Jan-Mendelt Tillema, MD

  • 1241 Citations
  • 21 Scopus h-Index
20072019

Research output per year

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Research Output

  • 1241 Citations
  • 21 Scopus h-Index
  • 53 Article
  • 4 Comment/debate
  • 3 Review article
2019

Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis

Aaen, G., Waltz, M., Vargas, W., Makhani, N., Ness, J., Harris, Y., Casper, T. C., Benson, L., Candee, M., Chitnis, T., Gorman, M., Graves, J., Greenberg, B., Lotze, T., Mar, S., Tillema, J-M., Rensel, M., Rodriguez, M., Rose, J., Rubin, J. & 6 others, Schreiner, T., Waldman, A., Weinstock-Guttman, B., Belman, A., Waubant, E. & Krupp, L., Mar 1 2019, In : Journal of Child Neurology. 34, 3, p. 148-152 5 p.

Research output: Contribution to journalArticle

Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry

Chi, C., Shao, X., Rhead, B., Gonzales, E., Smith, J. B., Xiang, A. H., Graves, J., Waldman, A., Lotze, T., Schreiner, T., Weinstock-Guttman, B., Aaen, G., Tillema, J-M., Ness, J., Candee, M., Krupp, L., Gorman, M., Benson, L., Chitnis, T., Mar, S. & 13 others, Belman, A., Casper, T. C., Rose, J., Moodley, M., Rensel, M., Rodriguez, M., Greenberg, B., Kahn, L., Rubin, J., Schaefer, C., Waubant, E., Langer-Gould, A. & Barcellos, L. F., Jan 1 2019, In : PLoS Genetics. 15, 1, p. e1007808

Research output: Contribution to journalArticle

3 Scopus citations

miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS

On behalf of the US Network of Pediatric MS Centers, Jan 1 2019, In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Vitamin D genes influence MS relapses in children

Graves, J. S., Barcellos, L. F., Krupp, L., Belman, A., Shao, X., Quach, H., Hart, J., Chitnis, T., Weinstock-Guttman, B., Aaen, G., Benson, L., Gorman, M., Greenberg, B., Lotze, T., Soe, M., Ness, J., Rodriguez, M., Rose, J., Schreiner, T., Tillema, J-M. & 3 others, Waldman, A., Casper, T. C. & Waubant, E., Jan 1 2019, In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Aquaporin-4 and Myelin Oligodendrocyte Glycoprotein Autoantibody Status Predict Outcome of Recurrent Optic Neuritis

Jitprapaikulsan, J., Chen, J., Flanagan, E., Tobin, W. O., Fryer, J. P., Weinshenker, B. G., McKeon, A., Lennon, V. A., Leavitt, J. A., Tillema, J-M., Lucchinetti, C. F., Keegan, B. M., Kantarci, O. H., Khanna, C., Jenkins, S. M., Spears, G. M., Sagan, J. & Pittock, S. J., Jan 1 2018, (Accepted/In press) In : Ophthalmology.

Research output: Contribution to journalArticle

25 Scopus citations

Association of MOG-IgG Serostatus with Relapse after Acute Disseminated Encephalomyelitis and Proposed Diagnostic Criteria for MOG-IgG-Associated Disorders

López-Chiriboga, A. S., Majed, M., Fryer, J., Dubey, D., McKeon, A., Flanagan, E., Jitprapaikulsan, J., Kothapalli, N., Tillema, J-M., Chen, J., Weinshenker, B. G., Wingerchuk, D. M., Sagen, J., Gadoth, A., Lennon, V. A., Keegan, B. M., Lucchinetti, C. F. & Pittock, S. J., Nov 1 2018, In : JAMA Neurology. 75, 11, p. 1355-1363 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Autoimmune encephalitis epidemiology and a comparison to infectious encephalitis

Dubey, D., Pittock, S. J., Kelly, C. R., McKeon, A., Lopez-Chiriboga, A. S., Lennon, V. A., Gadoth, A., Smith, C. Y., Bryant, S. C., Klein, C. J., Aksamit, A. J., Toledano, M., Boeve, B. F., Tillema, J-M. & Flanagan, E., Jan 1 2018, In : Annals of Neurology. 83, 1, p. 166-177 12 p.

