• 12912 Citations
  • 50 Scopus h-Index
1980 …2021
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Research Output 1993 2019

  • 12912 Citations
  • 50 Scopus h-Index
  • 186 Article
  • 4 Review article
  • 1 Comment/debate
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Article
2008
214 Citations (Scopus)

Mechanisms of chemoresistance to alkylating agents in malignant glioma

Sarkaria, J. N., Kitange, G. J., James, C. D., Plummer, R., Calvert, H., Weller, M. & Wick, W., May 15 2008, In : Clinical Cancer Research. 14, 10, p. 2900-2908 9 p.

Research output: Contribution to journalArticle

Alkylating Agents
Glioma
DNA Repair
DNA Mismatch Repair
DNA Adducts
27 Citations (Scopus)

Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells

Yu, C., Friday, B. B., Yang, L., Atadja, P., Wigle, D. A., Sarkaria, J. N. & Adjei, A., Jun 2008, In : Neuro-Oncology. 10, 3, p. 309-319 11 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Histone Deacetylase Inhibitors
Glioma
Glioblastoma
Apoptosis
6 Citations (Scopus)

Overview of cancer molecular radiobiology.

Sarkaria, J. N. & Bristow, R. G., 2008, In : Cancer Treatment and Research. 139, p. 117-133 17 p.

Research output: Contribution to journalArticle

Radiation-Sensitizing Agents
Radiobiology
Radiation Tolerance
Ionizing Radiation
Neoplasms
30 Citations (Scopus)

p53 small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts

Dinca, E. B., Lu, K. V., Sarkaria, J. N., Pieper, R. O., Prados, M. D., Haas-Kogan, D. A., VandenBerg, S. R., Berger, M. S. & James, C. D., Dec 15 2008, In : Cancer Research. 68, 24, p. 10034-10039 6 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Heterografts
Poly(ADP-ribose) Polymerases
Survival Analysis
184 Citations (Scopus)

Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North central cancer treatment group study N0177

Brown, P. D., Krishnan, S., Sarkaria, J. N., Wu, W., Jaeckle, K. A., Uhm, J. H., Geoffroy, F. J., Arusell, R., Kitange, G., Jenkins, R. B., Kugler, J. W., Morton, R. F., Rowland, K. M., Mischel, P., Yong, W. H., Scheithauer, B. W., Schiff, D., Giannini, C. & Buckner, J. C., Dec 1 2008, In : Journal of Clinical Oncology. 26, 34, p. 5603-5609 7 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Radiotherapy
Epidermal Growth Factor Receptor
Neoplasms
44 Citations (Scopus)

PTEN loss does not predict for response to RAD001 (everolimus) in a glioblastoma orthotopic xenograft test panel

Yang, L., Clarke, M. J., Carlson, B. L., Mladek, A. C., Schroeder, M. A., Decker, P., Wu, W., Kitange, G., Grogan, P., Goble, J. M., Uhm, J., Galanis, E., Giannini, C., Lane, H. A., James, C. D. & Sarkaria, J. N., Jun 15 2008, In : Clinical Cancer Research. 14, 12, p. 3993-4001 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
Sirolimus
Neoplasms
Sequence Deletion
21 Citations (Scopus)

Using fluorodeoxythymidine to monitor anti-egfr inhibitor therapy in squamous cell carcinoma xenografts

Atkinson, D. M., Clarke, M. J., Mladek, A. C., Carlson, B. L., Trump, D. P., Jacobson, M. S., Kemp, B. J., Lowe, V. & Sarkaria, J. N., Jun 2008, In : Head and Neck. 30, 6, p. 790-799 10 p.

Research output: Contribution to journalArticle

Heterografts
Squamous Cell Carcinoma
Epidermal Growth Factor Receptor
Positron-Emission Tomography
Placebos
2007
64 Citations (Scopus)

Bioluminescence monitoring of intracranial glioblastoma xenograft: Response to primary and salvage temozolomide therapy

Dinca, E. B., Sarkaria, J. N., Schroeder, M. A., Carlson, B. L., Voicu, R., Gupta, N., Berger, M. S. & James, C. D., Sep 2007, In : Journal of Neurosurgery. 107, 3, p. 610-616 7 p.

