• 14465 Citations
  • 54 Scopus h-Index
1993 …2020

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Article

4-Hydroxytamoxifen, an active metabolite of tamoxifen, does not alter the radiation sensitivity of MCF-7 breast carcinoma cells irradiated in vitro

Sarkaria, J. N., Miller, E. M., Parker, C. J., Jordan, V. C. & Mulcahy, R. T., Jan 1994, In : Breast Cancer Research and Treatment. 30, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

A comparison of the efficacy and complication rates of low dose-rate versus high dose-rate brachytherapy in the treatment of uterine cervical carcinoma

Sarkaria, J. N., Petereit, D. G., Stitt, J. A., Hartman, T., Chappell, R., Thomadsen, B. R., Buchler, D. A., Fowler, J. F. & Kinsella, T. J., Aug 30 1994, In : International journal of radiation oncology, biology, physics. 30, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

52 Scopus citations

Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain

Oliva, C. R., Nozell, S. E., Diers, A., McClugage, S. G., Sarkaria, J. N., Markert, J. M., Darley-Usmar, V. M., Bailey, S. M., Gillespie, G. Y., Landar, A. & Griguer, C. E., Dec 17 2010, In : Journal of Biological Chemistry. 285, 51, p. 39759-39767 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Activation of Rac1 by Src-dependent phosphorylation of Dock180 Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

Feng, H., Hu, B., Liu, K. W., Li, Y., Lu, X., Cheng, T., Yiin, J. J., Lu, S., Keezer, S., Fenton, T., Furnari, F. B., Hamilton, R. L., Vuori, K., Sarkaria, J. N., Nagane, M., Nishikawa, R., Cavenee, W. K. & Cheng, S. Y., Dec 1 2011, In : Journal of Clinical Investigation. 121, 12, p. 4670-4684 15 p.

Research output: Contribution to journalArticle

80 Scopus citations

Active efflux of dasatinib from the brain limits efficacy against murine glioblastoma: Broad implications for the clinical use of molecularly targeted agents

Agarwal, S., Mittapalli, R. K., Zellmer, D. M., Gallardo, J. L., Donelson, R., Seiler, C., Decker, S. A., SantaCruz, K. S., Pokorny, J. L., Sarkaria, J. N., Elmquist, W. F. & Ohlfest, J. R., Oct 2012, In : Molecular cancer therapeutics. 11, 10, p. 2183-2192 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas

Kushwaha, D., Ramakrishnan, V., Ng, K., Steed, T., Nguyen, T., Futalan, D., Akers, J. C., Sarkaria, J., Jiang, T., Chowdhury, D., Carter, B. S. & Chen, C. C., 2014, In : Oncotarget. 5, 12, p. 4026-4039 14 p.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations

Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma

Kurokawa, C., Geekiyanage, H., Allen, C., Iankov, I., Schroeder, M., Carlson, B., Bakken, K., Sarkaria, J. N., Ecsedy, J. A., D'Assoro, A., Friday, B. & Galanis, E., Nov 5 2016, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-8 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Alkylpurine - DNA - N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

Agnihotri, S., Gajadhar, A. S., Ternamian, C., Gorlia, T., Diefes, K. L., Mischel, P. S., Kelly, J., McGown, G., Thorncroft, M., Carlson, B. L., Sarkaria, J. N., Margison, G. P., Aldape, K., Hawkins, C., Hegi, M. & Guha, A., Jan 3 2012, In : Journal of Clinical Investigation. 122, 1, p. 253-266 14 p.

Research output: Contribution to journalArticle

83 Scopus citations

An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth

Guessous, F., Zhang, F., DiPierro, C., Marcinkiewicz, L., Sarkaria, J., Schiff, D., Buchanan, S. & Abounader, R., Jan 2010, In : Anti-Cancer Agents in Medicinal Chemistry. 10, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

Chen, X., Zhang, M., Gan, H., Wang, H., Lee, J. H., Fang, D., Kitange, G. J., He, L., Hu, Z., Parney, I. F., Meyer, F. B., Giannini, C., Sarkaria, J. N. & Zhang, Z., Dec 1 2018, In : Nature communications. 9, 1, 2949.

Research output: Contribution to journalArticle

30 Scopus citations

A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death

Shing, J. C., Choi, J. W., Chapman, R., Schroeder, M. A., Sarkaria, J. N., Fauq, A. & Bram, R. J., Jul 2014, In : Cancer Biology and Therapy. 15, 7, p. 895-905 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patientderived GBM tumor cells

Tivnan, A., Heilinger, T., Ramsey, J. M., O'Connor, G., Pokorny, J. L., Sarkaria, J. N., Stringer, B. W., Day, B. W., Boyd, A. W., Kim, E. L., Lode, H. N., Cryan, S. A. & Prehn, J. H. M., 2017, In : Oncotarget. 8, 10, p. 16605-16620 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

Jun, H. J., Appleman, V. A., Wu, H. J., Rose, C. M., Pineda, J. J., Yeo, A. T., Delcuze, B., Lee, C., Gyuris, A., Zhu, H., Woolfenden, S., Bronisz, A., Nakano, I., Chiocca, E. A., Bronson, R. T., Ligon, K. L., Sarkaria, J. N., Gygi, S. P., Michor, F., Mitchison, T. J. & 1 others, Charest, A., Dec 1 2018, In : Nature communications. 9, 1, 3116.

Research output: Contribution to journalArticle

5 Scopus citations

A phase 2 study of temsirolimus (CCI-779) in patients with soft tissue sarcomas: A study of the mayo phase 2 Consortium (P2C)

Okuno, S., Bailey, H., Mahoney, M. R., Adkins, D., Maples, W., Fitch, T., Ettinger, D., Erlichman, C. & Sarkaria, J. N., Aug 1 2011, In : Cancer. 117, 15, p. 3468-3475 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

A phase II trial of everolimus, temozolomide, and radiotherapy in patients with newly diagnosed glioblastoma: NCCTG N057K

Ma, D. J., Galanis, E., Anderson, S. K., Schiff, D., Kaufmann, T. J., Peller, P. J., Giannini, C., Brown, P. D., Uhm, J. H., McGraw, S., Jaeckle, K. A., Flynn, P. J., Ligon, K. L., Buckner, J. C. & Sarkaria, J. N., Sep 1 2015, In : Neuro-Oncology. 17, 9, p. 1261-1269 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S. Y., Taya, Y., Prives, C. & Abraham, R. T., Jan 15 1999, In : Genes and Development. 13, 2, p. 152-157 6 p.

Research output: Contribution to journalArticle

Open Access
800 Scopus citations

ATM as a target for novel radiosensitizers

Sarkaria, J. N. & Eshleman, J. S., Jan 1 2001, In : Seminars in Radiation Oncology. 11, 4, p. 316-327 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells

Nadkarni, A., Shrivastav, M., Mladek, A. C., Schwingler, P. M., Grogan, P. T., Chen, J. & Sarkaria, J. N., Dec 1 2012, In : Journal of neuro-oncology. 110, 3, p. 349-357 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma

Guo, G., Gong, K., Ali, S., Ali, N., Shallwani, S., Hatanpaa, K. J., Pan, E., Mickey, B., Burma, S., Wang, D. H., Kesari, S., Sarkaria, J. N., Zhao, D. & Habib, A. A., Aug 1 2017, In : Nature Neuroscience. 20, 8, p. 1074-1084 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Tu, X., Kahila, M. M., Zhou, Q., Yu, J., Kalari, K. R., Wang, L. M., Harmsen, W. S., Yuan, J., Boughey, J. C., Goetz, M. P., Sarkaria, J. N., Lou, Z. & Mutter, R., Nov 1 2018, In : Molecular Cancer Therapeutics. 17, 11, p. 2462-2472 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Automatic 3D Nonlinear Registration of Mass Spectrometry Imaging and Magnetic Resonance Imaging Data

