• 14882 Citations
  • 56 Scopus h-Index
1993 …2020

Research output per year

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Research Output

2011

Activation of Rac1 by Src-dependent phosphorylation of Dock180 Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

Feng, H., Hu, B., Liu, K. W., Li, Y., Lu, X., Cheng, T., Yiin, J. J., Lu, S., Keezer, S., Fenton, T., Furnari, F. B., Hamilton, R. L., Vuori, K., Sarkaria, J. N., Nagane, M., Nishikawa, R., Cavenee, W. K. & Cheng, S. Y., Dec 1 2011, In : Journal of Clinical Investigation. 121, 12, p. 4670-4684 15 p.

Research output: Contribution to journalArticle

81 Scopus citations

A phase 2 study of temsirolimus (CCI-779) in patients with soft tissue sarcomas: A study of the mayo phase 2 Consortium (P2C)

Okuno, S., Bailey, H., Mahoney, M. R., Adkins, D., Maples, W., Fitch, T., Ettinger, D., Erlichman, C. & Sarkaria, J. N., Aug 1 2011, In : Cancer. 117, 15, p. 3468-3475 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Effective radiovirotherapy for malignant gliomas by using oncolytic measles virus strains encoding the sodium iodide symporter (MV-NIS)

Opyrchal, M., Allen, C., Iankov, I., Aderca, I., Schroeder, M., Sarkaria, J. & Galanis, E., Dec 20 2011, In : Human gene therapy. 23, 4, p. 419-427 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
85 Scopus citations

Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines

Peasland, A., Wang, L. Z., Rowling, E., Kyle, S., Chen, T., Hopkins, A., Cliby, W. A., Sarkaria, J., Beale, G., Edmondson, R. J. & Curtin, N. J., Jul 26 2011, In : British journal of cancer. 105, 3, p. 372-381 10 p.

Research output: Contribution to journalArticle

126 Scopus citations

Incorporation of biomarker assessment in novel clinical trial designs: Personalizing brain tumor treatments

Galanis, E., Wu, W., Sarkaria, J., Chang, S. M., Colman, H., Sargent, D. & Reardon, D. A., Feb 2011, In : Current oncology reports. 13, 1, p. 42-49 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
313 Scopus citations
59 Scopus citations

Phenotypic variations in NF1-associated low grade astrocytomas: Possible role for increased mTOR activation in a subset

Jentoft, M., Giannini, C., Cen, L., Scheithauer, B. W., Hoesley, B., Sarkaria, J. N., Abell-Aleff, P. C., Rodriguez, E. F., Li, Y. & Rodriguez, F. J., 2011, In : International Journal of Clinical and Experimental Pathology. 4, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

Phenotypic variations in NF1-associated low grade astrocytomas: Possible role for increased mTOR activation in a subset

Jentoft, M., Giannini, C., Cen, L., Scheithauer, B. W., Hoesley, B., Sarkaria, J. N., Abell-Aleff, P. C., Rodriguez, E. F., Li, Y. & Rodriguez, F. J., Nov 2 2011, In : International Journal of Clinical and Experimental Pathology. 4, 1, p. 43-57 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma

Rodriguez, E. F., Scheithauer, B. W., Giannini, C., Rynearson, A., Cen, L., Hoesley, B., Gilmer-Flynn, H., Sarkaria, J. N., Jenkins, S., Long, J. & Rodriguez, F. J., Mar 2011, In : Acta neuropathologica. 121, 3, p. 407-420 14 p.

Research output: Contribution to journalArticle

95 Scopus citations

WE‐G‐214‐02: Utility of 18F‐FDOPA PET for Radiotherapy Target Delineation in Glioma Patients

Pafundi, D., Brinkmann, D. H., Laack, N. N., Sarkaria, J. N., Yan, E., Kemp, B. & Lowe, V., 2011, In : Medical Physics. 38, 6, p. 3830 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

WWP2 is an E3 ubiquitin ligase for PTEN

Maddika, S., Kavela, S., Rani, N., Palicharla, V. R., Pokorny, J. L., Sarkaria, J. N. & Chen, J., Jun 2011, In : Nature Cell Biology. 13, 6, p. 728-733 6 p.

Research output: Contribution to journalArticle

173 Scopus citations
2010

Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain

Oliva, C. R., Nozell, S. E., Diers, A., McClugage, S. G., Sarkaria, J. N., Markert, J. M., Darley-Usmar, V. M., Bailey, S. M., Gillespie, G. Y., Landar, A. & Griguer, C. E., Dec 17 2010, In : Journal of Biological Chemistry. 285, 51, p. 39759-39767 9 p.

