Hirohito Kita, MD

  • 13400 E Shea Blvd, Mayo Clinic Arizona, MCCRB Room 2-213

    85259 Scottsdale

    United States

  • 14961 Citations
  • 68 Scopus h-Index
1984 …2020

Research output per year

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Research Output

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Article
10 Scopus citations

Accuracy, safety, and tolerability of tissue collection by cytosponge vs endoscopy for evaluation of eosinophilic esophagitis

Katzka, D. A., Geno, D. M., Ravi, A., Smyrk, T. C., Lao-Sirieix, P., Miramedi, A., Debiram, I., O'Donovan, M., Kita, H., Kephart, G. M., Kryzer, L. A., Camilleri, M., Alexander, J. A. & Fitzgerald, R. C., Jan 1 2015, In : Clinical Gastroenterology and Hepatology. 13, 1, p. 77-83.e2

Research output: Contribution to journalArticle

76 Scopus citations

A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils

Logan, M. R., Lacy, P., Odemuyiwa, S. O., Steward, M., Davoine, F., Kita, H. & Moqbel, R., Jun 1 2006, In : Allergy: European Journal of Allergy and Clinical Immunology. 61, 6, p. 777-784 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

A crucial role for β2 integrin in the activation of eosinophils stimulated by IgG

Kaneko, M., Horie, S., Kato, M., Gleich, G. J. & Kita, H., Jan 1 1995, In : Journal of Immunology. 155, 5, p. 2631-2641 11 p.

Research output: Contribution to journalArticle

81 Scopus citations

Administration of interleukin-2 (IL-2) results in increased plasma concentrations of IL-5 and eosinophilia in patients with cancer

Van Haelst Pisani, C., Kovach, J. S., Kita, H., Leiferman, K. M., Gleich, G. J., Silver, J. E., Dennin, R. & Abrams, J. S., 1991, In : Blood. 78, 6, p. 1538-1544 7 p.

Research output: Contribution to journalArticle

Open Access
85 Scopus citations

Advances in asthma, asthma-COPD overlap, and related biologics in 2018

Bacharier, L. B., Mori, A. & Kita, H., Oct 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 906-919 14 p.

Research output: Contribution to journalArticle

Airway epithelial anion secretion and barrier function following exposure to fungal aeroallergens: Role of oxidative stress

Zaidman, N. A., O’Grady, K. E., Patil, N., Milavetz, F., Maniak, P. J., Kita, H. & O’Grady, S. M., 2017, In : American Journal of Physiology - Cell Physiology. 313, 1, p. C68-C79

Research output: Contribution to journalArticle

5 Scopus citations

Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice

Dolence, J. J., Kobayashi, T., Iijima, K., Krempski, J., Drake, L. Y., Dent, A. L. & Kita, H., Oct 2018, In : Journal of Allergy and Clinical Immunology. 142, 4, p. 1144-1158.e8

Research output: Contribution to journalArticle

17 Scopus citations

Airway responsiveness in CD38-deficient mice in allergic airway disease: Studies with bone marrow chimeras

Guedes, A. G. P., Jude, J. A., Paulin, J., Rivero-Nava, L., Kita, H., Lund, F. E. & Kannan, M. S., 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 308, 5, p. L485-L493

Research output: Contribution to journalArticle

7 Scopus citations

Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory Mucosa

Hara, K., Iijima, K., Elias, M. K., Seno, S., Tojima, I., Kobayashi, T., Kephart, G. M., Kurabayashi, M. & Kita, H., May 1 2014, In : Journal of Immunology. 192, 9, p. 4032-4042 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

Allergen-specific IgG1 and IgG3 through FcγRII induce eosinophil degranulation

Kaneko, M., Swanson, M. C., Gleich, G. J. & Kita, H., Jun 1995, In : Journal of Clinical Investigation. 95, 6, p. 2813-2821 9 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

Allergen-specific in vitro cytokine production in adult patients with eosinophilic esophagitis

Yamazaki, K., Murray, J. A., Arora, A. S., Alexander, J. A., Smyrk, T. C., Butterfield, J. H. & Kita, H., Nov 2006, In : Digestive diseases and sciences. 51, 11, p. 1934-1941 8 p.

