• 8268 Citations
  • 49 Scopus h-Index
1993 …2020

Research output per year

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Research Output

2019

Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice

Mattson, A. M., Begun, D. L., Molstad, D. H. H., Meyer, M. A., Oursler, M. J., Westendorf, J. J. & Bradley, E., Jan 1 2019, In : Journal of Biological Chemistry. 294, 31, p. 11772-11784 13 p.

Research output: Contribution to journalArticle

Open Access

Epigenetics as a New Frontier in Orthopedic Regenerative Medicine and Oncology

van Wijnen, A. J. & Westendorf, J. J., Jul 1 2019, In : Journal of Orthopaedic Research. 37, 7, p. 1465-1474 10 p.

Research output: Contribution to journalReview article

2 Scopus citations
Open Access
1 Scopus citations

Lung tumor cells inhibit bone mineralization and osteoblast activity

Berent, T. E., Dorschner, J. M., Craig, T. A., Drake, M. M., Westendorf, J. J. & Kumar, R., Jan 1 2019, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

1 Scopus citations

Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice

Zhang, C., Smith, M. P., Zhou, G. K., Lai, A., Hoy, R. C., Mroz, V., Torre, O. M., Laudier, D. M., Bradley, E. W., Westendorf, J. J., Iatridis, J. C. & Illien-Jünger, S., Oct 1 2019, In : Cell Death and Disease. 10, 10, 754.

Research output: Contribution to journalArticle

Open Access
2018

Bone biology and engineering

Westendorf, J. J., Lu, L. & Yaszemski, M. J., Jan 1 2018, Orthopaedic Basic Science: Foundations of Clinical Practice, Fourth Edition. Wolters Kluwer Health, p. 281-293 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Defining osteoblast and adipocyte lineages in the bone marrow

Pierce, J. L., Begun, D. L., Westendorf, J. J. & McGee-Lawrence, M. E., Jan 1 2018, (Accepted/In press) In : Bone.

Research output: Contribution to journalArticle

7 Scopus citations

DNA methylation and FoxO3a regulate PHLPP1 expression in chondrocytes

Castillejo Becerra, C. M., Mattson, A. M., Molstad, D. H. H., Lorang, I. M., Westendorf, J. J. & Bradley, E., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Biochemistry.

Research output: Contribution to journalArticle

Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer

Yan, Y., An, J., Yang, Y., Wu, D., Bai, Y., Cao, W., Ma, L., Chen, J., Yu, Z., He, Y., Jin, X., Pan, Y., Ma, T., Wang, S., Hou, X., Weroha, S. J., Karnes, R. J., Zhang, J., Westendorf, J. J., Wang, L. & 5 others, Chen, Y., Xu, W., Zhu, R., Wang, D. & Huang, H., Jan 1 2018, (Accepted/In press) In : EMBO Molecular Medicine.

Research output: Contribution to journalArticle

12 Scopus citations

Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice

Dudakovic, A., Camilleri, E. T., Paradise, C. R., Samsonraj, R. M., Gluscevic, M., Paggi, C. A., Begun, D. L., Khani, F., Pichurin, O., Ahmed, F. S., Elsayed, R., Elsalanty, M., McGee-Lawrence, M. E., Karperien, M., Riester, S. M., Thaler, R., Westendorf, J. J. & van Wijnen, A. J., Jan 1 2018, In : Journal of Biological Chemistry. 293, 33, p. 12894-12907 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Focusing on the Science: JBMR Manuscript Types

Civitelli, R., Westendorf, J. J., Hofbauer, L. & Rivadeneira, F., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity

McGee-Lawrence, M. E., Pierce, J. L., Yu, K., Culpepper, N. R., Bradley, E. & Westendorf, J. J., Apr 1 2018, In : Journal of Cellular Physiology. 233, 4, p. 2671-2680 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development

Camilleri, E. T., Dudakovic, A., Riester, S. M., Galeano-Garces, C., Paradise, C. R., Bradley, E., McGee-Lawrence, M. E., Im, H. J., Karperien, M., Krych, A., Westendorf, J. J., Noelle Larson, A. & van Wijnen, A. J., Jan 1 2018, In : Journal of Biological Chemistry. 293, 49, p. 19001-19011 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Osteoblasts: Function, development, and regulation

Bradley, E., Westendorf, J. J., van Wijnen, A. J. & Dudakovic, A., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 31-37 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis

Hwang, S. M., Feigenson, M., Begun, D. L., Shull, L. C., Culley, K. L., Otero, M., Goldring, M. B., Ta, L. E., Kakar, S., Bradley, E. W. & Westendorf, J. J., May 2018, In : Journal of Orthopaedic Research. 36, 5, p. 1487-1497 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

PTEN loss promotes intratumoral androgen synthesis and tumor microenvironment remodeling via aberrant activation of RUNX2 in castration-Resistant prostate cancer

Yang, Y., Bai, Y., He, Y., Zhao, Y., Chen, J., Ma, L., Pan, Y., Hinten, M., Zhang, J., Karnes, R. J., Kohli, M., Westendorf, J. J., Li, B., Zhu, R., Huang, H. & Xu, W., Feb 15 2018, In : Clinical Cancer Research. 24, 4, p. 834-846 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

The Deletion of Hdac4 in Mouse Osteoblasts Influences Both Catabolic and Anabolic Effects in Bone

Nakatani, T., Chen, T., Johnson, J., Westendorf, J. J. & Partridge, N. C., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

2 Scopus citations

Tissue-nonspecific alkaline phosphatase is required for MC3T3 osteoblast-mediated protection of acute myeloid leukemia cells from apoptosis

Sterner, R. M., Kremer, K. N., Dudakovic, A., Westendorf, J. J., van Wijnen, A. J. & Hedin, K. E., Aug 1 2018, In : Journal of Immunology. 201, 3, p. 1086-1096 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Histone Deacetylase 3 Deletion in Mesenchymal Progenitor Cells Hinders Long Bone Development

Feigenson, M., Shull, L. C., Taylor, E. L., Camilleri, E. T., Riester, S. M., van Wijnen, A. J., Bradley, E. & Westendorf, J. J., Dec 1 2017, In : Journal of Bone and Mineral Research. 32, 12, p. 2453-2465 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Histone deacetylase inhibitors reduce differentiating osteoblastmediated protection of acute myeloid leukemia cells from cytarabine

Sterner, R. M., Kremer, K. N., Al-Kali, A., Patnaik, M. M., Gangat, N., Litzow, M. R., Kaufmann, S. H., Westendorf, J. J., van Wijnen, A. J. & Hedin, K. E., Nov 1 2017, In : Oncotarget. 8, 55, p. 94569-94579 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Parallels between skeletal muscle and bone aging

LeBrasseur, N. K. & Westendorf, J. J., Jun 6 2017, Non-Pharmacological Management of Osteoporosis: Exercise, Nutrition, Fall and Fracture Prevention. Springer International Publishing, p. 45-52 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing

Dudakovic, A., Gluscevic, M., Paradise, C. R., Dudakovic, H., Khani, F., Thaler, R., Ahmed, F. S., Li, X., Dietz, A. B., Stein, G. S., Montecino, M. A., Deyle, D. R., Westendorf, J. J. & van Wijnen, A. J., Apr 20 2017, In : Gene. 609, p. 28-37 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

Xu, M., Bradley, E., Weivoda, M., Hwang, S. M., Pirtskhalava, T., Decklever, T., Curran, G. L., Ogrodnik, M., Jurk, D., Johnson, K. O., Lowe, V., Tchkonia, T., Westendorf, J. J. & Kirkland, J. L., Jun 1 2017, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 72, 6, p. 780-785 6 p.

Research output: Contribution to journalArticle

68 Scopus citations
2016

Enhancer of zeste homolog 2 inhibition stimulates bone formation and mitigates bone loss caused by ovariectomy in skeletally mature mice

Dudakovic, A., Camilleri, E. T., Riester, S. M., Paradise, C. R., Gluscevic, M., O'Toole, T. M., Thaler, R., Evans, J. M., Yan, H. D., Subramaniam, M., Hawse, J. R., Stein, G. S., Montecino, M. A., McGee-Lawrence, M. E., Westendorf, J. J. & van Wijnen, A. J., Nov 18 2016, In : Journal of Biological Chemistry. 291, 47, p. 24594-24606 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Fusion gene profile of biphenotypic sinonasal sarcoma: An analysis of 44 cases

Fritchie, K. J., Jin, L., Wang, X., Graham, R., Torbenson, M., Lewis, J. E., Rivera, M., Garcia, J. J., Schembri-Wismayer, D. J., Westendorf, J. J., Chou, M. M., Dong, J. & Oliveira, A. M., 2016, (Accepted/In press) In : Histopathology.

