• 7297 Citations
  • 45 Scopus h-Index
19962020

Research output per year

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Research Output

32-Year-Old Man With Dyspnea on Exertion and Dizziness

Adel, F. W., Esmaeilzadeh, S. & Chen, H. H., Apr 2020, In : Mayo Clinic proceedings. 95, 4, p. e37-e42

Research output: Contribution to journalShort survey

Open Access

68-Year-old man with anemia and renal failure

Chen, H. H., Shields, R. C. & Bardsley, W. T., Jan 1 1996, In : Mayo Clinic proceedings. 71, 2, p. 197-200 4 p.

Research output: Contribution to journalArticle

Open Access

76-Year-old woman with chest pain

Krajicek, B. J. & Chen, H. H., Nov 2004, In : Mayo Clinic proceedings. 79, 11, p. 1435-1438 4 p.

Research output: Contribution to journalArticle

Open Access

A Human Study to Evaluate Safety, Tolerability, and Cyclic GMP Activating Properties of Cenderitide in Subjects With Stable Chronic Heart Failure

Kawakami, R., Lee, C. Y. W., Scott, C., Bailey, K. R., Schirger, J. A., Chen, H. H., Benike, S. L., Cannone, V., Martin, F. L., Sangaralingham, S. J., Ichiki, T. & Burnett, J. C., Sep 2018, In : Clinical pharmacology and therapeutics. 104, 3, p. 546-552 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
27 Scopus citations

Annexin A1 is a Potential Novel Biomarker of Congestion in Acute Heart Failure

Adel, FADI. W., RIKHI, ARUNA., WAN, SIU. I. U. H. I. N., IYER, SEETHALAKSHMI. R., CHAKRABORTY, HRISHIKESH., MCNULTY, STEVEN., TANG, W. H. WILSON., FELKER, G. MICHAEL., GIVERTZ, MICHAEL. M. & CHEN, HORNG. H., Aug 2020, In : Journal of Cardiac Failure. 26, 8, p. 727-732 6 p.

Research output: Contribution to journalArticle

A novel atrial natriuretic peptide based therapeutic in experimental angiotensin II mediated acute hypertension

McKie, P. M., Cataliotti, A., Boerrigter, G., Chen, H. H., Sangaralingham, S. J., Martin, F. L., Ichiki, T. & Burnett, J. C., Dec 2010, In : Hypertension. 56, 6, p. 1152-1159 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Association of B-type natriuretic peptide activation to left ventricular end-systolic remodeling in organic and functional mitral regurgitation

Detaint, D., Messika-Zeitoun, D., Chen, H. H., Rossi, A., Avierinos, J. F., Scott, C., Burnett, J. C. & Enriquez-Sarano, M., Apr 1 2006, In : American Journal of Cardiology. 97, 7, p. 1029-1034 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Biodesign of a renal-protective peptide based on alternative splicing of B-type natriuretic peptide

Pan, S., Chen, H. H., Dickey, D. M., Boerrigter, G., Lee, C., Kleppe, L. S., Hall, J. L., Lerman, A., Redfield, M. M., Potter, L. R., Burnett, J. C. & Simari, R. D., Jul 7 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 27, p. 11282-11287 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Biomarker-based risk prediction in the community

Abou Ezzeddine, O., McKie, P., Scott, C. G., Rodeheffer, R. J., Chen, H. H., Michael Felker, G., Jaffe, A. S., Burnett, J. C. J. & Redfield, M. M., Nov 1 2016, In : European Journal of Heart Failure. 18, 11, p. 1342-1350 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction

Bishu, K., Deswal, A., Chen, H. H., Lewinter, M. M., Lewis, G. D., Semigran, M. J., Borlaug, B. A., McNulty, S., Hernandez, A. F., Braunwald, E. & Redfield, M. M., Nov 2012, In : American heart journal. 164, 5, p. 763-e3

Research output: Contribution to journalArticle

65 Scopus citations

Brain Natriuretic Peptide Enhances Renal Actions of Furosemide and Suppresses Furosemide-Induced Aldosterone Activation in Experimental Heart Failure

Cataliotti, A., Boerrigter, G., Costello-Boerrigter, L. C., Schirger, J. A., Tsuruda, T., Heublein, D. M., Chen, H. H., Malatino, L. S. & Burnett, J. C., Apr 6 2004, In : Circulation. 109, 13, p. 1680-1685 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Brain natriuretic peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases

Tsuruda, T., Boerrigter, G., Huntley, B. K., Noser, J. A., Cataliotti, A., Costello-Boerrigter, L. C., Chen, H. H. & Burnett, J. C., Dec 1 2002, In : Circulation research. 91, 12, p. 1127-1134 8 p.

