Hirohito Kita, MD

  • 13400 E Shea Blvd, Mayo Clinic Arizona, MCCRB Room 2-213

    85259 Scottsdale

    United States

  • 14961 Citations
  • 68 Scopus h-Index
1984 …2020

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Research Output

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2003

Eosinophilic-lymphocytic myocarditis after smallpox vaccination

Murphy, J. G., Wright, R. S., Bruce, G. K., Baddour, L. M., Farrell, M. A., Edwards, W. D., Kita, H. & Cooper, L. T., Oct 25 2003, In : Lancet. 362, 9393, p. 1378-1380 3 p.

Research output: Contribution to journalArticle

47 Scopus citations
18 Scopus citations

Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: Is the histopathology similar to asthma?

Ponikau, J. U., Sherris, D. A., Kephart, G. M., Kern, E. B., Gaffey, T. A., Tarara, J. E. & Kita, H., Nov 2003, In : Journal of Allergy and Clinical Immunology. 112, 5, p. 877-882 6 p.

Research output: Contribution to journalArticle

187 Scopus citations

Human eosinophils are activated by cysteine proteases and release inflammatory mediators

Miike, S. & Kita, H., Apr 1 2003, In : Journal of Allergy and Clinical Immunology. 111, 4, p. 704-713 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice

Kobayashi, T., Iijima, K. & Kita, H., Jun 1 2003, In : Journal of Immunology. 170, 11, p. 5756-5763 8 p.

Research output: Contribution to journalArticle

Open Access
56 Scopus citations

Oxidized Low-Density Lipoprotein Activates Migration and Degranulation of Human Granulocytes

Sedgwick, J. B., Hwang, Y. S., Gerbyshak, H. A., Kita, H. & Busse, W. W., Dec 1 2003, In : American journal of respiratory cell and molecular biology. 29, 6, p. 702-709 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Regulation of eosinophil membrane depolarization during NADPH oxidase activation

Bankers-Fulbright, J. L., Gleich, G. J., Kephart, G. M., Kita, H. & O'Grady, S. M., Aug 1 2003, In : Journal of cell science. 116, 15, p. 3221-3226 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

The chemotactic behavior of eosinophils in patients with chronic rhinosinusitis

Wei, J. L., Kita, H., Sherris, D. A., Kern, E. B., Weaver, A. & Ponikau, J. U., Feb 1 2003, In : Laryngoscope. 113, 2, p. 303-306 4 p.

Research output: Contribution to journalArticle

43 Scopus citations

The effect of nasal polyp epithelial cells on eosinophil activation

Shin, S. H., Lee, S. H., Jeong, H. S. & Kita, H., Aug 1 2003, In : Laryngoscope. 113, 8, p. 1374-1377 4 p.

Research output: Contribution to journalArticle

32 Scopus citations
2002

Biological activities of ecalectin: A novel eosinophil-activating factor

Matsumoto, R., Hirashima, M., Kita, H. & Gleich, G. J., Feb 15 2002, In : Journal of Immunology. 168, 4, p. 1961-1967 7 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

Decreased expression of membrane IL-5 receptor α on human eosinophils: I. Loss of membrane IL-5 receptor α on airway eosinophils and increased soluble IL-5 receptor α in the airway after allergen challenge

Liu, L. Y., Sedgwick, J. B., Bates, M. E., Vrtis, R. F., Gern, J. E., Kita, H., Jarjour, N. N., Busse, W. W. & Kelly, E. A. B., Dec 1 2002, In : Journal of Immunology. 169, 11, p. 6452-6458 7 p.

Research output: Contribution to journalArticle

Open Access
148 Scopus citations

Decreased expression of membrane IL-5 receptor α on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process

Liu, L. Y., Sedgwick, J. B., Bates, M. E., Vrtis, R. F., Gern, J. E., Kita, H., Jarjour, N. N., Busse, W. W. & Kelly, E. A. B., Dec 1 2002, In : Journal of Immunology. 169, 11, p. 6459-6466 8 p.

