Jennifer Lynn Whitwell, PhD

  • 14953 Citations
  • 64 Scopus h-Index
20012020

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2020

Brain volume and flortaucipir analysis of progressive supranuclear palsy clinical variants

Whitwell, J. L., Tosakulwong, N., Botha, H., Ali, F., Clark, H. M., Duffy, J. R., Utianski, R. L., Stevens, C. A., Weigand, S. D., Schwarz, C. G., Senjem, M. L., Jack, C. R., Lowe, V. J., Ahlskog, J. E., Dickson, D. W. & Josephs, K. A., 2020, In : NeuroImage: Clinical. 25, 102152.

Research output: Contribution to journalArticle

Open Access

Dementia with Lewy bodies presenting as Logopenic variant primary progressive Aphasia

Boes, S., Botha, H., Machulda, M. M., Lowe, V., Graff-Radford, J., Whitwell, J. L., Utianski, R., Duffy, J. R. & Josephs, K. A., 2020, In : Neurocase. p. 1-5 5 p.

Research output: Contribution to journalArticle

Dysphagia in Progressive Supranuclear Palsy

Clark, H. M., Stierwalt, J. A. G., Tosakulwong, N., Botha, H., Ali, F., Whitwell, J. L. & Josephs, K. A., Aug 1 2020, In : Dysphagia. 35, 4, p. 667-676 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effect Modifiers of TDP-43-Associated Hippocampal Atrophy Rates in Patients with Alzheimer's Disease Neuropathological Changes

Buciuc, M., Wennberg, A. M., Weigand, S. D., Murray, M. E., Senjem, M. L., Spychalla, A. J., Boeve, B. F., Knopman, D. S., Jack, C. R., Kantarci, K., Parisi, J. E., Dickson, D. W., Petersen, R. C., Whitwell, J. L. & Josephs, K. A., Jan 1 2020, In : Journal of Alzheimer's Disease. 73, 4, p. 1511-1523 13 p.

Research output: Contribution to journalArticle

Ioflupane 123I (DAT scan) SPECT identifies dopamine receptor dysfunction early in the disease course in progressive apraxia of speech

Seckin, Z. I., Whitwell, J. L., Utianski, R. L., Botha, H., Ali, F., Duffy, J. R., Clark, H. M., Machulda, M. M., Jordan, L. G., Min, H. K., Lowe, V. J. & Josephs, K. A., 2020, (Accepted/In press) In : Journal of Neurology.

Research output: Contribution to journalArticle

1 Scopus citations

Longitudinal amyloid-β PET in atypical Alzheimer's disease and frontotemporal lobar degeneration

Whitwell, J. L., Tosakulwong, N., Weigand, S. D., Graff-Radford, J., Duffy, J. R., Clark, H. M., Machulda, M. M., Botha, H., Utianski, R. L., Schwarz, C. G., Senjem, M. L., Strand, E., Ertekin-Taner, N., Jack, C. R., Lowe, V. J. & Josephs, K. A., Jan 1 2020, In : Journal of Alzheimer's Disease. 74, 1, p. 377-389 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Longitudinal flortaucipir ([18F]AV-1451) PET uptake in semantic dementia

Utianski, R. L., Botha, H., Whitwell, J. L., Martin, P. R., Schwarz, C. G., Duffy, J. R., Clark, H. M., Spychalla, A. J., Senjem, M. L., Petersen, R. C., Knopman, D. S., Jack, C. R., Lowe, V. J. & Josephs, K. A., Aug 2020, In : Neurobiology of aging. 92, p. 135-140 6 p.

Research output: Contribution to journalArticle

Open Access

Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia

Petroi, D., Duffy, J. R., Borgert, A., Strand, E., Machulda, M. M., Senjem, M. L., Jack, C. R., Josephs, K. A. & Whitwell, J. L., May 2020, In : Brain and Language. 204, 104773.

