• 10598 Citations
  • 53 Scopus h-Index
1976 …2019
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Research Output 1995 2019

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Article
2019

A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR

Safarova, M. S., Satterfield, B. A., Fan, X., Austin, E. E., Ye, Z., Bastarache, L., Zheng, N., Ritchie, M. D., Borthwick, K. M., Williams, M. S., Larson, E. B., Scrol, A., Jarvik, G. P., Crosslin, D. R., Leppig, K., Rasmussen-Torvik, L. J., Pendergrass, S. A., Sturm, A. C., Namjou, B., Shah, A. S. & 12 others, Carroll, R. J., Chung, W. K., Wei, W. Q., Feng, Q. P., Stein, C. M., Roden, D. M., Manolio, T. A., Schaid, D. J., Denny, J. C., Hebbring, S. J., De Andrade, M. & Kullo, I. J., Dec 1 2019, In : npj Genomic Medicine. 4, 1, 3.

Research output: Contribution to journalArticle

Open Access
Electronic Health Records
Precision Medicine
Genetic Models
Myopia
Linkage Disequilibrium
14 Citations (Scopus)

Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection

DISCO Consortium & CARDIoGRAMPlusC4D Study Group, Jan 8 2019, In : Journal of the American College of Cardiology. 73, 1, p. 58-66 9 p.

Research output: Contribution to journalArticle

Genetic Loci
Endothelin-1
Fibromuscular Dysplasia
Odds Ratio
Confidence Intervals
1 Citation (Scopus)

A trans-ethnic genome-wide association study of uterine fibroids

Edwards, T. L., Giri, A., Hellwege, J. N., Hartmann, K. E., Stewart, E. A., Jeff, J. M., Bray, M. J., Pendergrass, S. A., Torstenson, E. S., Keaton, J. M., Jones, S. H., Gogoi, R. P., Kuivaniemi, H., Jackson, K. L., Kho, A. N., Kullo, I. J., McCarty, C. A., Im, H. K., Pacheco, J. A., Pathak, J. & 7 others, Williams, M. S., Tromp, G., Kenny, E. E., Peissig, P. L., Denny, J. C., Roden, D. M. & Edwards, D. R. V., Jan 1 2019, In : Frontiers in Genetics. 10, JUN, 511.

Research output: Contribution to journalArticle

Open Access
Genome-Wide Association Study
Leiomyoma
Single Nucleotide Polymorphism
Meta-Analysis
Chromosomes, Human, Pair 10

DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass

Gordon, S. M., Neufeld, E. B., Yang, Z., Pryor, M., Freeman, L. A., Fan, X., Kullo, I. J., Biesecker, L. G. & Remaley, A. T., Dec 1 2019, In : Scientific reports. 9, 1, 3597.

Research output: Contribution to journalArticle

Chylomicrons
Intestinal Absorption
Triglycerides
Obesity
Exome

Detecting potential pleiotropy across cardiovascular and neurological diseases using univariate, bivariate, and multivariate methods on 43,870 individuals from the eMERGE network

Zhang, X., Veturi, Y., Verma, S., Bone, W., Verma, A., Lucas, A., Hebbring, S., Denny, J. C., Stanaway, I. B., Jarvik, G. P., Crosslin, D., Larson, E. B., Rasmussen-Torvik, L., Pendergrass, S. A., Smoller, J. W., Hakonarson, H., Sleiman, P., Weng, C., Fasel, D., Wei, W. Q. & 4 others, Kullo, I. J., Schaid, D. J., Chung, W. K. & Ritchie, M. D., Jan 1 2019, In : Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 24, p. 272-283 12 p.

Research output: Contribution to journalArticle

Electronic Health Records
Genomics
Cardiovascular Diseases
Phenotype
Nervous System Diseases
Information Dissemination
Electronic Health Records
Health Promotion
Social Support
Randomized Controlled Trials

Establishment of Specialized Clinical Cardiovascular Genetics Programs: Recognizing the Need and Meeting Standards: A Scientific Statement From the American Heart Association

Ahmad, F., McNally, E. M., Ackerman, M. J., Baty, L. C., Day, S. M., Kullo, I. J., Madueme, P. C., Maron, M. S., Martinez, M. W., Salberg, L., Taylor, M. R. & Wilcox, J. E., Jun 1 2019, In : Circulation. Genomic and precision medicine. 12, 6, p. e000054

Research output: Contribution to journalArticle

Open Access
Genetic Testing
Medicine
Channelopathies
Neuromuscular Diseases
Cardiomyopathies