Research output: Contribution to journalArticle

240 Scopus citations

B-Type Natriuretic Peptide: Beyond a Diagnostic

Martin, F. L., Chen, H. H., Cataliotti, A. & Burnett, J. C., Oct 2008, In : Heart Failure Clinics. 4, 4, p. 449-454 6 p.

Research output: Contribution to journalReview article

5 Scopus citations

B-type natriuretic peptide and acute heart failure: Fluid homeostasis, biomarker and therapeutics

Torres-Courchoud, I. & Chen, H. H., Jan 11 2016, (Accepted/In press) In : Revista Clinica Espanola.

Research output: Contribution to journalArticle

6 Scopus citations

B-type natriuretic peptide and cardiac remodelling after myocardial infarction: A randomised trial

Hubers, S. A., Schirger, J. A., Sangaralingham, S. J., Chen, Y., Burnett, J. C., Hodge, D. & Chen, H. H., 2020, (Accepted/In press) In : Heart.

Research output: Contribution to journalArticle

B-type natriuretic peptide and extracellular matrix protein interactions in human cardiac fibroblasts

Huntley, B. K., Ichiki, T., Sangaralingham, S. J., Chen, H. H. & Burnett, J. C., Oct 2010, In : Journal of Cellular Physiology. 225, 1, p. 251-255 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

B-type natriuretic peptide in organic mitral regurgitation: Determinants and impact on outcome

Detaint, D., Messika-Zeitoun, D., Avierinos, J. F., Scott, C., Chen, H., Burnett, J. C. & Enriquez-Sarano, M., May 10 2005, In : Circulation. 111, 18, p. 2391-2397 7 p.

Research output: Contribution to journalArticle

132 Scopus citations
7 Scopus citations

Cardiac resynchronization therapy improves myocardial conduction

Yang, M., Li, X., Yang, D., Li, Y., Zhou, S., Liang, J., Wu, G., Del-Carpio Munoz, F., Chen, H. H., Friedman, P. A. & Cha, Y-M., Jan 1 2018, (Accepted/In press) In : PACE - Pacing and Clinical Electrophysiology.

Research output: Contribution to journalArticle

1 Scopus citations

Cardiac Versus Renal Response to Volume Expansion in Preclinical Systolic Dysfunction With PDEV Inhibition and BNP

Wan, S. H., Torres-Courchoud, I., McKie, P. M., Slusser, J. P., Redfield, M. M., Burnett, J. C., Hodge, D. O. & Chen, H. H., Dec 2019, In : JACC: Basic to Translational Science. 4, 8, p. 962-972 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Cardiorenal rescue study in acute decompensated heart failure: Rationale and design of CARRESS-HF, for the heart failure clinical research network

Bart, B. A., Goldsmith, S. R., Lee, K. L., Redfield, M. M., Felker, G. M., O'Connor, C. M., Chen, H. H., Rouleau, J. L., Givertz, M. M., Semigran, M. J., Mann, D., Deswal, A., Bull, D. A., Lewinter, M. M. & Braunwald, E., Mar 2012, In : Journal of Cardiac Failure. 18, 3, p. 176-182 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Cardiotrophin-1 stimulation of cardiac fibroblast growth: Roles for glycoprotein 130/leukemia inhibitory factor receptor and the endothelin type A receptor

Tsuruda, T., Jougasaki, M., Boerrigter, G., Huntley, B. K., Chen, H. H., D'Assoro, A. B., Lee, S. C., Larsen, A. M., Cataliotti, A. & Burnett, J. C., Feb 8 2002, In : Circulation research. 90, 2, p. 128-134 7 p.

Research output: Contribution to journalArticle

76 Scopus citations

CD-NP: A Novel Engineered Dual Guanylyl Cyclase Activator with Anti-Fibrotic Actions in the Heart

Martin, F. L., Sangaralingham, S. J., Huntley, B. K., McKie, P. M., Ichiki, T., Chen, H. H., Korinek, J., Harders, G. E. & Burnett, J. C., Dec 18 2012, In : PloS one. 7, 12, e52422.

Research output: Contribution to journalArticle

41 Scopus citations

Cell surface protein disulfide isomerase regulates natriuretic peptide generation of cyclic guanosine monophosphate

Pan, S., Chen, H. H., Correia, C., Dai, H., Witt, T. A., Kleppe, L. S., Burnett, J. C. & Simari, R. D., Nov 24 2014, In : PloS one. 9, 11, e112986.

Research output: Contribution to journalArticle

3 Scopus citations

Cenderitide-Eluting Film for Potential Cardiac Patch Applications

Ng, X. W., Huang, Y., Chen, H. H., Burnett, J. C., Boey, F. Y. C. & Venkatraman, S. S., Jul 4 2013, In : PloS one. 8, 7, e68346.

Research output: Contribution to journalArticle

9 Scopus citations
9 Scopus citations

Changes in Diastolic Dysfunction in Diabetes Mellitus Over Time

From, A. M., Scott, C. G. & Chen, H. H., May 15 2009, In : American Journal of Cardiology. 103, 10, p. 1463-1466 4 p.

Research output: Contribution to journalArticle

103 Scopus citations

Chronic actions of a novel oral B-type natriuretic peptide conjugate in normal dogs and acute actions in angiotensin II-mediated hypertension

Cataliotti, A., Chen, H. H., Schirger, J. A., Martin, F. L., Boerrigter, G., Costello-Boerrigter, L. C., James, K. D., Polowy, K., Miller, M. A., Malkar, N. B., Bailey, K. R. & Burnett, J. C., Oct 21 2008, In : Circulation. 118, 17, p. 1729-1736 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Chronic Peptide Therapy With B-Type Natriuretic Peptide in Patients With Pre-Clinical Diastolic Dysfunction (Stage B Heart Failure)

Wan, S. H., McKie, P. M., Schirger, J. A., Slusser, J. P., Hodge, D. O., Redfield, M. M., Burnett, J. C. & Chen, H. H., Jul 1 2016, In : JACC: Heart Failure. 4, 7, p. 539-547 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Chronic subcutaneous brain natriuretic peptide therapy in asymptomatic systolic heart failure

McKie, P. M., Schirger, J. A., Benike, S. L., Harstad, L. K., Slusser, J. P., Hodge, D. O., Redfield, M. M., Burnett, J. C. & Chen, H. H., Apr 1 2016, In : European Journal of Heart Failure. 18, 4, p. 433-441 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Circulating C-Type Natriuretic Peptide and Its Relationship to Cardiovascular Disease in the General Population

Sangaralingham, S. J., McKie, P. M., Ichiki, T., Scott, C. G., Heublein, D. M., Chen, H. H., Bailey, K. R., Redfield, M. M., Rodeheffer, R. J. & Burnett, J. C., Jun 20 2015, In : Hypertension. 65, 6, p. 1187-1194 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Clinical application of the natriuretic peptides in heart failure

Chen, H. H. & Burnett, J. C., Sep 1 2006, In : European Heart Journal, Supplement. 8, E, p. E18-E25

Research output: Contribution to journalReview article

22 Scopus citations
2 Scopus citations
164 Scopus citations

Dapagliflozin effects on biomarkers, symptoms, and functional status in patients with heart failure with reduced ejection fraction

DEFINE-HF Trial, Oct 2019, In : Circulation. 140, 18, 042929.

Research output: Contribution to journalArticle

38 Scopus citations

Diabetes Mellitus Is an Independent Predictor for the Development of Heart Failure: A Population Study

Klajda, M. D., Scott, C. G., Rodeheffer, R. J. & Chen, H. H., Jan 2020, In : Mayo Clinic proceedings. 95, 1, p. 124-133 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
126 Scopus citations

Differential actions of vasopeptidase inhibition versus angiotensin-converting enzyme inhibition on diuretic therapy in experimental congestive heart failure

Cataliotti, A., Boerrigter, G., Chen, H. H., Jougasaki, M., Costello, L. C., Tsuruda, T., Lee, S. C., Malatino, L. S. & Burnett, J. C., Feb 5 2002, In : Circulation. 105, 5, p. 639-644 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Differential response to low-dose dopamine or low-dose nesiritide in acute heart failure with reduced or preserved ejection fraction

Wan, S. H., Stevens, S. R., Borlaug, B. A., Anstrom, K. J., Deswal, A., Felker, G. M., Givertz, M. M., Bart, B. A., Tang, W. H. W., Redfield, M. M. & Chen, H. H., Aug 1 2016, In : Circulation: Heart Failure. 9, 8, e002593.