Research output: Contribution to journalArticle

26 Scopus citations

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

Carpio, L. R., Bradley, E., McGee-Lawrence, M. E., Weivoda, M., Poston, D. D., Dudakovic, A., Xu, M., Tchkonia, T., Kirkland, J. L., van Wijnen, A. J., Oursler, M. J. & Westendorf, J. J., Aug 9 2016, In : Science Signaling. 9, 440, ra79.

Research output: Contribution to journalArticle

23 Scopus citations

Histone deacetylase 3 suppresses Erk phosphorylation and matrix metalloproteinase (Mmp)-13 activity in chondrocytes

Carpio, L. R., Bradley, E. & Westendorf, J. J., Nov 5 2016, (Accepted/In press) In : Connective Tissue Research. p. 1-10 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Histone Deacetylases in Cartilage Homeostasis and Osteoarthritis

Carpio, L. R. & Westendorf, J. J., Aug 1 2016, In : Current Rheumatology Reports. 18, 8, 52.

Research output: Contribution to journalReview article

15 Scopus citations

PPP6R3-USP6 amplification: Novel oncogenic mechanism in malignant nodular fasciitis

Guo, R., Wang, X., Chou, M. M., Asmann, Y., Wenger, D. E., Al-Ibraheemi, A., Molavi, D. W., Aboulafia, A., Jin, L., Fritchie, K., Oliveira, J., Jenkins, R. B., Westendorf, J. J., Dong, J. & Oliveira, A. M., Aug 1 2016, In : Genes Chromosomes and Cancer. 55, 8, p. 640-649 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

RNA-seq analysis of clinical-grade osteochondral allografts reveals activation of early response genes

Lin, Y., Lewallen, E. A., Camilleri, E. T., Bonin, C. A., Jones, D. L., Dudakovic, A., Galeano-Garces, C., Wang, W., Karperien, M. J., Larson, A. N., Dahm, D. L., Stuart, M. J., Levy, B. A., Smith, J., Ryssman, D. B., Westendorf, J. J., Im, H. J., van Wijnen, A. J., Riester, S. M. & Krych, A., 2016, (Accepted/In press) In : Journal of Orthopaedic Research.

Research output: Contribution to journalArticle

16 Scopus citations

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

Fang, D., Gan, H., Lee, J. H., Han, J., Wang, Z., Riester, S. M., Jin, L., Chen, J., Zhou, H., Wang, J., Zhang, H., Yang, N., Bradley, E., Ho, T. H., Rubin, B. P., Bridge, J. A., Thibodeau, S. N., Ordog, T., Chen, Y., van Wijnen, A. J. & 4 others, Oliveira, A. M., Xu, R. M., Westendorf, J. J. & Zhang, Z., Jun 10 2016, In : Science. 352, 6291, p. 1344-1348 5 p.

Research output: Contribution to journalArticle

80 Scopus citations

The synovial microenvironment of osteoarthritic joints alters RNA-seq expression profiles of human primary articular chondrocytes

Lewallen, E. A., Bonin, C. A., Li, X., Smith, J., Karperien, M., Larson, A. N., Lewallen, D. G., Cool, S. M., Westendorf, J. J., Krych, A., Leontovich, A. A., Im, H. J. & van Wijnen, A. J., Jun 27 2016, (Accepted/In press) In : Gene.

Research output: Contribution to journalArticle

8 Scopus citations

USP6 genetic rearrangements in cellular fibroma of tendon sheath

Carter, J., Wang, X., Dong, J., Westendorf, J. J., Chou, M. M. & Oliveira, A. M., Apr 29 2016, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

17 Scopus citations
2015
7 Scopus citations

Biological strategies for improved osseointegration and osteoinduction of porous metal orthopedic implants

Lewallen, E. A., Riester, S. M., Bonin, C. A., Maradit Kremers, H. D., Dudakovic, A., Kakar, S., Cohen, R. C., Westendorf, J. J., Lewallen, D. G. & van Wijnen, A. J., Apr 1 2015, In : Tissue Engineering - Part B: Reviews. 21, 2, p. 218-230 13 p.