Facilitating phenotype transfer using a common data model

Hripcsak, G., Shang, N., Peissig, P. L., Rasmussen, L. V., Liu, C., Benoit, B., Carroll, R. J., Carrell, D. S., Denny, J. C., Dikilitas, O., Gainer, V. S., Howell, K. M., Klann, J. G., Kullo, I. J., Lingren, T., Mentch, F. D., Murphy, S. N., Natarajan, K., Pacheco, J. A., Wei, W. Q. & 2 others, Wiley, K. & Weng, C., Aug 1 2019, In : Journal of Biomedical Informatics. 96, 103253.

Research output: Contribution to journalArticle

Electronic medical equipment
Data structures
Phenotype
Electronic Health Records
Health
1 Citation (Scopus)

GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network

Namjou, B., Lingren, T., Huang, Y., Parameswaran, S., Cobb, B. L., Stanaway, I. B., Connolly, J. J., Mentch, F. D., Benoit, B., Niu, X., Wei, W. Q., Carroll, R. J., Pacheco, J. A., Harley, I. T. W., Divanovic, S., Carrell, D. S., Larson, E. B., Carey, D. J., Verma, S., Ritchie, M. D. & 10 others, Gharavi, A. G., Murphy, S., Williams, M. S., Crosslin, D. R., Jarvik, G. P., Kullo, I. J., Hakonarson, H., Li, R., Xanthakos, S. A. & Harley, J. B., Jul 17 2019, In : BMC Medicine. 17, 1, 135.

Research output: Contribution to journalArticle

Open Access
Electronic Health Records
Genome-Wide Association Study
Genomics
Genes
Pediatrics
1 Citation (Scopus)

Harmonizing Clinical Sequencing and Interpretation for the eMERGE III Network

the eMERGE Consortium, Sep 5 2019, In : American journal of human genetics. 105, 3, p. 588-605 18 p.

Research output: Contribution to journalArticle

Genetic Testing
Clinical Decision Support Systems
Precision Medicine
Gene Targeting
Information Dissemination
4 Citations (Scopus)

Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates

Paige, E., Clément, M., Lareyre, F., Sweeting, M., Raffort, J., Grenier, C., Finigan, A., Harrison, J., Peters, J. E., Sun, B. B., Butterworth, A. S., Harrison, S. C., Bown, M. J., Lindholt, J. S., Badger, S. A., Kullo, I. J., Powell, J., Norman, P. E., Scott, D. J. A., Bailey, M. A. & 5 others, Rose-John, S., Danesh, J., Freitag, D. F., Paul, D. S. & Mallat, Z., Feb 1 2019, In : Circulation. Genomic and precision medicine. 12, 2, p. e002413

Research output: Contribution to journalArticle

Interleukin-6 Receptors
Abdominal Aortic Aneurysm
Growth
Interleukin-6
Aortic Rupture

Longitudinal low density lipoprotein cholesterol goal achievement and cardiovascular outcomes among adult patients with familial hypercholesterolemia: The CASCADE FH registry

Duell, P. B., Gidding, S. S., Andersen, R. L., Knickelbine, T., Anderson, L., Gianos, E., Shrader, P., Kindt, I., O'Brien, E. C., McCann, D., Hemphill, L. C., Ahmed, C. D., Martin, S. S., Larry, J. A., Ahmad, Z. S., Kullo, I. J., Underberg, J. A., Guyton, J., Thompson, P., Wilemon, K. & 7 others, Roe, M. T., Rader, D. J., Cuchel, M., Linton, M. F., Shapiro, M. D., Moriarty, P. M. & Knowles, J. W., Oct 2019, In : Atherosclerosis. 289, p. 85-93 9 p.

Research output: Contribution to journalArticle

Open Access
Hyperlipoproteinemia Type II
LDL Cholesterol
Registries
Lipids
Transient Ischemic Attack

Making work visible for electronic phenotype implementation: Lessons learned from the eMERGE network

Shang, N., Liu, C., Rasmussen, L. V., Ta, C. N., Caroll, R. J., Benoit, B., Lingren, T., Dikilitas, O., Mentch, F. D., Carrell, D. S., Wei, W. Q., Luo, Y., Gainer, V. S., Kullo, I. J., Pacheco, J. A., Hakonarson, H., Walunas, T. L., Denny, J. C., Wiley, K., Murphy, S. N. & 2 others, Hripcsak, G. & Weng, C., Nov 2019, In : Journal of Biomedical Informatics. 99, 103293.

