• 7167 Citations
  • 44 Scopus h-Index
19962020

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Article
2020

Diabetes Mellitus Is an Independent Predictor for the Development of Heart Failure: A Population Study

Klajda, M. D., Scott, C. G., Rodeheffer, R. J. & Chen, H. H., Jan 2020, In : Mayo Clinic proceedings. 95, 1, p. 124-133 10 p.

Research output: Contribution to journalArticle

Open Access

Long-term blood pressure lowering and cGMP-activating actions of the novel ANP analog MANP

Chen, Y., Schaefer, J. J., Iyer, S. R., Harders, G. E., Pan, S., Sangaralingham, S. J., Chen, H. H., Redfield, M. M. & Burnett, J. C., Apr 2020, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 318, 4, p. R669-R676

Research output: Contribution to journalArticle

1 Scopus citations
2019
6 Scopus citations

Cardiac Versus Renal Response to Volume Expansion in Preclinical Systolic Dysfunction With PDEV Inhibition and BNP

Wan, S. H., Torres-Courchoud, I., McKie, P. M., Slusser, J. P., Redfield, M. M., Burnett, J. C., Hodge, D. O. & Chen, H. H., Dec 2019, In : JACC: Basic to Translational Science. 4, 8, p. 962-972 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2 Scopus citations

Dapagliflozin effects on biomarkers, symptoms, and functional status in patients with heart failure with reduced ejection fraction

DEFINE-HF Trial, Oct 2019, In : Circulation. 140, 18, 042929.

Research output: Contribution to journalArticle

33 Scopus citations

Estimated Glomerular Filtration Rate, Activation of Cardiac Biomarkers and Long-Term Cardiovascular Outcomes: A Population-Based Cohort

Vinnakota, S., Scott, C. G., Rodeheffer, R. J. & Chen, H. H., Nov 2019, In : Mayo Clinic proceedings. 94, 11, p. 2189-2198 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Impaired cardiac performance, protein synthesis, and mitochondrial function in tumor-bearing mice

Berent, T. E., Dorschner, J. M., Meyer, T., Craig, T. A., Wang, X., Kunz, H., Jatoi, A., Lanza, I. R., Chen, H. & Kumar, R., 2019, In : PloS one. 14, 12, e0226440.

Research output: Contribution to journalArticle

Open Access
2018

A Human Study to Evaluate Safety, Tolerability, and Cyclic GMP Activating Properties of Cenderitide in Subjects With Stable Chronic Heart Failure

Kawakami, R., Lee, C. Y. W., Scott, C., Bailey, K. R., Schirger, J. A., Chen, H. H., Benike, S. L., Cannone, V., Martin, F. L., Sangaralingham, S. J., Ichiki, T. & Burnett, J. C., Sep 2018, In : Clinical pharmacology and therapeutics. 104, 3, p. 546-552 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cardiac resynchronization therapy improves myocardial conduction

Yang, M., Li, X., Yang, D., Li, Y., Zhou, S., Liang, J., Wu, G., Del-Carpio Munoz, F., Chen, H. H., Friedman, P. A. & Cha, Y-M., Jan 1 2018, (Accepted/In press) In : PACE - Pacing and Clinical Electrophysiology.

Research output: Contribution to journalArticle

1 Scopus citations

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity among Patients with Heart Failure with Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial

Borlaug, B. A., Anstrom, K. J., Lewis, G. D., Shah, S. J., Levine, J. A., Koepp, G. A., Givertz, M. M., Felker, G. M., Lewinter, M. M., Mann, D. L., Margulies, K. B., Smith, A. L., Tang, W. H. W., Whellan, D. J., Chen, H. H., Davila-Roman, V. G., McNulty, S., Desvigne-Nickens, P., Hernandez, A. F., Braunwald, E. & 1 others, Redfield, M. M., Nov 6 2018, In : JAMA - Journal of the American Medical Association. 320, 17, p. 1764-1773 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury

Ahmad, T., Jackson, K., Rao, V. S., Tang, W. H. W., Brisco-Bacik, M. A., Chen, H. H., Felker, G. M., Hernandez, A. F., O'Connor, C. M., Sabbisetti, V. S., Bonventre, J. V., Wilson, F. P., Coca, S. G. & Testani, J. M., May 8 2018, In : Circulation. 137, 19, p. 2016-2028 13 p.