Research output: Contribution to journalArticle

71 Scopus citations
15 Scopus citations

Alternaria fungus induces the production of GM-CSF, interleukin-6 and interleukin-8 and calcium signaling in human airway epithelium through protease-activated receptor 2

Matsuwaki, Y., Wada, K., White, T., Moriyama, H. & Kita, H., May 1 2012, In : International archives of allergy and immunology. 158, SUPPL. 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

51 Scopus citations

Alternaria inhibits double-stranded RNA-induced cytokine production through toll-like receptor 3

Wada, K., Kobayashi, T., Matsuwaki, Y., Moriyama, H. & Kita, H., Apr 12 2013, In : International archives of allergy and immunology. 161, p. 75-83 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Alternaria inhibits double-stranded RNA-induced cytokines productions through TLR3

Wada, K., Kobayashi, T., Matsuwaki, Y., Moriyama, H. & Kita, H., Jul 1 2015, In : Practica Otologica, Supplement. 143, p. 117-126 10 p.

Research output: Contribution to journalArticle

Ammonium chloride exposure inhibits cytokine-mediated eosinophil survival

Ide, M., Weiler, D., Kita, H. & Gleich, G. J., Feb 10 1994, In : Journal of Immunological Methods. 168, 2, p. 187-196 10 p.

Research output: Contribution to journalArticle

72 Scopus citations

An 8-year-old boy with hypereosinophilic syndrome

Hosoki, K., Nagao, M., Iguchi, K., Ihara, T., Yamada, Y., Higashigawa, M., Kephart, G. M., Kita, H. & Fujisawa, T., Jun 1 2011, In : International archives of allergy and immunology. 155, SUPPL. 1, p. 117-122 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Analysis of fluticasone propionate in induced sputum by mass spectrometry

Hagan, J. B., Taylor, R. L., Kita, H. & Singh, R. J., Jul 1 2011, In : Allergy and Asthma Proceedings. 32, 4, p. e18-e21

Research output: Contribution to journalArticle

3 Scopus citations

Analysis of global gene expression changes in human bronchial epithelial cells exposed to spores of the allergenic fungus, Alternaria alternata

Babiceanu, M. C., Howard, B. A., Rumore, A. C., Kita, H. & Lawrence, C. B., 2013, In : Frontiers in Microbiology. 4, JUL

Research output: Contribution to journalArticle

8 Scopus citations

An immunologic test for chronic rhinosinusitis based on free intranasal eosinophilic major basic protein

Ponikau, J. U., Winter, L. A., Kephart, G. M., Squillace, D. L., Hershcovitch, M. D., Moon, S., Sherris, D. A., Kern, E. B., Gleich, G. J. & Kita, H., Jan 1 2015, In : International Forum of Allergy and Rhinology. 5, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

A novel IL-1 family cytokine, IL-33, potently activates human eosinophils

Cherry, W. B., Yoon, J., Bartemes, K. R., Iijima, K. & Kita, H., Jun 1 2008, In : Journal of Allergy and Clinical Immunology. 121, 6, p. 1484-1490 7 p.

Research output: Contribution to journalArticle

340 Scopus citations

Antigen-specific IgG and IgA, but not IgE, activate the effector functions of eosinophils in the presence of antigen

Muraki, M., Gleich, G. J. & Kita, H., Jan 1 2011, In : International archives of allergy and immunology. 154, 2, p. 119-127 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: A randomised, placebo-controlled, double-blind trial

Straumann, A., Conus, S., Grzonka, P., Kita, H., Kephart, G., Bussmann, C., Beglinger, C., Smith, D. A., Patel, J., Byrne, M. & Simon, H. U., Jan 1 2010, In : Gut. 59, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

346 Scopus citations

Application of a Natural Language Processing Algorithm to Asthma Ascertainment. An Automated Chart Review

Wi, C. I., Sohn, S., Rolfes, M. C., Seabright, A., Ryu, E., Voge, G., Bachman, K. A., Park, M., Kita, H., Croghan, I. T., Liu, H. D. & Juhn, Y. J., Aug 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 4, p. 430-437 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

A proposed model to study immunologic changes during chronic rhinosinusitis exacerbations: Data from a pilot study

Rank, M. A., Hagan, J. B., Samant, S. A. & Kita, H., Mar 1 2013, In : American Journal of Rhinology and Allergy. 27, 2, p. 98-101 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Asthma and antibodies to pneumococcal virulence proteins

Zhao, H., Jung, J. A., Briles, D. E., Kita, H., Tsigrelis, C. & Juhn, Y. J., Oct 1 2013, In : Infection. 41, 5, p. 927-934 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Asthma outcomes: Biomarkers

Szefler, S. J., Wenzel, S., Brown, R., Erzurum, S. C., Fahy, J. V., Hamilton, R. G., Hunt, J. F., Kita, H., Liu, A. H., Panettieri, R. A., Schleimer, R. P. & Minnicozzi, M., Mar 1 2012, In : Journal of Allergy and Clinical Immunology. 129, 3 SUPPL., p. S9-S23