Research output: Contribution to journalArticle

104 Scopus citations

Detection of fungal organisms in eosinophilic mucin using a fluorescein-labeled chitin-specific binding protein

Taylor, M. J., Ponikau, J. U., Sherris, D. A., Kern, E. B., Gaffey, T. A., Kephart, G. & Kita, H., Nov 1 2002, In : Otolaryngology - Head and Neck Surgery. 127, 5, p. 377-383 7 p.

Research output: Contribution to journalArticle

96 Scopus citations

Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli

Kobayashi, H., Gleich, G. J., Butterfield, J. H. & Kita, H., Mar 15 2002, In : Blood. 99, 6, p. 2214-2220 7 p.

Research output: Contribution to journalArticle

137 Scopus citations

Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis

Ponikau, J. U., Sherris, D. A., Kita, H. & Kern, E. B., Dec 1 2002, In : Journal of Allergy and Clinical Immunology. 110, 6, p. 862-866 5 p.

Research output: Contribution to journalArticle

180 Scopus citations

Platelet-activating factor activates two distinct effector pathways in human eosinophils

Kato, M., Kimura, H., Motegi, Y., Tachibana, A., Minakami, H., Morikawa, A. & Kita, H., Nov 1 2002, In : Journal of Immunology. 169, 9, p. 5252-5259 8 p.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations

Removal of bronchoalveolar cells augments the late eosinophilic response to segmental allergen challenge

Hunt, L. W., Gleich, G. J., Kita, H., Weiler, D. A., Schroeder, D. R., Vuk Pavlovic, Z. & Sur, S., May 4 2002, In : Clinical and Experimental Allergy. 32, 2, p. 210-216 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

School examinations enhance airway inflammation to antigen challenge

Liu, L. Y., Coe, C. L., Swenson, C. A., Kelly, E. A., Kita, H. & Busse, W. W., Apr 15 2002, In : American journal of respiratory and critical care medicine. 165, 8, p. 1062-1067 6 p.

Research output: Contribution to journalArticle

209 Scopus citations
2001

Bile acids induce eosinophil degranulation by two different mechanisms

Yamazaki, K., Gleich, G. J. & Kita, H., 2001, In : Hepatology. 33, 3, p. 582-590 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cysteine protease secreted by Paragonimus westermani attenuates effector functions of human eosinophils stimulated with immunoglobulin G

Myeong Heon Shin, H. S., Kita, H., Hae Young Park, Y. P. & Ju Young Seoh, Y. S., Mar 14 2001, In : Infection and Immunity. 69, 3, p. 1599-1604 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Eosinophil-associated inflammation and elaboration of eosinophil-derived proteins in 2 children with raccoon roundworm (Baylisascaris procyonis) encephalitis.

Moertel, C. L., Kazacos, K. R., Butterfield, J. H., Kita, H., Watterson, J. & Gleich, G. J., Nov 2001, In : Pediatrics. 108, 5, p. E93

Research output: Contribution to journalArticle

31 Scopus citations

Regulation of human eosinophil NADPH oxidase activity: A central role for PKCδ

Bankers-Fulbright, J. L., Kita, H., Gleich, G. J. & O'Grady, S. M., Nov 26 2001, In : Journal of Cellular Physiology. 189, 3, p. 306-315 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2

Miike, S., McWilliam, A. S. & Kita, H., Dec 1 2001, In : Journal of Immunology. 167, 11, p. 6615-6622 8 p.

Research output: Contribution to journalArticle

Open Access
119 Scopus citations
2000

Ligation of IgE receptors causes an anaphylactic response and neutrophil infiltration but does not induce eosinophilic inflammation in mice

Kaneko, M., Schimming, A., Gleich, G. J. & Kita, H., Jan 1 2000, In : Journal of Allergy and Clinical Immunology. 105, 6 II, p. 1202-1210 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mechanism of topical glucocorticoid treatment of hay fever: IL-5, and eosinophil activation during natural allergen exposure are suppressed, but IL-4, IL-6, and IgE antibody production are unaffected

Kita, H., Jorgensen, R. K., Reed, C. E., Dunnette, S. L., Swanson, M. C., Bartemes, K. R., Squillace, D., Blomgren, J., Bachman, K. & Gleich, G. J., Jan 1 2000, In : Journal of Allergy and Clinical Immunology. 106, 3, p. 521-529 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Role of secretory IgA, secretory component, and eosinophils in mucosal inflammation

Motegi, Y., Kita, H., Kato, M. & Morikawa, A., Jan 1 2000, In : International archives of allergy and immunology. 122, SUPPL. 1, p. 25-27 3 p.

