Hirohito Kita, MD

  • 13400 E Shea Blvd, Mayo Clinic Arizona, MCCRB Room 2-213

    85259 Scottsdale

    United States

  • 14965 Citations
  • 68 Scopus h-Index
1984 …2020

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Research Output

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Article
2009

Extensive fractionation and identification of proteins within nasal lavage fluids from allergic rhinitis and asthmatic chronic rhinosinusitis patients

Benson, L. M., Mason, C. J., Friedman, O., Kita, H., Bergen, H. R. & Plager, D. A., Jan 1 2009, In : Journal of Separation Science. 32, 1, p. 44-56 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

IL-33-activated dendritic cells induce an atypical TH2-type response

Rank, M. A., Kobayashi, T., Kozaki, H., Bartemes, K. R., Squillace, D. L. & Kita, H., May 1 2009, In : Journal of Allergy and Clinical Immunology. 123, 5, p. 1047-1054 8 p.

Research output: Contribution to journalArticle

250 Scopus citations

Pimecrolimus reduces eosinophil activation associated with calcium mobilization

Plager, D. A., Henke, S. A., Matsuwaki, Y., Madaan, A., Squillace, D. L., Dierkhising, R. A. & Kita, H., May 1 2009, In : International archives of allergy and immunology. 149, 2, p. 119-126 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2

Kouzaki, H., O'Grady, S. M., Lawrence, C. B. & Kita, H., Jul 15 2009, In : Journal of Immunology. 183, 2, p. 1427-1434 8 p.

Research output: Contribution to journalArticle

235 Scopus citations

Protein microarray analysis in patients with asthma: Elevation of the chemokine PARC/CCL18 in sputum

Kim, H. B., Kim, C. K., Iijima, K., Kobayashi, T. & Kita, H., Feb 2009, In : Chest. 135, 2, p. 295-302 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils

Matsuwaki, Y., Wada, K., White, T. A., Benson, L. M., Charlesworth, M. C., Checkel, J. L., Inoue, Y., Hotta, K., Ponikau, J. U., Lawrence, C. B. & Kita, H., Nov 15 2009, In : Journal of Immunology. 183, 10, p. 6708-6716 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Regulation of TLR2 expression and function in human airway epithelial cells

Melkamu, T., Squillace, D., Kita, H. & O'Grady, S. M., May 1 2009, In : Journal of Membrane Biology. 229, 2, p. 101-113 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

β2-integrin-mediated adhesion and intracellular Ca 2+ release in human eosinophils

Bankers-Fulbright, J. L., Bartemes, K. R., Kephart, G. M., Kita, H. & O'Grady, S. M., Mar 1 2009, In : Journal of Membrane Biology. 228, 2, p. 99-109 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2008
10 Scopus citations

A novel IL-1 family cytokine, IL-33, potently activates human eosinophils

Cherry, W. B., Yoon, J., Bartemes, K. R., Iijima, K. & Kita, H., Jun 1 2008, In : Journal of Allergy and Clinical Immunology. 121, 6, p. 1484-1490 7 p.

Research output: Contribution to journalArticle

340 Scopus citations

Blood and sputum eosinophil levels in asthma and their relationship to sinus computed tomographic findings

Mehta, V., Campeau, N. G., Kita, H. & Hagan, J. B., Jun 2008, In : Mayo Clinic proceedings. 83, 6, p. 671-678 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Cigarette smoke-induced oxidative stress suppresses generation of dendritic cell IL-12 and IL-23 through ERK-dependent pathways

Kroening, P. R., Barnes, T. W., Pease, L., Limper, A., Kita, H. & Vassallo, R., Jul 15 2008, In : Journal of Immunology. 181, 2, p. 1536-1547 12 p.

Research output: Contribution to journalArticle

Open Access
67 Scopus citations

Increased risk of serious pneumococcal disease in patients with asthma

Juhn, Y. J., Kita, H., Yawn, B. P., Boyce, T. G., Yoo, K. H., McGree, M. E., Weaver, A. L., Wollan, P. & Jacobson, R. M., Oct 1 2008, In : Journal of Allergy and Clinical Immunology. 122, 4, p. 719-723 5 p.