Research output: Contribution to journalArticle

56 Scopus citations

Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease

Gordon, J. A. R., Stein, J. L., Westendorf, J. J. & van Wijnen, A. J., Jan 13 2015, In : Bone. 81

Research output: Contribution to journalArticle

31 Scopus citations

Conditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction

McGee-Lawrence, M. E., White, T. A., LeBrasseur, N. K. & Westendorf, J. J., Jul 5 2015, In : Molecular and Cellular Endocrinology. 410, p. 42-51 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Deletion of Estrogen Receptor Beta in Osteoprogenitor Cells Increases Trabecular but Not Cortical Bone Mass in Female Mice

Nicks, K. M., Fujita, K., Fraser, D., Mcgregor, U., Drake, M. M., Mcgee-Lawrence, M. E., Westendorf, J. J., Monroe, D. G. & Khosla, S., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

16 Scopus citations

Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3

Ryan, Z. C., Craig, T. A., Filoteo, A. G., Westendorf, J. J., Cartwright, E. J., Neyses, L., Strehler, E. E. & Kumar, R., Nov 6 2015, In : Biochemical and Biophysical Research Communications. 467, 1, p. 152-156 5 p.

Research output: Contribution to journalArticle

22 Scopus citations
18 Scopus citations

Epigenetic control of skeletal development by the histone methyltransferase Ezh2

Dudakovic, A., Camilleri, E. T., Xu, F., Riester, S. M., McGee-Lawrence, M. E., Bradley, E., Paradise, C. R., Lewallen, E. A., Thaler, R., Deyle, D. R., Larson, A. N., Lewallen, D. G., Dietz, A. B., Stein, G. S., Montecino, M. A., Westendorf, J. J. & van Wijnen, A. J., Nov 13 2015, In : Journal of Biological Chemistry. 290, 46, p. 27604-27617 14 p.

Research output: Contribution to journalArticle

58 Scopus citations

Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells

McGee-Lawrence, M. E., Carpio, L. R., Schulze, R. J., Pierce, J. L., Mc Niven, M. A., Farr, J., Khosla, S., Oursler, M. J. & Westendorf, J. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

27 Scopus citations

Histone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and β-catenin activity during endochondral ossification

Bradley, E. W., Carpio, L. R., Olson, E. N. & Westendorf, J. J., Jan 2 2015, In : Journal of Biological Chemistry. 290, 1, p. 118-126 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cells

Dudakovic, A., Camilleri, E. T., Lewallen, E. A., Mcgee-Lawrence, M. E., Riester, S. M., Kakar, S., Montecino, M., Stein, G. S., Ryoo, H. M., Dietz, A. B., Westendorf, J. J. & Van Wijnen, A. J., Jan 1 2015, In : Journal of Cellular Physiology. 230, 1, p. 52-62 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Histone deacetylase inhibitors target the leukemic microenvironment by enhancing a Nherf1-protein phosphatase 1α-TAZ signaling pathway in osteoblasts

Kremer, K. N., Dudakovic, A., Hess, A. D., Smith, B. D., Karp, J. E., Kaufmann, S. H., Westendorf, J. J., van Wijnen, A. J. & Hedin, K. E., Dec 4 2015, In : Journal of Biological Chemistry. 290, 49, p. 29478-29492 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Histone deacetylases in bone development and skeletal disorders

Bradley, E., Carpio, L. R., van Wijnen, A. J., McGee-Lawrence, M. E. & Westendorf, J. J., Sep 9 2015, In : Physiological Reviews. 95, 4, p. 1359-1381 23 p.

Research output: Contribution to journalArticle

48 Scopus citations

Identification of differentially methylated regions in new genes associated with knee osteoarthritis

Bonin, C. A., Lewallen, E. A., Baheti, S., Bradley, E., Stuart, M. J., Berry, D. J., van Wijnen, A. J. & Westendorf, J. J., Sep 22 2015, (Accepted/In press) In : Gene.

Research output: Contribution to journalArticle

17 Scopus citations

Ligament Tissue Engineering Using a Novel Porous Polycaprolactone Fumarate Scaffold and Adipose Tissue-Derived Mesenchymal Stem Cells Grown in Platelet Lysate

Wagner, E. R., Bravo, D., Dadsetan, M., Riester, S. M., Chase, S., Westendorf, J. J., Dietz, A. B., van Wijnen, A. J., Yaszemski, M. J. & Kakar, S., Nov 1 2015, In : Tissue Engineering - Part A. 21, 21-22, p. 2703-2713 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation

Weivoda, M., Ruan, M., Pederson, L., Hachfeld, C., Davey, R. A., Zajac, J. D., Westendorf, J. J., Khosla, S. & Oursler, M. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

26 Scopus citations

Osteoporosis and osteoarthritis. Preface

van Wijnen, A. J. & Westendorf, J. J., 2015, In : Methods in molecular biology (Clifton, N.J.). 1226, p. v

Research output: Contribution to journalArticle

1 Scopus citations