• 13070 Citations
  • 50 Scopus h-Index
1980 …2021
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Research Output 1993 2019

  • 13070 Citations
  • 50 Scopus h-Index
  • 187 Article
  • 4 Review article
  • 1 Comment/debate
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Article
Article
42 Citations (Scopus)

4-Hydroxytamoxifen, an active metabolite of tamoxifen, does not alter the radiation sensitivity of MCF-7 breast carcinoma cells irradiated in vitro

Sarkaria, J. N., Miller, E. M., Parker, C. J., Jordan, V. C. & Mulcahy, R. T., Jan 1994, In : Breast Cancer Research and Treatment. 30, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle

Radiation Tolerance
Tamoxifen
MCF-7 Cells
Breast Neoplasms
Estradiol
52 Citations (Scopus)

A comparison of the efficacy and complication rates of low dose-rate versus high dose-rate brachytherapy in the treatment of uterine cervical carcinoma

Sarkaria, J. N., Petereit, D. G., Stitt, J. A., Hartman, T., Chappell, R., Thomadsen, B. R., Buchler, D. A., Fowler, J. F. & Kinsella, T. J., Aug 30 1994, In : International Journal of Radiation Oncology, Biology, Physics. 30, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

Brachytherapy
cancer
Carcinoma
dosage
Therapeutics
84 Citations (Scopus)

Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain

Oliva, C. R., Nozell, S. E., Diers, A., McClugage, S. G., Sarkaria, J. N., Markert, J. M., Darley-Usmar, V. M., Bailey, S. M., Gillespie, G. Y., Landar, A. & Griguer, C. E., Dec 17 2010, In : Journal of Biological Chemistry. 285, 51, p. 39759-39767 9 p.

Research output: Contribution to journalArticle

temozolomide
Electron Transport
Glioma
Mitochondria
Glioblastoma
72 Citations (Scopus)

Activation of Rac1 by Src-dependent phosphorylation of Dock180 Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

Feng, H., Hu, B., Liu, K. W., Li, Y., Lu, X., Cheng, T., Yiin, J. J., Lu, S., Keezer, S., Fenton, T., Furnari, F. B., Hamilton, R. L., Vuori, K., Sarkaria, J. N., Nagane, M., Nishikawa, R., Cavenee, W. K. & Cheng, S. Y., Dec 1 2011, In : Journal of Clinical Investigation. 121, 12, p. 4670-4684 15 p.

Research output: Contribution to journalArticle

Glioma
Tyrosine
Carcinogenesis
Phosphorylation
Glioblastoma
40 Citations (Scopus)

Active efflux of dasatinib from the brain limits efficacy against murine glioblastoma: Broad implications for the clinical use of molecularly targeted agents

Agarwal, S., Mittapalli, R. K., Zellmer, D. M., Gallardo, J. L., Donelson, R., Seiler, C., Decker, S. A., SantaCruz, K. S., Pokorny, J. L., Sarkaria, J. N., Elmquist, W. F. & Ohlfest, J. R., Oct 2012, In : Molecular Cancer Therapeutics. 11, 10, p. 2183-2192 10 p.

Research output: Contribution to journalArticle

Glioblastoma
P-Glycoprotein
Breast Neoplasms
Brain
Glioma
42 Citations (Scopus)

A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas

Kushwaha, D., Ramakrishnan, V., Ng, K., Steed, T., Nguyen, T., Futalan, D., Akers, J. C., Sarkaria, J. N., Jiang, T., Chowdhury, D., Carter, B. S. & Chen, C. C., 2014, In : Oncotarget. 5, 12, p. 4026-4039 14 p.