Research output: Contribution to journalArticle

65 Scopus citations
2017

Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction

Saiki, H., Moulay, G., Guenzel, A. J., Liu, W., Decklever, T. D., Classic, K. L., Pham, L., Chen, H. H., Burnett, J. C., Russell, S. J. & Redfield, M. M., Aug 11 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 2, p. H392-H407

Research output: Contribution to journalArticle

14 Scopus citations

Implications of Alternative Hepatorenal Prognostic Scoring Systems in Acute Heart Failure (from DOSE-AHF and ROSE-AHF)

Grodin, J. L., Gallup, D., Anstrom, K. J., Felker, G. M., Chen, H. H. & Tang, W. H. W., Jun 15 2017, In : American Journal of Cardiology. 119, 12, p. 2003-2009 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Implications of Serum Chloride Homeostasis in Acute Heart Failure (from ROSE-AHF)

Grodin, J. L., Sun, J. L., Anstrom, K. J., Chen, H. H., Starling, R. C., Testani, J. M. & Tang, W. H. W., Jan 1 2017, In : American Journal of Cardiology. 119, 1, p. 78-83 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Suppression of tumorigenicity 2 in heart failure with preserved ejection fraction

AbouEzzeddine, O. F., McKie, P. M., Dunlay, S. M., Stevens, S. R., Felker, G. M., Borlaug, B. A., Chen, H. H., Tracy, R. P., Braunwald, E. & Redfield, M. M., 2017, In : Journal of the American Heart Association. 6, 2, e004382.

Research output: Contribution to journalArticle

25 Scopus citations

The renal–cardiac connection in subjects with preserved ejection fraction: a population based study

Jain, A., Scott, C. & Chen, H. H., Jan 1 2017, In : ESC heart failure. 4, 3, p. 266-273 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2016

Biomarker-based risk prediction in the community

Abou Ezzeddine, O., McKie, P., Scott, C. G., Rodeheffer, R. J., Chen, H. H., Michael Felker, G., Jaffe, A. S., Burnett, J. C. J. & Redfield, M. M., Nov 1 2016, In : European Journal of Heart Failure. 18, 11, p. 1342-1350 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

B-type natriuretic peptide and acute heart failure: Fluid homeostasis, biomarker and therapeutics

Torres-Courchoud, I. & Chen, H. H., Jan 11 2016, (Accepted/In press) In : Revista Clinica Espanola.

Research output: Contribution to journalArticle

6 Scopus citations

Chronic Peptide Therapy With B-Type Natriuretic Peptide in Patients With Pre-Clinical Diastolic Dysfunction (Stage B Heart Failure)

Wan, S. H., McKie, P., Schirger, J. A., Slusser, J. P., Hodge, D. O., Redfield, M. M., Burnett, J. C. J. & Chen, H. H., Jul 1 2016, In : JACC: Heart Failure. 4, 7, p. 539-547 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Chronic subcutaneous brain natriuretic peptide therapy in asymptomatic systolic heart failure

McKie, P., Schirger, J. A., Benike, S. L., Harstad, L. K., Slusser, J. P., Hodge, D. O., Redfield, M. M., Burnett, J. C. J. & Chen, H. H., 2016, (Accepted/In press) In : European Journal of Heart Failure.

Research output: Contribution to journalArticle

17 Scopus citations

Differential response to low-dose dopamine or low-dose nesiritide in acute heart failure with reduced or preserved ejection fraction

Wan, S. H., Stevens, S. R., Borlaug, B. A., Anstrom, K. J., Deswal, A., Felker, G. M., Givertz, M. M., Bart, B. A., Tang, W. H. W., Redfield, M. M. & Chen, H. H., Aug 1 2016, In : Circulation: Heart Failure. 9, 8, e002593.

Research output: Contribution to journalArticle

21 Scopus citations

Evaluation of a provocative dyspnea severity score in acute heart failure

Abou Ezzeddine, O., Lala, A., Khazanie, P. P., Shah, R., Ho, J. E., Chen, H. H., Pang, P. S., McNulty, S. E., Anstrom, K. J., Hernandez, A. F. & Redfield, M. M., Feb 1 2016, In : American Heart Journal. 172, p. 34-41 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Implications of using different definitions on outcomes in worsening heart failure

Kelly, J. P., Cooper, L. B., Gallup, D., Anstrom, K. J., Chen, H. H., Redfield, M. M., O'Connor, C. M., Mentz, R. J., Hernanadez, A. F. & Felker, G. M., Aug 1 2016, In : Circulation: Heart Failure. 9, 8, e003048.

Research output: Contribution to journalArticle

7 Scopus citations

Insulin-Like Growth Factor–Binding Protein-7 as a Biomarker of Diastolic Dysfunction and Functional Capacity in Heart Failure With Preserved Ejection Fraction: Results From the RELAX Trial

Gandhi, P. U., Gaggin, H. K., Redfield, M. M., Chen, H. H., Stevens, S. R., Anstrom, K. J., Semigran, M. J., Liu, P. & Januzzi, J. L., Nov 1 2016, In : JACC: Heart Failure. 4, 11, p. 860-869 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

In vivo Evaluation of Cenderitide-Eluting Stent (CES) II

Huang, Y., Ng, X. W., Lim, S. G., Chen, H. H., Burnett, J. C. J., Boey, Y. C. F. & Venkatraman, S. S., Feb 1 2016, In : Annals of Biomedical Engineering. 44, 2, p. 432-441 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

The Natural History of Patients with Isolated Metabolic Syndrome

Patel, P. A., Scott, C. G., Rodeheffer, R. J. & Chen, H. H., May 1 2016, In : Mayo Clinic Proceedings. 91, 5, p. 623-633 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Circulating C-Type Natriuretic Peptide and Its Relationship to Cardiovascular Disease in the General Population

Sangaralingham, S. J., McKie, P. M., Ichiki, T., Scott, C. G., Heublein, D. M., Chen, H. H., Bailey, K. R., Redfield, M. M., Rodeheffer, R. J. & Burnett, J. C., Jun 20 2015, In : Hypertension. 65, 6, p. 1187-1194 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Effects of Sildenafil on Ventricular and Vascular Function in Heart Failure with Preserved Ejection Fraction

Borlaug, B. A., Lewis, G. D., McNulty, S. E., Semigran, M. J., Lewinter, M., Chen, H., Lin, G., Deswal, A., Margulies, K. B. & Redfield, M. M., May 4 2015, In : Circulation: Heart Failure. 8, 3, p. 533-541 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Galectin-3 in heart failure with preservedejection fraction. A RELAX trial substudy (phosphodiesterase-5 inhibition to improve clinical status and exercise capacity in diastolic heartfailure).

AbouEzzeddine, O. F., Haines, P., Stevens, S., Nativi-Nicolau, J., Felker, G. M., Borlaug, B. A., Chen, H. H., Tracy, R. P., Braunwald, E. & Redfield, M. M., Mar 1 2015, In : JACC: Heart Failure. 3, 3, p. 245-252 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Intensification of Medication Therapy for Cardiorenal Syndrome in Acute Decompensated Heart Failure

Grodin, J. L., Stevens, S. R., de las Fuentes, L., Kiernan, M., Birati, E. Y., Gupta, D., Bart, B. A., Felker, G. M., Chen, H. H., Butler, J., Dávila-Román, V. G., Margulies, K. B., Hernandez, A. F., Anstrom, K. J. & Tang, W. H. W., Apr 5 2015, (Accepted/In press) In : Journal of Cardiac Failure.

Research output: Contribution to journalArticle

24 Scopus citations

Isosorbide mononitrate in heart failure with preserved ejection fraction

Redfield, M. M., Anstrom, K. J., Levine, J. A., Koepp, G. A., Borlaug, B. A., Chen, H. H., LeWinter, M. M., Joseph, S. M., Shah, S. J., Semigran, M. J., Felker, G. M., Cole, R. T., Reeves, G. R., Tedford, R. J., Tang, W. H. W., McNulty, S. E., Velazquez, E. J., Shah, M. R. & Braunwald, E., Dec 10 2015, In : New England Journal of Medicine. 373, 24, p. 2314-2324 11 p.

Research output: Contribution to journalArticle

227 Scopus citations

Targeting Preclinical Diastolic Dysfunction to Prevent Heart Failure: Contemporary Insights

Wan, S. H. & Chen, H. H., Aug 25 2015, In : Current Cardiovascular Risk Reports. 9, 8, 40.

Research output: Contribution to journalArticle

2014

Cell surface protein disulfide isomerase regulates natriuretic peptide generation of cyclic guanosine monophosphate

Pan, S., Chen, H. H., Correia, C., Dai, H., Witt, T. A., Kleppe, L. S., Burnett, J. C. & Simari, R. D., Nov 24 2014, In : PloS one. 9, 11, e112986.

Research output: Contribution to journalArticle

2 Scopus citations

In vitro evaluation of cenderitide-eluting stent I - An antirestenosis and proendothelization approach

Ng, X. W., Huang, Y., Liu, K. L., Lim, S. G., Chen, H. H., Burnett, J. C., Boey, Y. C. F. & Venkatraman, S. S., Sep 15 2014, In : Journal of Pharmaceutical Sciences. 103, 11, p. 3631-3640 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
17 Scopus citations

ROSE-AHF and lessons learned

Jain, A. K. & Chen, H. H., Sep 2014, In : Current heart failure reports. 11, 3, p. 260-265 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

The prevalence of diabetic cardiomyopathy: A population-based study in Olmsted County, Minnesota

Dandamudi, S., Slusser, J., Mahoney, D. W., Redfield, M. M., Rodeheffer, R. J. & Chen, H. H., May 2014, In : Journal of Cardiac Failure. 20, 5, p. 304-309 6 p.

Research output: Contribution to journalArticle

61 Scopus citations
2013

Cenderitide-Eluting Film for Potential Cardiac Patch Applications

Ng, X. W., Huang, Y., Chen, H. H., Burnett, J. C., Boey, F. Y. C. & Venkatraman, S. S., Jul 4 2013, In : PloS one. 8, 7, e68346.

Research output: Contribution to journalArticle

9 Scopus citations

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: A randomized clinical trial

Redfield, M. M., Chen, H. H., Borlaug, B. A., Semigran, M. J., Lee, K. L., Lewis, G., LeWinter, M. M., Rouleau, J. L., Bull, D. A., Mann, D. L., Deswal, A., Stevenson, L. W., Givertz Elizabeth O Ofili, M. M., O'Connor, C. M., Felker, G. M., Goldsmith, S. R., Bart, B. A., McNulty, S. E., Ibarra, J. C., Lin, G. & 9 others, Oh, J. K., Patel, M. R., Kim, R. J., Tracy, R. P., Velazquez, E. J., Anstrom, K. J., Hernandez, A. F., Mascette, A. M. & Braunwald, E., Mar 27 2013, In : JAMA - Journal of the American Medical Association. 309, 12, p. 1268-1277 10 p.

Research output: Contribution to journalArticle

652 Scopus citations

In-Vivo Evaluation of an In Situ Polymer Precipitation Delivery System for a Novel Natriuretic Peptide

Lim, S. G., Venkatraman, S. S., Burnett, J. C. & Chen, H. H., Feb 18 2013, In : PloS one. 8, 2, e52484.

