Irina V Kovtun, PhD

  • 1273 Citations
  • 15 Scopus h-Index
20002019

Research output per year

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Research Output

  • 1273 Citations
  • 15 Scopus h-Index
  • 22 Article
  • 1 Chapter
  • 1 Short survey
  • 1 Review article
2019

Large Chromosomal Rearrangements Yield Biomarkers to Distinguish Low-Risk From Intermediate- and High-Risk Prostate Cancer

Vasmatzis, G., Kosari, F., Murphy, S. J., Terra, S., Kovtun, I. V., Harris, F. R., Zarei, S., Smadbeck, J., Johnson, S. H., Gaitatzes, A. G., Therneau, T. M., Rangel, L. J., Knudson, R. A., Greipp, P. T., Sukov, W. R., Knutson, D. L., Kloft-Nelson, S. M., Karnes, R. J. & Cheville, J., Jan 1 2019, In : Mayo Clinic Proceedings. 94, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting HER2 in patient-derived xenograft ovarian cancer models sensitizes tumors to chemotherapy

Harris, F. R., Zhang, P., Yang, L., Hou, X., Leventakos, K., Weroha, S. J., Vasmatzis, G. & Kovtun, I. V., Feb 1 2019, In : Molecular Oncology. 13, 2, p. 132-152 21 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

EGFR mediates activation of RET in lung adenocarcinoma with neuroendocrine differentiation characterized by ASCL1 expression

Bhinge, K., Yang, L., Terra, S., Nasir, A., Muppa, P., Aubry, M. C., Yi, J., Janaki, N., Kovtun, I. V., Murphy, S. J., Halling, G., Rahi, H., Mansfield, A., de Andrade, M., Yang, P., Vasmatzis, G., Peikert, T. & Kosari, F., 2017, In : Oncotarget. 8, 16, p. 27155-27165 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Quantification of Somatic Chromosomal Rearrangements in Circulating Cell-Free DNA from Ovarian Cancers

Harris, F. R., Kovtun, I. V., Smadbeck, J., Multinu, F., Jatoi, A., Kosari, F., Kalli, K. R., Murphy, S. J., Halling, G. C., Johnson, S. H., Liu, M. C., Mariani, A. & Vasmatzis, G., Jul 20 2016, In : Scientific Reports. 6, 29831.

Research output: Contribution to journalArticle

24 Scopus citations
2015

Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer

Kovtun, I. V., Murphy, S. J., Johnson, S. H., Cheville, J. C. & Vasmatzis, G., 2015, In : Oncotarget. 6, 30, p. 29087-29096 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Topoisomerase 2 alpha cooperates with androgen receptor to contribute to prostate cancer progression

Schaefer-Klein, J. L., Murphy, S. J., Johnson, S. H., Vasmatzis, G. & Kovtun, I. V., Nov 1 2015, In : PloS one. 10, 11, e0142327.

Research output: Contribution to journalArticle

15 Scopus citations
2014

ASCL1 and RET expression defines a clinically relevant subgroup of lung adenocarcinoma characterized by neuroendocrine differentiation

Kosari, F., Ida, C. M., Aubry, M. C., Yang, L., Kovtun, I. V., Klein, J. L. S., Li, Y., Erdogan, S., Tomaszek, S. C., Murphy, S. J., Bolette, L. C., Kolbert, C. P., Yang, P., Wigle, D. A. & Vasmatzis, G., Jul 17 2014, In : Oncogene. 33, 29, p. 3776-3783 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
2013

Lineage relationship of gleason patterns in gleason score 7 prostate cancer

Kovtun, I. V., Cheville, J. C., Murphy, S. J., Johnson, S. H., Zarei, S., Kosari, F., Sukov, W. R., Karnes, R. J. & Vasmatzis, G., Jun 1 2013, In : Cancer research. 73, 11, p. 3275-3284 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
2012

Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas

Vasmatzis, G., Johnson, S. H., Knudson, R. A., Ketterling, R. P., Braggio, E., Fonseca, R., Viswanatha, D. S., Law, M. E., Kip, N. S., Özsan, N., Grebe, S. K., Frederick, L. A., Eckloff, B. W., Thompson, E. A., Kadin, M. E., Milosevic, D., Porcher, J. C., Asmann, Y. W., Smith, D. I., Kovtun, I. V. & 3 others, Ansell, S. M., Dogan, A. M. & Feldman, A. L., Sep 13 2012, In : Blood. 120, 11, p. 2280-2289 10 p.