Research output: Contribution to journalArticle

temozolomide
Salvage Therapy
Glioblastoma
Heterografts
Therapeutics
60 Citations (Scopus)

Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme

Liu, C., Sarkaria, J. N., Petell, C. A., Paraskevakou, G., Zollman, P. J., Schroeder, M., Carlson, B., Decker, P. A., Wu, W., James, C. D., Russell, S. J. & Galanis, E., Dec 1 2007, In : Clinical Cancer Research. 13, 23, p. 7155-7165 11 p.

Research output: Contribution to journalArticle

Measles virus
Glioblastoma
Radiotherapy
Glioma
Caspase Inhibitors
139 Citations (Scopus)

Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

Sarkaria, J. N., Yang, L., Grogan, P. T., Kitange, G. J., Carlson, B. L., Schroeder, M. A., Galanis, E., Giannini, C., Wu, W., Dinca, E. B. & James, C. D., Mar 2007, In : Molecular Cancer Therapeutics. 6, 3, p. 1167-1174 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Epidermal Growth Factor Receptor
Heterografts
Neoplasms
Complementary DNA
33 Citations (Scopus)

Phase I trial of sirolimus combined with radiation and cisplatin in non-small cell lung cancer

Sarkaria, J. N., Schwingler, P., Schild, S. E., Grogan, P. T., Mladek, A. C., Mandrekar, S. J., Tan, A. D., Kobayashi, T., Marks, R. S., Kita, H., Miller, R. C., Limper, A. H. & Leof, E. B., Aug 2007, In : Journal of Thoracic Oncology. 2, 8, p. 751-757 7 p.

Research output: Contribution to journalArticle

Sirolimus
Non-Small Cell Lung Carcinoma
Cisplatin
Radiation
Thorax
2006
89 Citations (Scopus)
Proteasome Inhibitors
JNK Mitogen-Activated Protein Kinases
Apoptosis
Tumor Cell Line
Glioma
174 Citations (Scopus)

Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response

Sarkaria, J. N., Carlson, B. L., Schroeder, M. A., Grogan, P., Brown, P. D., Giannini, C., Ballman, K. V., Kitange, C. J., Guha, A., Pandita, A. & James, C. D., Apr 1 2006, In : Clinical Cancer Research. 12, 7 I, p. 2264-2271 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Epidermal Growth Factor Receptor
Heterografts
Radiation
Neoplasms
2005
86 Citations (Scopus)

Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells

Rao, R. D., Mladek, A. C., Lamont, J. D., Goble, J. M., Erlichman, C., James, C. D. & Sarkaria, J. N., Oct 2005, In : Neoplasia. 7, 10, p. 921-929 9 p.

Research output: Contribution to journalArticle

Sirolimus
Glioblastoma
Epidermal Growth Factor Receptor
Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
238 Citations (Scopus)

Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme

Giannini, C., Sarkaria, J. N., Saito, A., Uhm, J. H., Galanis, E., Carlson, B. L., Schroeder, M. A. & James, C. D., Apr 2005, In : Neuro-Oncology. 7, 2, p. 164-176 13 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Gene Amplification
Glioblastoma
Heterografts
Neoplasms
2004
74 Citations (Scopus)

Mammalian target of rapamycin (mTOR) inhibitors as anti-cancer agents

Rao, R. D., Buckner, J. C. & Sarkaria, J. N., Dec 2004, In : Current Cancer Drug Targets. 4, 8, p. 621-635 15 p.

Research output: Contribution to journalArticle

Sirolimus
Neoplasms
Neoplastic Processes
Protein-Serine-Threonine Kinases
Cytotoxins
2003
26 Citations (Scopus)

Combination of epidermal growth factor receptor targeted therapy with radiation therapy for malignant gliomas

Krishnan, S., Rao, R. D., James, C. D. & Sarkaria, J. N., 2003, In : Frontiers in Bioscience. 8

Research output: Contribution to journalArticle

Radiotherapy
Epidermal Growth Factor Receptor
Glioma
Tumors
Chemotherapy
26 Citations (Scopus)

Development of investigational radiation modifiers

Colevas, A. D., Brown, J. M., Hahn, S., Mitchell, J., Camphausen, K., Coleman, C. N., Conley, B., Cumberlin, R., Stone, H. B., Wong, R., Freidlin, B., Kobayashi, K., Murgo, A. J., Shoemaker, R., Tofilon, P. J., Choy, H., Dicker, A., Doroshow, J. H., Formenti, S. C., Garden, A. & 12 others, Gately, S., Hill, R., Kinsella, T. J., Moore, M., Sarkaria, J. N., Siemann, D., Sokol, G., Teicher, B. A., Trotti, A., Turrisi, A. T., Urtasun, R. & Vokes, E. E., May 7 2003, In : Journal of the National Cancer Institute. 95, 9, p. 646-651 6 p.