Research output: Contribution to journalArticle

123 Scopus citations

Innate antifungal immunity of human eosinophils mediated by a β2 integrin, CD11b

Yoon, J., Ponikau, J. U., Lawrence, C. B. & Kita, H., Aug 15 2008, In : Journal of Immunology. 181, 4, p. 2907-2915 9 p.

Research output: Contribution to journalArticle

Open Access
66 Scopus citations

Innate immunomodulatory effects of cereal grains through induction of IL-10

Yamazaki, K., Murray, J. A. & Kita, H., Jan 2008, In : Journal of Allergy and Clinical Immunology. 121, 1, p. 172-178.e3

Research output: Contribution to journalArticle

17 Scopus citations

Nicotine and oxidative cigarette smoke constituents induce immune-modulatory and pro-inflammatory dendritic cell responses

Vassallo, R., Kroening, P. R., Parambil, J. & Kita, H., Jul 1 2008, In : Molecular Immunology. 45, 12, p. 3321-3329 9 p.

Research output: Contribution to journalArticle

76 Scopus citations

Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase

Ulrich, M., Petre, A., Youhnovski, N., Prömm, F., Schirle, M., Schumm, M., Pero, R. S., Doyle, A., Checkel, J., Kita, H., Thiyagarajan, N., Acharya, K. R., Schmid-Grendelmeier, P., Simon, H. U., Schwarz, H., Tsutsui, M., Shimokawa, H., Bellon, G., Lee, J. J., Przybylski, M. & 1 others, Döring, G., Oct 17 2008, In : Journal of Biological Chemistry. 283, 42, p. 28629-28640 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Preoperative evaluation of patients with history of allergy to penicillin: Comparison of 2 models of practice

Frigas, E., Park, M. A., Narr, B. J., Volcheck, G. W., Danielson, D. R., Markus, P. J., Olson, K. E. K., Schroeder, D. R. & Kita, H., Jun 2008, In : Mayo Clinic proceedings. 83, 6, p. 651-657 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

Role of CD38 in TNF-α-induced airway hyperresponsiveness

Guedes, A. G. P., Jude, J. A., Paulin, J., Kita, H., Lund, F. E. & Kannan, M. S., Feb 1 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 2, p. L290-L299

Research output: Contribution to journalArticle

38 Scopus citations

T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation

Heckman, K. L., Radhakrishnan, S., Peikert, T., Iijima, K., McGregor, H. C., Bell, M. P., Kita, H. & Pease, L. R., Sep 1 2008, In : European Journal of Immunology. 38, 9, p. 2464-2474 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
2007

CD66b regulates adhesion and activation of human eosinophils

Yoon, J., Terada, A. & Kita, H., Dec 15 2007, In : Journal of Immunology. 179, 12, p. 8454-8462 9 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Childhood asthma and human leukocyte antigen type

Juhn, Y. J., Kita, H., Lee, L. A., Smith, R. W., Bagniewski, S. M., Weaver, A. L., Pankratz, V. S., Jacobson, R. M. & Poland, G. A., Jan 1 2007, In : Tissue Antigens. 69, 1, p. 38-46 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Phase I trial of sirolimus combined with radiation and cisplatin in non-small cell lung cancer

Sarkaria, J. N., Schwingler, P., Schild, S. E., Grogan, P. T., Mladek, A. C., Mandrekar, S. J., Tan, A. D., Kobayashi, T., Marks, R. S., Kita, H., Miller, R. C., Limper, A. H. & Leof, E. B., Aug 1 2007, In : Journal of Thoracic Oncology. 2, 8, p. 751-757 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Severity of childhood asthma and human leukocyte antigens type

Juhn, Y. J., Kita, H., Bagniewski, S. M., Weaver, A. L., Pankratz, V. S., Jacobson, R. M. & Poland, G. A., Apr 1 2007, In : Journal of Asthma. 44, 3, p. 163-168 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
20 Scopus citations
2006

A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils

Logan, M. R., Lacy, P., Odemuyiwa, S. O., Steward, M., Davoine, F., Kita, H. & Moqbel, R., Jun 1 2006, In : Allergy: European Journal of Allergy and Clinical Immunology. 61, 6, p. 777-784 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

Allergen-specific in vitro cytokine production in adult patients with eosinophilic esophagitis

Yamazaki, K., Murray, J. A., Arora, A. S., Alexander, J. A., Smyrk, T. C., Butterfield, J. H. & Kita, H., Nov 2006, In : Digestive diseases and sciences. 51, 11, p. 1934-1941 8 p.

