• 14230 Citations
  • 54 Scopus h-Index
1993 …2020

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Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells

Rao, R. D., Mladek, A. C., Lamont, J. D., Goble, J. M., Erlichman, C., James, C. D. & Sarkaria, J. N., Oct 2005, In : Neoplasia. 7, 10, p. 921-929 9 p.

Research output: Contribution to journalArticle

88 Scopus citations

Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

Zhou, D., Alver, B. M., Li, S., Hlady, R. A., Thompson, J. J., Schroeder, M. A., Lee, J. H., Qiu, J., Schwartz, P. H., Sarkaria, J. N. & Robertson, K. D., Mar 27 2018, In : Genome biology. 19, 1, 43.

Research output: Contribution to journalArticle

15 Scopus citations

DNA repair capacity in multiple pathways predicts chemoresistance in glioblastoma multiforme

Nagel, Z. D., Kitange, G. J., Gupta, S. K., Joughin, B. A., Chaim, I. A., Mazzucato, P., Lauffenburger, D. A., Sarkaria, J. N. & Samson, L. D., Jan 1 2017, In : Cancer research. 77, 1, p. 198-206 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Drug and disease signature integration identifies synergistic combinations in glioblastoma

Stathias, V., Jermakowicz, A. M., Maloof, M. E., Forlin, M., Walters, W., Suter, R. K., Durante, M. A., Williams, S. L., Harbour, J. W., Volmar, C. H., Lyons, N. J., Wahlestedt, C., Graham, R. M., Ivan, M. E., Komotar, R. J., Sarkaria, J. N., Subramanian, A., Golub, T. R., Schürer, S. C. & Ayad, N. G., Dec 1 2018, In : Nature Communications. 9, 1, 5315.

Research output: Contribution to journalArticle

10 Scopus citations

Drug delivery to melanoma brain metastases: Can current challenges lead to new opportunities?

Gampa, G., Vaidhyanathan, S., Sarkaria, J. N. & Elmquist, W. F., Sep 1 2017, In : Pharmacological Research. 123, p. 10-25 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Effective radiovirotherapy for malignant gliomas by using oncolytic measles virus strains encoding the sodium iodide symporter (MV-NIS)

Opyrchal, M., Allen, C., Iankov, I., Aderca, I., Schroeder, M., Sarkaria, J. & Galanis, E., Dec 20 2011, In : Human gene therapy. 23, 4, p. 419-427 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma

Lines, X., Clarke, M. J., Mulligan, E. A., Grogan, P. T., Mladek, A. C., Carlson, B. L., Schroeder, M. A., Curtin, N. J., Lou, Z., Decker, P. A., Wu, W., Plummer, E. R. & Sarkaria, J. N., Feb 1 2009, In : Molecular cancer therapeutics. 8, 2, p. 407-414 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Effective treatment of established GL261 murine gliomas through picornavirus vaccination-enhanced tumor antigen-specific CD8+ T cell responses

Renner, D. N., Jin, F., Litterman, A. J., Balgeman, A. J., Hanson, L. M., Gamez, J. D., Chae, M., Carlson, B. L., Sarkaria, J. N., Parney, I. F., Ohlfest, J. R., Pirko, I., Pavelko, K. D. & Johnson, A. J., May 1 2015, In : PLoS One. 10, 5, e0125565.

Research output: Contribution to journalArticle

14 Scopus citations

Efficacy of EGFR plus TNF inhibition in a preclinical model of temozolomide-resistant glioblastoma

Guo, G., Gong, K., Puliyappadamba, V. T., Panchani, N., Pan, E., Mukherjee, B., Damanwalla, Z., Bharia, S., Hatanpaa, K. J., Gerber, D. E., Mickey, B. E., Patel, T. R., Sarkaria, J. N., Zhao, D., Burma, S. & Habib, A. A., Dec 17 2019, In : Neuro-oncology. 21, 12, p. 1529-1539 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Efficacy of PARP inhibitor rucaparib in orthotopic glioblastoma xenografts is limited by ineffective drug penetration into the central nervous system

Parrish, K. E., Cen, L., Murray, J., Calligaris, D., Kizilbash, S., Mittapalli, R. K., Carlson, B. L., Schroeder, M. A., Sludden, J., Boddy, A. V., Agar, N. Y. R., Curtin, N. J., Elmquist, W. F. & Sarkaria, J. N., Dec 1 2015, In : Molecular Cancer Therapeutics. 14, 12, p. 2735-2743 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models

Cen, L., Carlson, B. L., Pokorny, J. L., Mladek, A. C., Grogan, P. T., Schroeder, M. A., Decker, P. A., Anderson, S. K., Giannini, C., Wu, W., Ballman, K. V., Kitange, G. J. & Sarkaria, J. N., Jun 1 2013, In : Neuro-oncology. 15, 6, p. 735-746 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Efficacy of the MDM2 inhibitor SAR405838 in glioblastoma is limited by poor distribution across the blood–brain barrier

Kim, M., Ma, D. J., Calligaris, D., Zhang, S., Feathers, R. W., Vaubel, R. A., Meaux, I., Mladek, A. C., Parrish, K. E., Jin, F., Barriere, C., Debussche, L., Watters, J., Tian, S., Decker, P. A., Eckel-Passow, J. E., Kitange, G. J., Johnson, A. J., Parney, I. F., Anastasiadis, P. Z. & 3 others, Agar, N. Y. R., Elmquist, W. F. & Sarkaria, J. N., Sep 1 2018, In : Molecular Cancer Therapeutics. 17, 9, p. 1893-1901 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model

Parrish, K. E., Pokorny, J., Mittapalli, R. K., Bakken, K., Sarkaria, J. N. & Elmquist, W. F., Nov 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 355, 2, p. 264-271 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

EGFR signals through a DOCK180-MLK3 axis to drive glioblastoma cell invasion

Misek, S. A., Chen, J., Schroeder, L., Rattanasinchai, C., Sample, A., Sarkaria, J. N. & Gallo, K. A., Aug 1 2017, In : Molecular Cancer Research. 15, 8, p. 1085-1095 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180

Feng, H., Hu, B., Vuori, K., Sarkaria, J. N., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., May 8 2014, In : Oncogene. 33, 19, p. 2504-2512 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma

Gampa, G., Kenchappa, R. S., Mohammad, A. S., Parrish, K. E., Kim, M., Crish, J. F., Luu, A., West, R., Hinojosa, A. Q., Sarkaria, J. N., Rosenfeld, S. S. & Elmquist, W. F., Dec 1 2020, In : Scientific reports. 10, 1, 6524.

Research output: Contribution to journalArticle

Open Access

ENvironmental dynamics underlying responsive extreme survivors (ENDURES) of glioblastoma: A multidisciplinary team-based, multifactorial analytical approach

Johnston, S. K., Whitmire, P., Massey, S. C., Kumthekar, P., Porter, A. B., Raghunand, N., Gonzalez-Cuyar, L. F., Mrugala, M. M., Hawkins-Daarud, A., Jackson, P. R., Hu, L. S., Sarkaria, J. N., Wang, L., Gatenby, R. A., Egan, K. M., Canoll, P. & Swanson, K. R., Aug 1 2019, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 42, 8, p. 655-661 7 p.

