Iftikhar Jan Kullo

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Iftikhar Jan Kullo, MD

1995 …2023

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  • 2016

    Association of arrhythmia-related genetic variants with phenotypes documented in electronic medical records

    Van Driest, S. L., Wells, Q. S., Stallings, S., Bush, W. S., Gordon, A., Nickerson, D. A., Kim, J. H., Crosslin, D. R., Jarvik, G. P., Carrell, D. S., Ralston, J. D., Larson, E. B., Bielinski, S. J., Olson, J. E., Ye, Z., Kullo, I. J., Abul-Husn, N. S., Scott, S. A., Bottinger, E., Almoguera, B., & 25 othersConnolly, J., Chiavacci, R., Hakonarson, H., Rasmussen-Torvik, L. J., Pan, V., Persell, S. D., Smith, M., Chisholm, R. L., Kitchner, T. E., He, M. M., Brilliant, M. H., Wallace, J. R., Doheny, K. F., Shoemaker, M. B., Li, R., Manolio, T. A., Callis, T. E., Macaya, D., Williams, M. S., Carey, D., Kapplinger, J. D., Ackerman, M. J., Ritchie, M. D., Denny, J. C. & Roden, D. M., Jan 5 2016, In: JAMA - Journal of the American Medical Association. 315, 1, p. 47-57 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    114 Scopus citations

  • Associations Between Inflammation and Physical Function in African Americans and European Americans with Prevalent Cardiovascular Risk Factors

    Windham, B. G., Wilkening, S. R., Lirette, S. T., Kullo, I. J., Turner, S. T., Griswold, M. E. & Mosley, T. H., Jul 1 2016, In: Journal of the American Geriatrics Society. 64, 7, p. 1448-1455 8 p.

    Research output: Contribution to journal › Article › peer-review

    10 Scopus citations

  • Associations Between Serum Inflammatory Markers and Hippocampal Volume in a Community Sample

    Schmidt, M. F., Freeman, K. B., Windham, B. G., Griswold, M. E., Kullo, I. J., Turner, S. T. & Mosley, T. H., Sep 1 2016, In: Journal of the American Geriatrics Society. 64, 9, p. 1823-1829 7 p.

    Research output: Contribution to journal › Article › peer-review

    10 Scopus citations

  • Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data

    Mosley, J. D., Van Driest, S. L., Wells, Q. S., Shaffer, C. M., Edwards, T. L., Bastarache, L., McCarty, C. A., Thompson, W., Chute, C. G., Jarvik, G. P., Crosslin, D. R., Larson, E. B., Kullo, I. J., Pacheco, J. A., Peissig, P. L., Brilliant, M. H., Linneman, J. G., Denny, J. C. & Roden, D. M., Dec 1 2016, In: Circulation: Cardiovascular Genetics. 9, 6, p. 521-530 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    5 Scopus citations

  • Disclosing genetic risk for coronary heart disease: Effects on perceived personal control and genetic counseling satisfaction

    Robinson, C. L., Jouni, H., Kruisselbrink, T. M., Austin, E. E., Christensen, K. D., Green, R. C. & Kullo, I. J., Feb 1 2016, In: Clinical Genetics. 89, 2, p. 251-257 7 p.

    Research output: Contribution to journal › Article › peer-review

    8 Scopus citations

  • Effect of vitamin D3 treatment on endothelial function in obese adolescents

    Javed, A., Kullo, I. J., Balagopal, P. B. & Kumar, S., Aug 1 2016, In: Pediatric Obesity. 11, 4, p. 279-284 6 p.

    Research output: Contribution to journal › Article › peer-review

    14 Scopus citations

  • EMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants

    Verma, A., Verma, S. S., Pendergrass, S. A., Crawford, D. C., Crosslin, D. R., Kuivaniemi, H., Bush, W. S., Bradford, Y., Kullo, I., Bielinski, S. J., Li, R., Denny, J. C., Peissig, P., Hebbring, S., De Andrade, M., Ritchie, M. D. & Tromp, G., Aug 12 2016, In: BMC medical genomics. 9, 32.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    17 Scopus citations

  • Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium

    eMERGE Network & NEIGHBOR Consortium, Sep 2016, In: PLoS genetics. 12, 9, e1006186.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    21 Scopus citations

  • Family history of atherosclerotic vascular disease is associated with the presence of abdominal aortic aneurysm

    Ye, Z., Bailey, K. R., Austin, E. & Kullo, I. J., Feb 1 2016, In: Vascular Medicine (United Kingdom). 21, 1, p. 41-46 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    3 Scopus citations