Research output: Contribution to journalArticle

Electronic medical equipment
Electronic Health Records
Genomics
Phenotype
Engineers

Targeted Sequencing Study to Uncover Shared Genetic Susceptibility Between Peripheral Artery Disease and Coronary Heart Disease-Brief Report

Safarova, M. S., Fan, X., Austin, E. E., van Zuydam, N., Hopewell, J., Schaid, D. J. & Kullo, I. J., Jun 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 6, p. 1227-1233 7 p.

Research output: Contribution to journalArticle

Open Access
Peripheral Arterial Disease
Genetic Predisposition to Disease
Coronary Disease
Gene Frequency
Genes
2018

Adverse effects of long-term weight gain on microvascular endothelial function

Coutinho, T., Turner, S. T. & Kullo, I. J., Jan 1 2018, (Accepted/In press) In : Obesity Research and Clinical Practice.

Research output: Contribution to journalArticle

Hyperemia
Weight Gain
Dilatation
Waist Circumference
Adipose Tissue

Association of Ankle-Brachial Indices With Limb Revascularization or Amputation in Patients With Peripheral Artery Disease

Moussa Pacha, H., Mallipeddi, V. P., Afzal, N., Moon, S., Kaggal, V. C., Kalra, M., Oderich, G., Wennberg, P. W., Rooke, T. W., Scott, C. G., Kullo, I. J., McBane, R. D., Nishimura, R. A., Chaudhry, R., Liu, H. D. & Arruda-Olson, A. M., Dec 7 2018, In : JAMA Network Open. 1, 8, p. e185547

Research output: Contribution to journalArticle

Open Access
Ankle Brachial Index
Peripheral Arterial Disease
Amputation
Extremities
Arteries
1 Citation (Scopus)

A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers

Mosley, J. D., Feng, Q. P., Wells, Q. S., Van Driest, S. L., Shaffer, C. M., Edwards, T. L., Bastarache, L., Wei, W. Q., Davis, L. K., McCarty, C. A., Thompson, W., Chute, C. G., Jarvik, G. P., Gordon, A. S., Palmer, M. R., Crosslin, D. R., Larson, E. B., Carrell, D. S., Kullo, I. J., Pacheco, J. A. & 14 others, Peissig, P. L., Brilliant, M. H., Linneman, J. G., Namjou, B., Williams, M. S., Ritchie, M. D., Borthwick, K. M., Verma, S. S., Karnes, J. H., Weiss, S. T., Wang, T. J., Stein, C. M., Denny, J. C. & Roden, D. M., Dec 1 2018, In : Nature Communications. 9, 1, 3522.

Research output: Contribution to journalArticle

Electronic Health Records
biomarkers
Biomarkers
health
Health
1 Citation (Scopus)

Burden of hospitalization in clinically diagnosed peripheral artery disease: A community-based study

Arruda-Olson, A. M., Moussa Pacha, H., Afzal, N., Abram, S., Lewis, B. R., Isseh, I., Haddad, R., Scott, C. G., Bailey, K. R., Liu, H. D., Rooke, T. W. & Kullo, I. J., Feb 1 2018, In : Vascular Medicine (United Kingdom). 23, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

Peripheral Arterial Disease
Hospitalization
International Classification of Diseases
Arteries
1 Citation (Scopus)
Hyperlipoproteinemia Type II
Hypercholesterolemia
LDL Cholesterol
Lipids
Clinical Trials
1 Citation (Scopus)

Developing a Process for Returning Medically Actionable Genomic Variants to Latino Patients in a Federally Qualified Health Center

Shaibi, G. Q., Kullo, I. J., Singh, D. P., Sharp, R. R., De Filippis, E. A., Cuellar, I., Hernandez, V., Levey, S., Radecki Breitkopf, C., Olson, J. E., Cerhan, J. R., Mandarino, L. J., Thibodeau, S. N. & Lindor, N. M., Jan 1 2018, (Accepted/In press) In : Public Health Genomics.