Research output: Contribution to journalArticle

95 Scopus citations

An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth

Guessous, F., Zhang, F., DiPierro, C., Marcinkiewicz, L., Sarkaria, J., Schiff, D., Buchanan, S. & Abounader, R., Jan 2010, In : Anti-Cancer Agents in Medicinal Chemistry. 10, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Combination of temsirolimus (CCI-779) with chemoradiation in newly diagnosed glioblastoma multiforme (GBM) (NCCTG trial N027D) is associated with increased infectious risks

Sarkaria, J. N., Galanis, E., Wu, W., Dietz, A. B., Kaufmann, T. J., Gustafson, M. P., Brown, P. D., Uhm, J. H., Rao, R. D., Doyle, L., Giannini, C., Jaeckle, K. A. & Buckner, J. C., Nov 15 2010, In : Clinical Cancer Research. 16, 22, p. 5573-5580 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Expression of CD74 in high grade gliomas: A potential role in temozolomide resistance

Kitange, G. J., Carlson, B. L., Schroeder, M. A., Decker, P. A., Morlan, B. W., Wu, W., Ballman, K. V., Giannini, C. & Sarkaria, J. N., Nov 2010, In : Journal of neuro-oncology. 100, 2, p. 177-186 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

Verhaak, R. G. W., Hoadley, K. A., Purdom, E., Wang, V., Qi, Y., Wilkerson, M. D., Miller, C. R., Ding, L., Golub, T., Mesirov, J. P., Alexe, G., Lawrence, M., O'Kelly, M., Tamayo, P., Weir, B. A., Gabriel, S., Winckler, W., Gupta, S., Jakkula, L., Feiler, H. S. & 13 others, Hodgson, J. G., James, C. D., Sarkaria, J. N., Brennan, C., Kahn, A., Spellman, P. T., Wilson, R. K., Speed, T. P., Gray, J. W., Meyerson, M., Getz, G., Perou, C. M. & Hayes, D. N., Jan 19 2010, In : Cancer cell. 17, 1, p. 98-110 13 p.

Research output: Contribution to journalArticle

3811 Scopus citations

Misregulated E-Cadherin expression associated with an aggressive brain tumor phenotype

Lewis-Tuffin, L. J., Rodriguez, F., Giannini, C., Scheithauer, B., Necela, B. M., Sarkaria, J. N. & Anastasiadis, P. Z., 2010, In : PloS one. 5, 10, e13665.

Research output: Contribution to journalArticle

99 Scopus citations

ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain

Yiin, J. J., Hu, B., Schornack, P. A., Sengar, R. S., Liu, K. W., Feng, H., Lieberman, F. S., Chiou, S. H., Sarkaria, J. N., Wiener, E. C., Ma, H. I. & Cheng, S. Y., Apr 2010, In : Molecular cancer therapeutics. 9, 4, p. 929-941 13 p.

Research output: Contribution to journalArticle

30 Scopus citations
2009

Bioluminescent imaging of intracranial vestibular schwannoma xenografts in NOD/SCID mice

Neff, B. A., Voss, S. G., Allen, C., Schroeder, M. A., Driscoll, C. L. W., Link, M. J., Galanis, E. & Sarkaria, J. N., Jan 2009, In : Otology and Neurotology. 30, 1, p. 105-111 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma

Lines, X., Clarke, M. J., Mulligan, E. A., Grogan, P. T., Mladek, A. C., Carlson, B. L., Schroeder, M. A., Curtin, N. J., Lou, Z., Decker, P. A., Wu, W., Plummer, E. R. & Sarkaria, J. N., Feb 1 2009, In : Molecular cancer therapeutics. 8, 2, p. 407-414 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model

Kitange, G. J., Carlson, B. L., Mladek, A. C., Decker, P. A., Schroeder, M. A., Wu, W., Grogan, P. T., Giannini, C., Ballman, K. V., Buckner, J. C., David James, C. & Sarkaria, J. N., 2009, In : Journal of neuro-oncology. 92, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

Kitange, G. J., Carlson, B. L., Schroeder, M. A., Grogan, P. T., Lamont, J. D., Decker, P. A., Wu, W., James, C. D. & Sarkaria, J. N., Jun 2009, In : Neuro-oncology. 11, 3, p. 281-291 11 p.

Research output: Contribution to journalArticle

148 Scopus citations

Radiosensitizing Effects of Temozolomide Observed in vivo only in a Subset of O6-Methylguanine-DNA Methyltransferase Methylated Glioblastoma Multiforme Xenografts

Carlson, B. L., Grogan, P. T., Mladek, A. C., Schroeder, M. A., Kitange, G. J., Decker, P. A., Giannini, C., Wu, W., Ballman, K. A., James, C. D. & Sarkaria, J. N., Sep 1 2009, In : International Journal of Radiation Oncology Biology Physics. 75, 1, p. 212-219 8 p.

