• 25823 Citations
  • 76 Scopus h-Index
1980 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

Sieben, C. J., Jeganathan, K. B., Nelson, G. G., Sturmlechner, I., Zhang, C., Van Deursen, W. H., Bakker, B., Foijer, F., Li, H., Baker, D. J. & Van Deursen, J. M., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 171-188 18 p.

Research output: Contribution to journalArticle

Open Access

Requirement of the Cep57-Cep63 interaction for proper CEP152 recruitment and centriole duplication

Wei, Z., Kim, T. S., Ahn, J. I., Meng, L., Chen, Y., Ryu, E. K., Ku, B., Zhou, M., Kim, S. J., Bang, J. K., Van Deursen, J. M., Park, J. E. & Lee, K. S., May 1 2020, In : Molecular and cellular biology. 40, 10, 00535-19.

Research output: Contribution to journalArticle

Therapy-induced senescence drives bone loss

Yao, Z., Murali, B., Ren, Q., Luo, X., Faget, D. V., Cole, T., Ricci, B., Thotala, D., Monahan, J., Van Deursen, J. M., Baker, D., Faccio, R., Schwarz, J. K. & Stewart, S. A., Mar 1 2020, In : Cancer research. 80, 5, p. 1171-1182 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

Aguayo-Mazzucato, C., Andle, J., Lee, T. B., Midha, A., Talemal, L., Chipashvili, V., Hollister-Lock, J., van Deursen, J., Weir, G. & Bonner-Weir, S., Jul 2 2019, In : Cell Metabolism. 30, 1, p. 129-142.e4

Research output: Contribution to journalArticle

31 Scopus citations

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

Aziz, K., Limzerwala, J. F., Sturmlechner, I., Hurley, E., Zhang, C., Jeganathan, K. B., Nelson, G., Bronk, S., Fierro Velasco, R. O., van Deursen, E. J., O'Brien, D. R., Kocher, J. P. A., Youssef, S. A., van Ree, J. H., de Bruin, A., van den Bos, H., Spierings, D. C. J., Foijer, F., van de Sluis, B., Roberts, L. R. & 3 others, Gores, G. J., Li, H. & van Deursen, J. M., Jul 2019, In : Gastroenterology. 157, 1, p. 210-226.e12

Research output: Contribution to journalArticle

7 Scopus citations

Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL

Zhang, Y., Gundelach, J., Lindquist, L. D., Baker, D. J., Van Deursen, J. & Bram, R. J., 2019, In : PloS one. 14, 10, e0224172.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Crystallizing BubR1’s kinase activity

Limzerwala, J. F. & van Deursen, J. M., Aug 1 2019, In : Cell Research. 29, 8, p. 605-606 2 p.

Research output: Contribution to journalArticle

Open Access

FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements

Van Zutphen, T., Stroeve, J. H. M., Yang, J., Bloks, V. W., Jurdzinski, A., Roelofsen, H., Huijkman, N. C. A., Van Dijk, T. H., Vonk, R. J., Van Deursen, J., Staels, B., Groen, A. K. & Kuipers, F., 2019, In : Journal of Lipid Research. 60, 9, p. 1547-1561 15 p.

Research output: Contribution to journalArticle

Inhibition of ‘jumping genes’ promotes healthy ageing

Childs, B. & Van Deursen, J., Feb 7 2019, In : Nature. 566, 7742, p. 46-48 3 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death

Simmons, A. J., Park, R., Sterling, N. A., Jang, M. H., Van Deursen, J. M. A., Yen, T. J., Cho, S. H. & Kim, S., Jun 1 2019, In : Human molecular genetics. 28, 11, p. 1822-1836 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pak2 kinase promotes cellular senescence and organismal aging

Lee, J. S., Mo, Y., Gan, H., Burgess, R. J., Baker, D. J., van Deursen, J. M. & Zhang, Z. H., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13311-13319 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice

Cho, C. H., Yoo, K. H., Oliveros, A., Paulson, S., Hussaini, S. M. Q., van Deursen, J. M. & Jang, M. H., Apr 2019, In : Aging Cell. 18, 2, e12899.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Bussian, T. J., Aziz, A., Meyer, C. F., Swenson, B. L., van Deursen, J. M. & Baker, D. J., Oct 25 2018, In : Nature. 562, 7728, p. 578-582 5 p.

Research output: Contribution to journalArticle

171 Scopus citations

FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis

Heim, J. B., McDonald, C. A., Wyles, S. P., Sominidi-Damodaran, S., Squirewell, E. J., Li, M., Motsonelidze, C., Böttcher, R. T., van Deursen, J. & Meves, A., Jul 2018, In : PloS one. 13, 7, e0200558.

Research output: Contribution to journalArticle

2 Scopus citations

L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage

Nowsheen, S., Aziz, K., Aziz, A., Deng, M., Qin, B., Luo, K., Jeganathan, K. B., Zhang, H., Liu, T., Yu, J., Deng, Y., Yuan, J., Ding, W., Van Deursen, J. M. & Lou, Z., Apr 1 2018, In : Nature Cell Biology. 20, 4, p. 455-464 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mosaic-variegated aneuploidy syndrome mutation or haploinsufficiency in Cep57 impairs tumor suppression

Aziz, K., Sieben, C. J., Jeganathan, K. B., Hamada, M., Davies, B. A., Fierro Velasco, R. O., Rahman, N., Katzmann, D. J. & Van Deursen, J., Aug 1 2018, In : Journal of Clinical Investigation. 128, 8, p. 3517-3534 18 p.

Research output: Contribution to journalArticle

4 Scopus citations

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts

Dou, C., Liu, Z., Tu, K., Zhang, H., Chen, C., Yaqoob, U., Wang, Y., Wen, J., Van Deursen, J., Sicard, D., Tschumperlin, D. J., Zou, H., Huang, W. C., Urrutia, R., Shah, V. & Kang, N., Jun 1 2018, In : Gastroenterology. 154, 8, p. 2209-2221.e14

Research output: Contribution to journalArticle

32 Scopus citations

The COMMD family regulates plasma LDL levels and attenuates atherosclerosis through stabilizing the CCC complex in endosomal LDLR traffcking

Fedoseienko, A., Wijers, M., Wolters, J. C., Dekker, D., Smit, M., Huijkman, N., Kloosterhuis, N., Klug, H., Schepers, A., Van Dijk, K. W., Levels, J. H. M., Billadeau, D. D., Hofker, M. H., Van Deursen, J., Westerterp, M., Burstein, E., Kuivenhoven, J. A. & Van De Sluis, B., 2018, In : Circulation research. 122, 12, p. 1648-1660 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Nowsheen, S., Aziz, K., Luo, K., Deng, M., Qin, B., Yuan, J., Jeganathan, K. B., Yu, J., Zhang, H., Ding, W., Van Deursen, J. M. & Lou, Z., Dec 1 2018, In : Nature communications. 9, 1, 2736.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH

Van Der Pol, A., Gil, A., Silljé, H. H. W., Tromp, J., Ovchinnikova, E. S., Vreeswijk-Baudoin, I., Hoes, M., Domian, I. J., Van De Sluis, B., Van Deursen, J. M., Voors, A. A., Van Veldhuisen, D. J., Van Gilst, W. H., Berezikov, E., Van Der Harst, P., De Boer, R. A., Bischoff, R. & Van Der Meer, P., Nov 8 2017, In : Science translational medicine. 9, 415, 8574.

Research output: Contribution to journalArticle

13 Scopus citations

Age-related decline in BubR1 impairs adult hippocampal neurogenesis

Yang, Z., Jun, H., Choi, C. I., Yoo, K. H., Cho, C. H., Hussaini, S. M. Q., Simmons, A. J., Kim, S., Van Deursen, J., Baker, D. J. & Jang, M-H. D., Jun 1 2017, In : Aging Cell. 16, 3, p. 598-601 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Caloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast

Choi, K. M., Hong, S. J., Van Deursen, J., Kim, S., Kim, K. H. & Lee, C. K., Dec 12 2017, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 73, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Generation and phenotypic characterization of Pde1a mutant mice

Wang, X., Yamada, S., Lariviere, W. B., Ye, H., Bakeberg, J. L., Irazabal, M. V., Chebib, F. T., Van Deursen, J., Harris, P. C., Sussman, C. R., Behfar, A., Ward, C. J. & Torres, V. E., Jul 2017, In : PloS one. 12, 7, e0181087.

Research output: Contribution to journalArticle

7 Scopus citations

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice

de Boer, J. F., Schonewille, M., Boesjes, M., Wolters, H., Bloks, V. W., Bos, T., van Dijk, T. H., Jurdzinski, A., Boverhof, R., Wolters, J. C., Kuivenhoven, J. A., van Deursen, J. M., Oude Elferink, R. P. J., Moschetta, A., Kremoser, C., Verkade, H. J., Kuipers, F. & Groen, A. K., Apr 1 2017, In : Gastroenterology. 152, 5, p. 1126-1138.e6

Research output: Contribution to journalArticle

53 Scopus citations

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis

Zhu, S., Zhang, X., Weichert-Leahey, N., Dong, Z., Zhang, C., Lopez, G., Tao, T., He, S., Wood, A. C., Oldridge, D., Ung, C. Y., van Ree, J. H., Khan, A., Salazar, B. M., Lummertz da Rocha, E., Zimmerman, M. W., Guo, F., Cao, H., Hou, X., Weroha, S. J. & 8 others, Perez-Atayde, A. R., Neuberg, D. S., Meves, A., McNiven, M. A., van Deursen, J. M., Li, H., Maris, J. M. & Look, A. T., Sep 11 2017, In : Cancer cell. 32, 3, p. 310-323.e5

Research output: Contribution to journalArticle

28 Scopus citations

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Jeon, O. H., Kim, C., Laberge, R. M., Demaria, M., Rathod, S., Vasserot, A. P., Chung, J. W., Kim, D. H., Poon, Y., David, N., Baker, D. J., Van Deursen, J. M., Campisi, J. & Elisseeff, J. H., Jun 1 2017, In : Nature Medicine. 23, 6, p. 775-781 7 p.

Research output: Contribution to journalArticle

310 Scopus citations

Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis i

El Yakoubi, W., Buffin, E., Cladière, D., Gryaznova, Y., Berenguer, I., Touati, S. A., Gómez, R., Suja, J. A., Van Deursen, J. M. & Wassmann, K., Dec 1 2017, In : Nature communications. 8, 1, 694.

Research output: Contribution to journalArticle

7 Scopus citations

Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix

Heim, J. B., Squirewell, E. J., Neu, A., Zocher, G., Sominidi-Damodaran, S., Wyles, S. P., Nikolova, E., Behrendt, N., Saunte, D. M., Lock-Andersen, J., Gaonkar, K. S., Yan, H., Sarkaria, J. N., Krendel, M., Van Deursen, J., Sprangers, R., Stehle, T., Böttcher, R. T., Lee, J. H., Ordog, T. & 1 others, Meves, A., Apr 11 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 15, p. 3933-3938 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation

Riedlinger, T., Dommerholt, M. B., Wijshake, T., Kruit, J. K., Huijkman, N., Dekker, D., Koster, M., Kloosterhuis, N., Koonen, D. P. Y., de Bruin, A., Baker, D., Hofker, M. H., van Deursen, J., Jonker, J. W., Schmitz, M. L. & van de Sluis, B., Oct 2017, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 10, p. 1785-1798 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Oncogenic senescence: A multi-functional perspective

