• 7297 Citations
  • 45 Scopus h-Index
19962020

Research output per year

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Research Output

2014

The prevalence of diabetic cardiomyopathy: A population-based study in Olmsted County, Minnesota

Dandamudi, S., Slusser, J., Mahoney, D. W., Redfield, M. M., Rodeheffer, R. J. & Chen, H. H., May 2014, In : Journal of Cardiac Failure. 20, 5, p. 304-309 6 p.

Research output: Contribution to journalArticle

64 Scopus citations
2013

Cenderitide-Eluting Film for Potential Cardiac Patch Applications

Ng, X. W., Huang, Y., Chen, H. H., Burnett, J. C., Boey, F. Y. C. & Venkatraman, S. S., Jul 4 2013, In : PloS one. 8, 7, e68346.

Research output: Contribution to journalArticle

9 Scopus citations

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: A randomized clinical trial

Redfield, M. M., Chen, H. H., Borlaug, B. A., Semigran, M. J., Lee, K. L., Lewis, G., LeWinter, M. M., Rouleau, J. L., Bull, D. A., Mann, D. L., Deswal, A., Stevenson, L. W., Givertz Elizabeth O Ofili, M. M., O'Connor, C. M., Felker, G. M., Goldsmith, S. R., Bart, B. A., McNulty, S. E., Ibarra, J. C., Lin, G. & 9 others, Oh, J. K., Patel, M. R., Kim, R. J., Tracy, R. P., Velazquez, E. J., Anstrom, K. J., Hernandez, A. F., Mascette, A. M. & Braunwald, E., Mar 27 2013, In : JAMA - Journal of the American Medical Association. 309, 12, p. 1268-1277 10 p.

Research output: Contribution to journalArticle

666 Scopus citations

In-Vivo Evaluation of an In Situ Polymer Precipitation Delivery System for a Novel Natriuretic Peptide

Lim, S. G., Venkatraman, S. S., Burnett, J. C. & Chen, H. H., Feb 18 2013, In : PloS one. 8, 2, e52484.

Research output: Contribution to journalArticle

2 Scopus citations

Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: The ROSE acute heart failure randomized trial

Chen, H. H., Anstrom, K. J., Givertz, M. M., Stevenson, L. W., Semigran, M. J., Goldsmith, S. R., Bart, B. A., Bull, D. A., Stehlik, J., LeWinter, M. M., Konstam, M. A., Huggins, G. S., Rouleau, J. L., O'Meara, E., Tang, W. H. W., Starling, R. C., Butler, J., Deswal, A., Felker, G. M., O'Connor, C. M. & 14 others, Bonita, R. E., Margulies, K. B., Cappola, T. P., Ofili, E. O., Mann, D. L., Dávila-Román, V. G., McNulty, S. E., Borlaug, B. A., Velazquez, E. J., Lee, K. L., Shah, M. R., Hernandez, A. F., Braunwald, E. & Redfield, M. M., 2013, In : JAMA - Journal of the American Medical Association. 310, 23, p. 2533-2543 11 p.

Research output: Contribution to journalArticle

289 Scopus citations
11 Scopus citations

Targeting the kidney in acute heart failure: Can old drugs provide new benefit? Renal optimization strategies evaluation in acute heart failure (ROSE AHF) trial

Chen, H. H., AbouEzzeddine, O. F., Anstrom, K. J., Givertz, M. M., Bart, B. A., Felker, G. M., Hernandez, A. F., Lee, K. L., Braunwald, E. & Redfield, M. M., Sep 2013, In : Circulation: Heart Failure. 6, 5, p. 1087-1094 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012

Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction

Bishu, K., Deswal, A., Chen, H. H., Lewinter, M. M., Lewis, G. D., Semigran, M. J., Borlaug, B. A., McNulty, S., Hernandez, A. F., Braunwald, E. & Redfield, M. M., Nov 2012, In : American heart journal. 164, 5, p. 763-e3

Research output: Contribution to journalArticle

65 Scopus citations

Cardiorenal rescue study in acute decompensated heart failure: Rationale and design of CARRESS-HF, for the heart failure clinical research network

Bart, B. A., Goldsmith, S. R., Lee, K. L., Redfield, M. M., Felker, G. M., O'Connor, C. M., Chen, H. H., Rouleau, J. L., Givertz, M. M., Semigran, M. J., Mann, D., Deswal, A., Bull, D. A., Lewinter, M. M. & Braunwald, E., Mar 2012, In : Journal of Cardiac Failure. 18, 3, p. 176-182 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

CD-NP: A Novel Engineered Dual Guanylyl Cyclase Activator with Anti-Fibrotic Actions in the Heart

Martin, F. L., Sangaralingham, S. J., Huntley, B. K., McKie, P. M., Ichiki, T., Chen, H. H., Korinek, J., Harders, G. E. & Burnett, J. C., Dec 18 2012, In : PloS one. 7, 12, e52422.