  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

    Pattaro, C., Teumer, A., Gorski, M., Chu, A. Y., Li, M., Mijatovic, V., Garnaas, M., Tin, A., Sorice, R., Li, Y., Taliun, D., Olden, M., Foster, M., Yang, Q., Chen, M. H., Pers, T. H., Johnson, A. D., Ko, Y. A., Fuchsberger, C., Tayo, B., & 678 othersNalls, M., Feitosa, M. F., Isaacs, A., Dehghan, A., D'Adamo, P., Adeyemo, A., Dieffenbach, A. K., Zonderman, A. B., Nolte, I. M., Van Der Most, P. J., Wright, A. F., Shuldiner, A. R., Morrison, A. C., Hofman, A., Smith, A. V., Dreisbach, A. W., Franke, A., Uitterlinden, A. G., Metspalu, A., Tonjes, A., Lupo, A., Robino, A., Johansson, Å., Demirkan, A., Kollerits, B., Freedman, B. I., Ponte, B., Oostra, B. A., Paulweber, B., Krämer, B. K., Mitchell, B. D., Buckley, B. M., Peralta, C. A., Hayward, C., Helmer, C., Rotimi, C. N., Shaffer, C. M., Müller, C., Sala, C., Van Duijn, C. M., Saint-Pierre, A., Ackermann, D., Shriner, D., Ruggiero, D., Toniolo, D., Lu, Y., Cusi, D., Czamara, D., Ellinghaus, D., Siscovick, D. S., Ruderfer, D., Gieger, C., Grallert, H., Rochtchina, E., Atkinson, E. J., Holliday, E. G., Boerwinkle, E., Salvi, E., Bottinger, E. P., Murgia, F., Rivadeneira, F., Ernst, F., Kronenberg, F., Hu, F. B., Navis, G. J., Curhan, G. C., Ehret, G. B., Homuth, G., Coassin, S., Thun, G. A., Pistis, G., Gambaro, G., Malerba, G., Montgomery, G. W., Eiriksdottir, G., Jacobs, G., Li, G., Wichmann, H. E., Campbell, H., Schmidt, H., Wallaschofski, H., Völzke, H., Brenner, H., Kroemer, H. K., Kramer, H., Lin, H., Leach, I. M., Ford, I., Guessous, I., Rudan, I., Prokopenko, I., Borecki, I., Heid, I. M., Kolcic, I., Persico, I., Jukema, J. W., Wilson, J. F., Felix, J. F., Divers, J., Lambert, J. C., Stafford, J. M., Gaspoz, J. M., Smith, J. A., Faul, J. D., Wang, J. J., Ding, J., Hirschhorn, J. N., Attia, J., Whitfield, J. B., Chalmers, J., Viikari, J., Coresh, J., Denny, J. C., Karjalainen, J., Fernandes, J. K., Endlich, K., Butterbach, K., Keene, K. L., Lohman, K., Portas, L., Launer, L. J., Lyytikäinen, L. P., Yengo, L., Franke, L., Ferrucci, L., Rose, L. M., Kedenko, L., Rao, M., Struchalin, M., Kleber, M. E., Cavalieri, M., Haun, M., Cornelis, M. C., Ciullo, M., Pirastu, M., De Andrade, M., McEvoy, M. A., Woodward, M., Adam, M., Cocca, M., Nauck, M., Imboden, M., Waldenberger, M., Pruijm, M., Metzger, M., Stumvoll, M., Evans, M. K., Sale, M. M., Kähönen, M., Boban, M., Bochud, M., Rheinberger, M., Verweij, N., Bouatia-Naji, N., Martin, N. G., Hastie, N., Probst-Hensch, N., Soranzo, N., Devuyst, O., Raitakari, O., Gottesman, O., Franco, O. H., Polasek, O., Gasparini, P., Munroe, P. B., Ridker, P. M., Mitchell, P., Muntner, P., Meisinger, C., Smit, J. H., Abecasis, G. R., Adair, L. S., Alexander, M., Altshuler, D., Amin, N., Arking, D. E., Arora, P., Aulchenko, Y., Bakker, S. J. L., Bandinelli, S., Barroso, I., Beckmann, J. S., Beilby, J. P., Bergman, R. N., Bergmann, S., Bis, J. C., Boehnke, M., Bonnycastle, L. L., Bornstein, S. R., Bots, M. L., Bragg-Gresham, J. L., Brand, S. M., Brand, E., Braund, P. S., Brown, M. J., Burton, P. R., Casas, J. P., Caulfield, M. J., Chakravarti, A., Chambers, J. C., Chandak, G. R., Chang, Y. P. C., Charchar, F. J., Chaturvedi, N., Cho, Y. S., Clarke, R., Collins, F. S., Collins, R., Connell, J. M., Cooper, J. A., Cooper, M. N., Cooper, R. S., Corsi, A. M., Dörr, M., Dahgam, S., Danesh, J., Smith, G. D., Day, I. N. M., Deloukas, P., Denniff, M., Dominiczak, A. F., Dong, Y., Doumatey, A., Elliott, P., Elosua, R., Erdmann, J., Eyheramendy, S., Farrall, M., Fava, C., Forrester, T., Fowkes, F. G. R., Fox, E. R., Frayling, T. M., Galan, P., Ganesh, S. K., Garcia, M., Gaunt, T. R., Glazer, N. L., Go, M. J., Goel, A., Grässler, J., Grobbee, D. E., Groop, L., Guarrera, S., Guo, X., Hadley, D., Hamsten, A., Han, B. G., Hardy, R., Hartikainen, A. L., Heath, S., Heckbert, S. R., Hedblad, B., Hercberg, S., Hernandez, D., Hicks, A. A., Hilton, G., Hingorani, A. D., Hoffman Bolton, J. A., Hopewell, J. C., Howard, P., Humphries, S. E., Hunt, S. C., Hveem, K., Ikram, M. A., Islam, M., Iwai, N., Jarvelin, M. R., Jackson, A. U., Jafar, T. H., Janipalli, C. S., Johnson, T., Kathiresan, S., Khaw, K. T., Kim, H. L., Kinra, S., Kita, Y., Kivimaki, M., Kooner, J. S., Kumar, M. J. K., Kuh, D., Kulkarni, S. R., Kumari, M., Kuusisto, J., Kuznetsova, T., Laakso, M., Laan, M., Laitinen, J., Lakatta, E. G., Langefeld, C. D., Larson, M. G., Lathrop, M., Lawlor, D. A., Lawrence, R. W., Lee, J. Y., Lee, N. R., Levy, D., Li, Y., Longstreth, W. T., Luan, J., Lucas, G., Ludwig, B., Mangino, M., Mani, K. R., Marmot, M. G., Mattace-Raso, F. U. S., Matullo, G., McArdle, W. L., McKenzie, C. A., Meitinger, T., Melander, O., Meneton, P., Meschia, J. F., Miki, T., Milaneschi, Y., Mohlke, K. L., Mooser, V., Morken, M. A., Morris, R. W., Mosley, T. H., Najjar, S., Narisu, N., Newton-Cheh, C., Nguyen, K. D. H., Nilsson, P., Nyberg, F., O'Donnell, C. J., Ogihara, T., Ohkubo, T., Okamura, T., Ong, R. T. H., Ongen, H., Onland-Moret, N. C., O'Reilly, P. F., Org, E., Orru, M., Palmas, W., Palmen, J., Palmer, L. J., Palmer, N. D., Parker, A. N., Peden, J. F., Peltonen, L., Perola, M., Pihur, V., Platou, C. G. P., Plump, A., Prabhakaran, D., Psaty, B. M., Raffel, L. J., Rao, D. C., Rasheed, A., Ricceri, F., Rice, K. M., Rosengren, A., Rotter, J. I., Rudock, M. E., Sõber, S., Salako, T., Saleheen, D., Salomaa, V., Samani, N. J., Schwartz, S. M., Schwarz, P. E. H., Scott, L. J., Scott, J., Scuteri, A., Sehmi, J. S., Seielstad, M., Seshadri, S., Sharma, P., Shaw-Hawkins, S., Shi, G., Shrine, N. R. G., Sijbrands, E. J. G., Sim, X., Singleton, A., Sjögren, M., Smith, N. L., Artigas, M. S., Spector, T. D., Staessen, J. A., Stancakova, A., Steinle, N. I., Strachan, D. P., Stringham, H. M., Sun, Y. V., Swift, A. J., Tabara, Y., Tai, E. S., Talmud, P. J., Taylor, A., Terzic, J., Thelle, D. S., Tobin, M. D., Tomaszewski, M., Tripathy, V., Tuomilehto, J., Tzoulaki, I., Uda, M., Ueshima, H., Uiterwaal, C. S. P. M., Umemura, S., Van Der Harst, P., Van Der Schouw, Y. T., Van Gilst, W. H., Vartiainen, E., Vasan, R. S., Veldre, G., Verwoert, G. C., Viigimaa, M., Vinay, D. G., Vineis, P., Voight, B. F., Vollenweider, P., Wagenknecht, L. E., Wain, L. V., Wang, X., Wang, T. J., Wareham, N. J., Watkins, H., Weder, A. B., Whincup, P. H., Wiggins, K. L., Witteman, J. C. M., Wong, A., Wu, Y., Yajnik, C. S., Yao, J., Young, J. H., Zelenika, D., Zhai, G., Zhang, W., Zhang, F., Zhao, J. H., Zhu, H., Zhu, X., Zitting, P., Zukowska-Szczechowska, E., Okada, Y., Wu, J. Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S. C., Wong, T. Y., Liu, J., Young, T. L., Aung, T., Teo, Y. Y., Kim, Y. J., Kang, D., Chen, C. H., Tsai, F. J., Chang, L. C., Fann, S. J. C., Mei, H., Hixson, J. E., Chen, S., Katsuya, T., Isono, M., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, Y. T., Tanaka, T., Reilly, M. P., Schunkert, H., Assimes, T. L., Hall, A., Hengstenberg, C., König, I. R., Laaksonen, R., McPherson, R., Thompson, J. R., Thorsteinsdottir, U., Ziegler, A., Absher, D., Chen, L., Cupples, L. A., Halperin, E., Li, M., Musunuru, K., Preuss, M., Schillert, A., Thorleifsson, G., Wells, G. A., Holm, H., Roberts, R., Stewart, A. F. R., Fortmann, S., Go, A., Hlatky, M., Iribarren, C., Knowles, J., Myers, R., Quertermous, T., Sidney, S., Risch, N., Tang, H., Blankenberg, S., Schnabel, R., Sinning, C., Lackner, K. J., Tiret, L., Nicaud, V., Cambien, F., Bickel, C., Rupprecht, H. J., Perret, C., Proust, C., Münzel, T. F., Barbalic, M., Chen, I. Y. D., Demissie-Banjaw, S., Folsom, A., Lumley, T., Marciante, K., Taylor, K. D., Volcik, K., Gretarsdottir, S., Gulcher, J. R., Kong, A., Stefansson, K., Thorgeirsson, G., Andersen, K., Fischer, M., Grosshennig, A., Linsel-Nitschke, P., Stark, K., Schreiber, S., Aherrahrou, Z., Bruse, P., Doering, A., Klopp, N., Diemert, P., Loley, C., Medack, A., Nahrstedt, J., Peters, A., Wagner, A. K., Willenborg, C., Böhm, B. O., Dobnig, H., Grammer, T. B., Hoffmann, M. M., Meinitzer, A., Winkelmann, B. R., Pilz, S., Renner, W., Scharnagl, H., Stojakovic, T., Tomaschitz, A., Winkler, K., Guiducci, C., Burtt, N., Gabriel, S. B., Dandona, S., Jarinova, O., Qu, L., Wilensky, R., Matthai, W., Hakonarson, H. H., Devaney, J., Burnett, M. S., Pichard, A. D., Kent, K. M., Satler, L., Lindsay, J. M., Waksman, R., Knouff, C. W., Waterworth, D. M., Walker, M. C., Epstein, S. E., Rader, D. J., Nelson, C. P., Wright, B. J., Balmforth, A. J., Ball, S. G., Loehr, L. R., Rosamond, W. D., Benjamin, E., Haritunians, T., Couper, D., Murabito, J., Wang, Y. A., Stricker, B. H., Chang, P. P., Willerson, J. T., Felix, S. B., Watzinger, N., Aragam, J., Zweiker, R., Lind, L., Rodeheffer, R. J., Greiser, K. H., Deckers, J. W., Stritzke, J., Ingelsson, E., Kullo, I., Haerting, J., Reffelmann, T., Redfield, M. M., Werdan, K., Mitchell, G. F., Arnett, D. K., Gottdiener, J. S., Blettner, M., Friedrich, N., Kovacs, P., Wild, P. S., Froguel, P., Rettig, R., Mägi, R., Biffar, R., Schmidt, R., Middelberg, R. P. S., Carroll, R. J., Penninx, B. W., Scott, R. J., Katz, R., Sedaghat, S., Wild, S. H., Kardia, S. L. R., Ulivi, S., Hwang, S. J., Enroth, S., Kloiber, S., Trompet, S., Stengel, B., Hancock, S. J., Turner, S. T., Rosas, S. E., Stracke, S., Harris, T. B., Zeller, T., Zemunik, T., Lehtimäki, T., Illig, T., Aspelund, T., Nikopensius, T., Esko, T., Tanaka, T., Gyllensten, U., Völker, U., Emilsson, V., Vitart, V., Aalto, V., Gudnason, V., Chouraki, V., Chen, W. M., Igl, W., März, W., Koenig, W., Lieb, W., Loos, R. J. F., Liu, Y., Snieder, H., Pramstaller, P. P., Parsa, A., O'Connell, J. R., Susztak, K., Hamet, P., Tremblay, J., De Boer, I. H., Böger, C. A., Goessling, W., Chasman, D. I., Köttgen, A., Kao, W. H. L. & Fox, C. S., Jan 21 2016, In: Nature communications. 7, 10023.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    236 Scopus citations

  • Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network

    Bush, W. S., Crosslin, D. R., Owusu-Obeng, A., Wallace, J., Almoguera, B., Basford, M. A., Bielinski, S. J., Carrell, D. S., Connolly, J. J., Crawford, D., Doheny, K. F., Gallego, C. J., Gordon, A. S., Keating, B., Kirby, J., Kitchner, T., Manzi, S., Mejia, A. R., Pan, V., Perry, C. L., & 31 othersPeterson, J. F., Prows, C. A., Ralston, J., Scott, S. A., Scrol, A., Smith, M., Stallings, S. C., Veldhuizen, T., Wolf, W., Volpi, S., Wiley, K., Li, R., Manolio, T., Bottinger, E., Brilliant, M. H., Carey, D., Chisholm, R. L., Chute, C. G., Haines, J. L., Hakonarson, H., Harley, J. B., Holm, I. A., Kullo, I. J., Jarvik, G. P., Larson, E. B., McCarty, C. A., Williams, M. S., Denny, J. C., Rasmussen-Torvik, L. J., Roden, D. M. & Ritchie, M. D., Aug 1 2016, In: Clinical pharmacology and therapeutics. p. 160-169 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    90 Scopus citations

  • Identifying peripheral arterial disease cases using natural language processing of clinical notes

    Afzal, N., Sohn, S., Abram, S., Liu, H., Kullo, I. J. & Arruda-Olson, A. M., Apr 18 2016, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016. Institute of Electrical and Electronics Engineers Inc., p. 126-131 6 p. 7455851. (3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

    8 Scopus citations

  • Incorporating a genetic risk score into coronary heart disease risk estimates: Effect on low-density lipoprotein cholesterol levels (the MI-GENES Clinical Trial)

    Kullo, I. J., Jouni, H., Austin, E. E., Brown, S. A., Kruisselbrink, T. M., Isseh, I. N., Haddad, R. A., Marroush, T. S., Shameer, K., Olson, J. E., Broeckel, U., Green, R. C., Schaid, D. J., Montori, V. M. & Bailey, K. R., Mar 22 2016, In: Circulation. 133, 12, p. 1181-1188 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    102 Scopus citations

  • My Approach to the Patient With Familial Hypercholesterolemia

    Safarova, M. S. & Kullo, I. J., Jun 1 2016, In: Mayo Clinic proceedings. 91, 6, p. 770-786 17 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    14 Scopus citations

  • Peripheral artery disease

    Kullo, I. J. & Rooke, T. W., Mar 3 2016, In: New England Journal of Medicine. 374, 9, p. 861-871 11 p.

    Research output: Contribution to journal › Review article › peer-review

    99 Scopus citations

  • PHACTR1 Is a Genetic Susceptibility Locus for Fibromuscular Dysplasia Supporting Its Complex Genetic Pattern of Inheritance

    Kiando, S. R., Tucker, N. R., Castro-Vega, L. J., Katz, A., D’Escamard, V., Tréard, C., Fraher, D., Albuisson, J., Kadian-Dodov, D., Ye, Z., Austin, E., Yang, M. L., Hunker, K., Barlassina, C., Cusi, D., Galan, P., Empana, J. P., Jouven, X., Gimenez-Roqueplo, A. P., Bruneval, P., & 13 othersHyun Kim, E. S., Olin, J. W., Gornik, H. L., Azizi, M., Plouin, P. F., Ellinor, P. T., Kullo, I. J., Milan, D. J., Ganesh, S. K., Boutouyrie, P., Kovacic, J. C., Jeunemaitre, X. & Bouatia-Naji, N., Oct 2016, In: PLoS genetics. 12, 10, e1006367.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    84 Scopus citations

  • Plasma osteopontin levels and adverse cardiovascular outcomes in the peace trial

    Abdalrhim, A. D., Marroush, T. S., Austin, E. E., Gersh, B. J., Solak, N., Rizvi, S. A., Bailey, K. R. & Kullo, I. J., Jun 2016, In: PloS one. 11, 6, e0156965.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    12 Scopus citations

  • Rapid identification of familial hypercholesterolemia from electronic health records: The SEARCH study

    Safarova, M. S., Liu, H. & Kullo, I. J., Sep 1 2016, In: Journal of Clinical Lipidology. 10, 5, p. 1230-1239 10 p.

    Research output: Contribution to journal › Article › peer-review

    45 Scopus citations

  • Sex differences in the associations of hemodynamic load with left ventricular hypertrophy and concentric remodeling

    Coutinho, T., Pellikka, P. A., Bailey, K. R., Turner, S. T. & Kullo, I. J., Jan 1 2016, In: American journal of hypertension. 29, 1, p. 73-80 8 p.

    Research output: Contribution to journal › Article › peer-review

    17 Scopus citations

  • Shared genetic risk factors of intracranial, abdominal, and thoracic aneurysms

    Aneurysm Consortium, Vascular Research Consortium of New Zealand, Jul 2016, In: Journal of the American Heart Association. 5, 7, e002603.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    27 Scopus citations

  • The phenotypic legacy of admixture between modern humans and Neandertals

    Simonti, C. N., Vernot, B., Bastarache, L., Bottinger, E., Carrell, D. S., Chisholm, R. L., Crosslin, D. R., Hebbring, S. J., Jarvik, G. P., Kullo, I. J., Li, R., Pathak, J., Ritchie, M. D., Roden, D. M., Verma, S. S., Tromp, G., Prato, J. D., Bush, W. S., Akey, J. M., Denny, J. C., & 1 othersCapra, J. A., Feb 12 2016, In: Science. 351, 6274, p. 737-741 5 p.

    Research output: Contribution to journal › Article › peer-review

    132 Scopus citations

  • US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry

    Ahmad, Z. S., Andersen, R. L., Andersen, L. H., O'Brien, E. C., Kindt, I., Shrader, P., Vasandani, C., Newman, C. B., deGoma, E. M., Baum, S. J., Hemphill, L. C., Hudgins, L. C., Ahmed, C. D., Kullo, I. J., Gidding, S. S., Duffy, D., Neal, W., Wilemon, K., Roe, M. T., Rader, D. J., & 6 othersBallantyne, C. M., Linton, M. F., Duell, P. B., Shapiro, M. D., Moriarty, P. M. & Knowles, J. W., Sep 1 2016, In: Journal of Clinical Lipidology. 10, 5, p. 1223-1229 7 p.

    Research output: Contribution to journal › Article › peer-review

    32 Scopus citations

  • When Participants in Genomic Research Grow Up: Contact and Consent at the Age of Majority

    Pediatrics Workgroup of the Clinical Sequencing Exploratory Research (CSER) Consortium & Consent, Education, Regulation, and Consultation Workgroup of the Electronic Medical Records and Genomics (eMERGE) Network, Jan 1 2016, In: Journal of Pediatrics. 168, p. 226-231.e1

    Research output: Contribution to journal › Comment/debate › peer-review

    Open Access
    9 Scopus citations
  • 2015

    A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease

    Nikpay, M., Goel, A., Won, H. H., Hall, L. M., Willenborg, C., Kanoni, S., Saleheen, D., Kyriakou, T., Nelson, C. P., CHopewell, J., Webb, T. R., Zeng, L., Dehghan, A., Alver, M., MArmasu, S., Auro, K., Bjonnes, A., Chasman, D. I., Chen, S., Ford, I., & 131 othersFranceschini, N., Gieger, C., Grace, C., Gustafsson, S., Huang, J., Hwang, S. J., Kim, Y. K., Kleber, M. E., Lau, K. W., Lu, X., Lu, Y., Lyytikäinen, L. P., Mihailov, E., Morrison, A. C., Pervjakova, N., Qu, L., Rose, L. M., Salfati, E., Saxena, R., Scholz, M., Smith, A. V., Tikkanen, E., Uitterlinden, A., Yang, X., Zhang, W., Zhao, W., De Andrade, M., De Vries, P. S., Van Zuydam, N. R., Anand, S. S., Bertram, L., Beutner, F., Dedoussis, G., Frossard, P., Gauguier, D., Goodall, A. H., Gottesman, O., Haber, M., Han, B. G., Huang, J., Jalilzadeh, S., Kessler, T., König, I. R., Lannfelt, L., Lieb, W., Lind, L., MLindgren, C., Lokki, M. L., Magnusson, P. K., Mallick, N. H., Mehra, N., Meitinger, T., Memon, F. U. R., Morris, A. P., Nieminen, M. S., Pedersen, N. L., Peters, A., Rallidis, L. S., Rasheed, A., Samuel, M., Shah, S. H., Sinisalo, J., EStirrups, K., Trompet, S., Wang, L., Zaman, K. S., Ardissino, D., Boerwinkle, E., Borecki, I. B., Bottinger, E. P., Buring, J. E., Chambers, J. C., Collins, R., Cupples, L., Danesh, J., Demuth, I., Elosua, R., Epstein, S. E., Esko, T., Feitosa, M. F., Franco, O. H., Franzosi, M. G., Granger, C. B., Gu, D., Gudnason, V., SHall, A., Hamsten, A., Harris, T. B., LHazen, S., Hengstenberg, C., Hofman, A., Ingelsson, E., Iribarren, C., Jukema, J. W., Karhunen, P. J., Kim, B. J., Kooner, J. S., Kullo, I. J., Lehtimäki, T., Loos, R. J. F., Melander, O., Metspalu, A., März, W., Palmer, C. N., Perola, M., Quertermous, T., Rader, D. J., Ridker, P. M., Ripatti, S., Roberts, R., Salomaa, V., Sanghera, D. K., Schwartz, S. M., Seedorf, U., Stewart, A. F., Stott, D. J., Thiery, J., Zalloua, P. A., O'Donnell, C. J., Reilly, M. P., Assimes, T. L., Thompson, J. R., Erdmann, J., Clarke, R., Watkins, H., Kathiresan, S., McPherson, R., Deloukas, P., Schunkert, H., Samani, N. J. & Farrall, M., Sep 29 2015, In: Nature Genetics. 47, 10, p. 1121-1130 10 p.

    Research output: Contribution to journal › Article › peer-review

    901 Scopus citations

  • A patient-centered approach to the development and pilot of a warfarin pharmacogenomics patient education tool for health professionals

    Barajas, M. R., Formea, C. M., McCormick, J. B., Abdalrhim, A. D., Han, L. C., McBane, R. D., Fiksdal, A. S. & Kullo, I. J., Mar 1 2015, In: Currents in Pharmacy Teaching and Learning. 7, 2, p. 249-255 7 p.

    Research output: Contribution to journal › Article › peer-review

    2 Scopus citations

  • Associations of alterations in pulsatile arterial load with left ventricular longitudinal strain

    Ye, Z., Coutinho, T., Pellikka, P. A., Villarraga, H. R., Borlaug, B. A. & Kullo, I. J., Aug 5 2015, In: American journal of hypertension. 28, 11, p. 1325-1331 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    9 Scopus citations

  • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: A Mendelian randomisation analysis

    Freitag, D., Butterworth, A. S., Willeit, P., Howson, J. M. M., Burgess, S., Kaptoge, S., Young, R., Ho, W. K., Wood, A. M., Sweeting, M., Spackman, S., Staley, J. R., Ramond, A., Harshfield, E., Nielsen, S. F., Grande, P., Lange, L. A., Bown, M. J., Jones, G. T., Scott, R. A., & 133 othersBevan, S., Porcu, E., Thorleifsson, G., Zeng, L., Kessler, T., Nikpay, M., Do, R., Zhang, W., Hopewell, J. C., Kleber, M., Delgado, G. E., Nelson, C. P., Goel, A., Bis, J. C., Dehghan, A., Ligthart, S., Smith, A. V., Qu, L., van 't Hof, F. N. G., de Bakker, P. I. W., Baas, A. F., van Rij, A., Tromp, G., Kuivaniemi, H., Ritchie, M. D., Verma, S. S., Crawford, D. C., Malinowski, J., de Andrade, M., Kullo, I. J., Peissig, P. L., McCarty, C. A., Böttinger, E. P., Gottesman, O., Crosslin, D. R., Carrell, D. S., Rasmussen-Torvik, L. J., Pacheco, J. A., Huang, J., Timpson, N. J., Kettunen, J., Ala-Korpela, M., Mitchell, G. F., Parsa, A., Wilkinson, I. B., Gorski, M., Li, Y., Franceschini, N., Keller, M. F., Ganesh, S. K., Langefeld, C. D., Bruijn, L., Brown, M. A., Evans, D. M., Baltic, S., Ferreira, M. A., Baurecht, H., Weidinger, S., Franke, A., Lubitz, S. A., Müller-Nurasyid, M., Felix, J. F., Smith, N. L., Sudman, M., Thompson, S. D., Zeggini, E., Panoutsopoulou, K., Nalls, M. A., Singleton, A., Polychronakos, C., Bradfield, J. P., Hakonarson, H., Easton, D. F., Thompson, D., Tomlinson, I. P., Dunlop, M., Hemminki, K., Morgan, G., Eisen, T., Goldschmidt, H., Allan, J. M., Henrion, M., Whiffin, N., Wang, Y., Chubb, D., Iles, M. M., Bishop, D. T., Law, M. H., Hayward, N. K., Luo, Y., Nejentsev, S., Barbalic, M., Crossman, D., Sanna, S., Soranzo, N., Markus, H. S., Wareham, N. J., Rader, D. J., Reilly, M., Assimes, T., Harris, T. B., Hofman, A., Franco, O. H., Gudnason, V., Tracy, R., Psaty, B. M., Farrall, M., Watkins, H., Hall, A. S., Samani, N. J., März, W., Clarke, R., Collins, R., Kooner, J. S., Chambers, J. C., Kathiresan, S., McPherson, R., Erdmann, J., Kastrati, A., Schunkert, H., Stefánsson, K., Thorsteinsdottir, U., Walston, J. D., Tybjærg-Hansen, A., Alam, D. S., Al Shafi Majumder, A., Angelantonio, E. D., Chowdhury, R., Nordestgaard, B. G., Saleheen, D., Thompson, S. G., Danesh, J. & Houlston, R. S., Apr 1 2015, In: The Lancet Diabetes and Endocrinology. 3, 4, p. 243-253 11 p.

    Research output: Contribution to journal › Article › peer-review

    69 Scopus citations

  • Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction

    Caraballo, P., Parkulo, M., Blair, D., Elliott, M., Schultz, C., Sutton, J., Rao, P., Bruflat, J., Bleimeyer, R., Crooks, J., Gabrielson, D., Nicholson, W., Rohrer Vitek, C., Wix, K., Bielinski, S. J., Pathak, J. & Kullo, I. J., 2015, Studies in Health Technology and Informatics. IOS Press, Vol. 216. p. 946 1 p. (Studies in Health Technology and Informatics; vol. 216).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

    3 Scopus citations

  • Design of a randomized controlled trial of disclosing genomic risk of coronary heart disease: The Myocardial Infarction Genes (MI-GENES) study

    Kullo, I. J., Jouni, H., Olson, J. E., Montori, V. M. & Bailey, K. R., Aug 15 2015, In: BMC medical genomics. 8, 1, 51.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    16 Scopus citations

  • Epidemiology, risk factors and management of cardiovascular diseases in IBD

    Singh, S., Kullo, I. J., Pardi, D. S. & Loftus, E. V., Jan 1 2015, In: Nature Reviews Gastroenterology and Hepatology. 12, 1, p. 26-35 10 p.

    Research output: Contribution to journal › Review article › peer-review

    57 Scopus citations

  • Genetic variation in the HLA region is associated with susceptibility to herpes zoster

    Crosslin, D. R., Carrell, D. S., Burt, A., Kim, D. S., Underwood, J. G., Hanna, D. S., Comstock, B. A., Baldwin, E., De Andrade, M., Kullo, I. J., Tromp, G., Kuivaniemi, H., Borthwick, K. M., McCarty, C. A., Peissig, P. L., Doheny, K. F., Pugh, E., Kho, A., Pacheco, J., Hayes, M. G., & 17 othersRitchie, M. D., Verma, S. S., Armstrong, G., Stallings, S., Denny, J. C., Carroll, R. J., Crawford, D. C., Crane, P. K., Mukherjee, S., Bottinger, E., Li, R., Keating, B., Mirel, D. B., Carlson, C. S., Harley, J. B., Larson, E. B. & Jarvik, G. P., Jan 24 2015, In: Genes and Immunity. 16, 1, p. 1-7 7 p.

    Research output: Contribution to journal › Article › peer-review

    33 Scopus citations

  • Genome-wide association study of serum creatinine levels during vancomycin therapy

    Van Driest, S. L., McGregor, T. L., Velez Edwards, D. R., Saville, B. R., Kitchner, T. E., Hebbring, S. J., Brilliant, M., Jouni, H., Kullo, I. J., Creech, C. B., Kannankeril, P. J., Vear, S. I., Brothers, K. B., Bowton, E. A., Shaffer, C. M., Patel, N., Delaney, J. T., Bradford, Y., Wilson, S., Olson, L. M., & 5 othersCrawford, D. C., Potts, A. L., Ho, R. H., Roden, D. M. & Denny, J. C., Jun 1 2015, In: PloS one. 10, 6, e0127791.

    Research output: Contribution to journal › Article › peer-review

    14 Scopus citations

  • Identification d'un premier gène de prédisposition à dysplasie fibro-musculaire

    Translated title of the contribution: CO-43: Genetic study identifies common variation in phactr1 to associate with fibromuscular dysplasiaKiando, S., Tucker, N., Katz, A., Tréard, C., Desca-Mard, V., Castro-Vega, L., Barlasina, C., Cusi, D., Galan, P., Empana, J., Olin, J., Gornik, H., Plouin, P., Kullo, I., Milan, D., Ganesh, S., Boutouyrie, P., Kovacic, J., Jeunemaitre, X. & Bouatia-Naji, N., Dec 2015, In: Annales de Cardiologie et d'Angeiologie. 64, p. S20

    Research output: Contribution to journal › Article › peer-review

    3 Scopus citations

  • Influence of body fatness distribution and total lean mass on aortic stiffness in nonobese individuals

    Wohlfahrt, P., Somers, V. K., Sochor, O., Kullo, I., Jean, N. & Lopez-Jimenez, F., Mar 1 2015, In: American journal of hypertension. 28, 3, p. 401-408 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    13 Scopus citations

  • Osteocalcin and type 2 diabetes risk in Latinos: A life course approach.

    González-García, Z. M., Kullo, I. J., Coletta, D. K., Mandarino, L. J. & Shaibi, G. Q., Nov 1 2015, In: American Journal of Human Biology. 27, 6, p. 859-861 3 p.

    Research output: Contribution to journal › Article › peer-review

    7 Scopus citations

  • Penetrance of Hemochromatosis in HFE Genotypes Resulting in p.Cys282Tyr and p.[Cys282Tyr];[His63Asp] in the eMERGE Network

    Gallego, C. J., Burt, A., Sundaresan, A. S., Ye, Z., Shaw, C., Crosslin, D. R., Crane, P. K., Fullerton, S. M., Hansen, K., Carrell, D., Kuivaniemi, H., Derr, K., De Andrade, M., McCarty, C. A., Kitchner, T. E., Ragon, B. K., Stallings, S. C., Papa, G., Bochenek, J., Smith, M. E., & 18 othersAufox, S. A., Pacheco, J. A., Patel, V., Friesema, E. M., Erwin, A. L., Gottesman, O., Gerhard, G. S., Ritchie, M., Motulsky, A. G., Kullo, I. J., Larson, E. B., Tromp, G., Brilliant, M. H., Bottinger, E., Denny, J. C., Roden, D. M., Williams, M. S. & Jarvik, G. P., 2015, In: American journal of human genetics. 97, 4, p. 512-520 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    30 Scopus citations

  • Prospective participant selection and ranking to maximize actionable pharmacogenetic variants and discovery in the eMERGE Network

    Crosslin, D. R., Robertson, P. D., Carrell, D. S., Gordon, A. S., Hanna, D. S., Burt, A., Fullerton, S. M., Scrol, A., Ralston, J., Leppig, K., Hartzler, A., Baldwin, E., Andrade, M. D., Kullo, I. J., Tromp, G., Doheny, K. F., Ritchie, M. D., Crane, P. K., Nickerson, D. A., Larson, E. B., & 1 othersJarvik, G. P., Jul 3 2015, In: Genome medicine. 7, 1, 67.

    Research output: Contribution to journal › Article › peer-review

    9 Scopus citations

  • The Genetic Basis of Peripheral Arterial Disease: Current Knowledge, Challenges, and Future Directions

    Kullo, I. J. & Leeper, N. J., Apr 24 2015, In: Circulation research. 116, 9, p. 1551-1560 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    44 Scopus citations
  • 2014

    A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects

    Shameer, K., Denny, J. C., Ding, K., Jouni, H., Crosslin, D. R., De Andrade, M., Chute, C. G., Peissig, P., Pacheco, J. A., Li, R., Bastarache, L., Kho, A. N., Ritchie, M. D., Masys, D. R., Chisholm, R. L., Larson, E. B., McCarty, C. A., Roden, D. M., Jarvik, G. P. & Kullo, I. J., Jan 2014, In: Human genetics. 133, 1, p. 95-109 15 p.

