• 14646 Citations
  • 55 Scopus h-Index
1993 …2020

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Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

Feng, H., Hu, B., Jarzynka, M. J., Li, Y., Keezer, S., Johns, T. G., Tang, C. K., Hamilton, R. L., Vuori, K., Nishikawa, R., Sarkaria, J. N., Fenton, T., Cheng, T., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 3018-3023 6 p.

Research output: Contribution to journalArticle

49 Scopus citations

PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma

Rodriguez, E. F., Scheithauer, B. W., Giannini, C., Rynearson, A., Cen, L., Hoesley, B., Gilmer-Flynn, H., Sarkaria, J. N., Jenkins, S., Long, J. & Rodriguez, F. J., Mar 2011, In : Acta neuropathologica. 121, 3, p. 407-420 14 p.

Research output: Contribution to journalArticle

95 Scopus citations

Posttranscriptional regulation of per1 underlies the oncogenic function of IREα

Pluquet, O., Dejeans, N., Bouchecareilh, M., Lhomond, S., Pineau, R., Higa, A., Delugin, M., Combe, C., Loriot, S., Cubel, G., Dugot-Senant, N., Vital, A., Loiseau, H., Gosline, S. J. C., Taouji, S., Hallett, M., Sarkaria, J. N., Anderson, K., Wu, W., Rodriguez, F. J. & 4 others, Rosenbaum, J., Saltel, F., Fernandez-Zapico, M. E. & Chevet, E., Aug 1 2013, In : Cancer research. 73, 15, p. 4732-4743 12 p.

Research output: Contribution to journalArticle

75 Scopus citations

Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition

Marisol Herrera-Perez, R., Voytik-Harbin, S. L., Sarkaria, J. N., Pollok, K. E., Fishel, M. L. & Rickus, J. L., Mar 2018, In : PloS one. 13, 3, e0194183.

Research output: Contribution to journalArticle

11 Scopus citations

Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α

Feng, H., Li, Y., Yin, Y., Zhang, W., Hou, Y., Zhang, L., Li, Z., Xie, B., Gao, W. Q., Sarkaria, J. N., Raizer, J. J., James, C. D., Parsa, A. T., Hu, B. & Cheng, S. Y., 2015, In : Neuro-oncology. 17, 6, p. 832-842 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

PTEN loss does not predict for response to RAD001 (everolimus) in a glioblastoma orthotopic xenograft test panel

Yang, L., Clarke, M. J., Carlson, B. L., Mladek, A. C., Schroeder, M. A., Decker, P., Wu, W., Kitange, G., Grogan, P., Goble, J. M., Uhm, J., Galanis, E., Giannini, C., Lane, H. A., James, C. D. & Sarkaria, J. N., Jun 15 2008, In : Clinical Cancer Research. 14, 12, p. 3993-4001 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

Zhou, W., Yao, Y., Scott, A. J., Wilder-Romans, K., Dresser, J. J., Werner, C. K., Sun, H., Pratt, D., Sajjakulnukit, P., Zhao, S. G., Davis, M., Nelson, B. S., Halbrook, C. J., Zhang, L., Gatto, F., Umemura, Y., Walker, A. K., Kachman, M., Sarkaria, J. N., Xiong, J. & 8 others, Morgan, M. A., Rehemtualla, A., Castro, M. G., Lowenstein, P., Chandrasekaran, S., Lawrence, T. S., Lyssiotis, C. A. & Wahl, D. R., Dec 1 2020, In : Nature communications. 11, 1, 3811.

Research output: Contribution to journalArticle

Open Access

Quantifying the setup uncertainty of a stereotactic murine micro-image guided radiation therapy system

Walb, M. C., Carlson, B. L., Sarkaria, J. N. & Tryggestad, E. J., 2019, In : British Journal of Radiology. 92, 1095, 20180487.

Research output: Contribution to journalArticle

3 Scopus citations

Quantitative phosphoproteomics reveals wee1 kinase as a therapeutic target in a model of proneural glioblastoma

Lescarbeau, R. S., Lei, L., Bakken, K. K., Sims, P. A., Sarkaria, J. N., Canoll, P. & White, F. M., Jun 1 2016, In : Molecular Cancer Therapeutics. 15, 6, p. 1332-1343 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma

Gupta, K., Vuckovic, I., Zhang, S., Xiong, Y., Carlson, B. L., Jacobs, J., Olson, I., Petterson, X. M., Macura, S. I., Sarkaria, J. & Burns, T. C., May 5 2020, In : Frontiers in Oncology. 10, 535.

Research output: Contribution to journalArticle

Open Access

Radiogenomics to characterize regional genetic heterogeneity in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Baxter, L. C., Gaw, N., Ranjbar, S., Plasencia, J., Dueck, A. C., Peng, S., Smith, K. A., Nakaji, P., Karis, J. P., Quarles, C. C., Wu, T., Loftus, J. C., Jenkins, R. B., Sicotte, H., Kollmeyer, T. M., O'Neill, B. P., Elmquist, W. & 7 others, Hoxworth, J. M., Frakes, D., Sarkaria, J., Swanson, K. R., Tran, N. L., Li, J. & Mitchell, J. R., 2017, In : Neuro-oncology. 19, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

68 Scopus citations

Radiosensitizing Effects of Temozolomide Observed in vivo only in a Subset of O6-Methylguanine-DNA Methyltransferase Methylated Glioblastoma Multiforme Xenografts

Carlson, B. L., Grogan, P. T., Mladek, A. C., Schroeder, M. A., Kitange, G. J., Decker, P. A., Giannini, C., Wu, W., Ballman, K. A., James, C. D. & Sarkaria, J. N., Sep 1 2009, In : International Journal of Radiation Oncology Biology Physics. 75, 1, p. 212-219 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Radiosurgery in the initial management of malignant gliomas: Survival comparison with the RTOG recursive partitioning analysis

Sarkaria, J. N., Mehta, M. P., Loeffler, J. S., Buatti, J. M., Chappell, R. J., Levin, A. B., Alexander, E., Friedman, W. A. & Kinsella, T. J., Jul 15 1995, In : International journal of radiation oncology, biology, physics. 32, 4, p. 931-941 11 p.

Research output: Contribution to journalArticle

138 Scopus citations
4 Scopus citations

Restricted delivery of talazoparib across the blood–brain barrier limits the sensitizing effects of PARP inhibition on temozolomide therapy in glioblastoma

Kizilbash, S. H., Gupta, S. K., Chang, K., Kawashima, R., Parrish, K. E., Carlson, B. L., Bakken, K. K., Mladek, A. C., Schroeder, M. A., Decker, P. A., Kitange, G. J., Shen, Y., Feng, Y., Protter, A. A., Elmquist, W. F. & Sarkaria, J. N., Dec 2017, In : Molecular cancer therapeutics. 16, 12, p. 2735-2746 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

Kitange, G. J., Mladek, A. C., Schroeder, M. A., Pokorny, J. C., Carlson, B. L., Zhang, Y., Nair, A. A., Lee, J. H., Yan, H. D., Decker, P. A., Zhang, Z. & Sarkaria, J. N., Mar 4 2015, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

25 Scopus citations

SGEF is regulated via TWEAK/Fn14/NF-κB signaling and promotes survival by modulation of the DNA repair response to temozolomide

Fortin Ensign, S. P., Roos, A., Mathews, I. T., Dhruv, H. D., Tuncali, S., Sarkaria, J. N., Symons, M. H., Loftus, J. C., Berens, M. E. & Tran, N. L., Mar 2016, In : Molecular Cancer Research. 14, 3, p. 302-312 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Spatially graded hydrogels for preclinical testing of glioblastoma anticancer therapeutics

Pedron, S., Polishetty, H., Pritchard, A. M., Mahadik, B. P., Sarkaria, J. N. & Harley, B. A. C., Sep 1 2017, In : MRS Communications. 7, 3, p. 442-449 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Src family kinases differentially influence glioma growth and motility

Lewis-Tuffin, L. J., Feathers, R., Hari, P., Durand, N., Li, Z., Rodriguez, F. J., Bakken, K., Carlson, B., Schroeder, M., Sarkaria, J. N. & Anastasiadis, P. Z., Nov 2015, In : Molecular Oncology. 9, 9, p. 1783-1798 16 p.

Research output: Contribution to journalArticle

24 Scopus citations

Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Wang, H., Nguyen, A., Kamocka, M. M., Cai, W., Cohen-Gadol, A. A., Halum, S. L., Sarkaria, J. N., Pollok, K. E. & Safa, A. R., Dec 2017, In : Journal of neurosurgery. 127, 6, p. 1219-1230 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Tamoxifen-induced Increase in the Potential Doubling Time of MCF-7 Xenografts as Determined by Bromodeoxyuridine Labeling and Flow Cytometry

Sarkaria, J. N., Gibson, D. F. C., Jordan, V. C., Fowler, J. F., Lindstrom, M. J. & Mulcahy, R. T., Sep 1993, In : Cancer research. 53, 18, p. 4413-4417 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion

Huveldt, D., Lewis-Tuffin, L. J., Carlson, B. L., Schroeder, M. A., Rodriguez, F., Giannini, C., Galanis, E., Sarkaria, J. N. & Anastasiadis, P. Z., Feb 14 2013, In : PloS one. 8, 2, e56505.

Research output: Contribution to journalArticle

55 Scopus citations

Targeting the PI3K pathway in the brain - Efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier

Salphati, L., Heffron, T. P., Alicke, B., Nishimura, M., Barck, K., Carano, R. A., Cheong, J., Edgar, K. A., Greve, J., Kharbanda, S., Koeppen, H., Lau, S., Lee, L. B., Pang, J., Plise, E. G., Pokorny, J. L., Reslan, H. B., Sarkaria, J. N., Wallin, J. J., Zhang, X. & 3 others, Gould, S. E., Olivero, A. G. & Phillips, H. S., Nov 15 2012, In : Clinical Cancer Research. 18, 22, p. 6239-6248 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Temozolomide sensitizes MGMT-deficient tumor cells to ATR inhibitors

Jackson, C. B., Noorbakhsh, S. I., Sundaram, R. K., Kalathil, A. N., Ganesa, S., Jia, L., Breslin, H., Burgenske, D. M., Gilad, O., Sarkaria, J. N. & Bindra, R. S., Sep 1 2019, In : Cancer research. 79, 17, p. 4331-4338 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

The adverse effect of treatment prolongation in cervical carcinoma

Petereit, D. G., Sarkaria, J. N., Chappell, R., Fowler, J. F., Hartmann, T. J., Kinsella, T. J., Stitt, J. A., Thomadsen, B. R. & Buchler, D. A., Jul 30 1995, In : International journal of radiation oncology, biology, physics. 32, 5, p. 1301-1307 7 p.

Research output: Contribution to journalArticle

205 Scopus citations

The bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation

Pastori, C., Kapranov, P., Penas, C., Peschansky, V., Volmar, C. H., Sarkaria, J. N., Bregy, A., Komotar, R., Laurent, G. S., Ayad, N. G., Wahlestedt, C. & Roberts, T. C., Jul 7 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8326-8331 6 p.

Research output: Contribution to journalArticle

105 Scopus citations

The decreased influence of overall treatment time on the response of human breast tumor xenografts following prolongation of the potential doubling time (Tpot)

Sarkaria, J. N., Fowler, J. F., Lindstrom, M. J., Jordan, V. C. & Mulcahy, R. T., Feb 15 1995, In : International journal of radiation oncology, biology, physics. 31, 4, p. 833-840 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

The efficacy of the wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood-brain barrier in glioblastoma

Pokorny, J. L., Calligaris, D., Gupta, S. K., Iyekegbe, D. O., Mueller, D., Bakken, K. K., Carlson, B. L., Schroeder, M. A., Evans, D. L., Lou, Z., Decker, P. A., Eckel-Passow, J. E., Pucci, V., Ma, B., Shumway, S. D., Elmquist, W. F., Agar, N. Y. R. & Sarkaria, J. N., Apr 15 2015, In : Clinical Cancer Research. 21, 8, p. 1916-1924 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

Chan, K. M., Fang, D., Gan, H., Hashizume, R., Yu, C., Schroeder, M., Gupta, N., Mueller, S., David James, C., Jenkins, R., Sarkaria, J. & Zhang, Z., May 1 2013, In : Genes and Development. 27, 9, p. 985-990 6 p.

Research output: Contribution to journalArticle

328 Scopus citations

The medical necessity of advanced molecular testing in the diagnosis and treatment of brain tumor patients

Horbinski, C., Ligon, K. L., Brastianos, P., Huse, J. T., Venere, M., Chang, S., Buckner, J., Cloughesy, T., Jenkins, R. B., Giannini, C., Nabors, L. B., Wen, P. Y., Aldape, K. J., Lukas, R. V., Galanis, E., Eberhart, C. G., Brat, D. J. & Sarkaria, J. N., Dec 1 2019, In : Neuro-oncology. 21, 12, p. 1498-1508 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

Busby, E. C., Leistritz, D. F., Abraham, R. T., Karnitz, L. M. & Sarkaria, J. N., Apr 15 2000, In : Cancer research. 60, 8, p. 2108-2112 5 p.