Baker, D. J., Alimirah, F., van Deursen, J. M., Campisi, J. & Hildesheim, J., 2017, In : Oncotarget. 8, 16, p. 27661-27672 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis

Maskey, R. S., Flatten, K. S., Sieben, C. J., Peterson, K. L., Baker, D. J., Nam, H. J., Kim, M. S., Smyrk, T. C., Kojima, Y., Machida, Y., Santiago, A., Van Deursen, J. M., Kaufmann, S. H. & Machida, Y. J., 2017, In : Nucleic acids research. 45, 8, p. 4564-4576 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance

Aguayo-Mazzucato, C., van Haaren, M., Mruk, M., Lee, T. B., Crawford, C., Hollister-Lock, J., Sullivan, B. A., Johnson, J. W., Ebrahimi, A., Dreyfuss, J. M., Van Deursen, J., Weir, G. C. & Bonner-Weir, S., Apr 4 2017, In : Cell Metabolism. 25, 4, p. 898-910.e5

Research output: Contribution to journalArticle

55 Scopus citations
2016

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

Weaver, R. L., Limzerwala, J. F., Naylor, R. M., Jeganathan, K. B., Baker, D. J. & Van Deursen, J., Aug 16 2016, In : eLife. 5, AUGUST, e16620.

Research output: Contribution to journalArticle

6 Scopus citations

Cellular senescence in renal ageing and disease

Sturmlechner, I., Durik, M., Sieben, C. J., Baker, D. J. & Van Deursen, J., Dec 28 2016, (Accepted/In press) In : Nature Reviews Nephrology.

Research output: Contribution to journalArticle

84 Scopus citations

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation

Kanakkanthara, A., Jeganathan, K. B., Limzerwala, J. F., Baker, D. J., Hamada, M., Nam, H. J., Van Deursen, W. H., Hamada, N., Naylor, R. M., Becker, N. A., Davies, B. A., Van Ree, J. H., Mer, G., Shapiro, V. M., Maher III, L. J., Katzmann, D. J. & Van Deursen, J., Sep 30 2016, In : Science. 353, 6307, p. 1549-1552 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

Exercise prevents diet-induced cellular senescence in adipose tissue

Schafer, M. J., White, T. A., Evans, G., Tonne, J. M., Verzosa, G. C., Stout, M. B., Mazula, D. L., Palmer, A. K., Baker, D. J., Jensen, M. D., Torbenson, M. S., Miller, J. D., Ikeda, Y., Tchkonia, T., Van Deursen, J. M., Kirkland, J. L. & LeBrasseur, N. K., Jun 1 2016, In : Diabetes. 65, 6, p. 1606-1615 10 p.

Research output: Contribution to journalArticle

79 Scopus citations

Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1

Kim, T. D., Jin, F., Shin, S., Oh, S., Lightfoot, S. A., Grande, J. P., Johnson, A. J., Van Deursen, J. M., Wren, J. D. & Janknecht, R., Feb 1 2016, In : Journal of Clinical Investigation. 126, 2, p. 706-720 15 p.

Research output: Contribution to journalArticle

41 Scopus citations

Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer

van Ree, J. H., Nam, H. J. & Van Deursen, J., Jan 1 2016, In : Chromosome Research. 24, 1, p. 67-76 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Modulation of polycystic kidney disease severity by phosphodiesterase 1 and 3 subfamilies

Ye, H., Wang, X., Sussman, C. R., Hopp, K., Irazabal, M. V., Bakeberg, J. L., LaRiviere, W. B., Manganiello, V. C., Vorhees, C. V., Zhao, H., Harris, P. C., Van Deursen, J., Ward, C. J. & Torres, V. E., May 1 2016, In : Journal of the American Society of Nephrology. 27, 5, p. 1312-1320 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Naturally occurring p16 Ink4a-positive cells shorten healthy lifespan

Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., Khazaie, K., Miller, J. D. & Van Deursen, J., Feb 11 2016, In : Nature. 530, 7589, p. 184-189 6 p.

