• 12951 Citations
  • 60 Scopus h-Index
1973 …2021

Research output per year

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Research Output

17α-estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization

Stout, M. B., Steyn, F. J., Jurczak, M. J., Camporez, J. P. G., Zhu, Y., Hawse, J. R., Jurk, D., Palmer, A. K., Xu, M., Pirtskhalava, T., Evans, G. L., De Souza Santos, R., Frank, A. P., White, T. A., Monroe, D. G., Singh, R. J., Casaclang-Verzosa, G., Miller, J. D., Clegg, D. J., LeBrasseur, N. K. & 4 others, Von Zglinicki, T., Shulman, G. I., Tchkonia, T. & Kirkland, J. L., Jan 1 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 1, p. 3-15 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

A 13C nuclear magnetic resonance study of free fatty acid incorporation in acylated lipids in differentiating preadipocytes

Guo, W., Kirkland, J. L., Corkey, B. & Hamilton, J. A., Jun 18 1998, In : Lipids. 33, 5, p. 449-454 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots

Tchkonia, T., Tchoukalova, Y. D., Giorgadze, N., Pirtskhalava, T., Karagiannides, I., Forse, R. A., Koo, A., Stevenson, M., Chinnappan, D., Cartwright, A., Jensen, M. D. & Kirkland, J. L., Jan 1 2005, In : American Journal of Physiology - Endocrinology and Metabolism. 288, 1 51-1, p. E267-E277

Research output: Contribution to journalArticle

167 Scopus citations

Accelerated Accumulation of Multimorbidity After Bilateral Oophorectomy: A Population-Based Cohort Study

Rocca, W. A., Gazzuola-Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., Stewart, E. A. & Miller, V. M., Nov 1 2016, In : Mayo Clinic proceedings. 91, 11, p. 1577-1589 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

Accelerating the search for interventions aimed at expanding the health span in humans: The role of epidemiology

Newman, A. B., Kritchevsky, S. B., Guralnik, J. M., Cummings, S. R., Salive, M., Kuchel, G. A., Schrack, J., Morris, M. C., Weir, D., Baccarelli, A., Murabito, J. M., Ben-Shlomo, Y., Espeland, M. A., Kirkland, J., Melzer, D. & Ferrucci, L., Jan 1 2020, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 75, 1, p. 77-86 10 p.

Research output: Contribution to journalReview article

Activin A plays a critical role in proliferation and differentiation of human adipose progenitors

Zaragosi, L. E., Wdziekonski, B., Villageois, P., Keophiphath, M., Maumus, M., Tchkonia, T., Bourlier, V., Mohsen-Kanson, T., Ladoux, A., Elabd, C., Scheideler, M., Trajanoski, Z., Takashima, Y., Amri, E. Z., Lacasa, D., Sengenes, C., Ailhaud, G., Clément, K., Bouloumie, A., Kirkland, J. L. & 1 others, Dani, C., Oct 1 2010, In : Diabetes. 59, 10, p. 2513-2521 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Adipocyte Hormone Responsiveness and Aging in the Rat: Problems in the Interpretation of Aging Research

KIRKLAND, JAMES. L. & DAX, ELIZABETH. M., Mar 1984, In : Journal of the American Geriatrics Society. 32, 3, p. 219-228 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Adipogenesis and aging: Does aging make fat go MAD?

Kirkland, J. L., Tchkonia, T., Pirtskhalava, T., Han, J. & Karagiannides, I., Jun 1 2002, In : Experimental Gerontology. 37, 6, p. 757-767 11 p.

Research output: Contribution to journalReview article

225 Scopus citations

Adipose tissue endothelial cells from obese human subjects: Differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence

Villaret, A., Galitzky, J., Decaunes, P., Estève, D., Marques, M. A., Sengenès, C., Chiotasso, P., Tchkonia, T., Lafontan, M., Kirkland, J. L. & Bouloumié, A., Nov 1 2010, In : Diabetes. 59, 11, p. 2755-2763 9 p.

Research output: Contribution to journalArticle

133 Scopus citations

Age, anatomic site, and the replication and differentiation of adipocyte precursors

Kirkland, J. L., Hollenberg, C. H. & Gillon, W. S., Mar 20 1990, In : American Journal of Physiology - Cell Physiology. 258, 2 27-2, p. C206-C210

Research output: Contribution to journalArticle

147 Scopus citations

Aged-senescent cells contribute to impaired heart regeneration

Lewis-McDougall, F. C., Ruchaya, P. J., Domenjo-Vila, E., Shin Teoh, T., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., Tchkonia, T., Kirkland, J. L. & Ellison-Hughes, G. M., Jun 2019, In : Aging Cell. 18, 3, e12931.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Ageing, differentiation, and gene expression in rat epididymal preadipocytes.

Kirkland, J. L., Hollenberg, C. H. & Gillon, W. S., Jan 1 1993, In : Biochemistry and cell biology = Biochimie et biologie cellulaire. 71, 11-12, p. 556-561 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies

Tchkonia, T. & Kirkland, J. L., Jan 1 2018, (Accepted/In press) In : JAMA - Journal of the American Medical Association.

Research output: Contribution to journalArticle

43 Scopus citations

Aging, depot origin, and preadipocyte gene expression

Cartwright, M. J., Schlauch, K., Lenburg, M. E., Tchkonia, T., Pirtskhalava, T., Cartwright, A., Thomou, T. & Kirkland, J. L., Mar 1 2010, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65 A, 3, p. 242-251 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Aging and adipose tissue

Florido, R., Tchkonia, T. & Kirkland, J. L., Dec 1 2011, Handbook of the Biology of Aging. Elsevier Inc., p. 119-139 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Aging and adipose tissue: Potential interventions for diabetes and regenerative medicine

Palmer, A. K. & Kirkland, J. L., Jan 5 2016, (Accepted/In press) In : Experimental Gerontology.

Research output: Contribution to journalArticle

91 Scopus citations

Aging and regional differences in fat cell progenitors - A mini-review

Sepe, A., Tchkonia, T., Thomou, T., Zamboni, M. & Kirkland, J. L., Dec 1 2010, In : Gerontology. 57, 1, p. 66-75 10 p.

Research output: Contribution to journalReview article

114 Scopus citations

Aging in adipocytes: Potential impact of inherent, depot-specific mechanisms

Cartwright, M. J., Tchkonia, T. & Kirkland, J. L., Jun 1 2007, In : Experimental Gerontology. 42, 6, p. 463-471 9 p.

Research output: Contribution to journalShort survey

181 Scopus citations

Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity

Guo, W., Pirtskhalava, T., Tchkonia, T., Xie, W., Thomou, T., Han, J., Wang, T., Wong, S., Cartwright, A., Hegardt, F. G., Corkey, B. E. & Kirkland, J. L., Apr 1 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 292, 4, p. E1041-E1051

Research output: Contribution to journalArticle

48 Scopus citations

A longitudinal study of the prognostic significance of ventricular ectopic beats in the elderly

Kirkland, J. L., Lye, M., Faragher, E. B. & dos Santos, A. G. R., Jan 1 1983, In : Gerontology. 29, 3, p. 199-201 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Altered expression of C/EBP family members results in decreased adipogenesis with aging

Karagiannides, I., Tchkonia, T., Dobson, D. E., Steppan, C. M., Cummins, P., Chan, G., Salvatori, K., Hadzopoulou-Cladaras, M. & Kirkland, J. L., Jul 3 2001, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 280, 6 49-6, p. R1772-R1780

Research output: Contribution to journalArticle

115 Scopus citations

Analyses for roll force and torque in ring rolling, with some supporting experiments

Hawkyard, J. B., Johnson, W., Kirkland, J. & Appleton, E., Nov 1973, In : International Journal of Mechanical Sciences. 15, 11, p. 873-893 21 p.

Research output: Contribution to journalArticle

121 Scopus citations

Analysis of circadian rhythms by fitting a least squares sine curve

Hickey, D. S., Kirkland, J. L., Lucas, S. B. & Lye, M., 1984, In : Computers in Biology and Medicine. 14, 2, p. 217-223 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

A systems biology approach to the effect of aging, immunosenescence and vaccine response

Poland, G. A., Ovsyannikova, I. G., Kennedy, R. B., Lambert, N. D. & Kirkland, J. L., Aug 2014, In : Current Opinion in Immunology. 29, 1, p. 62-68 7 p.

Research output: Contribution to journalReview article

49 Scopus citations

Bacteriuria and Survival in Old Age

Kirkland, J. L., Robinson, J. M., Dontas, A. S., Kasviki-Charvati, P., Papanayiotou, P. C. & Marketos, S. G., Sep 3 1981, In : New England Journal of Medicine. 305, 10, p. 586-587 2 p.

Research output: Contribution to journalLetter

5 Scopus citations

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms

Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N. & Kirkland, J. L., Nov 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 11, p. 1388-1394 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Beta-mecaptoethanol suppresses inflammation and induces adipogenic differentiation in 3T3-F442A murine preadipocytes

Guo, W., Li, Y., Liang, W., Wong, S., Apovian, C., Kirkland, J. L. & Corkey, B. E., Jul 23 2012, In : PloS one. 7, 7, e40958.

Research output: Contribution to journalArticle

12 Scopus citations

Bilateral Oophorectomy and Accelerated Aging: Cause or Effect?

Rocca, W. A., Gazzuola Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., Stewart, E. A. & Miller, V. M., Sep 1 2017, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 72, 9, p. 1213-1217 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Biology of premature ageing in survivors of cancer

Cupit-Link, M. C., Kirkland, J. L., Ness, K. K., Armstrong, G. T., Tchkonia, T., LeBrasseur, N. K., Armenian, S. H., Ruddy, K. J. & Hashmi, S. K., Dec 1 2017, In : ESMO Open. 2, 5, e000250.

Research output: Contribution to journalReview article

33 Scopus citations

Cellular and Molecular Basis of Functional Differences among Fat Depots

Thomou, T., Tchkonia, T. & Kirkland, J. L., Apr 16 2010, Adipose Tissue in Health and Disease. Wiley-VCH, p. 21-47 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Cellular senescence: at the nexus between ageing and diabetes

Palmer, A. K., Gustafson, B., Kirkland, J. L. & Smith, U., Jan 1 2019, (Accepted/In press) In : Diabetologia.

Research output: Contribution to journalReview article

7 Scopus citations

Cellular Senescence: A Translational Perspective

Kirkland, J. L. & Tchkonia, T., Mar 13 2017, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

186 Scopus citations

Cellular Senescence and the Biology of Aging, Disease, and Frailty

LeBrasseur, N. K., Tchkonia, T. & Kirkland, J. L., 2015, In : Nestle Nutrition Institute Workshop Series. 83, p. 11-18 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities

Tchkonia, T., Zhu, Y., Van Deursen, J., Campisi, J. & Kirkland, J. L., Mar 1 2013, In : Journal of Clinical Investigation. 123, 3, p. 966-972 7 p.

Research output: Contribution to journalReview article

650 Scopus citations

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

Zhu, Y., Armstrong, J. L., Tchkonia, T. & Kirkland, J. L., Jul 2014, In : Current opinion in clinical nutrition and metabolic care. 17, 4, p. 324-328 5 p.

Research output: Contribution to journalReview article

108 Scopus citations

Cellular Senescence Biomarker p16 INK4a + Cell Burden in Thigh Adipose is Associated with Poor Physical Function in Older Women

Justice, J. N., Gregory, H., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Kritchevsky, S. B. & Nicklas, B. J., Jun 14 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 7, p. 939-945 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Cellular senescence drives age-dependent hepatic steatosis

Ogrodnik, M., Miwa, S., Tchkonia, T., Tiniakos, D., Wilson, C. L., Lahat, A., Day, C. P., Burt, A., Palmer, A., Anstee, Q. M., Grellscheid, S. N., Hoeijmakers, J. H. J., Barnhoorn, S., Mann, D. A., Bird, T. G., Vermeij, W. P., Kirkland, J. L., Passos, J. F., Von Zglinicki, T. & Jurk, D., Jun 13 2017, In : Nature communications. 8, 15691.

Research output: Contribution to journalArticle

161 Scopus citations

Cellular senescence in type 2 diabetes: A therapeutic opportunity

Palmer, A. K., Tchkonia, T., LeBrasseur, N. K., Chini, E. N., Xu, M. & Kirkland, J. L., Jul 1 2015, In : Diabetes. 64, 7, p. 2289-2298 10 p.

Research output: Contribution to journalArticle

108 Scopus citations

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J. F., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature communications. 8, 14532.