Abdelmoula, W. M., Regan, M. S., Lopez, B. G. C., Randall, E. C., Lawler, S., Mladek, A. C., Nowicki, M. O., Marin, B. M., Agar, J. N., Swanson, K. R., Kapur, T., Sarkaria, J. N., Wells, W. & Agar, N. Y. R., May 7 2019, In : Analytical Chemistry. 91, 9, p. 6206-6216 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

BET bromodomain proteins are required for glioblastoma cell proliferation

Pastori, C., Daniel, M., Penas, C., Volmar, C. H., Johnstone, A. L., Brothers, S. P., Graham, R. M., Allen, B., Sarkaria, J. N., Komotar, R. J., Wahlestedt, C. & Ayad, N. G., Feb 19 2014, In : Epigenetics. 9, 4, p. 611-620 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Bioluminescence monitoring of intracranial glioblastoma xenograft: Response to primary and salvage temozolomide therapy

Dinca, E. B., Sarkaria, J. N., Schroeder, M. A., Carlson, B. L., Voicu, R., Gupta, N., Berger, M. S. & James, C. D., Sep 1 2007, In : Journal of neurosurgery. 107, 3, p. 610-616 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Bioluminescent imaging of intracranial vestibular schwannoma xenografts in NOD/SCID mice

Neff, B. A., Voss, S. G., Allen, C., Schroeder, M. A., Driscoll, C. L. W., Link, M. J., Galanis, E. & Sarkaria, J. N., Jan 1 2009, In : Otology and Neurotology. 30, 1, p. 105-111 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Brain distributional kinetics of a novel MDM2 inhibitor SAR405838: Implications for use in brain tumor therapy

Kim, M., Laramy, J. K., Gampa, G., Parrish, K. E., Brundage, R., Sarkaria, J. N. & Elmquist, W. F., Jan 1 2019, In : Drug Metabolism and Disposition. 47, 12, p. 1403-1414 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Brain Distribution and Active Efflux of Three panRAF Inhibitors: Considerations in the Treatment of Melanoma Brain Metastases

Gampa, G., Kim, M., Mohammad, A. S., Parrish, K. E., Mladek, A. C., Sarkaria, J. N. & Elmquist, W. F., Mar 1 2019, In : The Journal of pharmacology and experimental therapeutics. 368, 3, p. 446-461 16 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Brain distribution of a novel MEK Inhibitor E6201: Implications in the treatment of melanoma brain metastases

Gampa, G., Kim, M., Cook-Rostie, N., Laramy, J. K., Sarkaria, J. N., Paradiso, L., DePalatis, L. & Elmquist, W. F., May 1 2018, In : Drug Metabolism and Disposition. 46, 5, p. 658-666 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Brain distribution of a panel of epidermal growth factor receptor inhibitors using cassette dosing in wild-type and ABCB1/ABCG2-deficient mice

Kim, M., Laramy, J. K., Mohammad, A. S., Talele, S., Fisher, J., Sarkaria, J. N. & Elmquist, W. F., Apr 2019, In : Drug Metabolism and Disposition. 47, 4, p. 393-404 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

Flavahan, W. A., Wu, Q., Hitomi, M., Rahim, N., Kim, Y., Sloan, A. E., Weil, R. J., Nakano, I., Sarkaria, J. N., Stringer, B. W., Day, B. W., Li, M., Lathia, J. D., Rich, J. N. & Hjelmeland, A. B., Oct 1 2013, In : Nature Neuroscience. 16, 10, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

216 Scopus citations

Brain tumor stem cell multipotency correlates with nanog expression and extent of passaging in human glioblastoma xenografts

Higgins, D. M., Wang, R., Milligan, B., Schroeder, M., Carlson, B., Pokorny, J., Cheshier, S. H., Meyer, F. B., Weissman, I. L., Sarkaria, J. N. & Henley, J. R., May 2013, In : Oncotarget. 4, 5, p. 792-801 10 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

CD90 expression controls migration and predicts dasatinib response in glioblastoma