Research output: Contribution to journalArticle

86 Scopus citations

Cervical spinal cord atrophy: An earlymarker of progressiveMSonset

Zeydan, B., Gu, X., Atkinson, E. J., Keegan, B. M., Weinshenker, B. G., Tillema, J-M., Pelletier, D., Azevedo, C. J., Lebrun-Frenay, C., Siva, A., Okuda, D. T., Kantarci, K. M. & Kantarci, O. H., Mar 1 2018, In : Neurology: Neuroimmunology and NeuroInflammation. 5, 2, e435.

Research output: Contribution to journalArticle

22 Scopus citations

Clinical, Radiologic, and Prognostic Features of Myelitis Associated with Myelin Oligodendrocyte Glycoprotein Autoantibody

Dubey, D., Pittock, S. J., Krecke, K. N., Morris, P. P., Sechi, E., Zalewski, N. L., Weinshenker, B. G., Shosha, E., Lucchinetti, C. F., Fryer, J. P., Lopez-Chiriboga, A. S., Chen, J., Jitprapaikulsan, J., McKeon, A., Gadoth, A., Keegan, B. M., Tillema, J-M., Naddaf, E., Patterson, M. C., Messacar, K. & 2 others, Tyler, K. L. & Flanagan, E., Jan 1 2018, (Accepted/In press) In : JAMA Neurology.

Research output: Contribution to journalArticle

31 Scopus citations

Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis

Azary, S., Schreiner, T., Graves, J., Waldman, A., Belman, A., Guttman, B. W., Aaen, G., Tillema, J-M., Mar, S., Hart, J., Ness, J., Harris, Y., Krupp, L., Gorman, M., Benson, L., Rodriguez, M., Chitnis, T., Rose, J., Barcellos, L. F., Lotze, T. & 4 others, Carmichael, S. L., Roalstad, S., Casper, C. T. & Waubant, E., Jan 1 2018, In : Journal of neurology, neurosurgery, and psychiatry. 89, 1, p. 28-33 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Dark rims: Novel sequence enhances diagnostic specificity in multiple sclerosis

Tillema, J-M., Weigand, S. D., Dayan, M., Shu, Y., Kantarci, O. H., Lucchinetti, C. F. & Port, J. D., Jun 1 2018, In : American Journal of Neuroradiology. 39, 6, p. 1052-1058 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

De Novo Pathogenic Variants in CACNA1E Cause Developmental and Epileptic Encephalopathy with Contractures, Macrocephaly, and Dyskinesias

Deciphering Developmental Disorders Study, Nov 1 2018, In : American Journal of Human Genetics. 103, 5, p. 666-678 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis

on behalf of the Network of Pediatric Multiple Sclerosis Centers., May 1 2018, In : Multiple Sclerosis and Related Disorders. 22, p. 103-107 5 p.

Research output: Contribution to journalArticle

Erratum to: Neuroimmune disorders of the central nervous system in children in the molecular era (Nature Reviews Neurology, (2018), 14, 7, (433-445), 10.1038/s41582-018-0024-9)

on behalf of the attendees of the International Neuroimmune Meeting, Jul 1 2018, In : Nature Reviews Neurology. 14, 12, 1 p.

Research output: Contribution to journalComment/debate

Heterogeneity in association of remote herpesvirus infections and pediatric MS

On behalf of the US Network of Pediatric MS Centers, Oct 1 2018, In : Annals of Clinical and Translational Neurology. 5, 10, p. 1222-1228 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

LGI1 and CASPR2 neurological autoimmunity in children

López-Chiriboga, A. S., Klein, C. J., Zekeridou, A., McKeon, A., Dubey, D., Flanagan, E., Lennon, V. A., Tillema, J-M., Wirrell, E. C., Patterson, M. C., Gadoth, A., Aaen, J. G., Brenton, J. N., Bui, J. D., Moen, A., Otten, C., Piquet, A. & Pittock, S. J., Sep 1 2018, In : Annals of Neurology. 84, 3, p. 473-480 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Myelin Oligodendrocyte Glycoprotein Antibody–Positive Optic Neuritis: Clinical Characteristics, Radiologic Clues, and Outcome