Research output: Contribution to journalArticle

79 Scopus citations

Estrogen-related receptor β activation and isoform shifting by cdc2-like kinase inhibition restricts migration and intracranial tumor growth in glioblastoma

Tiek, D. M., Khatib, S. A., Trepicchio, C. J., Heckler, M. M., Divekar, S. D., Sarkaria, J. N., Glasgow, E. & Riggins, R. B., Dec 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 12, p. 13476-13491 16 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Evaluating infusate parameters for direct drug delivery to the brainstem: a comparative study of convection-enhanced delivery versus osmotic pump delivery

Rechberger, J. S., Power, E. A., Lu, V. M., Zhang, L., Sarkaria, J. N. & Daniels, D. J., Jan 1 2020, In : Neurosurgical focus. 48, 1, p. E2

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model

Kitange, G. J., Carlson, B. L., Mladek, A. C., Decker, P. A., Schroeder, M. A., Wu, W., Grogan, P. T., Giannini, C., Ballman, K. V., Buckner, J. C., David James, C. & Sarkaria, J. N., Jan 1 2009, In : Journal of neuro-oncology. 92, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth

Ramirez, Y. P., Mladek, A. C., Phillips, R. M., Gynther, M., Rautio, J., Ross, A. H., Wheelhouse, R. T. & Sakaria, J. N., Jan 1 2015, In : Molecular cancer therapeutics. 14, 1, p. 111-119 9 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Expression of CD74 in high grade gliomas: A potential role in temozolomide resistance

Kitange, G. J., Carlson, B. L., Schroeder, M. A., Decker, P. A., Morlan, B. W., Wu, W., Ballman, K. V., Giannini, C. & Sarkaria, J. N., Nov 1 2010, In : Journal of neuro-oncology. 100, 2, p. 177-186 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Extracellular Hyaluronic Acid Influences the Efficacy of EGFR Tyrosine Kinase Inhibitors in a Biomaterial Model of Glioblastoma

Pedron, S., Hanselman, J. S., Schroeder, M. A., Sarkaria, J. N. & Harley, B. A. C., 2017, (Accepted/In press) In : Advanced healthcare materials.

Research output: Contribution to journalArticle

15 Scopus citations

Factors influencing the central nervous system distribution of a novel phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor GSK2126458: Implications for overcoming resistance with combination therapy for melanoma brain metastasess

Vaidhyanathan, S., Wilken-Resman, B., Ma, D. J., Parrish, K. E., Mittapalli, R. K., Carlson, B. L., Sarkaria, J. N. & Elmquist, W. F., Feb 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 356, 2, p. 251-259 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Factors influencing the CNS distribution of a novel MEK-1/2 inhibitor: Implications for combination therapy for melanoma brain metastases

Vaidhyanathan, S., Mittapalli, R. K., Sarkaria, J. N. & Elmquist, W. F., Aug 2014, In : Drug Metabolism and Disposition. 42, 8, p. 1292-1300 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells

Nagel, Z. D., Beharry, A. A., Mazzucato, P., Kitange, G. J., Sarkaria, J. N., Kool, E. T. & Samson, L. D., Feb 1 2019, In : PloS one. 14, 2, e0208341.

Research output: Contribution to journalArticle

Open Access

Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes

Rodriguez, F. J., Giannini, C., Asmann, Y. W., Sharma, M. K., Perry, A., Tibbetts, K. M., Jenkins, R. B., Scheithauer, B. W., Anant, S., Jenkins, S., Eberhart, C. G., Sarkaria, J. N. & Gutmann, D. H., Dec 1 2008, In : Journal of Neuropathology and Experimental Neurology. 67, 12, p. 1194-1204 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Genomic and phenotypic characterization of a broad panel of patient-derived xenografts reflects the diversity of glioblastoma

Vaubel, R. A., Tian, S., Remonde, D., Schroeder, M. A., Mladek, A. C., Kitange, G. J., Caron, A., Kollmeyer, T. M., Grove, R., Peng, S., Carlson, B. L., Ma, D. J., Sarkar, G., Evers, L., Decker, P. A., Yan, H., Dhruv, H. D., Berens, M. E., Wang, Q., Marin, B. M. & 14 others, Klee, E. W., Califano, A., LaChance, D. H., Eckel-Passow, J. E., Verhaak, R. G., Sulman, E. P., Burns, T. C., Meyer, F. B., O'Neill, B. P., Tran, N. L., Giannini, C., Jenkins, R. B., Parney, I. F. & Sarkaria, J. N., Mar 1 2020, In : Clinical Cancer Research. 26, 5, p. 1094-1104 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma

Cosset, É., Ilmjärv, S., Dutoit, V., Elliott, K., von Schalscha, T., Camargo, M. F., Reiss, A., Moroishi, T., Seguin, L., Gomez, G., Moo, J. S., Preynat-Seauve, O., Krause, K. H., Chneiweiss, H., Sarkaria, J. N., Guan, K. L., Dietrich, P. Y., Weis, S. M., Mischel, P. S. & Cheresh, D. A., Dec 11 2017, In : Cancer cell. 32, 6, p. 856-868.e5

Research output: Contribution to journalArticle

40 Scopus citations

H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers

Fang, D., Gan, H., Cheng, L., Lee, J. H., Zhou, H., Sarkaria, J. N., Daniels, D. & Zhang, Z., Jun 22 2018, In : eLife. 7, e36696.

Research output: Contribution to journalArticle

19 Scopus citations

Heterogeneous binding and central nervous system distribution of the multitargeted kinase inhibitor ponatinib restrict orthotopic efficacy in a patient-derived xenograft model of glioblastoma

Laramy, J. K., Kim, M., Gupta, S. K., Parrish, K. E., Zhang, S., Bakken, K. K., Carlson, B. L., Mladek, A. C., Ma, D. J., Sarkaria, J. N. & Elmquist, W. F., Nov 1 2017, In : Journal of Pharmacology and Experimental Therapeutics. 363, 2, p. 136-147 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
92 Scopus citations

Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma

Miklossy, G., Youn, U. J., Yue, P., Zhang, M., Chen, C. H., Hilliard, T. S., Paladino, D., Li, Y., Choi, J., Sarkaria, J. N., Kawakami, J. K., Wongwiwatthananukit, S., Chen, Y., Sun, D., Chang, L. C. & Turkson, J., Oct 8 2015, In : Journal of Medicinal Chemistry. 58, 19, p. 7734-7748 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens

Pedron, S., Wolter, G. L., Chen, J. W. E., Laken, S. E., Sarkaria, J. N. & Harley, B. A. C., Oct 2019, In : Biomaterials. 219, 119371.

Research output: Contribution to journalArticle

1 Scopus citations

Hypoxia-inducible factor 2α: A novel target in gliomas

Renfrow, J. J., Soike, M. H., Debinski, W., Ramkissoon, S. H., Mott, R. T., Frenkel, M. B., Sarkaria, J. N., Lesser, G. J. & Strowd, R. E., Sep 1 2018, In : Future Medicinal Chemistry. 10, 18, p. 2227-2236 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines

Peasland, A., Wang, L. Z., Rowling, E., Kyle, S., Chen, T., Hopkins, A., Cliby, W. A., Sarkaria, J., Beale, G., Edmondson, R. J. & Curtin, N. J., Jul 26 2011, In : British journal of cancer. 105, 3, p. 372-381 10 p.

Research output: Contribution to journalArticle

118 Scopus citations

Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

Sarkaria, J. N., Yang, L., Grogan, P. T., Kitange, G. J., Carlson, B. L., Schroeder, M. A., Galanis, E., Giannini, C., Wu, W., Dinca, E. B. & James, C. D., Mar 1 2007, In : Molecular cancer therapeutics. 6, 3, p. 1167-1174 8 p.

Research output: Contribution to journalArticle

144 Scopus citations
1 Scopus citations

Image-based metric of invasiveness predicts response to adjuvant temozolomide for primary glioblastoma

Massey, S. C., White, H., Whitmire, P., Doyle, T., Johnston, S. K., Singleton, K. W., Jackson, P. R., Hawkins-Daarud, A., Bendok, B. R., Porter, A. B., Vora, S., Sarkaria, J. N., Hu, L. S., Mrugala, M. M. & Swanson, K. R., Jan 1 2020, In : PloS one. 15, 3, e0230492.