Research output: Contribution to journalArticle

Hyperlipidemias
Hispanic Americans
Community Health Planning
Clinical Decision Support Systems
Community Health Centers
4 Citations (Scopus)

Empowering genomic medicine by establishing critical sequencing result data flows: The eMERGE example

Aronson, S., Babb, L., Ames, D., Gibbs, R. A., Venner, E., Connelly, J. J., Marsolo, K., Weng, C., Williams, M. S., Hartzler, A. L., Liang, W. H., Ralston, J. D., Devine, E. B., Murphy, S., Chute, C. G., Caraballo, P., Kullo, I. J., Freimuth, R., Rasmussen, L. V., Wehbe, F. H. & 4 others, Peterson, J. F., Robinson, J. R., Wiley, K. & Overby Taylor, C., Oct 1 2018, In : Journal of the American Medical Informatics Association. 25, 10, p. 1375-1381 7 p.

Research output: Contribution to journalArticle

Clinical Decision Support Systems
Point-of-Care Systems
Medicine
Health Personnel
12 Citations (Scopus)

Ethical considerations related to return of results from genomic medicine projects: The eMERGE network (phase III) experience

Fossey, R., Kochan, D., Winkler, E., Pacyna, J. E., Olson, J. E., Thibodeau, S. N., Connolly, J. J., Harr, M., Behr, M. A., Prows, C. A., Cobb, B., Myers, M. F., Leslie, N. D., Namjou-Khales, B., Rasouly, H. M., Wynn, J., Fedotov, A., Chung, W. K., Gharavi, A., Williams, J. L. & 13 others, Pais, L., Holm, I., Aufox, S., Smith, M. E., Scrol, A., Leppig, K., Jarvik, G. P., Wiesner, G. L., Li, R., Stroud, M., Smoller, J. W., Sharp, R. R. & Kullo, I. J., Mar 1 2018, In : Journal of Personalized Medicine. 8, 1, 2.

Research output: Contribution to journalArticle

Electronic Health Records
Research Ethics Committees
Genomics
Medicine
Informed Consent
2 Citations (Scopus)

Higher plasma leptin levels are associated with reduced left ventricular mass and left ventricular diastolic stiffness in black women: insights from the Genetic Epidemiology Network of Arteriopathy (GENOA) study

Kamimura, D., Suzuki, T., Wang, W., DeShazo, M., Hall, J. E., Winniford, M. D., Kullo, I. J., Mosley, T. H., Butler, K. R. & Hall, M. E., Jun 15 2018, (Accepted/In press) In : Hypertension Research. p. 1-10 10 p.

Research output: Contribution to journalArticle

Molecular Epidemiology
Leptin
Heart Failure
Cluster Analysis
Echocardiography
1 Citation (Scopus)

Leveraging the electronic health record to create an automated real-time prognostic tool for peripheral arterial disease

Arruda-Olson, A. M., Afzal, N., Mallipeddi, V. P., Said, A., Pacha, H. M., Moon, S., Chaudhry, A. P., Scott, C. G., Bailey, K. R., Rooke, T. W., Wennberg, P. W., Kaggal, V. C., Oderich, G., Kullo, I. J., Nishimura, R. A., Chaudhry, R. & Liu, H. D., Dec 1 2018, In : Journal of the American Heart Association. 7, 23, e009680.

Research output: Contribution to journalArticle

Electronic Health Records
Peripheral Arterial Disease
Point-of-Care Systems
Confidence Intervals
Survival
17 Citations (Scopus)

LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins

Wei, W. Q., Li, X., Feng, Q., Kubo, M., Kullo, I. J., Peissig, P. L., Karlson, E. W., Jarvik, G. P., Lee, M. T. M., Shang, N., Larson, E. A., Edwards, T., Shaffer, C. M., Mosley, J. D., Maeda, S., Horikoshi, M., Ritchie, M., Williams, M. S., Larson, E. B., Crosslin, D. R. & 13 others, Bland, S. T., Pacheco, J. A., Rasmussen-Torvik, L. J., Cronkite, D., Hripcsak, G., Cox, N. J., Wilke, R. A., Stein, C. M., Rotter, J. I., Momozawa, Y., Roden, D. M., Krauss, R. M. & Denny, J. C., Oct 23 2018, In : Circulation. 138, 17, p. 1839-1849 11 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Coronary Disease
LDL Cholesterol
Odds Ratio
Confidence Intervals
13 Citations (Scopus)

Natural language processing of clinical notes for identification of critical limb ischemia

Afzal, N., Mallipeddi, V. P., Sohn, S., Liu, H. D., Chaudhry, R., Scott, C. G., Kullo, I. J. & Arruda-Olson, A. M., Mar 1 2018, In : International Journal of Medical Informatics. 111, p. 83-89 7 p.