Research output: Contribution to journalArticle

Utility of FDG-PET in diagnosis of Alzheimer-related TDP-43 proteinopathy

Buciuc, M., Botha, H., Murray, M. E., Schwarz, C. G., Senjem, M. L., Jones, D. T., Knopman, D. S., Boeve, B. F., Petersen, R. C., Jack, C. R., Petrucelli, L., Parisi, J. E., Dickson, D. W., Lowe, V., Whitwell, J. L. & Josephs, K. A., Jul 7 2020, In : Neurology. 95, 1, p. e23-e34

Research output: Contribution to journalArticle

Validation of the movement disorder society criteria for the diagnosis of 4-repeat tauopathies

for the Movement Disorder Society–Endorsed Progressive Supranuclear Palsy Study Group, Jan 1 2020, In : Movement Disorders. 35, 1, p. 171-176 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
Open Access
2 Scopus citations
2019
5 Scopus citations

An Evaluation of the Progressive Supranuclear Palsy Speech/Language Variant

Whitwell, J. L., Stevens, C. A., Duffy, J. R., Clark, H. M., Machulda, M. M., Strand, E. A., Martin, P. R., Utianski, R. L., Botha, H., Spychalla, A. J., Senjem, M. L., Schwarz, C. G., Jack, C. R., Ali, F., Hassan, A. & Josephs, K. A., Jul 2019, In : Movement Disorders Clinical Practice. 6, 6, p. 452-461 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration

Bejanin, A., Murray, M. E., Martin, P., Botha, H., Tosakulwong, N., Schwarz, C. G., Senjem, M. L., Chételat, G., Kantarci, K., Jack, C. R., Boeve, B. F., Knopman, D. S., Petersen, R. C., Giannini, C., Parisi, J. E., Dickson, D. W., Whitwell, J. L. & Josephs, K. A., Nov 1 2019, In : Brain. 142, 11, p. 3621-3635 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Atrophy in midbrain & cerebral/cerebellar pedunculi is characteristic for progressive supranuclear palsy – A double-validation whole-brain meta-analysis

Albrecht, F., Bisenius, S., Neumann, J., Whitwell, J. & Schroeter, M. L., Jan 1 2019, In : NeuroImage: Clinical. 22, 101722.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
5 Scopus citations

Clinical and neuroimaging characteristics of clinically unclassifiable primary progressive aphasia

Utianski, R. L., Botha, H., Martin, P. R., Schwarz, C. G., Duffy, J. R., Clark, H. M., Machulda, M. M., Butts, A. M., Lowe, V. J., Jack, C. R., Senjem, M. L., Spychalla, A. J., Whitwell, J. L. & Josephs, K. A., Oct 1 2019, In : Brain and Language. 197, 104676.

Research output: Contribution to journalArticle

2 Scopus citations

How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy

for the Movement Disorder Society-Endorsed PSP Study Group, 2019, In : Movement Disorders. 34, 8, p. 1228-1232 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Longitudinal tau-PET uptake and atrophy in atypical Alzheimer's disease

Sintini, I., Martin, P. R., Graff-Radford, J., Senjem, M. L., Schwarz, C. G., Machulda, M. M., Spychalla, A. J., Drubach, D. A., Knopman, D. S., Petersen, R. C., Lowe, V. J., Jack, C. R., Josephs, K. A. & Whitwell, J. L., 2019, In : NeuroImage: Clinical. 23, 101823.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Multimodal neuroimaging relationships in progressive supranuclear palsy

Sintini, I., Schwarz, C., Senjem, M. L., Reid, R. I., Botha, H., Ali, F., Ahlskog, J. E., Jack, C. R. J., Lowe, V., Josephs, K. A. & Whitwell, J. L., Jan 1 2019, In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

3 Scopus citations

Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains

Josephs, K. A., Murray, M. E., Tosakulwong, N., Weigand, S. D., Serie, A. M., Perkerson, R. B., Matchett, B. J., Jack, C. R., Knopman, D. S., Petersen, R. C., Parisi, J. E., Petrucelli, L., Baker, M., Rademakers, R., Whitwell, J. L. & Dickson, D. W., Feb 11 2019, In : Acta neuropathologica. 137, 2, p. 227-238 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Progressive agrammatic aphasia without apraxia of speech as a distinct syndrome

Tetzloff, K. A., Duffy, J. R., Clark, H. M., Utianski, R. L., Strand, E. A., Machulda, M. M., Botha, H., Martin, P. R., Schwarz, C. G., Senjem, M. L., Reid, R. I., Gunter, J. L., Spychalla, A. J., Knopman, D. S., Petersen, R. C., Jack, C. R., Lowe, V. J., Josephs, K. A. & Whitwell, J. L., Aug 1 2019, In : Brain. 142, 8, p. 2466-2482 17 p.