Research output: Contribution to journalArticle

Open Access

Imaging and Dosimetry Study of Inter-fraction Setup Error in a Murine Xenograft Flank Tumor Radiation Model

Smith, E. J., Tryggestad, E. J., Carlson, B. L., Walb, M. C. & Sarkaria, J. N., Feb 1 2020, In : Radiation Research. 193, 2, p. 161-170 10 p.

Research output: Contribution to journalArticle

Immunovirotherapy with measles virus strains in combination with anti-PD-1 antibody blockade enhances antitumor activity in glioblastoma treatment

Hardcastle, J., Mills, L., Malo, C. S., Jin, F., Kurokawa, C., Geekiyanage, H., Schroeder, M., Sarkaria, J. N., Johnson, A. J. & Galanis, E., Apr 1 2017, In : Neuro-Oncology. 19, 4, p. 493-502 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Impairment of glioma stem cell survival and growth by a novel inhibitor for survivin-ran protein complex

Guvenc, H., Pavlyukov, M. S., Joshi, K., Kurt, H., Banasavadi-Siddegowda, Y. K., Mao, P., Hong, C., Yamada, R., Kwon, C. H., Bhasin, D., Chettiar, S., Kitange, G., Park, I. H., Sarkaria, J. N., Li, C., Shakhparonov, M. I. & Nakano, I., Feb 1 2013, In : Clinical Cancer Research. 19, 3, p. 631-642 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

Improving drug delivery to primary and metastatic brain tumors: strategies to overcome the blood-brain barrier

Parrish, K. E., Sarkaria, J. N. & Elmquist, W. F., Apr 1 2015, In : Clinical Pharmacology and Therapeutics. 97, 4, p. 336-346 11 p.

Research output: Contribution to journalArticle

59 Scopus citations

Incorporation of biomarker assessment in novel clinical trial designs: Personalizing brain tumor treatments

Galanis, E., Wu, W., Sarkaria, J., Chang, S. M., Colman, H., Sargent, D. & Reardon, D. A., Feb 1 2011, In : Current oncology reports. 13, 1, p. 42-49 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Increased bowel toxicity in patients treated with a vascular endothelial growth factor inhibitor (VEGFI) after stereotactic body radiation therapy (SBRT)

Barney, B. M., Markovic, S. N., Laack, N. N., Miller, R. C., Sarkaria, J. N., Macdonald, O. K., Bauer, H. J. & Olivier, K. R., Sep 1 2013, In : International Journal of Radiation Oncology Biology Physics. 87, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

Kitange, G. J., Carlson, B. L., Schroeder, M. A., Grogan, P. T., Lamont, J. D., Decker, P. A., Wu, W., James, C. D. & Sarkaria, J. N., Jun 1 2009, In : Neuro-oncology. 11, 3, p. 281-291 11 p.

Research output: Contribution to journalArticle

139 Scopus citations

Influence of hyaluronic acid transitions in tumor microenvironment on glioblastoma malignancy and invasive behavior

Chen, J. W. E., Pedron, S., Shyu, P., Hu, Y., Sarkaria, J. N. & Harley, B. A. C., Jun 26 2018, In : Frontiers in Materials. 5, 39.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells

Mamo, T., Mladek, A. C., Shogren, K. L., Gustafson, C., Gupta, S. K., Riester, S. M., Maran, A., Galindo, M., van Wijnen, A. J., Sarkaria, J. N. & Yaszemski, M. J., Apr 29 2017, In : Biochemical and Biophysical Research Communications. 486, 2, p. 307-313 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine

Sarkaria, J. N., Busby, E. C., Tibbetts, R. S., Roos, P., Taya, Y., Karnitz, L. M. & Abraham, R. T., Sep 1 1999, In : Cancer research. 59, 17, p. 4375-4382 8 p.

Research output: Contribution to journalArticle

893 Scopus citations