Research output: Contribution to journalArticle

Radiation
Appointments and Schedules
Maximum Tolerated Dose
Standard of Care
Clinical Trials
10 Citations (Scopus)

Identifying inhibitors of ATM and ATR kinase activities.

Sarkaria, J. N., 2003, In : Methods in molecular medicine. 85, p. 49-56 8 p.

Research output: Contribution to journalArticle

Neoplasm Proteins
Manganese Compounds
Precipitin Tests
Tumor Suppressor Proteins
Cell Cycle Proteins
2002
164 Citations (Scopus)

Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy

Eshleman, J. S., Carlson, B. L., Mladek, A. C., Kastner, B. D., Shide, K. L. & Sarkaria, J. N., Dec 15 2002, In : Cancer Research. 62, 24, p. 7291-7297 7 p.

Research output: Contribution to journalArticle

Sirolimus
Heterografts
Radiotherapy
Radiation
Glioblastoma
19 Citations (Scopus)

Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases

Peng, H., Kim, D. I., Sarkaria, J. N., Cho, Y. S., Abraham, R. T. & Zalkow, L. H., 2002, In : Bioorganic and Medicinal Chemistry. 10, 1, p. 167-174 8 p.

Research output: Contribution to journalArticle

Sirolimus
Phosphatidylinositol 3-Kinases
Ataxia Telangiectasia
Phosphotransferases
Derivatives
2001
41 Citations (Scopus)

ATM as a target for novel radiosensitizers

Sarkaria, J. N. & Eshleman, J. S., 2001, In : Seminars in Radiation Oncology. 11, 4, p. 316-327 12 p.

Research output: Contribution to journalArticle

ataxia
Ataxia Telangiectasia
caffeine
Ionizing Radiation
Caffeine
2000
301 Citations (Scopus)

The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

Busby, E. C., Leistritz, D. F., Abraham, R. T., Karnitz, L. M. & Sarkaria, J. N., Apr 15 2000, In : Cancer Research. 60, 8, p. 2108-2112 5 p.

Research output: Contribution to journalArticle

Radiation-Sensitizing Agents
DNA Damage
Phosphotransferases
Antineoplastic Agents
cdc25 Phosphatases
1999
789 Citations (Scopus)

A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S. Y., Taya, Y., Prives, C. & Abraham, R. T., Jan 15 1999, In : Genes and Development. 13, 2, p. 152-157 6 p.

Research output: Contribution to journalArticle

DNA Damage
Phosphorylation
DNA
Ultraviolet Rays
Up-Regulation
90 Citations (Scopus)
Brachytherapy
Uterine Cervical Neoplasms
tumors
cancer
Recurrence
873 Citations (Scopus)

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine

Sarkaria, J. N., Busby, E. C., Tibbetts, R. S., Roos, P., Taya, Y., Karnitz, L. M. & Abraham, R. T., Sep 1 1999, In : Cancer Research. 59, 17, p. 4375-4382 8 p.

Research output: Contribution to journalArticle

Radiation-Sensitizing Agents
Caffeine
Phosphotransferases
Ataxia Telangiectasia
DNA Damage
1998
23 Citations (Scopus)

Comparison between pulsed-field gel electrophoresis and the comet assay as predictive assays for radiosensitivity in fibroblasts

Sarkaria, J. N., Bush, C., Eady, J. J., Peacock, J. H., Steel, G. G. & Yarnold, J. R., Jul 1998, In : Radiation Research. 150, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

Comet Assay
Pulsed Field Gel Electrophoresis
Radiation Tolerance
fibroblasts
pulsed-field gel electrophoresis
486 Citations (Scopus)

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin

Sarkaria, J. N., Tibbetts, R. S., Busby, E. C., Kennedy, A. P., Hill, D. E. & Abraham, R. T., Oct 1 1998, In : Cancer Research. 58, 19, p. 4375-4382 8 p.

Research output: Contribution to journalArticle

Radiation-Sensitizing Agents
Ataxia Telangiectasia
1-Phosphatidylinositol 4-Kinase
DNA-Activated Protein Kinase
Phosphotransferases
30 Citations (Scopus)

Perioperative morbidity and mortality of high-dose-rate gynecologic brachytherapy

Petereit, D. G., Sarkaria, J. N. & Chappell, R. J., Dec 1 1998, In : International Journal of Radiation Oncology Biology Physics. 42, 5, p. 1025-1031 7 p.

Research output: Contribution to journalArticle

mortality
Brachytherapy
Morbidity
dosage
Mortality
1995
138 Citations (Scopus)

Radiosurgery in the initial management of malignant gliomas: Survival comparison with the RTOG recursive partitioning analysis

Sarkaria, J. N., Mehta, M. P., Loeffler, J. S., Buatti, J. M., Chappell, R. J., Levin, A. B., Alexander, E., Friedman, W. A. & Kinsella, T. J., Jul 15 1995, In : International Journal of Radiation Oncology, Biology, Physics. 32, 4, p. 931-941 11 p.

Research output: Contribution to journalArticle

Radiosurgery
Astrocytoma
Glioblastoma
Survival Analysis
Treatment Failure
191 Citations (Scopus)

The adverse effect of treatment prolongation in cervical carcinoma

Petereit, D. G., Sarkaria, J. N., Chappell, R., Fowler, J. F., Hartmann, T. J., Kinsella, T. J., Stitt, J. A., Thomadsen, B. R. & Buchler, D. A., Jul 30 1995, In : International Journal of Radiation Oncology, Biology, Physics. 32, 5, p. 1301-1307 7 p.

Research output: Contribution to journalArticle

prolongation
cancer
Carcinoma
Survival
Therapeutics
17 Citations (Scopus)

The decreased influence of overall treatment time on the response of human breast tumor xenografts following prolongation of the potential doubling time (Tpot)

Sarkaria, J. N., Fowler, J. F., Lindstrom, M. J., Jordan, V. C. & Mulcahy, R. T., Feb 15 1995, In : International Journal of Radiation Oncology, Biology, Physics. 31, 4, p. 833-840 8 p.

Research output: Contribution to journalArticle

prolongation
Heterografts
breast
tumors
Breast Neoplasms
1994
42 Citations (Scopus)

4-Hydroxytamoxifen, an active metabolite of tamoxifen, does not alter the radiation sensitivity of MCF-7 breast carcinoma cells irradiated in vitro

Sarkaria, J. N., Miller, E. M., Parker, C. J., Jordan, V. C. & Mulcahy, R. T., Jan 1994, In : Breast Cancer Research and Treatment. 30, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle

Radiation Tolerance
Tamoxifen
MCF-7 Cells
Breast Neoplasms
Estradiol
52 Citations (Scopus)

A comparison of the efficacy and complication rates of low dose-rate versus high dose-rate brachytherapy in the treatment of uterine cervical carcinoma

Sarkaria, J. N., Petereit, D. G., Stitt, J. A., Hartman, T., Chappell, R., Thomadsen, B. R., Buchler, D. A., Fowler, J. F. & Kinsella, T. J., Aug 30 1994, In : International Journal of Radiation Oncology, Biology, Physics. 30, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

Brachytherapy
cancer
Carcinoma
dosage
Therapeutics
146 Citations (Scopus)

Oral tongue cancer in young adults less than 40 years of age: Rationale for aggressive therapy

Sarkaria, J. N. & Harari, P. M., 1994, In : Head and Neck. 16, 2, p. 107-111 5 p.

Research output: Contribution to journalArticle

Tongue Neoplasms
Mouth Neoplasms
Young Adult
Tongue
Squamous Cell Carcinoma
1993
23 Citations (Scopus)

Tamoxifen-induced increase in the potential doubling time of MCF-7 xenografts as determined by bromodeoxyuridine labeling and flow cytometry

Sarkaria, J. N., Gibson, D. F. C., Jordan, V. C., Fowler, J. F., Lindstrom, M. J. & Mulcahy, R. T., 1993, In : Cancer Research. 53, 18, p. 4413-4417 5 p.

Research output: Contribution to journalArticle

Bromodeoxyuridine
Tamoxifen
Heterografts
Flow Cytometry
Neoplasms