Research output: Contribution to journalArticle

Prominent auditory deficits in primary progressive aphasia: A case study

Utianski, R. L., Duffy, J. R., Clark, H. M., Machulda, M. M., Dickson, D. W., Whitwell, J. L. & Josephs, K. A., Aug 2019, In : Cortex. 117, p. 396-406 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Regional multimodal relationships between tau, hypometabolism, atrophy, and fractional anisotropy in atypical Alzheimer's disease

Sintini, I., Schwarz, C. G., Martin, P. R., Graff-Radford, J., Machulda, M. M., Senjem, M. L., Reid, R. I., Spychalla, A. J., Drubach, D. A., Lowe, V. J., Jack, C. R., Josephs, K. A. & Whitwell, J. L., Apr 1 2019, In : Human Brain Mapping. 40, 5, p. 1618-1631 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Sensitivity and Specificity of Diagnostic Criteria for Progressive Supranuclear Palsy

Ali, F., Martin, P. R., Botha, H., Ahlskog, J. E., Bower, J. H., Masumoto, J. Y., Maraganore, D., Hassan, A., Eggers, S., Boeve, B. F., Knopman, D. S., Drubach, D., Petersen, R. C., Dunkley, E. D., van Gerpen, J., Uitti, R., Whitwell, J. L., Dickson, D. W. & Josephs, K. A., 2019, In : Movement Disorders. 34, 8, p. 1144-1153 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
18 Scopus citations

The influence of β-amyloid on [ 18 F]AV-1451 in semantic variant of primary progressive aphasia

Whitwell, J. L., Martin, P. R., Duffy, J. R., Clark, H., Machulda, M. M., Schwarz, C., Weigand, S. D., Sintini, I., Senjem, M. L., Taner, N., Botha, H., Utianski, R., Graff-Radford, J., Jones, D. T., Boeve, B. F., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Josephs, K. A., Feb 12 2019, In : Neurology. 92, 7, p. e710-e722

Research output: Contribution to journalArticle

3 Scopus citations

The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease

Whitwell, J. L., Martin, P., Graff-Radford, J., Machulda, M. M., Senjem, M. L., Schwarz, C. G., Weigand, S. D., Spychalla, A. J., Drubach, D. A., Jack, C. R., Lowe, V. J. & Josephs, K. A., May 2019, In : Alzheimer's and Dementia. 15, 5, p. 675-685 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
5 Scopus citations

Von economo neurons in behavioral variant frontotemporal dementia with underlying Alzheimer's disease

Tan, R. H., Yang, Y., McCann, H., Shepherd, C., Halliday, G. M. & Whitwell, J. L., Jan 1 2019, In : Journal of Alzheimer's Disease. 69, 4, p. 963-967 5 p.

Research output: Contribution to journalArticle

2018

[18F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease

Whitwell, J. L., Graff-Radford, J., Tosakulwong, N., Weigand, S. D., Machulda, M. M., Senjem, M. L., Schwarz, C., Spychalla, A. J., Jones, D. T., Drubach, D., Knopman, D. S., Boeve, B. F., Taner, N., Petersen, R. C., Lowe, V., Jack, C. R. J. & Josephs, K. A., Feb 1 2018, In : Annals of Neurology. 83, 2, p. 248-257 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

[18F]AV-1451 tau-PET and primary progressive aphasia

Josephs, K. A., Martin, P. R., Botha, H., Schwarz, C., Duffy, J. R., Clark, H., Machulda, M. M., Graff-Radford, J., Weigand, S. D., Senjem, M. L., Utianski, R., Drubach, D., Boeve, B. F., Jones, D. T., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Whitwell, J. L., Jan 1 2018, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