Research output: Contribution to journalArticle

Glioblastoma
MicroRNAs
Genome
temozolomide
Transfection
9 Citations (Scopus)

Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma

Kurokawa, C., Geekiyanage, H., Allen, C., Iankov, I., Schroeder, M., Carlson, B., Bakken, K., Sarkaria, J. N., Ecsedy, J. A., D'Assoro, A., Friday, B. & Galanis, E., Nov 5 2016, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Aurora Kinase A
Heterografts
Neoplasms
Caudate Nucleus
76 Citations (Scopus)

Alkylpurine - DNA - N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

Agnihotri, S., Gajadhar, A. S., Ternamian, C., Gorlia, T., Diefes, K. L., Mischel, P. S., Kelly, J., McGown, G., Thorncroft, M., Carlson, B. L., Sarkaria, J. N., Margison, G. P., Aldape, K., Hawkins, C., Hegi, M. & Guha, A., Jan 3 2012, In : Journal of Clinical Investigation. 122, 1, p. 253-266 14 p.

Research output: Contribution to journalArticle

temozolomide
DNA Glycosylases
Glioblastoma
Heterografts
Survival

Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients (Journal of Clinical Investigation (2012) 122, 1, (253-266) DOI: 10.1172/JCI59334)

Agnihotri, S., Gajadhar, A. S., Ternamian, C., Gorlia, T., Diefes, K. L., Mischel, P. S., Kelly, J., McGown, G., Thorncroft, M., Carlson, B. L., Sarkaria, J. N., Margison, G. P., Aldape, K., Hawkins, C., Hegi, M. & Guha, A., Feb 2012, In : Journal of Clinical Investigation. 122, 2, p. 782 1 p.

Research output: Contribution to journalArticle

temozolomide
DNA Glycosylases
Glioblastoma
Heterografts
Survival
44 Citations (Scopus)

An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth

Guessous, F., Zhang, F., DiPierro, C., Marcinkiewicz, L., Sarkaria, J. N., Schiff, D., Buchanan, S. & Abounader, R., Jan 2010, In : Anti-Cancer Agents in Medicinal Chemistry. 10, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Phosphotransferases
Growth
Glioma
Hepatocyte Growth Factor
11 Citations (Scopus)

A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

Chen, X., Zhang, M., Gan, H., Wang, H., Lee, J. H., Fang, D., Kitange, G. J., He, L., Hu, Z., Parney, I. F., Meyer, F. B., Giannini, C., Sarkaria, J. N. & Zhang, Z., Dec 1 2018, In : Nature Communications. 9, 1, 2949.

Research output: Contribution to journalArticle

temozolomide
Methyltransferases
Glioblastoma
deoxyribonucleic acid
DNA
13 Citations (Scopus)

A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death

Shing, J. C., Choi, J. W., Chapman, R., Schroeder, M. A., Sarkaria, J. N., Fauq, A. & Bram, R. J., 2014, In : Cancer Biology and Therapy. 15, 7, p. 895-905 11 p.

Research output: Contribution to journalArticle

Phenylthiourea
Microtubules
Polymerization
Prometaphase
Cell Death
9 Citations (Scopus)

Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patientderived GBM tumor cells

Tivnan, A., Heilinger, T., Ramsey, J. M., O'Connor, G., Pokorny, J. L., Sarkaria, J. N., Stringer, B. W., Day, B. W., Boyd, A. W., Kim, E. L., Lode, H. N., Cryan, S. A. & Prehn, J. H. M., 2017, In : Oncotarget. 8, 10, p. 16605-16620 16 p.

Research output: Contribution to journalArticle

letrozole
Aromatase Inhibitors
Glioblastoma
Nanoparticles
Aromatase
3 Citations (Scopus)

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

Jun, H. J., Appleman, V. A., Wu, H. J., Rose, C. M., Pineda, J. J., Yeo, A. T., Delcuze, B., Lee, C., Gyuris, A., Zhu, H., Woolfenden, S., Bronisz, A., Nakano, I., Chiocca, E. A., Bronson, R. T., Ligon, K. L., Sarkaria, J. N., Gygi, S. P., Michor, F., Mitchison, T. J. & 1 others, Charest, A., Dec 1 2018, In : Nature Communications. 9, 1, 3116.