Research output: Contribution to journalArticle

71 Scopus citations

CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge

Guedes, A. G. P., Paulin, J., Rivero-Nava, L., Kita, H., Lund, F. E. & Kannan, M. S., Dec 1 2006, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 291, 6, p. L1286-L1293

Research output: Contribution to journalArticle

47 Scopus citations

Childhood asthma and measles vaccine response

Juhn, Y. J., Kita, H., Lee, L. A., Swanson, R. J., Smith, R., Bagniewski, S. M., Weaver, A. L., Pankratz, V. S., Jacobson, R. M. & Poland, G. A., Oct 2006, In : Annals of Allergy, Asthma and Immunology. 97, 4, p. 469-476 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Immunomodulation using the recombinant monoclonal human B7-DC cross-linking antibody rHIgM12

Van Keulen, V. P., Ciric, B., Radhakrishnan, S., Heckman, K. L., Mitsunaga, Y., Iijima, K., Kita, H., Rodriguez, M. & Pease, L. R., Feb 1 2006, In : Clinical and Experimental Immunology. 143, 2, p. 314-321 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Intranasal exposure to bacterial superantigens induces airway inflammation in HLA class II transgenic mice

Rajagopalan, G., Iijima, K., Singh, M., Kita, H., Patel, R. & David, C. S., Feb 2006, In : Infection and Immunity. 74, 2, p. 1284-1296 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Intranasal exposure to staphylococcal enterotoxin B elicits an acute systemic inflammatory response

Rajagopalan, G., Sen, M. M., Singh, M., Murali, N. S., Nath, K. A., Iijima, K., Kita, H., Leontovich, A. A., Gopinathan, U., Patel, R. & David, C. S., Jun 2006, In : Shock. 25, 6, p. 647-656 10 p.

Research output: Contribution to journalArticle

47 Scopus citations
2005

Degranulation of human eosinophils induced by Paragonimus westermani-secreted protease.

Shin, M. H., Chung, Y. B. & Kita, H., Mar 2005, In : The Korean journal of parasitology. 43, 1, p. 33-37 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Dendritic cells activated by cross-linking B7-DC (PD-L2) block inflammatory airway disease

Radhakrishnan, S., Iijima, K., Kobayashi, T., Kita, H. & Pease, L. R., Sep 2005, In : Journal of Allergy and Clinical Immunology. 116, 3, p. 668-674 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Effects of (R)- and (S)-isomers of β-adrenergic agonists on eosinophil response to interleukin-5

Volcheck, G. W., Kelkar, P., Bartemes, K. R., Gleich, G. J. & Kita, H., Oct 1 2005, In : Clinical and Experimental Allergy. 35, 10, p. 1341-1346 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Effects of the very late adhesion molecule 4 antagonist WAY103 on human peripheral blood eosinophil vascular cell adhesion molecule 1-dependent functions

Sedgwick, J. B., Jansen, K. J., Kennedy, J. D., Kita, H. & Busse, W. W., Oct 1 2005, In : Journal of Allergy and Clinical Immunology. 116, 4, p. 812-819 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Nonpathogenic, environmental fungi induce activation and degranulation of human eosinophils

Inoue, Y., Matsuwaki, Y., Shin, S. H., Ponikau, J. U. & Kita, H., Oct 15 2005, In : Journal of Immunology. 175, 8, p. 5439-5447 9 p.

Research output: Contribution to journalArticle

Open Access
110 Scopus citations

Secretory IgA induces antigen-independent eosinophil survival and cytokine production without inducing effector functions

Bartemes, K. R., Cooper, K. M., Drain, K. L. & Kita, H., Oct 1 2005, In : Journal of Allergy and Clinical Immunology. 116, 4, p. 827-835 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Striking deposition of toxic eosinophil major basic protein in mucus: Implications for chronic rhinosinusitis

Ponikau, J. U., Sherris, D. A., Kephart, G. M., Kern, E. B., Congdon, D. J., Adolphson, C. R., Springett, M. J., Gleich, G. J. & Kita, H., Aug 1 2005, In : Journal of Allergy and Clinical Immunology. 116, 2, p. 362-369 8 p.