Research output: Contribution to journalArticle

279 Scopus citations

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Roos, C. M., Zhang, B., Palmer, A. K., Ogrodnik, M. B., Pirtskhalava, T., Thalji, N. M., Hagler, M., Jurk, D., Smith, L. A., Casaclang-Verzosa, G., Zhu, Y., Schafer, M. J., Tchkonia, T., Kirkland, J. L. & Miller, J. D., Oct 1 2016, In : Aging Cell. 15, 5, p. 973-977 5 p.

Research output: Contribution to journalArticle

193 Scopus citations

Clearance of p16 Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., Lebrasseur, N. K., Childs, B. G., Van De Sluis, B., Kirkland, J. L. & Van Deursen, J. M., Nov 10 2011, In : Nature. 479, 7372, p. 232-236 5 p.

Research output: Contribution to journalArticle

1371 Scopus citations

Clinical strategies and animal models for developing senolytic agents

Kirkland, J. L. & Tchkonia, T., Aug 1 2015, In : Experimental Gerontology. 68, p. 19-25 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Cluster deaths in long-term care institutions: An investigation of excess deaths in two Ontario institutions

Naglie, G., Goldlist, B., Kirkland, J., Gordon, M., Klapecki, K., Young, J. & Clark, P., Jan 1 1995, In : Canadian Journal of Public Health. 86, 2, p. 120-123 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Commentary: Aging, differentiation-dependent gene expression, and fat cell function

Kirkland, J. L., Hotta, K., Bodkin, N. L., Gustafson, T. A., Yoshioka, S., Ortmeyer, H. K. & Hansen, B. C., Jun 9 1999, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 54, 5, p. B189-B191

Research output: Contribution to journalComment/debate

2 Scopus citations

Concerted action of aldehyde dehydrogenases influences depot-specific fat formation

Reichert, B., Yasmeen, R., Jeyakumar, S. M., Yang, F., Thomou, T., Alder, H., Duester, G., Maiseyeu, A., Mihai, G., Harrison, E. H., Rajagopalan, S., Kirkland, J. L. & Ziouzenkova, O., May 1 2011, In : Molecular Endocrinology. 25, 5, p. 799-809 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Constipation in long-stay elderly patients: Its treatment and prevention by lactulose, poloxalkol-dihydroxyanthroquinolone and phosphate enemas

Brocklehurst, J. C., Kirkland, J. L., Martin, J. & Ashford, J., Jan 1 1983, In : Gerontology. 29, 3, p. 181-184 4 p.

Research output: Contribution to journalArticle

27 Scopus citations

Corrigendum to: Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging (Journals of Gerontology - Series A Biological Sciences and Medical Sciences DOI: 10.1093/gerona/glx015)

Hadley, E. C., Kuchel, G. A., Newman, A. B., Allore, H. G., Bartley, J. M., Bergeman, C. S., Blinov, M. L., Colon-Emeric, C. S., Dabhar, F. S., Dugan, L. L., Dutta, C., Eldadah, B. A., Ferrucci, L., Kirkland, J. L., Kritchevsky, S. B., Lipsitz, L. A., Nadkarni, N. K., Reed, M. J., Schmader, K. E., Sierra, F. & 5 others, Studenski, S. A., Varadhan, R., Walston, J. D., Whitson, H. E. & Yung, R., Jun 14 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 7, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Creating the Next Generation of Translational Geroscientists

Newman, J. C., Sokoloski, J. L., Robbins, P. D., Niedernhofer, L. J., Reed, M. J., Wei, J., Austad, S. N., Barzilai, N., Cohen, H. J., Kuchel, G. A., Kirkland, J. L. & Pignolo, R. J., Sep 1 2019, In : Journal of the American Geriatrics Society. 67, 9, p. 1934-1939 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice

Cavalcante, M. B., Saccon, T. D., Nunes, A. D. C., Kirkland, J. L., Tchkonia, T., Schneider, A. & Masternak, M. M., Jan 18 2020, In : Aging. 12, 3, p. 2711-2722 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Deleted in breast cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype

Escande, C., Nin, V., Pirtskhalava, T., Chini, C. C. S., Tchkonia, T., Kirkland, J. L. & Chini, E. N., Jan 1 2015, In : Diabetes. 64, 1, p. 12-22 11 p.

Research output: Contribution to journalArticle

10 Scopus citations