    Research output: Contribution to journal › Article › peer-review

    87 Scopus citations

  • A perspective on the New American College of Cardiology/American Heart Association guidelines for cardiovascular risk assessment

    Kullo, I. J., Sep 1 2014, In: Mayo Clinic proceedings. 89, 9, p. 1244-1256 13 p.

    Research output: Contribution to journal › Review article › peer-review

    17 Scopus citations

  • Arterial stiffness is associated with increase in blood pressure over time in treated hypertensives

    Coutinho, T., Bailey, K. R., Turner, S. T. & Kullo, I. J., Jun 2014, In: Journal of the American Society of Hypertension. 8, 6, p. 414-421 8 p.

    Research output: Contribution to journal › Article › peer-review

    20 Scopus citations

  • Associations between inflammation and cognitive function in African Americans and European Americans

    Windham, B. G., Simpson, B. N., Lirette, S., Bridges, J., Bielak, L., Peyser, P. A., Kullo, I., Turner, S., Griswold, M. E. & Mosley, T. H., Dec 1 2014, In: Journal of the American Geriatrics Society. 62, 12, p. 2303-2310 8 p.

    Research output: Contribution to journal › Article › peer-review

    40 Scopus citations

  • A Template for Authoring and Adapting Genomic Medicine Content in the eMERGE Infobutton Project

    Overby, C. L., Rasmussen, L. V., Hartzler, A., Connolly, J. J., Peterson, J. F., Hedberg, R. M. E., Freimuth, R. R., Shirts, B. H., Denny, J. C., Larson, E. B., Chute, C. G., Jarvik, G. P., Ralston, J. D., Shuldiner, A. R., Starren, J., Kullo, I. J., Tarczy-Hornoch, P. & Williams, M. S., 2014, In: AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium. 2014, p. 944-953 10 p.

    Research output: Contribution to journal › Article › peer-review

    7 Scopus citations

  • Design and anticipated outcomes of the eMERGE-PGx project: A multicenter pilot for preemptive pharmacogenomics in electronic health record systems

    Rasmussen-Torvik, L. J., Stallings, S. C., Gordon, A. S., Almoguera, B., Basford, M. A., Bielinski, S. J., Brautbar, A., Brilliant, M. H., Carrell, D. S., Connolly, J. J., Crosslin, D. R., Doheny, K. F., Gallego, C. J., Gottesman, O., Kim, D. S., Leppig, K. A., Li, R., Lin, S., Manzi, S., Mejia, A. R., & 33 othersPacheco, J. A., Pan, V., Pathak, J., Perry, C. L., Peterson, J. F., Prows, C. A., Ralston, J., Rasmussen, L. V., Ritchie, M. D., Sadhasivam, S., Scott, S. A., Smith, M., Vega, A., Vinks, A. A., Volpi, S., Wolf, W. A., Bottinger, E., Chisholm, R. L., Chute, C. G., Haines, J. L., Harley, J. B., Keating, B., Holm, I. A., Kullo, I. J., Jarvik, G. P., Larson, E. B., Manolio, T., McCarty, C. A., Nickerson, D. A., Scherer, S. E., Williams, M. S., Roden, D. M. & Denny, J. C., Oct 1 2014, In: Clinical pharmacology and therapeutics. 96, 4, p. 482-489 8 p.

    Research output: Contribution to journal › Article › peer-review

    144 Scopus citations

  • EMERGEing progress in genomics-the first seven years

    Crawford, D. C., Crosslin, D. R., Tromp, G., Kullo, I. J., Kuivaniemi, H., Hayes, M. G., Denny, J. C., Bush, W. S., Haines, J. L., Roden, D. M., McCarty, C. A., Jarvik, G. P. & Ritchie, M. D., 2014, In: Frontiers in Genetics. 5, JUN, 184.

    Research output: Contribution to journal › Review article › peer-review

    51 Scopus citations

  • Family history as a risk factor for carotid artery stenosis

    Khaleghi, M., Isseh, I. N., Jouni, H., Sohn, S., Bailey, K. R. & Kullo, I. J., Aug 2014, In: Stroke. 45, 8, p. 2252-2256 5 p.

    Research output: Contribution to journal › Review article › peer-review

    9 Scopus citations

  • Family history as a risk factor for peripheral arterial disease

    Khaleghi, M., Isseh, I. N., Bailey, K. R. & Kullo, I. J., Sep 15 2014, In: American Journal of Cardiology. 114, 6, p. 928-932 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    18 Scopus citations

  • Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network

    Malinowski, J. R., Denny, J. C., Bielinski, S. J., Basford, M. A., Bradford, Y., Peissig, P. L., Carrell, D., Crosslin, D. R., Pathak, J., Rasmussen, L., Pacheco, J., Kho, A., Newton, K. M., Li, R., Kullo, I. J., Chute, C. G., Chisholm, R. L., Jarvik, G. P., Larson, E. B., McCarty, C. A., & 5 othersMasys, D. R., Roden, D. M., De Andrade, M., Ritchie, M. D. & Crawford, D. C., Dec 1 2014, In: PloS one. 9, 12, e111301.

    Research output: Contribution to journal › Article › peer-review

    23 Scopus citations

  • Inactivating mutations in NPC1L1 and protection from coronary heart disease

    The Myocardial Infarction Genetics Consortium Investigators, Nov 27 2014, In: New England Journal of Medicine. 371, 22, p. 2072-2082 11 p.

    Research output: Contribution to journal › Article › peer-review

    281 Scopus citations

  • Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

    The MAGIC investigators & The GIANT consortium, Aug 7 2014, In: PLoS genetics. 10, 8, e1004517.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    123 Scopus citations
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