Research output: Contribution to journalArticle

41 Scopus citations

Experimental mild renal insufficiency mediates early cardiac apoptosis, fibrosis, and diastolic dysfunction: A kidney-heart connection

Martin, F. L., McKie, P. M., Cataliotti, A., Jeson Sangaralingham, S., Korinek, J., Huntley, B. K., Oehler, E. A., Harders, G. E., Ichiki, T., Mangiafico, S., Nath, K. A., Redfield, M. M., Chen, H. H. & Burnett, J. C., Jan 2012, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 302, 2, p. R292-R299

Research output: Contribution to journalArticle

54 Scopus citations

Human hypertension is characterized by a lack of activation of the antihypertensive cardiac hormones ANP and BNP

MacHeret, F., Heublein, D., Costello-Boerrigter, L. C., Boerrigter, G., McKie, P., Bellavia, D., Mangiafico, S., Ikeda, Y., Bailey, K., Scott, C. G., Sandberg, S., Chen, H. H., Malatino, L., Redfield, M. M., Rodeheffer, R., Burnett, J. & Cataliotti, A., Oct 16 2012, In : Journal of the American College of Cardiology. 60, 16, p. 1558-1565 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Measurement of left and right ventricular volumes with tomographic equilibrium radionuclide angiocardiography and cardiac MRI

Clements, I. P., Akerem Khan, S. K., Chen, H. H. & Mullan, B. P., May 1 2012, In : Nuclear medicine communications. 33, 5, p. 481-485 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Novel protein therapeutics for systolic heart failure: Chronic subcutaneous B-type natriuretic peptide

Chen, H. H., Glockner, J. F., Schirger, J. A., Cataliotti, A., Redfield, M. M. & Burnett, J. C., Dec 4 2012, In : Journal of the American College of Cardiology. 60, 22, p. 2305-2312 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Sustained blood pressure-lowering actions of subcutaneous B-type natriuretic peptide (nesiritide) in a patient with uncontrolled hypertension

Cataliotti, A., Costello-Boerrigter, L. C., Chen, H. H., Textor, S. C. & Burnett, J. C., Apr 2012, In : Mayo Clinic proceedings. 87, 4, p. 413-415 3 p.

Research output: Contribution to journalLetter

25 Scopus citations

The ASCEND-HF trial: An acute study of clinical effectiveness of nesiritide and decompensated heart failure

Dandamudi, S. & Chen, H. H., May 1 2012, In : Expert Review of Cardiovascular Therapy. 10, 5, p. 557-563 7 p.

Research output: Contribution to journalReview article

12 Scopus citations

The natural history of preclinical diastolic dysfunction a population-based study

Vogel, M. W., Slusser, J. P., Hodge, D. O. & Chen, H. H., Mar 2012, In : Circulation: Heart Failure. 5, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Ultrafiltration in decompensated heart failure with cardiorenal syndrome

Bart, B. A., Goldsmith, S. R., Lee, K. L., Givertz, M. M., O'Connor, C. M., Bull, D. A., Redfield, M. M., Deswal, A., Rouleau, J. L., LeWinter, M. M., Ofili, E. O., Stevenson, L. W., Semigran, M. J., Felker, G. M., Chen, H. H., Hernandez, A. F., Anstrom, K. J., McNulty, S. E., Velazquez, E. J., Ibarra, J. C. & 2 others, Mascette, A. M. & Braunwald, E., Dec 13 2012, In : New England Journal of Medicine. 367, 24, p. 2296-2304 9 p.

Research output: Contribution to journalArticle

522 Scopus citations
2011

Diuretic strategies in patients with acute decompensated heart failure

Felker, G. M., Lee, K. L., Bull, D. A., Redfield, M. M., Stevenson, L. W., Goldsmith, S. R., LeWinter, M. M., Deswal, A., Rouleau, J. L., Ofili, E. O., Anstrom, K. J., Hernandez, A. F., McNulty, S. E., Velazquez, E. J., Kfoury, A. G., Chen, H. H., Givertz, M. M., Semigran, M. J., Bart, B. A., Mascette, A. M. & 2 others, Braunwald, E. & O'Connor, C. M., Mar 3 2011, In : New England Journal of Medicine. 364, 9, p. 797-805 9 p.

Research output: Contribution to journalArticle

904 Scopus citations

Effect of cardiac resynchronization therapy on broad neurohormone biomarkers in heart failure.

Dong, Y. X., Burnett, J. C., Chen, H. H., Sandberg, S., Yang, Y. Z., Zhang, Y., Chen, P. S. & Cha, Y. M., Apr 1 2011, In : Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. 30, 3, p. 241-249 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Evolving treatment strategies for management of cardiorenal syndrome

Dandamudi, S. & Chen, H. H., Dec 1 2011, In : Current Treatment Options in Cardiovascular Medicine. 13, 6, p. 556-569 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Impaired natriuretic and renal endocrine response to acute volume expansion in pre-clinical systolic and diastolic dysfunction

McKie, P. M., Schirger, J. A., Costello-Boerrigter, L. C., Benike, S. L., Harstad, L. K., Bailey, K. R., Hodge, D. O., Redfield, M. M., Simari, R. D., Burnett, J. C. & Chen, H. H., Nov 8 2011, In : Journal of the American College of Cardiology. 58, 20, p. 2095-2103 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Novel natriuretic peptides: New compounds and new approaches

Vogel, M. W. & Chen, H. H., Mar 1 2011, In : Current heart failure reports. 8, 1, p. 22-27 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

The aging heart, myocardial fibrosis, and its relationship to circulating C-type natriuretic peptide

Sangaralingham, S. J., Huntley, B. K., Martin, F. L., McKie, P. M., Bellavia, D., Ichiki, T., Harders, G. E., Chen, H. H. & Burnett, J. C., Feb 2011, In : Hypertension. 57, 2, p. 201-207 7 p.

Research output: Contribution to journalArticle

67 Scopus citations
2010

A novel atrial natriuretic peptide based therapeutic in experimental angiotensin II mediated acute hypertension

McKie, P. M., Cataliotti, A., Boerrigter, G., Chen, H. H., Sangaralingham, S. J., Martin, F. L., Ichiki, T. & Burnett, J. C., Dec 2010, In : Hypertension. 56, 6, p. 1152-1159 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

B-type natriuretic peptide and extracellular matrix protein interactions in human cardiac fibroblasts

Huntley, B. K., Ichiki, T., Sangaralingham, S. J., Chen, H. H. & Burnett, J. C., Oct 2010, In : Journal of Cellular Physiology. 225, 1, p. 251-255 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Is cystatin C an important prognostic marker independent of renal function?

Chen, H. H., Nov 30 2010, In : Journal of the American College of Cardiology. 56, 23, p. 1937-1938 2 p.

Research output: Contribution to journalEditorial

5 Scopus citations

Progression of preclinical diastolic dysfunction to the development of symptoms

Correa De Sa, D. D., Hodge, D. O., Slusser, J. P., Redfield, M. M., Simari, R. D., Burnett, J. C. & Chen, H. H., Apr 2010, In : Heart. 96, 7, p. 528-532 5 p.

Research output: Contribution to journalArticle

57 Scopus citations

Regulation of circulating progenitor cells in left ventricular dysfunction.

Boilson, B. A., Larsen, K., Harbuzariu, A., Delacroix, S., Korinek, J., Froehlich, H., Bailey, K. R., Scott, C. G., Shapiro, B. P., Boerrigter, G., Chen, H. H., Redfield, M. M., Burnett, J. C. & Simari, R. D., Sep 1 2010, In : Circulation. Heart failure. 3, 5, p. 635-642 8 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
274 Scopus citations

Biodesign of a renal-protective peptide based on alternative splicing of B-type natriuretic peptide

Pan, S., Chen, H. H., Dickey, D. M., Boerrigter, G., Lee, C., Kleppe, L. S., Hall, J. L., Lerman, A., Redfield, M. M., Potter, L. R., Burnett, J. C. & Simari, R. D., Jul 7 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 27, p. 11282-11287 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Changes in Diastolic Dysfunction in Diabetes Mellitus Over Time

From, A. M., Scott, C. G. & Chen, H. H., May 15 2009, In : American Journal of Cardiology. 103, 10, p. 1463-1466 4 p.

Research output: Contribution to journalArticle

103 Scopus citations

Local Renal Delivery of a Natriuretic Peptide. A Renal-Enhancing Strategy for B-Type Natriuretic Peptide in Overt Experimental Heart Failure

Chen, H. H., Cataliotti, A., Schirger, J. A., Martin, F. L., Harstad, L. K. & Burnett, J. C., Apr 14 2009, In : Journal of the American College of Cardiology. 53, 15, p. 1302-1308 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Low-dose nesiritide in human anterior myocardial infarction suppresses aldosterone and preserves ventricular function and structure: A proof of concept study

Chen, H. H., Martin, F. L., Gibbons, R. J., Schirger, J. A., Wright, R. S., Schears, R. M., Redfield, M. M., Simari, R. D., Lerman, A., Cataliotti, A. & Burnett, J. C., Aug 2009, In : Heart. 95, 16, p. 1315-1319 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

Pharmacodynamics of a novel designer natriuretic peptide, CD-NP, in a first-in-human clinical trial in healthy subjects

Lee, C. Y. W., Chen, H. H., Lisy, O., Swan, S., Cannon, C., Lieu, H. D. & Burnett, J. C., Jun 2009, In : Journal of Clinical Pharmacology. 49, 6, p. 668-673 6 p.