Research output: Contribution to journalArticle

Natural Language Processing
Ischemia
Extremities
International Classification of Diseases
Electronic Health Records
1 Citation (Scopus)

Patient and provider perspectives on a decision aid for familial hypercholesterolemia

Farwati, M., Kumbamu, A., Kochan, D. C. & Kullo, I. J., Dec 1 2018, In : Journal of Personalized Medicine. 8, 4, 35.

Research output: Contribution to journalArticle

Hyperlipoproteinemia Type II
Decision Support Techniques
Focus Groups
Decision Making
Audiovisual Aids
1 Citation (Scopus)

Probing the Virtual Proteome to Identify Novel Disease Biomarkers

Mosley, J. D., Benson, M. D., Smith, J. G., Melander, O., Ngo, D., Shaffer, C. M., Ferguson, J. F., Herzig, M. S., McCarty, C. A., Chute, C. G., Jarvik, G. P., Gordon, A. S., Palmer, M. R., Crosslin, D. R., Larson, E. B., Carrell, D. S., Kullo, I. J., Pacheco, J. A., Peissig, P. L., Brilliant, M. H. & 18 others, Kitchner, T. E., Linneman, J. G., Namjou, B., Williams, M. S., Ritchie, M. D., Borthwick, K. M., Kiryluk, K., Mentch, F. D., Sleiman, P. M., Karlson, E. W., Verma, S. S., Zhu, Y., Vasan, R. S., Yang, Q., Denny, J. C., Roden, D. M., Gerszten, R. E. & Wang, T. J., Nov 27 2018, In : Circulation. 138, 22, p. 2469-2481 13 p.

Research output: Contribution to journalArticle

Proteome
Biomarkers
Proteins
Proteomics
C-Type Lectins
Genetic Counseling
Health Literacy
National Institutes of Health (U.S.)
Genetic Testing
Self Efficacy
4 Citations (Scopus)
Electronic Health Records
Herpes Zoster
Genomics
Medical Records
Genotype
3 Citations (Scopus)

The Return of Actionable Variants Empirical (RAVE) Study, a Mayo Clinic Genomic Medicine Implementation Study: Design and Initial Results

Kullo, I. J., Olson, J. E., Fan, X., Jose, M., Safarova, M., Radecki Breitkopf, C., Winkler, E., Kochan, D. C., Snipes, S., Pacyna, J. E., Carney, M., Chute, C. G., Gupta, J., Jose, S., Venner, E., Murugan, M., Jiang, Y., Zordok, M., Farwati, M., Philogene, M. & 7 others, Smith, E., Shaibi, G. Q., Caraballo, P., Freimuth, R., Lindor, N. M., Sharp, R. R. & Thibodeau, S. N., Nov 1 2018, In : Mayo Clinic Proceedings. 93, 11, p. 1600-1610 11 p.

Research output: Contribution to journalArticle

Medicine
Electronic Health Records
Genes
Cardiovascular Diseases
Penetrance
2017
3 Citations (Scopus)

A DAB2IP genotype: Sex interaction is associated with abdominal aortic aneurysm expansion

Ye, Z., Austin, E., Schaid, D. J., Bailey, K. R., Pellikka, P. & Kullo, I. J., Oct 1 2017, In : Journal of Investigative Medicine. 65, 7, p. 1077-1082 6 p.

Research output: Contribution to journalArticle

Abdominal Aortic Aneurysm
Genotype
Blood Pressure
Aneurysm
Arterial Pressure
7 Citations (Scopus)

Concordance between Research Sequencing and Clinical Pharmacogenetic Genotyping in the eMERGE-PGx Study

Rasmussen-Torvik, L. J., Almoguera, B., Doheny, K. F., Freimuth, R., Gordon, A. S., Hakonarson, H., Hawkins, J. B., Husami, A., Ivacic, L. C., Kullo, I. J., Linderman, M. D., Manolio, T. A., Obeng, A. O., Pellegrino, R., Prows, C. A., Ritchie, M. D., Smith, M. E., Stallings, S. C., Wolf, W. A., Zhang, K. & 1 others, Scott, S. A., Jul 1 2017, In : Journal of Molecular Diagnostics. 19, 4, p. 561-566 6 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Research
Genotype
Alleles
1 Citation (Scopus)

Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals

Holzinger, E. R., Verma, S. S., Moore, C. B., Hall, M., De, R., Gilbert-Diamond, D., Lanktree, M. B., Pankratz, N., Amuzu, A., Burt, A., Dale, C., Dudek, S., Furlong, C. E., Gaunt, T. R., Kim, D. S., Riess, H., Sivapalaratnam, S., Tragante, V., Van Iperen, E. P. A., Brautbar, A. & 32 others, Carrell, D. S., Crosslin, D. R., Jarvik, G. P., Kuivaniemi, H., Kullo, I. J., Larson, E. B., Rasmussen-Torvik, L. J., Tromp, G., Baumert, J., Cruickshanks, K. J., Farrall, M., Hingorani, A. D., Hovingh, G. K., Kleber, M. E., Klein, B. E., Klein, R., Koenig, W., Lange, L. A., MOrz, W., North, K. E., Charlotte Onland-Moret, N., Reiner, A. P., Talmud, P. J., Van Der Schouw, Y. T., Wilson, J. G., Kivimaki, M., Kumari, M., Moore, J. H., Drenos, F., Asselbergs, F. W., Keating, B. J. & Ritchie, M. D., Jul 24 2017, In : BioData Mining. 10, 1, 25.

Research output: Contribution to journalArticle

Single nucleotide Polymorphism
Nucleotides
Lipids
Polymorphism
Replication
7 Citations (Scopus)

Effect of Disclosing Genetic Risk for Coronary Heart Disease on Information Seeking and Sharing: The MI-GENES Study (Myocardial Infarction Genes)

Brown, S. A. N., Jouni, H., Marroush, T. S. & Kullo, I. J., Aug 1 2017, In : Circulation: Cardiovascular Genetics. 10, 4, e001613.

Research output: Contribution to journalArticle

Information Dissemination
Coronary Disease
Myocardial Infarction
Odds Ratio
Confidence Intervals

Elevated serum osteoprotegerin is associated with increased left ventricular mass index and myocardial stiffness

Kamimura, D., Suzuki, T., Furniss, A. L., Griswold, M. E., Kullo, I. J., Lindsey, M. L., Winniford, M. D., Butler, K. R., Mosley, T. H. & Hall, M. E., Dec 1 2017, In : Journal of Cardiovascular Medicine. 18, 12, p. 954-961 8 p.

Research output: Contribution to journalArticle

Osteoprotegerin
Heart Ventricles
Serum
Heart Failure
African Americans
9 Citations (Scopus)

Genome-wide study of resistant hypertension identified from electronic health records

Dumitrescu, L., Ritchie, M. D., Denny, J. C., Rouby, N. M. E., McDonough, C. W., Bradford, Y., Ramirez, A. H., Bielinski, S. J., Basford, M. A., Chai, H. S., Peissig, P., Carrell, D., Pathak, J., Rasmussen, L. V., Wang, X., Pacheco, J. A., Kho, A. N., Hayes, M. G., Matsumoto, M., Smith, M. E. & 15 others, Li, R., Cooper-DeHoff, R. M., Kullo, I. J., Chute, C. G., Chisholm, R. L., Jarvik, G. P., Larson, E. B., Carey, D., McCarty, C. A., Williams, M. S., Roden, D. M., Bottinger, E., Johnson, J. A., De Andrade, M. & Crawford, D. C., Feb 1 2017, In : PLoS One. 12, 2, e0171745.

Research output: Contribution to journalArticle

Electronic Health Records
hypertension
electronics
Genes
Blood pressure
11 Citations (Scopus)

Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry

Amrock, S. M., Duell, P. B., Knickelbine, T., Martin, S. S., O'Brien, E. C., Watson, K. E., Mitri, J., Kindt, I., Shrader, P., Baum, S. J., Hemphill, L. C., Ahmed, C. D., Andersen, R. L., Kullo, I. J., McCann, D., Larry, J. A., Murray, M. F., Fishberg, R., Guyton, J. R., Wilemon, K. & 11 others, Roe, M. T., Rader, D. J., Ballantyne, C. M., Underberg, J. A., Thompson, P., Duffy, D., Linton, M. F., Shapiro, M. D., Moriarty, P. M., Knowles, J. W. & Ahmad, Z. S., Dec 1 2017, In : Atherosclerosis. 267, p. 19-26 8 p.