Research output: Contribution to journalArticle

22 Scopus citations

Distinct roles for renal particulate and soluble guanylyl cyclases in preserving renal function in experimental acute heart failure

Martin, F. L., Supaporn, T., Chen, H. H., Sandberg, S. M., Matsuda, Y., Jougasaki, M. & Burnett, J. C., Oct 1 2007, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 293, 4, p. R1580-R1585

Research output: Contribution to journalArticle

8 Scopus citations

Diuretic strategies in patients with acute decompensated heart failure

Felker, G. M., Lee, K. L., Bull, D. A., Redfield, M. M., Stevenson, L. W., Goldsmith, S. R., LeWinter, M. M., Deswal, A., Rouleau, J. L., Ofili, E. O., Anstrom, K. J., Hernandez, A. F., McNulty, S. E., Velazquez, E. J., Kfoury, A. G., Chen, H. H., Givertz, M. M., Semigran, M. J., Bart, B. A., Mascette, A. M. & 2 others, Braunwald, E. & O'Connor, C. M., Mar 3 2011, In : New England Journal of Medicine. 364, 9, p. 797-805 9 p.

Research output: Contribution to journalArticle

904 Scopus citations
3 Scopus citations

Effect of cardiac resynchronization therapy on broad neurohormone biomarkers in heart failure.

Dong, Y. X., Burnett, J. C., Chen, H. H., Sandberg, S., Yang, Y. Z., Zhang, Y., Chen, P. S. & Cha, Y. M., Apr 1 2011, In : Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. 30, 3, p. 241-249 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity among Patients with Heart Failure with Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial

Borlaug, B. A., Anstrom, K. J., Lewis, G. D., Shah, S. J., Levine, J. A., Koepp, G. A., Givertz, M. M., Felker, G. M., Lewinter, M. M., Mann, D. L., Margulies, K. B., Smith, A. L., Tang, W. H. W., Whellan, D. J., Chen, H. H., Davila-Roman, V. G., McNulty, S., Desvigne-Nickens, P., Hernandez, A. F., Braunwald, E. & 1 others, Redfield, M. M., Nov 6 2018, In : JAMA - Journal of the American Medical Association. 320, 17, p. 1764-1773 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: A randomized clinical trial

Redfield, M. M., Chen, H. H., Borlaug, B. A., Semigran, M. J., Lee, K. L., Lewis, G., LeWinter, M. M., Rouleau, J. L., Bull, D. A., Mann, D. L., Deswal, A., Stevenson, L. W., Givertz Elizabeth O Ofili, M. M., O'Connor, C. M., Felker, G. M., Goldsmith, S. R., Bart, B. A., McNulty, S. E., Ibarra, J. C., Lin, G. & 9 others, Oh, J. K., Patel, M. R., Kim, R. J., Tracy, R. P., Velazquez, E. J., Anstrom, K. J., Hernandez, A. F., Mascette, A. M. & Braunwald, E., Mar 27 2013, In : JAMA - Journal of the American Medical Association. 309, 12, p. 1268-1277 10 p.

Research output: Contribution to journalArticle

666 Scopus citations

Effects of Sildenafil on Ventricular and Vascular Function in Heart Failure with Preserved Ejection Fraction

Borlaug, B. A., Lewis, G. D., McNulty, S. E., Semigran, M. J., Lewinter, M., Chen, H., Lin, G., Deswal, A., Margulies, K. B. & Redfield, M. M., May 4 2015, In : Circulation: Heart Failure. 8, 3, p. 533-541 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Endogenous natriuretic peptides participate in renal and humoral actions of acute vasopeptidase inhibition in experimental mild heart failure

Chen, H. H., Lainchbury, J. G., Matsuda, Y., Harty, G. J. & Burnett, J. C., Jan 1 2001, In : Hypertension. 38, 2, p. 187-191 5 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

Endothelin A Receptor Antagonism in Experimental Congestive Heart Failure Results in Augmentation of the Renin-Angiotensin System and Sustained Sodium Retention

Schirger, J. A., Chen, H. H., Jougasaki, M., Lisy, O., Boerrigter, G., Cataliotti, A. & Burnett, J. C., Jan 20 2004, In : Circulation. 109, 2, p. 249-254 6 p.

Research output: Contribution to journalArticle

26 Scopus citations