Research output: Contribution to journalArticle

82 Scopus citations
2008

B-Type Natriuretic Peptide: Beyond a Diagnostic

Martin, F. L., Chen, H. H., Cataliotti, A. & Burnett, J. C., Oct 2008, In : Heart Failure Clinics. 4, 4, p. 449-454 6 p.

Research output: Contribution to journalReview article

5 Scopus citations

Chronic actions of a novel oral B-type natriuretic peptide conjugate in normal dogs and acute actions in angiotensin II-mediated hypertension

Cataliotti, A., Chen, H. H., Schirger, J. A., Martin, F. L., Boerrigter, G., Costello-Boerrigter, L. C., James, K. D., Polowy, K., Miller, M. A., Malkar, N. B., Bailey, K. R. & Burnett, J. C., Oct 21 2008, In : Circulation. 118, 17, p. 1729-1736 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Nesiritide in acute decompensated heart failure: Current status and future perspectives

Mohammed, S. F., Korinek, J., Chen, H. H., Burnett, J. C. & Redfield, M. M., Jun 1 2008, In : Reviews in cardiovascular medicine. 9, 3, p. 151-158 8 p.

Research output: Contribution to journalReview article

12 Scopus citations

Targeting the kidney in acute decompensated heart failure: Conventional diuretics and renal-acting vasodilators

Martin, F. L., Chen, H. H., Cataliotti, A. & Burnett, J. C., Dec 1 2008, In : Reviews in cardiovascular medicine. 9, 1, p. 39-45 7 p.

Research output: Contribution to journalReview article

4 Scopus citations

The Effects of Nesiritide on Renal Function and Diuretic Responsiveness in Acutely Decompensated Heart Failure Patients With Renal Dysfunction

Owan, T. E., Chen, H. H., Frantz, R. P., Karon, B. L., Miller, W. L., Rodeheffer, R. J., Hodge, D. O., Burnett, J. C. & Redfield, M. M., May 2008, In : Journal of Cardiac Failure. 14, 4, p. 267-275 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

The FDA and the new biology.

Simari, R. D., Chen, H. & Burnett, J. C., Dec 2008, In : Journal of cardiovascular translational research. 1, 4, p. 246-247 2 p.

Research output: Contribution to journalEditorial

The role of natriuretic peptides in heart failure

Correa de Sa, D. D. & Chen, H. H., Dec 1 2008, In : Current cardiology reports. 10, 3, p. 182-189 8 p.

Research output: Contribution to journalReview article

13 Scopus citations

The role of natriuretic peptides in heart failure

Correa de Sa, D. D. & Chen, H. H., Dec 1 2008, In : Current heart failure reports. 5, 3, p. 177-184 8 p.

Research output: Contribution to journalReview article

7 Scopus citations
2007

Distinct roles for renal particulate and soluble guanylyl cyclases in preserving renal function in experimental acute heart failure

Martin, F. L., Supaporn, T., Chen, H. H., Sandberg, S. M., Matsuda, Y., Jougasaki, M. & Burnett, J. C., Oct 1 2007, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 293, 4, p. R1580-R1585

Research output: Contribution to journalArticle

8 Scopus citations

Heart Failure. A State of Brain Natriuretic Peptide Deficiency or Resistance or Both!

Chen, H. H., Mar 13 2007, In : Journal of the American College of Cardiology. 49, 10, p. 1089-1091 3 p.

Research output: Contribution to journalEditorial

58 Scopus citations

Low dose nesiritide and the preservation of renal function in patients with renal dysfunction undergoing cardiopulmonary-bypass surgery: A double-blind placebo-controlled pilot study

Chen, H. H., Sundt, T. M., Cook, D. J., Heublein, D. M. & Burnett, J. C., Sep 1 2007, In : Circulation. 116, 11 SUPPL. 1, p. I134-I138

Research output: Contribution to journalArticle

90 Scopus citations

Oral Brain Natriuretic Peptide: A Novel Strategy for Chronic Protein Therapy for Cardiovascular Disease

Cataliotti, A., Chen, H. H., James, K. D. & Burnett, J. C., Jan 1 2007, In : Trends in cardiovascular medicine. 17, 1, p. 10-14 5 p.

Research output: Contribution to journalReview article

13 Scopus citations