Research output: Contribution to journalArticle

Hyperlipoproteinemia Type II
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Registries
Health
Population
27 Citations (Scopus)

Identification of four novel loci in Asthma in European American and African American Populations

Almoguera, B., Vazquez, L., Mentch, F., Connolly, J., Pacheco, J. A., Sundaresan, A. S., Peissig, P. L., Linneman, J. G., McCarty, C. A., Crosslin, D., Carrell, D. S., Lingren, T., Namjou-Khales, B., Harley, J. B., Larson, E., Jarvik, G. P., Brilliant, M., Williams, M. S., Kullo, I. J., Hysinger, E. B. & 2 others, Sleiman, P. M. A. & Hakonarson, H., Feb 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 4, p. 456-463 8 p.

Research output: Contribution to journalArticle

African Americans
Asthma
Population
Airway Remodeling
Electronic Health Records
8 Citations (Scopus)

Identification of unique venous thromboembolism-susceptibility variants in African-Americans

Heit, J. A., Armasu, S. M., McCauley, B. M., Kullo, I. J., Sicotte, H., Pathak, J., Chute, C. G., Gottesman, O., Bottinger, E. P., Denny, J. C., Roden, D. M., Li, R., Ritchie, M. D. & De Andrade, M., 2017, In : Thrombosis and Haemostasis. 117, 4, p. 758-768 11 p.

Research output: Contribution to journalArticle

Venous Thromboembolism
African Americans
Single Nucleotide Polymorphism
Electronic Health Records
Gene Expression
3 Citations (Scopus)

Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes

Mosley, J. D., Shoemaker, M. B., Wells, Q. S., Darbar, D., Shaffer, C. M., Edwards, T. L., Bastarache, L., McCarty, C. A., Thompson, W., Chute, C. G., Jarvik, G. P., Crosslin, D. R., Larson, E. B., Kullo, I. J., Pacheco, J. A., Peissig, P. L., Brilliant, M. H., Linneman, J. G., Witte, J. S., Denny, J. C. & 1 others, Roden, D. M., Apr 1 2017, In : Circulation: Cardiovascular Genetics. 10, 2, e001482.

Research output: Contribution to journalArticle

Phenotype
Atrial Fibrillation
Electronic Health Records
Waist Circumference
Genomics
32 Citations (Scopus)

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

Jones, G. T., Tromp, G., Kuivaniemi, H., Gretarsdottir, S., Baas, A. F., Giusti, B., Strauss, E., Van'T Hof, F. N. G., Webb, T. R., Erdman, R., Ritchie, M. D., Elmore, J. R., Verma, A., Pendergrass, S., Kullo, I. J., Ye, Z., Peissig, P. L., Gottesman, O., Verma, S. S., Malinowski, J. & 97 others, Rasmussen-Torvik, L. J., Borthwick, K. M., Smelser, DI. T., Crosslin, D. R., De Andrade, M., Ryer, E. J., McCarty, C. A., Böttinger, E. P., Pacheco, J. A., Crawford, D. C., Carrell, D. S., Gerhard, G. S., Franklin, D. P., Carey, D. J., Phillips, V. L., Williams, M. J. A., Wei, W., Blair, R., Hill, A. A., Vasudevan, T. M., Lewis, D. R., Thomson, I. A., Krysa, J., Hill, G. B., Roake, J., Merriman, T. R., Oszkinis, G., Galora, S., Saracini, C., Abbate, R., Pulli, R., Pratesi, C., Saratzis, A., Verissimo, A. R., Bumpstead, S., Badger, S. A., Clough, R. E., Cockerill, G., Hafez, H., Scott, D. J. A., Futers, T. S., Romaine, S. P. R., Bridge, K., Griffin, K. J., Bailey, M. A., Smith, A., Thompson, M. M., Van Bockxmeer, F. M., Matthiasson, S. E., Thorleifsson, G., Thorsteinsdottir, U., Blankensteijn, J. D., Teijink, J. A. W., Wijmenga, C., De Graaf, J., Kiemeney, L. A., Lindholt, J. S., Hughes, A., Bradley, D. T., Stirrups, K., Golledge, J., Norman, P. E., Powell, J. T., Humphries, S. E., Hamby, S. E., Goodall, A. H., Nelson, C. P., Sakalihasan, N., Courtois, A., Ferrell, R. E., Eriksson, P., Folkersen, L., Franco-Cereceda, A., Eicher, J. D., Johnson, A. D., Betsholtz, C., Ruusalepp, A., Franzén, O., Schadt, E. E., Björkegren, J. L. M., Lipovich, L., Drolet, A. M., Verhoeven, E. L., Zeebregts, C. J., Geelkerken, R. H., Van Sambeek, M. R., Van Sterkenburg, S. M., De Vries, J. P., Stefansson, K., Thompson, J. R., De Bakker, P. I. W., Deloukas, P., Sayers, R. D., Harrison, S. C., Van Rij, A. M., Samani, N. J. & Bown, M. J., Jan 20 2017, In : Circulation Research. 120, 2, p. 341-353 13 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Abdominal Aortic Aneurysm
Meta-Analysis
Validation Studies
Risk Management
1 Citation (Scopus)

