• 12951 Citations
  • 60 Scopus h-Index
1973 …2021

Research output per year

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Research Output

2013

Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice

Strong, R., Miller, R. A., Astle, C. M., Baur, J. A., De Cabo, R., Fernandez, E., Guo, W., Javors, M., Kirkland, J. L., Nelson, J. F., Sinclair, D. A., Teter, B., Williams, D., Zaveri, N., Nadon, N. L. & Harrison, D. E., Jan 1 2013, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 68, 1, p. 6-16 11 p.

Research output: Contribution to journalArticle

118 Scopus citations

IGF-I attenuates FFA-induced activation of JNK1 phosphorylation and TNFα expression in human subcutaneous preadipocytes

Neacsu, O., Cleveland, K., Xu, H., Tchkonia, T. T., Kirkland, J. L. & Boney, C. M., Sep 1 2013, In : Obesity. 21, 9, p. 1843-1849 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mechanisms and metabolic implications of regional differences among fat depots

Tchkonia, T., Thomou, T., Zhu, Y., Karagiannides, I., Pothoulakis, C., Jensen, M. D. & Kirkland, J. L., May 7 2013, In : Cell Metabolism. 17, 5, p. 644-656 13 p.

Research output: Contribution to journalReview article

252 Scopus citations
18 Scopus citations

Translating advances from the basic biology of aging into clinical application

Kirkland, J. L., Jan 1 2013, In : Experimental Gerontology. 48, 1, p. 1-5 5 p.

Research output: Contribution to journalReview article

64 Scopus citations
2012

Beta-mecaptoethanol suppresses inflammation and induces adipogenic differentiation in 3T3-F442A murine preadipocytes

Guo, W., Li, Y., Liang, W., Wong, S., Apovian, C., Kirkland, J. L. & Corkey, B. E., Jul 23 2012, In : PloS one. 7, 7, e40958.

Research output: Contribution to journalArticle

12 Scopus citations

Role of microRNA processing in adipose tissue in stress defense and longevity

Mori, M. A., Raghavan, P., Thomou, T., Boucher, J., Robida-Stubbs, S., MacOtela, Y., Russell, S. J., Kirkland, J. L., Blackwell, T. K. & Kahn, C. R., Sep 5 2012, In : Cell Metabolism. 16, 3, p. 336-347 12 p.

Research output: Contribution to journalArticle

122 Scopus citations

Testosterone Plus Low-Intensity Physical Training in Late Life Improves Functional Performance, Skeletal Muscle Mitochondrial Biogenesis, and Mitochondrial Quality Control in Male Mice

Guo, W., Wong, S., Li, M., Liang, W., Liesa, M., Serra, C., Jasuja, R., Bartke, A., Kirkland, J. L., Shirihai, O. & Bhasin, S., Dec 11 2012, In : PloS one. 7, 12, e51180.

Research output: Contribution to journalArticle

32 Scopus citations
2011

Aging and adipose tissue

Florido, R., Tchkonia, T. & Kirkland, J. L., Dec 1 2011, Handbook of the Biology of Aging. Elsevier Inc., p. 119-139 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Clearance of p16 Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., Lebrasseur, N. K., Childs, B. G., Van De Sluis, B., Kirkland, J. L. & Van Deursen, J. M., Nov 10 2011, In : Nature. 479, 7372, p. 232-236 5 p.

Research output: Contribution to journalArticle

1371 Scopus citations

Concerted action of aldehyde dehydrogenases influences depot-specific fat formation

Reichert, B., Yasmeen, R., Jeyakumar, S. M., Yang, F., Thomou, T., Alder, H., Duester, G., Maiseyeu, A., Mihai, G., Harrison, E. H., Rajagopalan, S., Kirkland, J. L. & Ziouzenkova, O., May 1 2011, In : Molecular Endocrinology. 25, 5, p. 799-809 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

Schulz, T. J., Huang, T. L., Tran, T. T., Zhang, H., Townsend, K. L., Shadrach, J. L., Cerletti, M., McDougall, L. E., Giorgadze, N., Tchkonia, T., Schrier, D., Falb, D., Kirkland, J. L., Wagers, A. J. & Tseng, Y. H., Jan 4 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 1, p. 143-148 6 p.