Research output: Contribution to journalArticle

32 Scopus citations

Stimulation of the β2 integrin α(M)β2, triggers tyrosine phosphorylation and cellular degranulation on human eosinophils

Kato, M., Kita, H., Kimura, H., Tachibana, A., Motegi, Y., Tokuyama, K. & Morikawa, A., Jan 1 2000, In : International archives of allergy and immunology. 122, SUPPL. 1, p. 33-35 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

The relationship of sputum eosinophilia and sputum cell generation of IL-5

Liu, L. Y., Swensen, C. A., Kelly, E. A. B., Kita, H. & Busse, W. W., Jan 1 2000, In : Journal of Allergy and Clinical Immunology. 106, 6, p. 1063-1069 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

β2 integrin-dependent tyrosine phosphorylation of proline-rich tyrosine kinase 2 in platelet-activating factor-activated eosinophils

Ohashi, H., Takei, M., Kita, H., Gleich, G. J., Serizawa, I. & Fukamachi, H., Jan 1 2000, In : Allergology International. 49, 4, p. 245-252 8 p.

Research output: Contribution to journalArticle

1999

Does IgE bind to and activate eosinophils from patients with allergy?

Kita, H., Kaneko, M., Bartemes, K. R., Weiler, D. A., Schimming, A. W., Reed, C. E. & Gleich, G. J., Jun 1 1999, In : Journal of Immunology. 162, 11, p. 6901-6911 11 p.

Research output: Contribution to journalArticle

88 Scopus citations

Endogenous platelet-activating factor is critically involved in effector functions of eosinophils stimulated with IL-5 or IgG

Bartemes, K. R., McKinney, S., Gleich, G. J. & Kita, H., Mar 1 1999, In : Journal of Immunology. 162, 5, p. 2982-2989 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

Eosinophilia in a 23-year-old woman with asthma

Sanico, A. M., Kita, H., Leiferman, K. M. & Saini, S. S., Sep 1999, In : Annals of Allergy, Asthma and Immunology. 83, 3, p. 193-199 7 p.

Research output: Contribution to journalArticle

Intracellular signaling pathways in human eosinophil activation: Role of a β2 integrin, α(M)β2

Kato, M., Kimura, H., Tachibana, A., Motegi, Y., Tokuyama, K., Kita, H. & Morikawa, A., Oct 8 1999, In : International archives of allergy and immunology. 120, SUPPL. 1, p. 51-53 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Ligation of FcγRII (CD32) pivotally regulates survival of human eosinophils

Kim, J. T., Schimming, A. W. & Kita, H., Apr 1 1999, In : Journal of Immunology. 162, 7, p. 4253-4259 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Localization of eosinophil-derived neurotoxin and eosinophil cationic protein in neutrophilic leukocytes

Sur, S., Glitz, D. G., Kita, H., Kujawa, S. M., Peterson, E. A., Weiler, D. A., Kephart, G. M., Wagner, J. M., George, T. J., Gleich, G. J. & Leiferman, K. M., Jan 1 1999, In : International archives of allergy and immunology. 118, 2-4, p. 255-258 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Reactivity of monoclonal antibodies EG1 and EG2 with eosinophils and their granule proteins

Nakajima, H., Loegering, D. A., Kita, H., Kephart, G. M. & Gleich, G. J., Jan 1 1999, In : Journal of Leukocyte Biology. 66, 3, p. 447-454 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Ursodeoxycholic acid inhibits eosinophil degranulation in patients with primary biliary cirrhosis

Yamazaki, K., Suzuki, K., Nakamura, A., Sato, S., Llndor, K. D., Batts, K. P., Tarara, J. E., Kephart, G. M., Kita, H. & Gleich, G. J., 1999, In : Hepatology. 30, 1, p. 71-78 8 p.