Motivation, Perception, and Treatment Beliefs in the Myocardial Infarction Genes (MI-GENES) Randomized Clinical Trial

Kattel, S., Onyekwelu, T., Brown, S. A., Jouni, H., Austin, E. & Kullo, I. J., Apr 6 2017, (Accepted/In press) In : Journal of Genetic Counseling. p. 1-9 9 p.

Research output: Contribution to journalArticle

Motivation
Randomized Controlled Trials
Myocardial Infarction
Genetic Testing
Genes
26 Citations (Scopus)

Multidisciplinary model to implement pharmacogenomics at the point of care

Caraballo, P., Hodge, L. S., Bielinski, S. J., Stewart, A. K., Farrugia, G., Schultz, C. G., Rohrer-Vitek, C. R., Olson, J. E., St. Sauver, J., Roger, V. L., Parkulo, M. A., Kullo, I. J., Nicholson, W. T., Elliott, M. A., Black, J. L. & Weinshilboum, R. M., Apr 1 2017, In : Genetics in Medicine. 19, 4, p. 421-429 9 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Clinical Decision Support Systems
Pharmacogenetics
Drug Interactions
Clinical Governance
8 Citations (Scopus)

Relationship of circulating spexin with markers of cardiovascular disease: A pilot study in adolescents with obesity

Kumar, S., Hossain, M. J., Javed, A., Kullo, I. J. & Balagopal, P. B., 2017, (Accepted/In press) In : Pediatric obesity.

Research output: Contribution to journalArticle

Pediatric Obesity
Leptin
Cardiovascular Diseases
Biomarkers
Doppler Ultrasonography
1 Citation (Scopus)
Left Ventricular Function
Ankle
Sex Characteristics
Blood Vessels
Vascular Stiffness
5 Citations (Scopus)

Shared decision-making following disclosure of coronary heart disease genetic risk: Results from a randomized clinical trial

Jouni, H., Haddad, R. A., Marroush, T. S., Brown, S. A., Kruisselbrink, T. M., Austin, E. E., Shameer, K., Behnken, E. M., Chaudhry, R., Montori, V. M. & Kullo, I. J., Mar 1 2017, In : Journal of Investigative Medicine. 65, 3, p. 681-688 8 p.

Research output: Contribution to journalArticle

Disclosure
Coronary Disease
Decision Making
Randomized Controlled Trials
Decision making
2 Citations (Scopus)

Temporal trends in lipid testing among children and adolescents: A population based study

Sriram, S., St. Sauver, J., Jacobson, D. J., Fan, C., Lynch, B. A., Cristiani, V., Kullo, I. J., Lteif, A. N. & Kumar, S., Dec 1 2017, In : Preventive Medicine Reports. 8, p. 267-272 6 p.

Research output: Contribution to journalArticle

Lipids
Population
Young Adult
Age Groups
Poisson Distribution
12 Citations (Scopus)

The association between cigarette smoking and inflammation: The Genetic Epidemiology Network of Arteriopathy (GENOA) study

Tibuakuu, M., Kamimura, D., Kianoush, S., DeFilippis, A. P., Al Rifai, M., Reynolds, L. M., White, W. B., Butler, K. R., Mosley, T. H., Turner, S. T., Kullo, I. J., Hall, M. E. & Blaha, M. J., Sep 1 2017, In : PLoS One. 12, 9, e0184914.

Research output: Contribution to journalArticle

Molecular Epidemiology
smoking (habit)
Biomarkers
Tobacco Products
epidemiology
4 Citations (Scopus)

Variability in assigning pathogenicity to incidental findings: insights from LDLR sequence linked to the electronic health record in 1013 individuals

Safarova, M. S., Klee, E. W., Baudhuin, L. M., Winkler, E. M., Kluge, M. L., Bielinski, S. J., Olson, J. E. & Kullo, I. J., Feb 1 2017, (Accepted/In press) In : European Journal of Human Genetics.

Research output: Contribution to journalArticle

Incidental Findings
Electronic Health Records
Virulence
Hyperlipoproteinemia Type II
Medical Genetics