Research output: Contribution to journalArticle

129 Scopus citations
2011

A qualitative study of the ramifications of rash from epidermal growth factor receptor (EGFR) inhibitors

Coleman, S., Kovtun, I., Nguyen, P. L., Pittelkow, M. & Jatoi, A., Nov 1 2011, In : Psycho-Oncology. 20, 11, p. 1246-1249 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cockayne syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo

Kovtun, I. V., Johnson, K. O. & McMurray, C. T., May 2011, In : Aging. 3, 5, p. 509-514 6 p.

Research output: Contribution to journalArticle

34 Scopus citations
4 Scopus citations
2008
2 Scopus citations

Features of trinucleotide repeat instability in vivo

Kovtun, I. V. & McMurray, C. T., Jan 1 2008, In : Cell Research. 18, 1, p. 198-213 16 p.

Research output: Contribution to journalReview article

99 Scopus citations

Gene panel model predictive of outcome in men at high-risk of systemic progression and death from prostate cancer after radical retropubic prostatectomy

Cheville, J. C., Karnes, R. J., Therneau, T. M., Kosari, F., Munz, J. M., Tillmans, L., Basal, E., Rangel, L. J., Bergstralh, E., Kovtun, I. V., Savci-Heijink, C. D., Klee, E. W. & Vasmatzis, G., Sep 15 2008, In : Journal of Clinical Oncology. 26, 24, p. 3930-3936 7 p.

Research output: Contribution to journalArticle

66 Scopus citations
2007

Crosstalk of DNA glycosylases with pathways other than base excision repair

Kovtun, I. V. & McMurray, C. T., Apr 1 2007, In : DNA Repair. 6, 4, p. 517-529 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

Kovtun, I. V., Liu, Y., Bjoras, M., Klungland, A., Wilson, S. H. & McMurray, C. T., May 24 2007, In : Nature. 447, 7143, p. 447-452 6 p.

Research output: Contribution to journalArticle

312 Scopus citations
2006

Models of repair underlying trinucleotide DNA expansion

Kovtun, I. V. & McMurray, C. T., Dec 1 2006, Genetic Instabilities and Neurological Diseases, Second Edition. Elsevier Inc., p. 679-690 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations
2004

CAG Repeat Lengths in X- and Y-bearing Sperm Indicate That Gender Bias during Transmission of Huntington's Disease Gene Is Determined in the Embryo

Kovtun, I. V., Welch, G., Guthrie, H. D., Hafner, K. L. & McMurray, C. T., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9389-9391 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Somatic deletion events occur during early embryonic development and modify the extent of CAG expansion in subsequent generations

Kovtun, I. V., Thornhill, A. R. & McMurray, C. T., Dec 15 2004, In : Human molecular genetics. 13, 24, p. 3057-3068 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Triplet repeats and DNA repair: germ cell and somatic cell instability in transgenic mice.

Kovtun, I. V., Spiro, C. & McMurray, C. T., 2004, In : Methods in molecular biology (Clifton, N.J.). 277, p. 309-319 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
2003

Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease

Trushina, E., Heldebrant, M. P., Perez-Terzic, C. M., Bortolon, R., Kovtun, I. V., Badger, J. D., Terzic, A., Estévez, A., Windebank, A. J., Dyer, R. B., Yao, J. & McMurray, C. T., Oct 14 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 21, p. 12171-12176 6 p.

Research output: Contribution to journalArticle

69 Scopus citations
2001

Structural features of trinucleotide repeats associated with DNA expansion

Kovtun, I. V., Goellner, G. & McMurray, C. T., Jan 1 2001, In : Biochemistry and Cell Biology. 79, 3, p. 325-336 12 p.

Research output: Contribution to journalShort survey

38 Scopus citations

Trinucleotide expansion in haploid germ cells by gap repair

Kovtun, I. V. & McMurray, C. T., Apr 17 2001, In : Nature Genetics. 27, 4, p. 407-411 5 p.

Research output: Contribution to journalArticle

223 Scopus citations
2000

Gender of the embryo contributes to CAG instability in transgenic mice containing a Huntington's disease gene

Kovtun, I. V., Therneau, T. M. & McMurray, C. T., Nov 1 2000, In : Human molecular genetics. 9, 18, p. 2767-2775 9 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations