• 14090 Citations
  • 53 Scopus h-Index
1980 …2021

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Article
2015

The efficacy of the wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood-brain barrier in glioblastoma

Pokorny, J. L., Calligaris, D., Gupta, S. K., Iyekegbe, D. O., Mueller, D., Bakken, K. K., Carlson, B. L., Schroeder, M. A., Evans, D. L., Lou, Z., Decker, P. A., Eckel-Passow, J. E., Pucci, V., Ma, B., Shumway, S. D., Elmquist, W. F., Agar, N. Y. R. & Sarkaria, J. N., Apr 15 2015, In : Clinical Cancer Research. 21, 8, p. 1916-1924 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody

Zhu, S., Kisiel, W., Lu, Y. J., Petersen, L. C., Ndungu, J. M., Moore, T. W., Parker, E. T., Sun, A., Sarkaria, J. N., Snyder, J. P., Liotta, D. C., Brat, D. J., El-Rayes, B. F. & Shoji, M., Apr 1 2015, In : Journal of Drug Targeting. 23, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2014

A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas

Kushwaha, D., Ramakrishnan, V., Ng, K., Steed, T., Nguyen, T., Futalan, D., Akers, J. C., Sarkaria, J., Jiang, T., Chowdhury, D., Carter, B. S. & Chen, C. C., 2014, In : Oncotarget. 5, 12, p. 4026-4039 14 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death

Shing, J. C., Choi, J. W., Chapman, R., Schroeder, M. A., Sarkaria, J. N., Fauq, A. & Bram, R. J., Jul 2014, In : Cancer Biology and Therapy. 15, 7, p. 895-905 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

BET bromodomain proteins are required for glioblastoma cell proliferation

Pastori, C., Daniel, M., Penas, C., Volmar, C. H., Johnstone, A. L., Brothers, S. P., Graham, R. M., Allen, B., Sarkaria, J. N., Komotar, R. J., Wahlestedt, C. & Ayad, N. G., Feb 19 2014, In : Epigenetics. 9, 4, p. 611-620 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Cyclophilin B supports MYC and mutant p53-dependent survival of glioblastoma multiforme cells

Choi, J. W., Schroeder, M. A., Sarkaria, J. N. & Bram, R. J., Jan 15 2014, In : Cancer research. 74, 2, p. 484-496 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Design and characterization of an economical 192Ir hemi-brain small animal irradiator

Grams, M. P., Wilson, Z. C., Sio, T. T., Beltran, C. J., Tryggestad, E. J., Gupta, S. K., Blackwell, C. R., McCollough, K. P., Sarkaria, J. N. & Furutani, K. M., Oct 1 2014, In : International Journal of Radiation Biology. 90, 10, p. 936-942 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Discordant in vitro and in vivo chemopotentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts

Gupta, S. K., Mladek, A. C., Carlson, B. L., Boakye-Agyeman, F., Bakken, K. K., Kizilbash, S. H., Schroeder, M. A., Reid, J. & Sarkaria, J. N., Jul 15 2014, In : Clinical Cancer Research. 20, 14, p. 3730-3741 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180

Feng, H., Hu, B., Vuori, K., Sarkaria, J. N., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., May 8 2014, In : Oncogene. 33, 19, p. 2504-2512 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Factors influencing the CNS distribution of a novel MEK-1/2 inhibitor: Implications for combination therapy for melanoma brain metastases

Vaidhyanathan, S., Mittapalli, R. K., Sarkaria, J. N. & Elmquist, W. F., Aug 2014, In : Drug Metabolism and Disposition. 42, 8, p. 1292-1300 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

NT113, A pan-ERBB inhibitor with high brain penetrance, inhibits the growth of glioblastoma xenografts with EGFR amplification

Yoshida, Y., Ozawa, T., Yao, T. W., Shen, W., Brown, D., Parsa, A. T., Raizer, J. J., Cheng, S. Y., Stegh, A. H., Mazar, A. P., Giles, F. J., Sarkaria, J. N., Butowski, N., Nicolaides, T. & James, C. D., Dec 1 2014, In : Molecular cancer therapeutics. 13, 12, p. 2919-2929 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
37 Scopus citations
13 Scopus citations

Tumorgrafts as in vivo surrogates for women with ovarian cancer

Weroha, S. J., Becker, M. A., Enderica-Gonzalez, S., Harrington, S. C., Oberg, A. L., Maurer, M. J., Perkins, S. E., AlHilli, M., Butler, K. A., McKinstry, S., Fink, S., Jenkins, R. B., Hou, X., Kalli, K. R., Goodman, K. M., Sarkaria, J. N., Karlan, B. Y., Kumar, A., Kaufmann, S. H., Hartmann, L. C. & 1 others, Haluska, P., Jan 1 2014, In : Clinical Cancer Research. 20, 5, p. 1288-1297 10 p.