Research output: Contribution to journalArticle

94 Scopus citations

The synthetic chemoattractant peptide WKYMVm induces superoxide production by human eosinophils via the phosphoinositide 3-kinase-mediated activation of ERK1/2

Myeong, H. S., Lee, Y. A., Bae, Y. S., Kita, H., Kim, Y. & Sung, H. R., Jul 5 2005, In : International archives of allergy and immunology. 137, SUPPL., p. 21-26 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Treatment of chronic rhinosinusitis with intranasal amphotericin B: A randomized, placebo-controlled, double-blind pilot trial

Ponikau, J. U., Sherris, D. A., Weaver, A. & Kita, H., Jan 1 2005, In : Journal of Allergy and Clinical Immunology. 115, 1, p. 125-131 7 p.

Research output: Contribution to journalArticle

186 Scopus citations
2004

Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody

Radhakrishnan, S., Iijima, K., Kobayashi, T., Rodriguez, M., Kita, H. & Pease, L. R., Jul 15 2004, In : Journal of Immunology. 173, 2, p. 1360-1365 6 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Chronic rhinosinusitis: An enhanced immune response to ubiquitous airborne fungi

Shin, S. H., Ponikau, J. U., Sherris, D. A., Congdon, D., Frigas, E., Homburger, H. A., Swanson, M. C., Gleich, G. J. & Kita, H., Dec 1 2004, In : Journal of Allergy and Clinical Immunology. 114, 6, p. 1369-1375 7 p.

Research output: Contribution to journalArticle

217 Scopus citations

Covalent interaction between proform of eosinophil major basic protein (proMBP) and pregnancy-associated plasma protein-A (PAPP-A) is a cell-mediated event and required for proMBP inhibition of the catalytic activity of PAPP-A

Sivanandam, A. S., Mohan, S., Kapur, S., Kita, H., Lau, K. H. W., Bagi, G., Baylink, D. J. & Qin, X., Mar 15 2004, In : Archives of Biochemistry and Biophysics. 423, 2, p. 343-350 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Dual signaling and effector pathways mediate human eosinophil activation by platelet-activating factor

Kato, M., Kita, H., Tachibana, A., Hayashi, Y., Tsuchida, Y. & Kimura, H., Jun 15 2004, In : International archives of allergy and immunology. 134, SUPPL. 1, p. 37-43 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Peripheral blood eosinophils from patients with allergic asthma contain increased intracellular eosinophil-derived neurotoxin

Sedgwick, J. B., Vrtis, R. F., Jansen, K. J., Kita, H., Bartemes, K. & Busse, W. W., Sep 1 2004, In : Journal of Allergy and Clinical Immunology. 114, 3, p. 568-574 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Platelet-activating factor stimulates cytoplasmic alkalinization and granule acidification in human eosinophils

Bankers-Fulbright, J. L., Kephart, G. M., Bartemes, K. R., Kita, H. & O'Grady, S. M., Nov 15 2004, In : Journal of cell science. 117, 24, p. 5749-5757 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Studies on regulation of IGF (insulin-like growth factor)-binding protein (IGFBP) 4 proteolysis by pregnancy-associated plasma protein-A (PAPP-A) in cells treated with phorbol ester

Sivanandam, A. S., Mohan, S., Kita, H., Kapur, S., Chen, S. T., Linkhart, T. A., Bagi, G., Baylink, D. J. & Qin, X., Apr 1 2004, In : Biochemical Journal. 379, 1, p. 57-64 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Treatment of asthma with nebulized lidocaine: A randomized, placebo-controlled study

Hunt, L. W., Frigas, E., Butterfield, J. H., Kita, H., Blomgren, J., Dunnette, S. L., Offord, K. P. & Gleich, G. J., May 2004, In : Journal of Allergy and Clinical Immunology. 113, 5, p. 853-859 7 p.

Research output: Contribution to journalArticle

68 Scopus citations
2003

Comparison of the effects of repetitive low-dose and single-dose antigen challenge on airway inflammation

Liu, L. Y., Swenson, C. A., Kelly, E. A., Kita, H., Jarjour, N. N. & Busse, W. W., Apr 1 2003, In : Journal of Allergy and Clinical Immunology. 111, 4, p. 818-825 8 p.

Research output: Contribution to journalArticle

16 Scopus citations