Research output: Contribution to journalArticle

2 Scopus citations

Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: The ROSE acute heart failure randomized trial

Chen, H. H., Anstrom, K. J., Givertz, M. M., Stevenson, L. W., Semigran, M. J., Goldsmith, S. R., Bart, B. A., Bull, D. A., Stehlik, J., LeWinter, M. M., Konstam, M. A., Huggins, G. S., Rouleau, J. L., O'Meara, E., Tang, W. H. W., Starling, R. C., Butler, J., Deswal, A., Felker, G. M., O'Connor, C. M. & 14 others, Bonita, R. E., Margulies, K. B., Cappola, T. P., Ofili, E. O., Mann, D. L., Dávila-Román, V. G., McNulty, S. E., Borlaug, B. A., Velazquez, E. J., Lee, K. L., Shah, M. R., Hernandez, A. F., Braunwald, E. & Redfield, M. M., Dec 20 2013, In : JAMA - Journal of the American Medical Association. 310, 23, p. 2533-2543 11 p.

Research output: Contribution to journalArticle

282 Scopus citations
10 Scopus citations

Targeting the kidney in acute heart failure: Can old drugs provide new benefit? Renal optimization strategies evaluation in acute heart failure (ROSE AHF) trial

Chen, H. H., AbouEzzeddine, O. F., Anstrom, K. J., Givertz, M. M., Bart, B. A., Felker, G. M., Hernandez, A. F., Lee, K. L., Braunwald, E. & Redfield, M. M., Sep 2013, In : Circulation: Heart Failure. 6, 5, p. 1087-1094 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012

Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction

Bishu, K., Deswal, A., Chen, H. H., Lewinter, M. M., Lewis, G. D., Semigran, M. J., Borlaug, B. A., McNulty, S., Hernandez, A. F., Braunwald, E. & Redfield, M. M., Nov 2012, In : American Heart Journal. 164, 5, p. 763-e3

Research output: Contribution to journalArticle

63 Scopus citations

Cardiorenal rescue study in acute decompensated heart failure: Rationale and design of CARRESS-HF, for the heart failure clinical research network

Bart, B. A., Goldsmith, S. R., Lee, K. L., Redfield, M. M., Felker, G. M., O'Connor, C. M., Chen, H. H., Rouleau, J. L., Givertz, M. M., Semigran, M. J., Mann, D., Deswal, A., Bull, D. A., Lewinter, M. M. & Braunwald, E., Mar 1 2012, In : Journal of Cardiac Failure. 18, 3, p. 176-182 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

CD-NP: A Novel Engineered Dual Guanylyl Cyclase Activator with Anti-Fibrotic Actions in the Heart

Martin, F. L., Sangaralingham, S. J., Huntley, B. K., McKie, P. M., Ichiki, T., Chen, H. H., Korinek, J., Harders, G. E. & Burnett, J. C., Dec 18 2012, In : PloS one. 7, 12, e52422.

Research output: Contribution to journalArticle

40 Scopus citations

Experimental mild renal insufficiency mediates early cardiac apoptosis, fibrosis, and diastolic dysfunction: A kidney-heart connection

Martin, F. L., McKie, P. M., Cataliotti, A., Jeson Sangaralingham, S., Korinek, J., Huntley, B. K., Oehler, E. A., Harders, G. E., Ichiki, T., Mangiafico, S., Nath, K. A., Redfield, M. M., Chen, H. H. & Burnett, J. C., Jan 2012, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 302, 2, p. R292-R299

Research output: Contribution to journalArticle

53 Scopus citations

Human hypertension is characterized by a lack of activation of the antihypertensive cardiac hormones ANP and BNP

MacHeret, F., Heublein, D., Costello-Boerrigter, L. C., Boerrigter, G., McKie, P., Bellavia, D., Mangiafico, S., Ikeda, Y., Bailey, K., Scott, C. G., Sandberg, S., Chen, H. H., Malatino, L., Redfield, M. M., Rodeheffer, R., Burnett, J. & Cataliotti, A., Oct 16 2012, In : Journal of the American College of Cardiology. 60, 16, p. 1558-1565 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Measurement of left and right ventricular volumes with tomographic equilibrium radionuclide angiocardiography and cardiac MRI

Clements, I. P., Akerem Khan, S. K., Chen, H. H. & Mullan, B. P., May 1 2012, In : Nuclear medicine communications. 33, 5, p. 481-485 5 p.

Research output: Contribution to journalArticle

3 Scopus citations