Research output: Contribution to journalArticle

91 Scopus citations
2013

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

Flavahan, W. A., Wu, Q., Hitomi, M., Rahim, N., Kim, Y., Sloan, A. E., Weil, R. J., Nakano, I., Sarkaria, J. N., Stringer, B. W., Day, B. W., Li, M., Lathia, J. D., Rich, J. N. & Hjelmeland, A. B., Oct 1 2013, In : Nature Neuroscience. 16, 10, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

210 Scopus citations

Brain tumor stem cell multipotency correlates with nanog expression and extent of passaging in human glioblastoma xenografts

Higgins, D. M., Wang, R., Milligan, B., Schroeder, M., Carlson, B., Pokorny, J., Cheshier, S. H., Meyer, F. B., Weissman, I. L., Sarkaria, J. N. & Henley, J. R., May 2013, In : Oncotarget. 4, 5, p. 792-801 10 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models

Cen, L., Carlson, B. L., Pokorny, J. L., Mladek, A. C., Grogan, P. T., Schroeder, M. A., Decker, P. A., Anderson, S. K., Giannini, C., Wu, W., Ballman, K. V., Kitange, G. J. & Sarkaria, J. N., Jun 1 2013, In : Neuro-oncology. 15, 6, p. 735-746 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Impairment of glioma stem cell survival and growth by a novel inhibitor for survivin-ran protein complex

Guvenc, H., Pavlyukov, M. S., Joshi, K., Kurt, H., Banasavadi-Siddegowda, Y. K., Mao, P., Hong, C., Yamada, R., Kwon, C. H., Bhasin, D., Chettiar, S., Kitange, G., Park, I. H., Sarkaria, J. N., Li, C., Shakhparonov, M. I. & Nakano, I., Feb 1 2013, In : Clinical Cancer Research. 19, 3, p. 631-642 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

Increased bowel toxicity in patients treated with a vascular endothelial growth factor inhibitor (VEGFI) after stereotactic body radiation therapy (SBRT)

Barney, B. M., Markovic, S. N., Laack, N. N., Miller, R. C., Sarkaria, J. N., Macdonald, O. K., Bauer, H. J. & Olivier, K. R., Sep 1 2013, In : International Journal of Radiation Oncology Biology Physics. 87, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Oncolytic measles virus strains have significant antitumor activity against glioma stem cells

Allen, C., Opyrchal, M., Aderca, I., Schroeder, M. A., Sarkaria, J. N., Domingo, E., Federspiel, M. J. & Galanis, E., Apr 1 2013, In : Gene Therapy. 20, 4, p. 444-449 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

P53 isoform profiling in glioblastoma and injured brain

Takahashi, R., Giannini, C., Sarkaria, J. N., Schroeder, M., Rogers, J., Mastroeni, D. & Scrable, H., Jun 27 2013, In : Oncogene. 32, 26, p. 3165-3174 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Posttranscriptional regulation of per1 underlies the oncogenic function of IREα

Pluquet, O., Dejeans, N., Bouchecareilh, M., Lhomond, S., Pineau, R., Higa, A., Delugin, M., Combe, C., Loriot, S., Cubel, G., Dugot-Senant, N., Vital, A., Loiseau, H., Gosline, S. J. C., Taouji, S., Hallett, M., Sarkaria, J. N., Anderson, K., Wu, W., Rodriguez, F. J. & 4 others, Rosenbaum, J., Saltel, F., Fernandez-Zapico, M. E. & Chevet, E., Aug 1 2013, In : Cancer research. 73, 15, p. 4732-4743 12 p.

Research output: Contribution to journalArticle

72 Scopus citations

Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion

Huveldt, D., Lewis-Tuffin, L. J., Carlson, B. L., Schroeder, M. A., Rodriguez, F., Giannini, C., Galanis, E., Sarkaria, J. N. & Anastasiadis, P. Z., Feb 14 2013, In : PloS one. 8, 2, e56505.

Research output: Contribution to journalArticle

50 Scopus citations

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

Chan, K. M., Fang, D., Gan, H., Hashizume, R., Yu, C., Schroeder, M., Gupta, N., Mueller, S., David James, C., Jenkins, R., Sarkaria, J. & Zhang, Z., May 1 2013, In : Genes and Development. 27, 9, p. 985-990 6 p.