Research output: Contribution to journalArticle

302 Scopus citations

The role of LAT1 in 18F-DOPA uptake in malignant gliomas

Youland, R. S., Kitange, G. J., Peterson, T. E., Pafundi, D. H., Ramiscal, J. A., Pokorny, J. L., Giannini, C., Laack, N. N., Parney, I. F., Lowe, V. J., Brinkmann, D. H. & Sarkaria, J. N., Jan 2013, In : Journal of neuro-oncology. 111, 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Tumorgrafts as in vivo surrogates for women with ovarian cancer

Weroha, S. J., Becker, M. A., Enderica-Gonzalez, S., Harrington, S. C., Oberg, A. L., Maurer, M. J., Perkins, S. E., AlHilli, M., Butler, K. A., McKinstry, S., Fink, S., Jenkins, R. B., Hou, X., Kalli, K. R., Goodman, K. M., Sarkaria, J. N., Karlan, B. Y., Kumar, A., Kaufmann, S. H., Hartmann, L. C. & 1 others, Haluska, P., Jan 1 2014, In : Clinical Cancer Research. 20, 5, p. 1288-1297 10 p.

Research output: Contribution to journalArticle

93 Scopus citations

Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response

Sarkaria, J. N., Carlson, B. L., Schroeder, M. A., Grogan, P., Brown, P. D., Giannini, C., Ballman, K. V., Kitange, C. J., Guha, A., Pandita, A. & James, C. D., Apr 1 2006, In : Clinical Cancer Research. 12, 7 I, p. 2264-2271 8 p.

Research output: Contribution to journalArticle

181 Scopus citations

Using fluorodeoxythymidine to monitor anti-egfr inhibitor therapy in squamous cell carcinoma xenografts

Atkinson, D. M., Clarke, M. J., Mladek, A. C., Carlson, B. L., Trump, D. P., Jacobson, M. S., Kemp, B. J., Lowe, V. J. & Sarkaria, J. N., Jun 2008, In : Head and Neck. 30, 6, p. 790-799 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody

Zhu, S., Kisiel, W., Lu, Y. J., Petersen, L. C., Ndungu, J. M., Moore, T. W., Parker, E. T., Sun, A., Sarkaria, J. N., Snyder, J. P., Liotta, D. C., Brat, D. J., El-Rayes, B. F. & Shoji, M., Apr 1 2015, In : Journal of Drug Targeting. 23, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

WE‐G‐214‐02: Utility of 18F‐FDOPA PET for Radiotherapy Target Delineation in Glioma Patients

Pafundi, D., Brinkmann, D. H., Laack, N. N., Sarkaria, J. N., Yan, E., Kemp, B. & Lowe, V., 2011, In : Medical Physics. 38, 6, p. 3830 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

WWP2 is an E3 ubiquitin ligase for PTEN

Maddika, S., Kavela, S., Rani, N., Palicharla, V. R., Pokorny, J. L., Sarkaria, J. N. & Chen, J., Jun 2011, In : Nature Cell Biology. 13, 6, p. 728-733 6 p.

Research output: Contribution to journalArticle

171 Scopus citations

Xenograft-based, platform-independent gene signatures to predict response to alkylating chemotherapy, radiation, and combination therapy for glioblastoma

Zhao, S. G., Yu, M., Spratt, D. E., Chang, S. L., Feng, F. Y., Kim, M. M., Speers, C. W., Carlson, B. L., Mladek, A. C., Lawrence, T. S., Sarkaria, J. N. & Wahl, D. R., Sep 6 2019, In : Neuro-oncology. 21, 9, p. 1141-1149 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain

Yiin, J. J., Hu, B., Schornack, P. A., Sengar, R. S., Liu, K. W., Feng, H., Lieberman, F. S., Chiou, S. H., Sarkaria, J. N., Wiener, E. C., Ma, H. I. & Cheng, S. Y., Apr 2010, In : Molecular cancer therapeutics. 9, 4, p. 929-941 13 p.

Research output: Contribution to journalArticle

30 Scopus citations