20 Scopus citations
7 Scopus citations

Association of Apolipoprotein e ϵ4 with Transactive Response DNA-Binding Protein 43

Wennberg, A. M., Tosakulwong, N., Lesnick, T. G., Murray, M. E., Whitwell, J. L., Liesinger, A. M., Petrucelli, L., Boeve, B. F., Parisi, J. E., Knopman, D. S., Petersen, R. C., Dickson, D. W. & Josephs, K. A., Jan 1 2018, (Accepted/In press) In : JAMA Neurology. p. E1-E8

Research output: Contribution to journalArticle

19 Scopus citations

Clinical and imaging progression over 10 years in a patient with primary progressive apraxia of speech and autopsy-confirmed corticobasal degeneration

Tetzloff, K. A., Duffy, J. R., Strand, E. A., Machulda, M. M., Boland, S. M., Utianski, R., Botha, H., Senjem, M. L., Schwarz, C., Josephs, K. A. & Whitwell, J. L., May 26 2018, (Accepted/In press) In : Neurocase. p. 1-10 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Clinical Progression in Four Cases of Primary Progressive Apraxia of Speech

Utianski, R. L., Duffy, J. R., Clark, H. M., Strand, E., Boland, S. M., Machulda, M. M., Whitwell, J. L. & Josephs, K. A., Nov 21 2018, In : American Journal of Speech-Language Pathology. 27, 4, p. 1303-1318 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Disrupted functional connectivity in primary progressive apraxia of speech

Botha, H., Utianski, R., Whitwell, J. L., Duffy, J. R., Clark, H., Strand, E. A., Machulda, M. M., Tosakulwong, N., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Josephs, K. A. & Jones, D. T., Jan 1 2018, In : NeuroImage: Clinical. 18, p. 617-629 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
1 Scopus citations
18 Scopus citations

Longitudinal structural and molecular neuroimaging in agrammatic primary progressive aphasia

Tetzloff, K. A., Duffy, J. R., Clark, H., Strand, E. A., Machulda, M. M., Schwarz, C., Senjem, M. L., Reid, R. I., Spychalla, A. J., Tosakulwong, N., Lowe, V., Jack, C. R. J., Josephs, K. A. & Whitwell, J. L., Jan 1 2018, In : Brain. 141, 1, p. 302-317 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Molecular neuroimaging in primary progressive aphasia with predominant agraphia

Utianski, R., Duffy, J. R., Savica, R., Whitwell, J. L., Machulda, M. M. & Josephs, K. A., Mar 25 2018, (Accepted/In press) In : Neurocase. p. 1-3 3 p.

Research output: Contribution to journalArticle

MRI Outperforms [18F]AV-1451 PET as a Longitudinal Biomarker in Progressive Supranuclear Palsy

Whitwell, J. L., Tosakulwong, N., Schwarz, C., Botha, H., Senjem, M. L., Spychalla, A. J., Ahlskog, J. E., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Josephs, K. A., Jan 1 2018, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

7 Scopus citations

Non-right handed primary progressive apraxia of speech

Botha, H., Duffy, J. R., Whitwell, J. L., Strand, E. A., Machulda, M. M., Spychalla, A. J., Tosakulwong, N., Senjem, M. L., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Josephs, K. A., Jul 15 2018, In : Journal of the Neurological Sciences. 390, p. 246-254 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia

Owens, T. E., Machulda, M. M., Duffy, J. R., Strand, E., Clark, H. M., Boland, S., Martin, P. R., Lowe, V. J., Jack, C. R., Whitwell, J. L. & Josephs, K. A., Jan 1 2018, In : Journal of Alzheimer's Disease. 66, 3, p. 1015-1025 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Prosodic and phonetic subtypes of primary progressive apraxia of speech

Utianski, R., Duffy, J. R., Clark, H., Strand, E. A., Botha, H., Schwarz, C., Machulda, M. M., Senjem, M. L., Spychalla, A. J., Jack, C. R. J., Petersen, R. C., Lowe, V., Whitwell, J. L. & Josephs, K. A., Sep 1 2018, In : Brain and Language. 184, p. 54-65 12 p.

Research output: Contribution to journalArticle

17 Scopus citations