Avril, T., Etcheverry, A., Pineau, R., Obacz, J., Jegou, G., Jouan, F., Le Reste, P. J., Hatami, M., Colen, R. R., Carlson, B. L., Decker, P. A., Sarkaria, J. N., Vauléon, E., Chiforeanu, D. C., Clavreul, A., Mosser, J., Chevet, E. & Quillien, V., Dec 1 2017, In : Clinical Cancer Research. 23, 23, p. 7360-7374 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Characterization of relative biological effectiveness for conventional radiation therapy: A comparison of clinical 6 MV X-rays and 137Cs

Howard, M., Beltran, C., Sarkaria, J. & Herman, M. G., Sep 1 2017, In : Journal of Radiation Research. 58, 5, p. 608-613 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Chemically Modified Variants of Fenofibrate with Antiglioblastoma Potential

Stalinska, J., Zimolag, E., Pianovich, N. A., Zapata, A., Lassak, A., Rak, M., Dean, M., Ucar-Bilyeu, D., Wyczechowska, D., Culicchia, F., Marrero, L., Del Valle, L., Sarkaria, J. N., Peruzzi, F., Jursic, B. S. & Reiss, K., Jul 1 2019, In : Translational Oncology. 12, 7, p. 895-907 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme

Liu, C., Sarkaria, J. N., Petell, C. A., Paraskevakou, G., Zollman, P. J., Schroeder, M., Carlson, B., Decker, P. A., Wu, W., James, C. D., Russell, S. J. & Galanis, E., Dec 1 2007, In : Clinical Cancer Research. 13, 23, p. 7155-7165 11 p.

Research output: Contribution to journalArticle

61 Scopus citations
56 Scopus citations

Combination therapy in a xenograft model of glioblastoma: Enhancement of the antitumor activity of temozolomide by an MDM2 antagonist

Wang, H., Cai, S., Bailey, B. J., Saadatzadeh, M. R., Ding, J., Tonsing-Carter, E., Georgiadis, T. M., Gunter, T. Z., Long, E. C., Minto, R. E., Gordon, K. R., Sen, S. E., Cai, W., Eitel, J. A., Waning, D. L., Bringman, L. R., Wells, C. D., Murray, M. E., Sarkaria, J. N., Gelbert, L. M. & 5 others, Jones, D. R., Cohen-Gadol, A. A., Mayo, L. D., Shannon, H. E. & Pollok, K. E., Feb 2017, In : Journal of neurosurgery. 126, 2, p. 446-459 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

McNeill, R. S., Canoutas, D. A., Stuhlmiller, T. J., Dhruv, H. D., Irvin, D. M., Bash, R. E., Angus, S. P., Herring, L. E., Simon, J. M., Skinner, K. R., Limas, J. C., Chen, X., Schmid, R. S., Siegel, M. B., Van Swearingen, A. E. D., Hadler, M. J., Sulman, E. P., Sarkaria, J. N., Anders, C. K., Graves, L. M. & 3 others, Berens, M. E., Johnson, G. L. & Miller, C. R., Nov 1 2017, In : Neuro-oncology. 19, 11, p. 1469-1480 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Comparison between pulsed-field gel electrophoresis and the comet assay as predictive assays for radiosensitivity in fibroblasts

Sarkaria, J. N., Bush, C., Eady, J. J., Peacock, J. H., Steel, G. G. & Yarnold, J. R., Jul 1 1998, In : Radiation Research. 150, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Constitutive Interferon Pathway Activation in Tumors as an Efficacy Determinant Following Oncolytic Virotherapy

Kurokawa, C., Iankov, I. D., Anderson, S. K., Aderca, I., Leontovich, A. A., Maurer, M. J., Oberg, A. L., Schroeder, M. A., Giannini, C., Greiner, S. M., Becker, M. A., Thompson, E. A., Haluska, P. R. J., Jentoft, M. E., Parney, I. F., Weroha, S. J., Jen, J., Sarkaria, J. N. & Galanis, E., Oct 1 2018, In : Journal of the National Cancer Institute. 110, 10, p. 1123-1132 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Convertible MRI contrast: Sensing the delivery and release of anti-glioma nano-drugs

Zhang, L., Zhang, Z., Mason, R. P., Sarkaria, J. N. & Zhao, D., May 12 2015, In : Scientific reports. 5, 9874.