Research output: Contribution to journalArticle

Vinblastine
Glioblastoma
mice
sensitivity
Tubulin
66 Citations (Scopus)

A phase 2 study of temsirolimus (CCI-779) in patients with soft tissue sarcomas: A study of the mayo phase 2 Consortium (P2C)

Okuno, S. H., Bailey, H., Mahoney, M. R., Adkins, D., Maples, W., Fitch, T., Ettinger, D., Erlichman, C. & Sarkaria, J. N., Aug 1 2011, In : Cancer. 117, 15, p. 3468-3475 8 p.

Research output: Contribution to journalArticle

Sarcoma
Confidence Intervals
Adjuvant Chemotherapy
Leiomyosarcoma
Premedication
49 Citations (Scopus)

A phase II trial of everolimus, temozolomide, and radiotherapy in patients with newly diagnosed glioblastoma: NCCTG N057K

Ma, D. J., Galanis, E., Anderson, S. K., Schiff, D., Kaufmann, T. J., Peller, P. J., Giannini, C., Brown, P. D., Uhm, J. H., McGraw, S., Jaeckle, K. A., Flynn, P. J., Ligon, K. L., Buckner, J. C. & Sarkaria, J. N., Sep 1 2015, In : Neuro-Oncology. 17, 9, p. 1261-1269 9 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Radiotherapy
Sirolimus
Phosphatidylinositol 3-Kinase
790 Citations (Scopus)

A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S. Y., Taya, Y., Prives, C. & Abraham, R. T., Jan 15 1999, In : Genes and Development. 13, 2, p. 152-157 6 p.

Research output: Contribution to journalArticle

DNA Damage
Phosphorylation
DNA
Ultraviolet Rays
Up-Regulation
41 Citations (Scopus)

ATM as a target for novel radiosensitizers

Sarkaria, J. N. & Eshleman, J. S., 2001, In : Seminars in Radiation Oncology. 11, 4, p. 316-327 12 p.

Research output: Contribution to journalArticle

ataxia
Ataxia Telangiectasia
caffeine
Ionizing Radiation
Caffeine
32 Citations (Scopus)

ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells

Nadkarni, A., Shrivastav, M., Mladek, A. C., Schwingler, P. M., Grogan, P. T., Chen, J. & Sarkaria, J. N., Dec 2012, In : Journal of Neuro-Oncology. 110, 3, p. 349-357 9 p.

Research output: Contribution to journalArticle

temozolomide
Ataxia Telangiectasia
Glioblastoma
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one
23 Citations (Scopus)

A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma

Guo, G., Gong, K., Ali, S., Ali, N., Shallwani, S., Hatanpaa, K. J., Pan, E., Mickey, B., Burma, S., Wang, D. H., Kesari, S., Sarkaria, J. N., Zhao, D. & Habib, A. A., Aug 1 2017, In : Nature Neuroscience. 20, 8, p. 1074-1084 11 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
Glioblastoma
Epidermal Growth Factor Receptor
Tumor Necrosis Factor-alpha
3 Citations (Scopus)

ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Tu, X., Kahila, M. M., Zhou, Q., Yu, J., Kalari, K. R., Wang, L. M., Harmsen, W. S., Yuan, J., Boughey, J. C., Goetz, M. P., Sarkaria, J. N., Lou, Z. & Mutter, R., Nov 1 2018, In : Molecular Cancer Therapeutics. 17, 11, p. 2462-2472 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Radiotherapy
Exome
Homologous Recombination
Neoplasms
1 Citation (Scopus)

Automatic 3D Nonlinear Registration of Mass Spectrometry Imaging and Magnetic Resonance Imaging Data

Abdelmoula, W. M., Regan, M. S., Lopez, B. G. C., Randall, E. C., Lawler, S., Mladek, A. C., Nowicki, M. O., Marin, B. M., Agar, J. N., Swanson, K., Kapur, T., Sarkaria, J. N., Wells, W. & Agar, N. Y. R., May 7 2019, In : Analytical Chemistry. 91, 9, p. 6206-6216 11 p.

