., Tu, X., Gao, X., Lou, Z., Luo, K., Qiao, H. & 1 others, Yuan, J., May 1 2019, In : Cancer Letters. 449, p. 114-124 11 p.

Research output: Contribution to journalArticle

Checkpoint Kinase 2
DNA Damage
Radiation
Apoptosis
Protein-Serine-Threonine Kinases

ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex

Kim, W., Zhao, F., Wu, R., Qin, S., Nowsheen, S., Huang, J., Zhou, Q., Chen, Y., Deng, M., Guo, G., Luo, K., Lou, Z. & Yuan, J., Dec 1 2019, In : Nature communications. 10, 1, 5304.

Research output: Contribution to journalArticle

Open Access
forks
Genomic Instability
maintenance
Maintenance
Chemical activation