Research output: Contribution to journalArticle

321 Scopus citations

Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways

Karagiannides, I., Bakirtzi, K., Kokkotou, E., Stavrakis, D., Margolis, K. G., Thomou, T., Giorgadze, N., Kirkland, J. L. & Pothoulakis, C., Dec 1 2011, In : Endocrinology. 152, 12, p. 4571-4580 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action

Karagiannides, I., Stavrakis, D., Bakirtzi, K., Kokkotou, E., Pirtskhalava, T., Nayeb-Hashemi, H., Bowe, C., Bugni, J. M., Nuño, M., Lu, B., Gerard, N. P., Leeman, S. E., Kirkland, J. L. & Pothoulakis, C., Jun 1 2011, In : Endocrinology. 152, 6, p. 2197-2205 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
2010

Activin A plays a critical role in proliferation and differentiation of human adipose progenitors

Zaragosi, L. E., Wdziekonski, B., Villageois, P., Keophiphath, M., Maumus, M., Tchkonia, T., Bourlier, V., Mohsen-Kanson, T., Ladoux, A., Elabd, C., Scheideler, M., Trajanoski, Z., Takashima, Y., Amri, E. Z., Lacasa, D., Sengenes, C., Ailhaud, G., Clément, K., Bouloumie, A., Kirkland, J. L. & 1 others, Dani, C., Oct 1 2010, In : Diabetes. 59, 10, p. 2513-2521 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Adipose tissue endothelial cells from obese human subjects: Differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence

Villaret, A., Galitzky, J., Decaunes, P., Estève, D., Marques, M. A., Sengenès, C., Chiotasso, P., Tchkonia, T., Lafontan, M., Kirkland, J. L. & Bouloumié, A., Nov 1 2010, In : Diabetes. 59, 11, p. 2755-2763 9 p.

Research output: Contribution to journalArticle

133 Scopus citations

Aging, depot origin, and preadipocyte gene expression

Cartwright, M. J., Schlauch, K., Lenburg, M. E., Tchkonia, T., Pirtskhalava, T., Cartwright, A., Thomou, T. & Kirkland, J. L., Mar 1 2010, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65 A, 3, p. 242-251 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Aging and regional differences in fat cell progenitors - A mini-review

Sepe, A., Tchkonia, T., Thomou, T., Zamboni, M. & Kirkland, J. L., Dec 1 2010, In : Gerontology. 57, 1, p. 66-75 10 p.

Research output: Contribution to journalReview article

114 Scopus citations

Cellular and Molecular Basis of Functional Differences among Fat Depots

Thomou, T., Tchkonia, T. & Kirkland, J. L., Apr 16 2010, Adipose Tissue in Health and Disease. Wiley-VCH, p. 21-47 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Fat tissue, aging, and cellular senescence

Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D. & Kirkland, J. L., Oct 1 2010, In : Aging Cell. 9, 5, p. 667-684 18 p.

Research output: Contribution to journalReview article

440 Scopus citations

IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects

Cleveland-Donovan, K., Maile, L. A., Tsiaras, W. G., Tchkonia, T., Kirkland, J. L. & Boney, C. M., Aug 1 2010, In : Endocrinology. 151, 8, p. 3752-3763 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Perspectives on cellular senescence and short term dietary restriction in adults

Kirkland, J. L., Sep 2010, In : Aging. 2, 9, p. 542-544 3 p.

Research output: Contribution to journalComment/debate

8 Scopus citations

Perspectives on cellular senescence and short term dietary restriction in adults

Kirkland, J. L., Dec 2010, In : Aging. 2, 12, p. 894-896 3 p.

Research output: Contribution to journalComment/debate

7 Scopus citations

Regional differences in cellular mechanisms of adipose tissue gain with overfeeding

Tchoukalova, Y. D., Votruba, S. B., Tchkonia, T., Giorgadze, N., Kirkland, J. L. & Jensen, M. D., Oct 19 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 42, p. 18226-18231 6 p.

Research output: Contribution to journalArticle

204 Scopus citations

Sex- and depot-dependent differences in adipogenesis in normal-weight humans

Tchoukalova, Y. D., Koutsari, C., Votruba, S. B., Tchkonia, T., Giorgadze, N., Thomou, T., Kirkland, J. L. & Jensen, M. D., Oct 1 2010, In : Obesity. 18, 10, p. 1875-1880 6 p.

Research output: Contribution to journalArticle

90 Scopus citations
2009

Healthspan, translation, and new outcomes for animal studies of aging

Kirkland, J. L. & Peterson, C., Feb 1 2009, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 64, 2, p. 209-212 4 p.

Research output: Contribution to journalArticle

63 Scopus citations

Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways

Gross, K., Karagiannides, I., Thomou, T., Hon, W. K., Bowe, C., Kim, H., Giorgadze, N., Tchkonia, T., Pirtskhalava, T., Kirkland, J. L. & Pothoulakis, C., May 1 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 5, p. G1012-G1019

Research output: Contribution to journalArticle

36 Scopus citations
2008

Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes

Gupta, V., Bhasin, S., Guo, W., Singh, R., Miki, R., Chauhan, P., Choong, K., Tchkonia, T., Lebrasseur, N. K., Flanagan, J. N., Hamilton, J. A., Viereck, J. C., Narula, N. S., Kirkland, J. L. & Jasuja, R., Dec 16 2008, In : Molecular and Cellular Endocrinology. 296, 1-2, p. 32-40 9 p.

Research output: Contribution to journalArticle

108 Scopus citations

Inducible toll-like receptor and NF-κB regulatory pathway expression in human adipose tissue

Vitseva, O. I., Tanriverdi, K., Tchkonia, T. T., Kirkland, J. L., McDonnell, M. E., Apovian, C. M., Freedman, J. & Gokce, N., May 1 2008, In : Obesity. 16, 5, p. 932-937 6 p.

Research output: Contribution to journalArticle

154 Scopus citations
79 Scopus citations
2007

Aging in adipocytes: Potential impact of inherent, depot-specific mechanisms

Cartwright, M. J., Tchkonia, T. & Kirkland, J. L., Jun 1 2007, In : Experimental Gerontology. 42, 6, p. 463-471 9 p.

Research output: Contribution to journalShort survey

181 Scopus citations

Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity

Guo, W., Pirtskhalava, T., Tchkonia, T., Xie, W., Thomou, T., Han, J., Wang, T., Wong, S., Cartwright, A., Hegardt, F. G., Corkey, B. E. & Kirkland, J. L., Apr 1 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 292, 4, p. E1041-E1051

Research output: Contribution to journalArticle

48 Scopus citations

Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects

Han, J. R., Deng, B., Sun, J., Chen, C. G., Corkey, B. E., Kirkland, J. L., Ma, J. & Guo, W., Jul 1 2007, In : Metabolism: Clinical and Experimental. 56, 7, p. 985-991 7 p.

Research output: Contribution to journalArticle

52 Scopus citations

Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns

Tchkonia, T., Lenburg, M., Thomou, T., Giorgadze, N., Frampton, G., Pirtskhalava, T., Cartwright, A., Cartwright, M., Flanagan, J., Karagiannides, I., Gerry, N., Forse, R. A., Tchoukalova, Y., Jensen, M. D., Pothoulakis, C. & Kirkland, J. L., Jan 1 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 292, 1, p. E298-E307

Research output: Contribution to journalArticle

243 Scopus citations

Increased TNFα and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis

Tchkonia, T., Pirtskhalava, T., Thomou, T., Cartwright, M. J., Wise, B., Karagiannides, I., Shpilman, A., Lash, T. L., Becherer, J. D. & Kirkland, J. L., Dec 1 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 293, 6, p. E1810-E1819

Research output: Contribution to journalArticle

35 Scopus citations

New scanning electron microscopic method for determination of adipocyte size in humans and mice

Guo, W., Bigornia, S., Leizerman, I., Xie, W., McDonnell, M., Clemente, K., Pirtskhalava, T., Kirkland, J. L., Gokce, N., Corkey, B. E., Sullivan, L. M. & Apovian, C. M., Jul 1 2007, In : Obesity. 15, 7, p. 1657-1665 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2006

Fat depot-specific characteristics are retained in strains derived from single human preadipocytes

Tchkonia, T., Giorgadze, N., Pirtskhalava, T., Thomou, T., DePonte, M., Koo, A., Forse, R. A., Chinnappan, D., Martin-Ruiz, C., Von Zglinicki, T. & Kirkland, J. L., Sep 1 2006, In : Diabetes. 55, 9, p. 2571-2578 8 p.

Research output: Contribution to journalArticle

164 Scopus citations

Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging

Karagiannides, I., Thomou, T., Tchkonia, T., Pirtskhalava, T., Kypreos, K. E., Cartwright, A., Dalagiorgou, G., Lash, T. L., Stephen, R., Timchenko, N. A. & Kirkland, J. L., Aug 11 2006, In : Journal of Biological Chemistry. 281, 32, p. 23025-23033 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Induction of colitis causes inflammatory responses in fat depots: Evidence for substance P pathways in human mesenteric preadipocytes

Karagiannides, I., Kokkotou, E., Tansky, M., Tchkonia, T., Giorgadza, N., O'Brien, M., Leeman, S. E., Kirkland, J. L. & Pothoulakis, C., Mar 28 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 13, p. 5207-5212 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

Oleate-induced formation of fat cells with impaired insulin sensitivity

Xie, W., Hamilton, J. A., Kirkland, J. L., Corkey, B. E. & Guo, W., May 1 2006, In : Lipids. 41, 3, p. 267-271 5 p.

Research output: Contribution to journalArticle

20 Scopus citations
2005

Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots

Tchkonia, T., Tchoukalova, Y. D., Giorgadze, N., Pirtskhalava, T., Karagiannides, I., Forse, R. A., Koo, A., Stevenson, M., Chinnappan, D., Cartwright, A., Jensen, M. D. & Kirkland, J. L., Jan 1 2005, In : American Journal of Physiology - Endocrinology and Metabolism. 288, 1 51-1, p. E267-E277

Research output: Contribution to journalArticle

167 Scopus citations
2003

Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats

Han, J., Hamilton, J. A., Kirkland, J. L., Corkey, B. E. & Guo, W., Jan 1 2003, In : Obesity research. 11, 6, p. 734-744 11 p.

Research output: Contribution to journalArticle

83 Scopus citations
2002

Adipogenesis and aging: Does aging make fat go MAD?

Kirkland, J. L., Tchkonia, T., Pirtskhalava, T., Han, J. & Karagiannides, I., Jun 1 2002, In : Experimental Gerontology. 37, 6, p. 757-767 11 p.

Research output: Contribution to journalReview article

225 Scopus citations

Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes

Tchkonia, T., Giorgadze, N., Pirtskhalava, T., Tchoukalova, Y., Karagiannides, I., Armour Forse, R., Deponte, M., Stevenson, M., Guo, W., Han, J., Waloga, G., Lash, T. L., Jensen, M. D. & Kirkland, J. L., Jul 2 2002, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 282, 5 51-5, p. R1286-R1296

Research output: Contribution to journalArticle

202 Scopus citations

Interdisciplinary inpatient care for elderly people with hip fracture: A randomized controlled trial

Naglie, G., Tansey, C., Kirkland, J. L., Ogilvie-Harris, D. J., Detsky, A. S., Etchells, E., Tomlinson, G., O'Rourke, K. & Goldlist, B., Jul 17 2002, In : CMAJ. 167, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

126 Scopus citations

Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes

Han, J., Farmer, S. R., Kirkland, J. L., Corkey, B. E., Yoon, R., Pirtskhalava, T., Ido, Y. & Guo, W., May 20 2002, In : Journal of Nutrition. 132, 5, p. 904-910 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

The biology of senescence: Potential for prevention of disease

Kirkland, J. L., Aug 1 2002, In : Clinics in Geriatric Medicine. 18, 3, p. 383-405 23 p.

Research output: Contribution to journalReview article

21 Scopus citations
2001

Altered expression of C/EBP family members results in decreased adipogenesis with aging

Karagiannides, I., Tchkonia, T., Dobson, D. E., Steppan, C. M., Cummins, P., Chan, G., Salvatori, K., Hadzopoulou-Cladaras, M. & Kirkland, J. L., Jul 3 2001, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 280, 6 49-6, p. R1772-R1780

Research output: Contribution to journalArticle

115 Scopus citations

Different fat depots are distinct mini-organs

Tchkonia, T., Karagiannides, I., Armour Forse, R. & Kirkland, J. L., Jan 1 2001, In : Current Opinion in Endocrinology and Diabetes. 8, 5, p. 227-234 8 p.

Research output: Contribution to journalReview article

12 Scopus citations

Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes

Caserta, F., Tchkonia, T., Civelek, V. N., Prentki, M., Brown, N. F., McGarry, J. D., Forse, R. A., Corkey, B. E., Hamilton, J. A. & Kirkland, J. L., Feb 1 2001, In : American Journal of Physiology - Endocrinology and Metabolism. 280, 2 43-2, p. E238-E247

Research output: Contribution to journalArticle

73 Scopus citations