Research output: Contribution to journalArticle

Mass spectrometry
Imaging techniques
Magnetic resonance
Magnetic Resonance Imaging
Brain models
66 Citations (Scopus)

BET bromodomain proteins are required for glioblastoma cell proliferation

Pastori, C., Daniel, M., Penas, C., Volmar, C. H., Johnstone, A. L., Brothers, S. P., Graham, R. M., Allen, B., Sarkaria, J. N., Komotar, R. J., Wahlestedt, C. & Ayad, N. G., Feb 19 2014, In : Epigenetics. 9, 4, p. 611-620 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Proliferation
temozolomide
Cell Cycle
Protein Domains
64 Citations (Scopus)

Bioluminescence monitoring of intracranial glioblastoma xenograft: Response to primary and salvage temozolomide therapy

Dinca, E. B., Sarkaria, J. N., Schroeder, M. A., Carlson, B. L., Voicu, R., Gupta, N., Berger, M. S. & James, C. D., Sep 2007, In : Journal of Neurosurgery. 107, 3, p. 610-616 7 p.

Research output: Contribution to journalArticle

temozolomide
Salvage Therapy
Glioblastoma
Heterografts
Therapeutics
8 Citations (Scopus)

Bioluminescent imaging of intracranial vestibular schwannoma xenografts in NOD/SCID mice

Neff, B. A., Voss, S. G., Allen, C., Schroeder, M. A., Driscoll, C. L. W., Link, M. J., Galanis, E. & Sarkaria, J. N., Jan 2009, In : Otology and Neurotology. 30, 1, p. 105-111 7 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
Acoustic Neuroma
SCID Mice
Heterografts
Photons
77 Citations (Scopus)

Biopsy validation of 18F-DOPA PET and biodistribution in gliomas for neurosurgical planning and radiotherapy target delineation: Results of a prospective pilot study

Pafundi, D. H., Laack, N. N., Youland, R. S., Parney, I. F., Lowe, V., Giannini, C., Kemp, B. J., Grams, M. P., Morris, J. M., Hoover, J. M., Hu, L. S., Sarkaria, J. N. & Brinkmann, D. H., Aug 2013, In : Neuro-Oncology. 15, 8, p. 1058-1067 10 p.

Research output: Contribution to journalArticle

Glioma
Radiotherapy
Prospective Studies
Biopsy
Astrocytoma
2 Citations (Scopus)

Brain Distribution and Active Efflux of Three panRAF Inhibitors: Considerations in the Treatment of Melanoma Brain Metastases

Gampa, G., Kim, M., Mohammad, A. S., Parrish, K. E., Mladek, A. C., Sarkaria, J. N. & Elmquist, W. F., Mar 1 2019, In : The Journal of pharmacology and experimental therapeutics. 368, 3, p. 446-461 16 p.

Research output: Contribution to journalArticle

Melanoma
Neoplasm Metastasis
P-Glycoprotein
Brain
Mitogen-Activated Protein Kinase Kinases
7 Citations (Scopus)

Brain distribution of a novel MEK Inhibitor E6201: Implications in the treatment of melanoma brain metastases

Gampa, G., Kim, M., Cook-Rostie, N., Laramy, J. K., Sarkaria, J. N., Paradiso, L., DePalatis, L. & Elmquist, W. F., May 1 2018, In : Drug Metabolism and Disposition. 46, 5, p. 658-666 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Melanoma
Neoplasm Metastasis
Brain
P-Glycoprotein
2 Citations (Scopus)

Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice

Kim, M., Laramy, J. K., Mohammad, A. S., Talele, S., Fisher, J., Sarkaria, J. N. & Elmquist, W. F., Apr 1 2019, In : Drug metabolism and disposition: the biological fate of chemicals. 47, 4, p. 393-404 12 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Brain
Blood-Brain Barrier
Non-Small Cell Lung Carcinoma
Brain Neoplasms
19 Citations (Scopus)

Brain Malignancy Steering Committee clinical trials planning workshop: Report from the Targeted Therapies Working Group

Alexander, B. M., Galanis, E., Yung, W. K. A., Ballman, K. V., Boyett, J. M., Cloughesy, T. F., Degroot, J. F., Huse, J. T., Mann, B., Mason, W., Mellinghoff, I. K., Mikkelsen, T., Mischel, P. S., O'Neill, B. P., Prados, M. D., Sarkaria, J. N., Tawab-Amiri, A., Trippa, L., Ye, X., Ligon, K. L. & 2 others, Berry, D. A. & Wen, P. Y., Feb 1 2015, In : Neuro-Oncology. 17, 2, p. 180-188 9 p.

Research output: Contribution to journalArticle

Group Psychotherapy
Clinical Trials
Education
Hope
Brain
188 Citations (Scopus)

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

Flavahan, W. A., Wu, Q., Hitomi, M., Rahim, N., Kim, Y., Sloan, A. E., Weil, R. J., Nakano, I., Sarkaria, J. N., Stringer, B. W., Day, B. W., Li, M., Lathia, J. D., Rich, J. N. & Hjelmeland, A. B., Oct 2013, In : Nature Neuroscience. 16, 10, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Brain Neoplasms
Glucose
Glucose Transporter Type 3
Neoplasms
24 Citations (Scopus)

Brain tumor stem cell multipotency correlates with nanog expression and extent of passaging in human glioblastoma xenografts

Higgins, D. M., Wang, R., Milligan, B., Schroeder, M., Carlson, B., Pokorny, J., Cheshier, S. H., Meyer, F. B., Weissman, I. L., Sarkaria, J. N. & Henley, J. R., May 2013, In : Oncotarget. 4, 5, p. 792-801 10 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Glioblastoma
Heterografts
Brain Neoplasms
Survival
3 Citations (Scopus)

CD90 expression controls migration and predicts dasatinib response in glioblastoma

Avril, T., Etcheverry, A., Pineau, R., Obacz, J., Jegou, G., Jouan, F., Le Reste, P. J., Hatami, M., Colen, R. R., Carlson, B. L., Decker, P. A., Sarkaria, J. N., Vauléon, E., Chiforeanu, D. C., Clavreul, A., Mosser, J., Chevet, E. & Quillien, V., Dec 1 2017, In : Clinical Cancer Research. 23, 23, p. 7360-7374 15 p.

Research output: Contribution to journalArticle

Glioblastoma
Stem Cells
Dasatinib
Transcriptome
Heterografts
4 Citations (Scopus)

Characterization of relative biological effectiveness for conventional radiation therapy: A comparison of clinical 6 MV X-rays and 137Cs

Howard, M., Beltran, C., Sarkaria, J. N. & Herman, M. G., Sep 1 2017, In : Journal of Radiation Research. 58, 5, p. 608-613 6 p.

Research output: Contribution to journalArticle

Relative Biological Effectiveness
radiation therapy
Radiotherapy
X-Rays
Radiation

Chemically Modified Variants of Fenofibrate with Antiglioblastoma Potential

Stalinska, J., Zimolag, E., Pianovich, N. A., Zapata, A., Lassak, A., Rak, M., Dean, M., Ucar-Bilyeu, D., Wyczechowska, D., Culicchia, F., Marrero, L., Del Valle, L., Sarkaria, J. N., Peruzzi, F., Jursic, B. S. & Reiss, K., Jul 1 2019, In : Translational Oncology. 12, 7, p. 895-907 13 p.

Research output: Contribution to journalArticle

Open Access
Fenofibrate
Cell Death
Glioblastoma
Solubility
Neoplasms
15 Citations (Scopus)

CNS Anticancer Drug Discovery and Development Conference White Paper

Levin, V. A., Tonge, P. J., Gallo, J. M., Birtwistle, M. R., Dar, A. C., Iavarone, A., Paddison, P. J., Heffron, T. P., Elmquist, W. F., Lachowicz, J. E., Johnson, T. W., White, F. M., Sul, J., Smith, Q. R., Shen, W., Sarkaria, J. N., Samala, R., Wen, P. Y., Berry, D. A. & Petter, R. C., May 24 2015, In : Neuro-Oncology. 17, p. vi1-vi26

Research output: Contribution to journalArticle

Drug Discovery
Pharmaceutical Preparations
Critical Pathways
Drug Industry
Brain Neoplasms
26 Citations (Scopus)

Combination of epidermal growth factor receptor targeted therapy with radiation therapy for malignant gliomas

Krishnan, S., Rao, R. D., James, C. D. & Sarkaria, J. N., 2003, In : Frontiers in Bioscience. 8

Research output: Contribution to journalArticle

Radiotherapy
Epidermal Growth Factor Receptor
Glioma
Tumors
Chemotherapy
60 Citations (Scopus)

Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme

Liu, C., Sarkaria, J. N., Petell, C. A., Paraskevakou, G., Zollman, P. J., Schroeder, M., Carlson, B., Decker, P. A., Wu, W., James, C. D., Russell, S. J. & Galanis, E., Dec 1 2007, In : Clinical Cancer Research. 13, 23, p. 7155-7165 11 p.

Research output: Contribution to journalArticle

Measles virus
Glioblastoma
Radiotherapy
Glioma
Caspase Inhibitors
54 Citations (Scopus)
temozolomide
Glioblastoma
Radiation
Antibiotic Prophylaxis
Chemoradiotherapy
8 Citations (Scopus)

Combination therapy in a xenograft model of glioblastoma: Enhancement of the antitumor activity of temozolomide by an MDM2 antagonist

Wang, H., Cai, S., Bailey, B. J., Saadatzadeh, M. R., Ding, J., Tonsing-Carter, E., Georgiadis, T. M., Gunter, T. Z., Long, E. C., Minto, R. E., Gordon, K. R., Sen, S. E., Cai, W., Eitel, J. A., Waning, D. L., Bringman, L. R., Wells, C. D., Murray, M. E., Sarkaria, J. N., Gelbert, L. M. & 5 others, Jones, D. R., Cohen-Gadol, A. A., Mayo, L. D., Shannon, H. E. & Pollok, K. E., Feb 1 2017, In : Journal of Neurosurgery. 126, 2, p. 446-459 14 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Heterografts
Therapeutics
Growth
14 Citations (Scopus)

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

McNeill, R. S., Canoutas, D. A., Stuhlmiller, T. J., Dhruv, H. D., Irvin, D. M., Bash, R. E., Angus, S. P., Herring, L. E., Simon, J. M., Skinner, K. R., Limas, J. C., Chen, X., Schmid, R. S., Siegel, M. B., Van Swearingen, A. E. D., Hadler, M. J., Sulman, E. P., Sarkaria, J. N., Anders, C. K., Graves, L. M. & 3 others, Berens, M. E., Johnson, G. L. & Miller, C. R., Nov 1 2017, In : Neuro-Oncology. 19, 11, p. 1469-1480 12 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Glioblastoma
Protein Kinase Inhibitors
Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase Kinases
23 Citations (Scopus)

Comparison between pulsed-field gel electrophoresis and the comet assay as predictive assays for radiosensitivity in fibroblasts

Sarkaria, J. N., Bush, C., Eady, J. J., Peacock, J. H., Steel, G. G. & Yarnold, J. R., Jul 1998, In : Radiation Research. 150, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

Comet Assay
Pulsed Field Gel Electrophoresis
Radiation Tolerance
fibroblasts
pulsed-field gel electrophoresis
10 Citations (Scopus)

Constitutive Interferon Pathway Activation in Tumors as an Efficacy Determinant Following Oncolytic Virotherapy

Kurokawa, C., Iankov, I. D., Anderson, S. K., Aderca, I., Leontovich, A. A., Maurer, M. J., Oberg, A. L., Schroeder, M. A., Giannini, C., Greiner, S. M., Becker, M. A., Thompson, E. A., Haluska, P., Jentoft, M. E., Parney, I. F., Weroha, S. J., Jen, J., Sarkaria, J. N. & Galanis, E., Oct 1 2018, In : Journal of the National Cancer Institute. 110, 10, p. 1123-1132 10 p.