Research output: Contribution to journalArticle

320 Scopus citations

The role of LAT1 in 18F-DOPA uptake in malignant gliomas

Youland, R. S., Kitange, G. J., Peterson, T. E., Pafundi, D. H., Ramiscal, J. A., Pokorny, J. L., Giannini, C., Laack, N. N., Parney, I. F., Lowe, V. J., Brinkmann, D. H. & Sarkaria, J. N., Jan 1 2013, In : Journal of neuro-oncology. 111, 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

62 Scopus citations
2012

Active efflux of dasatinib from the brain limits efficacy against murine glioblastoma: Broad implications for the clinical use of molecularly targeted agents

Agarwal, S., Mittapalli, R. K., Zellmer, D. M., Gallardo, J. L., Donelson, R., Seiler, C., Decker, S. A., SantaCruz, K. S., Pokorny, J. L., Sarkaria, J. N., Elmquist, W. F. & Ohlfest, J. R., Oct 1 2012, In : Molecular cancer therapeutics. 11, 10, p. 2183-2192 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Alkylpurine - DNA - N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

Agnihotri, S., Gajadhar, A. S., Ternamian, C., Gorlia, T., Diefes, K. L., Mischel, P. S., Kelly, J., McGown, G., Thorncroft, M., Carlson, B. L., Sarkaria, J. N., Margison, G. P., Aldape, K., Hawkins, C., Hegi, M. & Guha, A., Jan 3 2012, In : Journal of Clinical Investigation. 122, 1, p. 253-266 14 p.

Research output: Contribution to journalArticle

82 Scopus citations

ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells

Nadkarni, A., Shrivastav, M., Mladek, A. C., Schwingler, P. M., Grogan, P. T., Chen, J. & Sarkaria, J. N., Dec 1 2012, In : Journal of neuro-oncology. 110, 3, p. 349-357 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts

Kitange, G. J., Mladek, A. C., Carlson, B. L., Schroeder, M. A., Pokorny, J. L., Cen, L., Decker, P. A., Wu, W., Lomberk, G. A., Gupta, S. K., Urrutia, R. A. & Sarkaria, J. N., Aug 1 2012, In : Clinical Cancer Research. 18, 15, p. 4070-4079 10 p.

Research output: Contribution to journalArticle

72 Scopus citations

Molecular characterization of EGFR and EGFRvIII signaling networks in human glioblastoma tumor xenografts

Johnson, H., Del Rosario, A. M., Bryson, B. D., Schroeder, M. A., Sarkaria, J. N. & White, F. M., Dec 1 2012, In : Molecular and Cellular Proteomics. 11, 12, p. 1724-1740 17 p.

Research output: Contribution to journalArticle

59 Scopus citations

P16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells

Cen, L., Carlson, B. L., Schroeder, M. A., Ostrem, J. L., Kitange, G. J., Mladek, A. C., Fink, S. R., Decker, P. A., Wu, W., Kim, J. S., Waldman, T., Jenkins, R. B. & Sarkaria, J. N., Jul 1 2012, In : Neuro-oncology. 14, 7, p. 870-881 12 p.

Research output: Contribution to journalArticle

92 Scopus citations

Phase i study of temsirolimus in combination with EKB-569 in patients with advanced solid tumors

Bryce, A. H., Rao, R., Sarkaria, J., Reid, J. M., Qi, Y., Qin, R., James, C. D., Jenkins, R. B., Boni, J., Erlichman, C. & Haluska, P., Oct 1 2012, In : Investigational New Drugs. 30, 5, p. 1934-1941 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

Feng, H., Hu, B., Jarzynka, M. J., Li, Y., Keezer, S., Johns, T. G., Tang, C. K., Hamilton, R. L., Vuori, K., Nishikawa, R., Sarkaria, J. N., Fenton, T., Cheng, T., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 3018-3023 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Targeting the PI3K pathway in the brain - Efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier

Salphati, L., Heffron, T. P., Alicke, B., Nishimura, M., Barck, K., Carano, R. A., Cheong, J., Edgar, K. A., Greve, J., Kharbanda, S., Koeppen, H., Lau, S., Lee, L. B., Pang, J., Plise, E. G., Pokorny, J. L., Reslan, H. B., Sarkaria, J. N., Wallin, J. J., Zhang, X. & 3 others, Gould, S. E., Olivero, A. G. & Phillips, H. S., Nov 15 2012, In : Clinical Cancer Research. 18, 22, p. 6239-6248 10 p.

Research output: Contribution to journalArticle

48 Scopus citations
2011

Activation of Rac1 by Src-dependent phosphorylation of Dock180 Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

Feng, H., Hu, B., Liu, K. W., Li, Y., Lu, X., Cheng, T., Yiin, J. J., Lu, S., Keezer, S., Fenton, T., Furnari, F. B., Hamilton, R. L., Vuori, K., Sarkaria, J. N., Nagane, M., Nishikawa, R., Cavenee, W. K. & Cheng, S. Y., Dec 1 2011, In : Journal of Clinical Investigation. 121, 12, p. 4670-4684 15 p.

Research output: Contribution to journalArticle

79 Scopus citations

A phase 2 study of temsirolimus (CCI-779) in patients with soft tissue sarcomas: A study of the mayo phase 2 Consortium (P2C)

Okuno, S., Bailey, H., Mahoney, M. R., Adkins, D., Maples, W., Fitch, T., Ettinger, D., Erlichman, C. & Sarkaria, J. N., Aug 1 2011, In : Cancer. 117, 15, p. 3468-3475 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Effective radiovirotherapy for malignant gliomas by using oncolytic measles virus strains encoding the sodium iodide symporter (MV-NIS)

Opyrchal, M., Allen, C., Iankov, I., Aderca, I., Schroeder, M., Sarkaria, J. & Galanis, E., Dec 20 2011, In : Human gene therapy. 23, 4, p. 419-427 9 p.

Research output: Contribution to journalArticle

27 Scopus citations
79 Scopus citations

Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines

Peasland, A., Wang, L. Z., Rowling, E., Kyle, S., Chen, T., Hopkins, A., Cliby, W. A., Sarkaria, J., Beale, G., Edmondson, R. J. & Curtin, N. J., Jul 26 2011, In : British journal of cancer. 105, 3, p. 372-381 10 p.

Research output: Contribution to journalArticle

118 Scopus citations

Incorporation of biomarker assessment in novel clinical trial designs: Personalizing brain tumor treatments

Galanis, E., Wu, W., Sarkaria, J., Chang, S. M., Colman, H., Sargent, D. & Reardon, D. A., Feb 1 2011, In : Current oncology reports. 13, 1, p. 42-49 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
288 Scopus citations
57 Scopus citations

Phenotypic variations in NF1-associated low grade astrocytomas: Possible role for increased mTOR activation in a subset

Jentoft, M., Giannini, C., Cen, L., Scheithauer, B. W., Hoesley, B., Sarkaria, J. N., Abell-Aleff, P. C., Rodriguez, E. F., Li, Y. & Rodriguez, F. J., Nov 2 2011, In : International Journal of Clinical and Experimental Pathology. 4, 1, p. 43-57 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Phenotypic variations in NF1-associated low grade astrocytomas: Possible role for increased mTOR activation in a subset

Jentoft, M., Giannini, C., Cen, L., Scheithauer, B. W., Hoesley, B., Sarkaria, J. N., Abell-Aleff, P. C., Rodriguez, E. F., Li, Y. & Rodriguez, F. J., 2011, In : International Journal of Clinical and Experimental Pathology. 4, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma

Rodriguez, E. F., Scheithauer, B. W., Giannini, C., Rynearson, A., Cen, L., Hoesley, B., Gilmer-Flynn, H., Sarkaria, J. N., Jenkins, S., Long, J. & Rodriguez, F. J., Mar 1 2011, In : Acta neuropathologica. 121, 3, p. 407-420 14 p.

Research output: Contribution to journalArticle

93 Scopus citations

WE‐G‐214‐02: Utility of 18F‐FDOPA PET for Radiotherapy Target Delineation in Glioma Patients

Pafundi, D., Brinkmann, D. H., Laack, N. N., Sarkaria, J. N., Yan, E., Kemp, B. & Lowe, V., 2011, In : Medical Physics. 38, 6, p. 3830 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

WWP2 is an E3 ubiquitin ligase for PTEN

Maddika, S., Kavela, S., Rani, N., Palicharla, V. R., Pokorny, J. L., Sarkaria, J. N. & Chen, J., Jun 1 2011, In : Nature Cell Biology. 13, 6, p. 728-733 6 p.

Research output: Contribution to journalArticle

162 Scopus citations
2010

Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain

Oliva, C. R., Nozell, S. E., Diers, A., McClugage, S. G., Sarkaria, J. N., Markert, J. M., Darley-Usmar, V. M., Bailey, S. M., Gillespie, G. Y., Landar, A. & Griguer, C. E., Dec 17 2010, In : Journal of Biological Chemistry. 285, 51, p. 39759-39767 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth

Guessous, F., Zhang, F., DiPierro, C., Marcinkiewicz, L., Sarkaria, J., Schiff, D., Buchanan, S. & Abounader, R., Jan 2010, In : Anti-Cancer Agents in Medicinal Chemistry. 10, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

44 Scopus citations
55 Scopus citations