Research output: Contribution to journalArticle

24 Scopus citations

Critical functions of RhoB in support of glioblastoma tumorigenesis

Ma, Y., Gong, Y., Cheng, Z., Loganathan, S., Kao, C., Sarkaria, J. N., Abel, T. W. & Wang, J., 2015, In : Neuro-oncology. 17, 4, p. 516-525 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Cyclophilin B supports MYC and mutant p53-dependent survival of glioblastoma multiforme cells

Choi, J. W., Schroeder, M. A., Sarkaria, J. N. & Bram, R. J., Jan 15 2014, In : Cancer research. 74, 2, p. 484-496 13 p.

Research output: Contribution to journalArticle

18 Scopus citations
89 Scopus citations

Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma

Becker, C. M., Oberoi, R. K., McFarren, S. J., Muldoon, D. M., Pafundi, D. H., Pokorny, J. L., Brinkmann, D. H., Ohlfest, J. R., Sarkaria, J. N., Largaespada, D. A. & Elmquist, W. F., Sep 1 2015, In : Neuro-Oncology. 17, 9, p. 1210-1219 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Delineation of MGMT Hypermethylation as a Biomarker for Veliparib-Mediated Temozolomide-Sensitizing Therapy of Glioblastoma

Gupta, S. K., Kizilbash, S., Carlson, B. L., Mladek, A. C., Boakye-Agyeman, F., Bakken, K. K., Pokorny, J. L., Schroeder, M. A., Decker, P. A., Cen, L., Eckel-Passow, J. E., Sarkar, G., Ballman, K. V., Reid, J. M., Jenkins, R. B., Verhaak, R. G., Sulman, E. P., Kitange, G. J. & Sarkaria, J. N., May 1 2016, In : Journal of the National Cancer Institute. 108, 5, djv369.

Research output: Contribution to journalArticle

38 Scopus citations

Design and characterization of an economical 192Ir hemi-brain small animal irradiator

Grams, M. P., Wilson, Z. C., Sio, T. T., Beltran, C. J., Tryggestad, E. J., Gupta, S. K., Blackwell, C. R., McCollough, K. P., Sarkaria, J. N. & Furutani, K. M., Oct 1 2014, In : International Journal of Radiation Biology. 90, 10, p. 936-942 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Development of investigational radiation modifiers

Colevas, A. D., Brown, J. M., Hahn, S., Mitchell, J., Camphausen, K., Coleman, C. N., Conley, B., Cumberlin, R., Stone, H. B., Wong, R., Freidlin, B., Kobayashi, K., Murgo, A. J., Shoemaker, R., Tofilon, P. J., Choy, H., Dicker, A., Doroshow, J. H., Formenti, S. C., Garden, A. & 12 others, Gately, S., Hill, R., Kinsella, T. J., Moore, M., Sarkaria, J., Siemann, D., Sokol, G., Teicher, B. A., Trotti, A., Turrisi, A. T., Urtasun, R. & Vokes, E. E., May 7 2003, In : Journal of the National Cancer Institute. 95, 9, p. 646-651 6 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Discordant in vitro and in vivo chemopotentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts

Gupta, S. K., Mladek, A. C., Carlson, B. L., Boakye-Agyeman, F., Bakken, K. K., Kizilbash, S. H., Schroeder, M. A., Reid, J. & Sarkaria, J. N., Jul 15 2014, In : Clinical Cancer Research. 20, 14, p. 3730-3741 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells

Rao, R. D., Mladek, A. C., Lamont, J. D., Goble, J. M., Erlichman, C., James, C. D. & Sarkaria, J. N., Oct 2005, In : Neoplasia. 7, 10, p. 921-929 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

Zhou, D., Alver, B. M., Li, S., Hlady, R. A., Thompson, J. J., Schroeder, M. A., Lee, J. H., Qiu, J., Schwartz, P. H., Sarkaria, J. N. & Robertson, K. D., Mar 27 2018, In : Genome biology. 19, 1, 43.

Research output: Contribution to journalArticle

17 Scopus citations