Research output: Contribution to journalArticle

59 Scopus citations
2008

Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes

Rodriguez, F. J., Giannini, C., Asmann, Y. W., Sharma, M. K., Perry, A., Tibbetts, K. M., Jenkins, R. B., Scheithauer, B. W., Anant, S., Jenkins, S., Eberhart, C. G., Sarkaria, J. N. & Gutmann, D. H., Dec 2008, In : Journal of Neuropathology and Experimental Neurology. 67, 12, p. 1194-1204 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Interleukin-13 displaying retargeted oncolytic measles virus strains have significant activity against gliomas with improved specificity

Allen, C., Paraskevakou, G., Iankov, I., Giannini, C., Schroeder, M., Sarkaria, J., Schroeder, M., Puri, R. K., Russell, S. J. & Galanis, E., 2008, In : Molecular Therapy. 16, 9, p. 1556-1564 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Mechanisms of chemoresistance to alkylating agents in malignant glioma

Sarkaria, J. N., Kitange, G. J., James, C. D., Plummer, R., Calvert, H., Weller, M. & Wick, W., May 15 2008, In : Clinical Cancer Research. 14, 10, p. 2900-2908 9 p.

Research output: Contribution to journalReview article

235 Scopus citations

Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells

Yu, C., Friday, B. B., Yang, L., Atadja, P., Wigle, D., Sarkaria, J. & Adjei, A. A., Jun 2008, In : Neuro-oncology. 10, 3, p. 309-319 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Overview of cancer molecular radiobiology.

Sarkaria, J. N. & Bristow, R. G., 2008, In : Cancer treatment and research. 139, p. 117-133 17 p.

Research output: Contribution to journalReview article

6 Scopus citations

p53 small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts

Dinca, E. B., Lu, K. V., Sarkaria, J. N., Pieper, R. O., Prados, M. D., Haas-Kogan, D. A., VandenBerg, S. R., Berger, M. S. & James, C. D., Dec 15 2008, In : Cancer research. 68, 24, p. 10034-10039 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North central cancer treatment group study N0177

Brown, P. D., Krishnan, S., Sarkaria, J. N., Wu, W., Jaeckle, K. A., Uhm, J. H., Geoffroy, F. J., Arusell, R., Kitange, G., Jenkins, R. B., Kugler, J. W., Morton, R. F., Rowland, K. M., Mischel, P., Yong, W. H., Scheithauer, B. W., Schiff, D., Giannini, C. & Buckner, J. C., Dec 1 2008, In : Journal of Clinical Oncology. 26, 34, p. 5603-5609 7 p.

Research output: Contribution to journalArticle

199 Scopus citations

PTEN loss does not predict for response to RAD001 (everolimus) in a glioblastoma orthotopic xenograft test panel

Yang, L., Clarke, M. J., Carlson, B. L., Mladek, A. C., Schroeder, M. A., Decker, P., Wu, W., Kitange, G., Grogan, P., Goble, J. M., Uhm, J., Galanis, E., Giannini, C., Lane, H. A., James, C. D. & Sarkaria, J. N., Jun 15 2008, In : Clinical Cancer Research. 14, 12, p. 3993-4001 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Using fluorodeoxythymidine to monitor anti-egfr inhibitor therapy in squamous cell carcinoma xenografts

Atkinson, D. M., Clarke, M. J., Mladek, A. C., Carlson, B. L., Trump, D. P., Jacobson, M. S., Kemp, B. J., Lowe, V. J. & Sarkaria, J. N., Jun 2008, In : Head and Neck. 30, 6, p. 790-799 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
2007

Bioluminescence monitoring of intracranial glioblastoma xenograft: Response to primary and salvage temozolomide therapy

Dinca, E. B., Sarkaria, J. N., Schroeder, M. A., Carlson, B. L., Voicu, R., Gupta, N., Berger, M. S. & James, C. D., Sep 2007, In : Journal of neurosurgery. 107, 3, p. 610-616 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme

Liu, C., Sarkaria, J. N., Petell, C. A., Paraskevakou, G., Zollman, P. J., Schroeder, M., Carlson, B., Decker, P. A., Wu, W., James, C. D., Russell, S. J. & Galanis, E., Dec 1 2007, In : Clinical Cancer Research. 13, 23, p. 7155-7165 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

Sarkaria, J. N., Yang, L., Grogan, P. T., Kitange, G. J., Carlson, B. L., Schroeder, M. A., Galanis, E., Giannini, C., Wu, W., Dinca, E. B. & James, C. D., Mar 2007, In : Molecular cancer therapeutics. 6, 3, p. 1167-1174 8 p.