Research output: Contribution to journalArticle

859 Scopus citations

Nuclear pore protein NUP88 activates anaphasepromoting complex to promote aneuploidy

Naylor, R. M., Jeganathan, K. B., Cao, X. & Van Deursen, J., Feb 1 2016, In : Journal of Clinical Investigation. 126, 2, p. 543-559 17 p.

Research output: Contribution to journalArticle

20 Scopus citations

Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development

Booij, H. G., Yu, H., De Boer, R. A., Van De Kolk, C. W. A., Van De Sluis, B., Van Deursen, J., Van Gilst, W. H., Silljé, H. H. W. & Westenbrink, B. D., Aug 1 2016, In : Cardiovascular Research. 111, 3, p. 217-226 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes

Van Ree, J. H., Nam, H. J., Jeganathan, K. B., Kanakkanthara, A. & Van Deursen, J., Jun 28 2016, In : Nature. 18, 7, p. 814-821 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Role of hypothalamic Creb-binding protein in obesity and molecular reprogramming of metabolic substrates

Moreno, C. L., Yang, L., Dacks, P. A., Isoda, F., Van Deursen, J. M. A. & Mobbs, C. V., Nov 1 2016, In : PloS one. 11, 11, e0166381.

Research output: Contribution to journalArticle

5 Scopus citations

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Childs, B. G., Baker, D. J., Wijshake, T., Conover, C. A., Campisi, J. & Van Deursen, J., Oct 28 2016, In : Science. 354, 6311, p. 472-477 6 p.

Research output: Contribution to journalArticle

288 Scopus citations

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia

Giotopoulos, G., Chan, W. I., Horton, S. J., Ruau, D., Gallipoli, P., Fowler, A., Crawley, C., Papaemmanuil, E., Campbell, P. J., Göttgens, B., Van Deursen, J., Cole, P. A. & Huntly, B. J. P., Jan 21 2016, In : Oncogene. 35, 3, p. 279-289 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

The progeroid g ene BubR1 regulates axon myelination and motor function

Choi, C. I., Yoo, K. H., Hussaini, S. M. Q., Jeon, B. T., Welby, J., Gan, H., Scarisbrick, I. A., Zhang, Z., Baker, D. J., Van Deursen, J., Rodriguez, M. & Jang, M-H. D., 2016, In : Aging. 8, 11, p. 2667-2688 22 p.

Research output: Contribution to journalArticle

14 Scopus citations

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model

Kakkar, V., Månsson, C., de Mattos, E. P., Bergink, S., van der Zwaag, M., van Waarde, M. A. W. H., Kloosterhuis, N. J., Melki, R., van Cruchten, R. T. P., Al-Karadaghi, S., Arosio, P., Dobson, C. M., Knowles, T. P. J., Bates, G. P., van Deursen, J. M., Linse, S., van de Sluis, B., Emanuelsson, C. & Kampinga, H. H., Apr 21 2016, In : Molecular Cell. 62, 2, p. 272-283 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Vascular cell senescence contributes to blood-brain barrier breakdown

Yamazaki, Y., Baker, D. J., Tachibana, M., Liu, C. C., Van Deursen, J. M., Brott, T. G., Bu, G. & Kanekiyo, T., 2016, In : Stroke. 47, 4, p. 1068-1077 10 p.

Research output: Contribution to journalArticle

47 Scopus citations
2015

Activation of the transforming growth factor-β/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma

Dhanasekaran, R., Nakamura, I., Hu, C., Chen, G., Oseini, A. M., Seven, E. S., Miamen, A. G., Moser, C. D., Zhou, W., van Kuppevelt, T. H., van Deursen, J. M., Mounajjed, T., Fernandez-Zapico, M. E. & Roberts, L. R., Apr 1 2015, In : Hepatology. 61, 4, p. 1269-1283 15 p.

Research output: Contribution to journalArticle

26 Scopus citations