Research output: Contribution to journalArticle

Oncolytic Virotherapy
Measles virus
Interferons
Glioblastoma
Heterografts
19 Citations (Scopus)

Convertible MRI contrast: Sensing the delivery and release of anti-glioma nano-drugs

Zhang, L., Zhang, Z., Mason, R. P., Sarkaria, J. N. & Zhao, D., May 12 2015, In : Scientific Reports. 5, 09874.

Research output: Contribution to journalArticle

temozolomide
Manganese
Glioma
Glioblastoma
Pharmaceutical Preparations
9 Citations (Scopus)

Critical functions of RhoB in support of glioblastoma tumorigenesis

Ma, Y., Gong, Y., Cheng, Z., Loganathan, S., Kao, C., Sarkaria, J. N., Abel, T. W. & Wang, J., 2015, In : Neuro-Oncology. 17, 4, p. 516-525 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Carcinogenesis
Neoplasms
Heterografts
rhoB GTP-Binding Protein
17 Citations (Scopus)

Cyclophilin B supports MYC and mutant p53-dependent survival of glioblastoma multiforme cells

Choi, J. W., Schroeder, M. A., Sarkaria, J. N. & Bram, R. J., Jan 15 2014, In : Cancer Research. 74, 2, p. 484-496 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival
Endoplasmic Reticulum
Cell Survival
Peptidylprolyl Isomerase
89 Citations (Scopus)
Proteasome Inhibitors
JNK Mitogen-Activated Protein Kinases
Apoptosis
Tumor Cell Line
Glioma
5 Citations (Scopus)

Dasatinib in recurrent glioblastoma: Failure as a teacher

Schiff, D. & Sarkaria, J. N., Jul 1 2015, In : Neuro-Oncology. 17, 7, p. 910-911 2 p.

Research output: Contribution to journalArticle

Glioblastoma
Brain Neoplasms
Antineoplastic Agents
Dasatinib
19 Citations (Scopus)

Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma

Becker, C. M., Oberoi, R. K., McFarren, S. J., Muldoon, D. M., Pafundi, D. H., Pokorny, J. L., Brinkmann, D. H., Ohlfest, J. R., Sarkaria, J. N., Largaespada, D. A. & Elmquist, W. F., Sep 1 2015, In : Neuro-Oncology. 17, 9, p. 1210-1219 10 p.

Research output: Contribution to journalArticle

Penetrance
Glioblastoma
Phosphatidylinositol 3-Kinases
P-Glycoprotein
Blood-Brain Barrier
29 Citations (Scopus)

Delineation of MGMT Hypermethylation as a Biomarker for Veliparib-Mediated Temozolomide-Sensitizing Therapy of Glioblastoma

Gupta, S. K., Kizilbash, S., Carlson, B. L., Mladek, A. C., Boakye-Agyeman, F., Bakken, K. K., Pokorny, J. L., Schroeder, M. A., Decker, P. A., Cen, L., Eckel-Passow, J. E., Sarkar, G., Ballman, K. V., Reid, J. M., Jenkins, R. B., Verhaak, R. G., Sulman, E. P., Kitange, G. J. & Sarkaria, J. N., May 1 2016, In : Journal of the National Cancer Institute. 108, 5, djv369.

Research output: Contribution to journalArticle

temozolomide
Methyltransferases
Glioblastoma
Biomarkers
Heterografts