Research output: Contribution to journalArticle

146 Scopus citations

Phase I trial of sirolimus combined with radiation and cisplatin in non-small cell lung cancer

Sarkaria, J. N., Schwingler, P., Schild, S. E., Grogan, P. T., Mladek, A. C., Mandrekar, S. J., Tan, A. D., Kobayashi, T., Marks, R. S., Kita, H., Miller, R. C., Limper, A. H. & Leof, E. B., Aug 2007, In : Journal of Thoracic Oncology. 2, 8, p. 751-757 7 p.

Research output: Contribution to journalArticle

36 Scopus citations
2006
89 Scopus citations

Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response

Sarkaria, J. N., Carlson, B. L., Schroeder, M. A., Grogan, P., Brown, P. D., Giannini, C., Ballman, K. V., Kitange, C. J., Guha, A., Pandita, A. & James, C. D., Apr 1 2006, In : Clinical Cancer Research. 12, 7 I, p. 2264-2271 8 p.

Research output: Contribution to journalArticle

181 Scopus citations
2005

Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells

Rao, R. D., Mladek, A. C., Lamont, J. D., Goble, J. M., Erlichman, C., James, C. D. & Sarkaria, J. N., Oct 2005, In : Neoplasia. 7, 10, p. 921-929 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme

Giannini, C., Sarkaria, J. N., Saito, A., Uhm, J. H., Galanis, E., Carlson, B. L., Schroeder, M. A. & James, C. D., Apr 2005, In : Neuro-oncology. 7, 2, p. 164-176 13 p.

Research output: Contribution to journalArticle

247 Scopus citations
2004

Mammalian target of rapamycin (mTOR) inhibitors as anti-cancer agents

Rao, R. D., Buckner, J. C. & Sarkaria, J. N., Dec 2004, In : Current Cancer Drug Targets. 4, 8, p. 621-635 15 p.

Research output: Contribution to journalReview article

74 Scopus citations
2003

Combination of epidermal growth factor receptor targeted therapy with radiation therapy for malignant gliomas

Krishnan, S., Rao, R. D., James, C. D. & Sarkaria, J. N., Dec 1 2003, In : Frontiers in Bioscience. 8, p. e1-e14

Research output: Contribution to journalReview article

26 Scopus citations

Development of investigational radiation modifiers

Colevas, A. D., Brown, J. M., Hahn, S., Mitchell, J., Camphausen, K., Coleman, C. N., Conley, B., Cumberlin, R., Stone, H. B., Wong, R., Freidlin, B., Kobayashi, K., Murgo, A. J., Shoemaker, R., Tofilon, P. J., Choy, H., Dicker, A., Doroshow, J. H., Formenti, S. C., Garden, A. & 12 others, Gately, S., Hill, R., Kinsella, T. J., Moore, M., Sarkaria, J., Siemann, D., Sokol, G., Teicher, B. A., Trotti, A., Turrisi, A. T., Urtasun, R. & Vokes, E. E., May 7 2003, In : Journal of the National Cancer Institute. 95, 9, p. 646-651 6 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Identifying inhibitors of ATM and ATR kinase activities.

Sarkaria, J. N., 2003, In : Methods in molecular medicine. 85, p. 49-56 8 p.

Research output: Contribution to journalReview article

11 Scopus citations
2002

Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy

Eshleman, J. S., Carlson, B. L., Mladek, A. C., Kastner, B. D., Shide, K. L. & Sarkaria, J. N., Dec 15 2002, In : Cancer research. 62, 24, p. 7291-7297 7 p.

Research output: Contribution to journalArticle

167 Scopus citations

Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases

Peng, H., Kim, D. I., Sarkaria, J. N., Cho, Y. S., Abraham, R. T. & Zalkow, L. H., Jan 1 2002, In : Bioorganic and Medicinal Chemistry. 10, 1, p. 167-174 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2001

ATM as a target for novel radiosensitizers

Sarkaria, J. N. & Eshleman, J. S., 2001, In : Seminars in Radiation Oncology. 11, 4, p. 316-327 12 p.

Research output: Contribution to journalArticle

43 Scopus citations
2000

The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

Busby, E. C., Leistritz, D. F., Abraham, R. T., Karnitz, L. M. & Sarkaria, J. N., Apr 15 2000, In : Cancer research. 60, 8, p. 2108-2112 5 p.

Research output: Contribution to journalArticle

302 Scopus citations