Chen, J., Flanagan, E., Jitprapaikulsan, J., López-Chiriboga, A. S. S., Fryer, J. P., Leavitt, J. A., Weinshenker, B. G., McKeon, A., Tillema, J-M., Lennon, V. A., Tobin, W. O., Keegan, B. M., Lucchinetti, C. F., Kantarci, O. H., McClelland, C. M., Lee, M. S., Bennett, J. L., Pelak, V. S., Chen, Y., VanStavern, G. & 7 others, Adesina, O. O. O., Eggenberger, E. R., Acierno, M. D., Wingerchuk, D. M., Brazis, P. W., Sagen, J. & Pittock, S. J., Nov 1 2018, In : American Journal of Ophthalmology. 195, p. 8-15 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Neuroimmune disorders of the central nervous system in children in the molecular era

Wells, E., Hacohen, Y., Waldman, A., Tillema, J-M., Soldatos, A., Ances, B., Benseler, S., Bielekova, B., Dale, R. C., Dalmau, J., Gaillard, W., Gorman, M., Greenberg, B., Hyslop, A., Pardo, C. A., Tasker, R. C., Yeh, E. A., Bar-Or, A., Pittock, S. J., Vanderver, A. & 1 others, Banwell, B., Jul 1 2018, In : Nature Reviews Neurology. 14, 7, p. 433-445 13 p.

Research output: Contribution to journalReview article

9 Scopus citations
2 Scopus citations

Predictors of neural-specific autoantibodies and immunotherapy response in patients with cognitive dysfunction

Dubey, D., Kothapalli, N., McKeon, A., Flanagan, E., Lennon, V. A., Klein, C. J., Britton, J. W., So, E., Boeve, B. F., Tillema, J-M., Sadjadi, R. & Pittock, S. J., Oct 15 2018, In : Journal of Neuroimmunology. 323, p. 62-72 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pseudo status cataplecticus in narcolepsy type 1

Meinen, C. N., Smith, K. M., Tillema, J-M. & Kotagal, S., Sep 15 2018, In : Journal of Clinical Sleep Medicine. 14, 9, p. 1625-1627 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Several household chemical exposures are associated with pediatric-onset multiple sclerosis

the U.S. Network of Pediatric Multiple Sclerosis Centers, Jan 1 2018, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

Urban air quality and associations with pediatric multiple sclerosis

Lavery, A. M., Waubant, E., Casper, T. C., Roalstad, S., Candee, M., Rose, J., Belman, A., Weinstock-Guttman, B., Aaen, G., Tillema, J-M., Rodriguez, M., Ness, J., Harris, Y., Graves, J., Krupp, L., Charvet, L., Benson, L., Gorman, M., Moodley, M., Rensel, M. & 9 others, Goyal, M., Mar, S., Chitnis, T., Schreiner, T., Lotze, T., Greenberg, B., Kahn, I., Rubin, J. & Waldman, A. T., Oct 1 2018, In : Annals of Clinical and Translational Neurology. 5, 10, p. 1146-1153 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Correction to: Impact of an electronic monitoring device and behavioural feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial

On Behalf Of The Pediatric Ms Adherence Study Group, Dec 23 2017, (Accepted/In press) In : Quality of Life Research. 1 p.

Research output: Contribution to journalArticle

Dietary factors and pediatric multiple sclerosis: A case-control study

for the US Network of Pediatric Multiple Sclerosis Centers, Jun 1 2017, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

9 Scopus citations

Evaluating the association of allergies with multiple sclerosis susceptibility risk and disease activity in a pediatric population

US Network of Pediatric MS Centers & Rodriguez, M., Apr 15 2017, In : Journal of the Neurological Sciences. 375, p. 371-375 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Evidence for a causal relationship between low Vitamin D, high BMI, and pediatric-onset MS

Gianfrancesco, M. A., Stridh, P., Rhead, B., Shao, X., Xu, E., Graves, J. S., Chitnis, T., Waldman, A., Lotze, T., Schreiner, T., Belman, A., Greenberg, B., Weinstock-Guttman, B., Aaen, G., Tillema, J-M., Hart, J., Caillier, S., Ness, J., Harris, Y., Rubin, J. & 23 others, Candee, M., Krupp, L., Gorman, M., Benson, L., Rodriguez, M., Mar, S., Kahn, I., Rose, J., Roalstad, S., Casper, T. C., Shen, L., Quach, H., Quach, D., Hillert, J., Bäärnhielm, M., Hedstrom, A., Olsson, T., Kockum, I., Alfredsson, L., Metayer, C., Schaefer, C., Barcellos, L. F. & Waubant, E., Apr 25 2017, In : Neurology. 88, 17, p. 1623-1629 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Examining the contributions of environmental quality to pediatric multiple sclerosis

for the U.S. Network of Pediatric MS Centers, Nov 1 2017, In : Multiple Sclerosis and Related Disorders. 18, p. 164-169 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Genetic risk factors for pediatric-onset multiple sclerosis

for the Network of Pediatric Multiple Sclerosis Centers, Oct 1 2017, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

12 Scopus citations

Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial

On Behalf Of The Pediatric Ms Adherence Study Group, Apr 9 2017, (Accepted/In press) In : Quality of Life Research. p. 1-17 17 p.

Research output: Contribution to journalArticle

5 Scopus citations

In vivo detection of connectivity between cortical and white matter lesions in early MS

Tillema, J-M., Weigand, S. D., Mandrekar, J., Shu, Y., Lucchinetti, C. F., Pirko, I. & Port, J. D., Jun 1 2017, In : Multiple Sclerosis. 23, 7, p. 973-981 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Maternal and perinatal exposures are associated with risk for pediatric-onset multiple sclerosis

Network of Pediatric Multiple Sclerosis Centers, Apr 1 2017, In : Pediatrics. 139, 4, e20162838.

Research output: Contribution to journalArticle

7 Scopus citations

NeuroDebian Virtual Machine Deployment Facilitates Trainee-Driven Bedside Neuroimaging Research

Cohen, A., Kenney-Jung, D., Botha, H. & Tillema, J-M., Jan 1 2017, In : Journal of Child Neurology. 32, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

Predictive models in the diagnosis and treatment of autoimmune epilepsy

Dubey, D., Singh, J., Britton, J. W., Pittock, S. J., Flanagan, E., Lennon, V. A., Tillema, J-M., Wirrell, E. C., Shin, C., So, E., Cascino, G. D., Wingerchuk, D. M., Hoerth, M. T., Shih, J. J., Nickels, K. C. & McKeon, A., 2017, (Accepted/In press) In : Epilepsia.

Research output: Contribution to journalArticle

30 Scopus citations
2016

A case-control study of dietary salt intake in pediatric-onset multiple sclerosis

McDonald, J., Graves, J., Waldman, A., Lotze, T., Schreiner, T., Belman, A., Greenberg, B., Weinstock-Guttman, B., Aaen, G., Tillema, J-M., Hart, J., Lulu, S., Ness, J., Harris, Y., Rubin, J., Candee, M., Krupp, L. B., Gorman, M., Benson, L., Rodriguez, M. & 9 others, Chitnis, T., Mar, S., Barcellos, L. F., Laraia, B., Rose, J., Roalstad, S., Simmons, T., Casper, T. C. & Waubant, E., Mar 1 2016, In : Multiple Sclerosis and Related Disorders. 6, p. 87-92 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Characteristics of children and adolescents with multiple sclerosis

the US Network of Pediatric MS Centers & Rodriguez, M., Jul 1 2016, In : Pediatrics. 138, 1, e20160120.

Research output: Contribution to journalArticle

38 Scopus citations

Dietary salt intake and time to relapse in paediatric multiple sclerosis

The Network of Pediatric Multiple Sclerosis Centers & Rodriguez, M., Jun 24 2016, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticle

30 Scopus citations

Distinct effects of obesity and puberty on risk and age at onset of pediatric MS

the U.S. Network of Pediatric MS Centers & Rodriguez, M., Dec 1 2016, In : Annals of Clinical and Translational Neurology. 3, 12, p. 897-907 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Gut microbiota composition and relapse risk in pediatric MS: A pilot study

Tremlett, H., Fadrosh, D. W., Faruqi, A. A., Hart, J., Roalstad, S., Graves, J., Lynch, S., Waubant, E., Aaen, G., Belman, A., Benson, L., Casper, C., Chitnis, T., Gorman, M., Harris, Y., Krupp, L., Lotze, T. E., Lulu, S., Ness, J., Olsen, C. & 7 others, Roan, E., Rodriguez, M., Rose, J., Simmons, T. C., Tillema, J-M., Weber, W. & Weinstock-Guttman, B., Apr 15 2016, In : Journal of the Neurological Sciences. 363, p. 153-157 5 p.

Research output: Contribution to journalArticle

69 Scopus citations

Gut microbiota in early pediatric multiple sclerosis: a case−control study

the US Network of Pediatric MS Centers, Aug 1 2016, In : European Journal of Neurology. 23, 8, p. 1308-1321 14 p.

Research output: Contribution to journalArticle

101 Scopus citations

MRI in the evaluation of pediatric multiple sclerosis

Banwell, B., Arnold, D. L., Tillema, J-M., Rocca, M. A., Filippi, M., Weinstock-Guttman, B., Zivadinov, R. & Sormani, M. P., Aug 30 2016, In : Neurology. 87, 9, p. S88-S96

Research output: Contribution to journalArticle

19 Scopus citations

Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study

Tillema, J-M., Hulst, H. E., Rocca, M. A., Vrenken, H., Steenwijk, M. D., Damjanovic, D., Enzinger, C., Ropele, S., Tedeschi, G., Gallo, A., Ciccarelli, O., Rovira, A., Montalban, X., De Stefano, N., Stromillo, M. L., Filippi, M. & Barkhof, F., Jun 1 2016, In : Multiple Sclerosis. 22, 7, p. 901-909 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2015

The US Network of Pediatric Multiple Sclerosis Centers: Development, Progress, and Next Steps

Casper, T. C., Rose, J. W., Roalstad, S., Waubant, E., Aaen, G., Belman, A., Chitnis, T., Gorman, M., Krupp, L., Lotze, T. E., Ness, J., Patterson, M., Rodriguez, M., Weinstock-Guttman, B., Browning, B., Graves, J., Tillema, J-M., Benson, L. & Harris, Y., Sep 18 2015, In : Journal of Child Neurology. 30, 10, p. 1381-1387 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

A CNS multifocal disease: Important diagnostic considerations regarding multiple sclerosis

Tillema, J. M., Renaud, D. & Keegan, B. M., May 2014, In : Multiple Sclerosis and Related Disorders. 3, 3, p. 402-407 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mean upper cervical cord area (MUCCA) measurement in long-standing multiple sclerosis: Relation to brain findings and clinical disability

Daams, M., Weiler, F., Steenwijk, M. D., Hahn, H. K., Geurts, J. J. G., Vrenken, H., Van Schijndel, R. A., Balk, L. J., Tewarie, P. K., Tillema, J. M., Killestein, J., Uitdehaag, B. M. J. & Barkhof, F., Dec 16 2014, In : Multiple Sclerosis Journal. 20, 14, p. 1860-1865 6 p.

Research output: Contribution to journalArticle

38 Scopus citations
2013

Imaging of multiple sclerosis and related acquired demyelinating disorders in childhood

Tillema, J-M., Hopkins, S., Rodriguez, M. & Leach, J. L., 2013, In : Journal of Pediatric Neuroradiology. 2, 1, p. 57-72 16 p.

Research output: Contribution to journalArticle

1 Scopus citations