Research output: Contribution to journalArticle

55 Scopus citations
1998

Cross-linking of the β2 integrin, CD11b/CD18, on human eosinophils induces protein tyrosine phosphorylation and cellular degranulation

Kato, M., Kita, H., Tokuyama, K. & Morikwa, A., Sep 1998, In : International archives of allergy and immunology. 117, SUPPL. 1, p. 68-71 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms

Levy, A. M., Kita, H., Phillips, S. F., Schkade, P. A., Dyer, P. D., Gleich, G. J. & Dubravec, V. A., Jan 1 1998, In : Journal of Allergy and Clinical Immunology. 101, 5, p. 613-620 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Granulocyte macrophage colony-stimulating factor augments ICAM-1 and VCAM-1 activation of eosinophil function

Nagata, M., Sedgwick, J. B., Kita, H. & Busse, W. W., Jan 1 1998, In : American journal of respiratory cell and molecular biology. 19, 1, p. 158-166 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

Inhibition of interleukin-5 mediated eosinophil viability by fluticasone 17-propionate: Comparison with other glucocorticoids

Hagan, J. B., Kita, H. & Gleich, G. J., Sep 9 1998, In : Clinical and Experimental Allergy. 28, 8, p. 999-1006 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Interaction with secretory component stimulates effector functions of human eosinophils but not of neutrophils

Motegi, Y. & Kita, H., Oct 15 1998, In : Journal of Immunology. 161, 8, p. 4340-4346 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

Lidocaine and its analogues inhibit IL-5-mediated survival and activation of human eosinophils

Okada, S., Hagan, J. B., Kato, M., Bankers-Fulbright, J. L., Hunt, L. W., Gleich, G. J. & Kita, H., Apr 15 1998, In : Journal of Immunology. 160, 8, p. 4010-4017 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Ligation of the β2 integrin triggers activation and degranulation of human eosinophils

Kato, M., Abraham, R. T., Okada, S. & Kita, H., Jan 1 1998, In : American journal of respiratory cell and molecular biology. 18, 5, p. 675-686 12 p.

Research output: Contribution to journalArticle

65 Scopus citations

Localization of eosinophil-derived neurotoxin and eosinophil cationic protein in neutrophilic leukocytes

Sur, S., Glitz, D. G., Kita, H., Kujawa, S. M., Peterson, E. A., Weiler, D. A., Kephart, G. M., Wagner, J. M., George, T. J., Gleich, G. J. & Leiferman, K. M., Jun 1998, In : Journal of Leukocyte Biology. 63, 6, p. 715-722 8 p.

Research output: Contribution to journalArticle

113 Scopus citations

Signal transduction in activation of human eosinophils: G protein-dependent and -independent pathways

Kato, M., Kita, H., Tokuyama, K. & Morikawa, A., Sep 1 1998, In : International archives of allergy and immunology. 117, SUPPL. 1, p. 63-67 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Sulfonylureas inhibit cytokine-induced eosinophil survival and activation

Bankers-Fulbright, J. L., Kephart, G. M., Loegering, D. A., Bradford, A. L., Okada, S., Kita, H. & Gleich, G. J., Jun 1 1998, In : Journal of Immunology. 160, 11, p. 5546-5553 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Sulochrin inhibits eosinophil activation and chemotaxis

Ohashi, H., Motegi, Y., Kita, H., Gleich, G. J., Miura, T., Ishikawa, M., Kawai, H. & Fukamachi, H., Nov 10 1998, In : Inflammation Research. 47, 10, p. 409-415 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
1997

Migration of Eosinophils through Basement Membrane Components in Vitro: Role of Matrix Metalloproteinase-9

Okada, S., Kita, H., George, T. J., Gleich, G. J. & Leiferman, K. M., Jan 1 1997, In : American journal of respiratory cell and molecular biology. 17, 4, p. 519-528 10 p.

Research output: Contribution to journalArticle

228 Scopus citations

Production of IL-8 and Release of Eosinophil-Derived Neurotoxin by Normal Peripheral Blood Eosinophils

Nakajima, H., Gleich, G. J., Fukuda, T., Makino, S. & Kita, H., Jan 1 1997, In : International archives of allergy and immunology. 114, 1, p. 36-39 4 p.

Research output: Contribution to journalArticle

4 Scopus citations