Research output: Contribution to journalArticle

252 Scopus citations

Asthma-related environmental fungus, Alternaria, activates dendritic cells and produces potent TH2 adjuvant activity

Kobayashi, T., Iijima, K., Radhakrishnan, S., Mehta, V., Vassallo, R., Lawrence, C. B., Cyong, J. C., Pease, L. R., Oguchi, K. & Kita, H., Feb 15 2009, In : Journal of Immunology. 182, 4, p. 2502-2510 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

ATP drives eosinophil effector responses through P2 purinergic receptors

Kobayashi, T., Soma, T., Noguchi, T., Nakagome, K., Nakamoto, H., Kita, H. & Nagata, M., Sep 1 2015, In : Allergology International. 64, p. S30-S36 71.

Research output: Contribution to journalArticle

15 Scopus citations

ATP release and Ca2+ signalling by human bronchial epithelial cells following Alternaria aeroallergen exposure

O'Grady, S. M., Patil, N., Melkamu, T., Maniak, P. J., Lancto, C. & Kita, H., Sep 1 2013, In : Journal of Physiology. 591, 18, p. 4595-4609 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Automated chart review utilizing natural language processing algorithm for asthma predictive index

Kaur, H., Sohn, S., Wi, C. I., Ryu, E., Park, M. A., Bachman, K., Kita, H., Croghan, I., Castro-Rodriguez, J. A., Voge, G. A., Liu, H. & Juhn, Y. J., Feb 13 2018, In : BMC Pulmonary Medicine. 18, 1, 34.

Research output: Contribution to journalArticle

10 Scopus citations

Baseline gastrointestinal eosinophilia is common in oral immunotherapy subjects with IgE-mediated peanut allergy

Wright, B. L., Fernandez-Becker, N. Q., Kambham, N., Purington, N., Tupa, D., Zhang, W., Rank, M. A., Kita, H., Shim, K. P., Bunning, B. J., Doyle, A. D., Jacobsen, E. A., Boyd, S. D., Tsai, M., Maecker, H., Manohar, M., Galli, S. J., Nadeau, K. C. & Chinthrajah, R. S., Nov 22 2018, In : Frontiers in immunology. 9, NOV, 2624.

Research output: Contribution to journalArticle

10 Scopus citations

B cells play key roles in Th2-type airway immune responses in mice exposed to natural airborne allergens

Drake, L. Y., Iijima, K., Hara, K., Kobayashi, T., Kephart, G. M. & Kita, H., Mar 24 2015, In : PloS one. 10, 3, e0121660.

Research output: Contribution to journalArticle

11 Scopus citations

BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection

Zhu, B., Zhang, R., Li, C., Jiang, L., Xiang, M., Ye, Z., Kita, H., Melnick, A. M., Dent, A. L. & Sun, J., Jun 11 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 24, p. 11888-11893 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Bile acids induce eosinophil degranulation by two different mechanisms

Yamazaki, K., Gleich, G. J. & Kita, H., 2001, In : Hepatology. 33, 3, p. 582-590 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Biological activities of ecalectin: A novel eosinophil-activating factor

Matsumoto, R., Hirashima, M., Kita, H. & Gleich, G. J., Feb 15 2002, In : Journal of Immunology. 168, 4, p. 1961-1967 7 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody

Radhakrishnan, S., Iijima, K., Kobayashi, T., Rodriguez, M., Kita, H. & Pease, L. R., Jul 15 2004, In : Journal of Immunology. 173, 2, p. 1360-1365 6 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Blood and sputum eosinophil levels in asthma and their relationship to sinus computed tomographic findings

Mehta, V., Campeau, N. G., Kita, H. & Hagan, J. B., Jun 2008, In : Mayo Clinic proceedings. 83, 6, p. 671-678 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Calcitonin gene-related peptide and vascular endothelial growth factor are expressed in lesional but not uninvolved skin in chronic spontaneous urticaria

Kay, A. B., Ying, S., Ardelean, E., Mlynek, A., Kita, H., Clark, P. & Maurer, M., Aug 2014, In : Clinical and Experimental Allergy. 44, 8, p. 1053-1060 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

Yarova, P. L., Stewart, A. L., Sathish, V., Britt, R. D., Thompson, M. A., Lowe, A. P. P., Freeman, M., Aravamudan, B., Kita, H., Brennan, S. C., Schepelmann, M., Davies, T., Yung, S., Cholisoh, Z., Kidd, E. J., Ford, W. R., Broadley, K. J., Rietdorf, K., Chang, W., Bin Khayat, M. E. & 7 others, Ward, D. T., Corrigan, C. J., Ward, J. P. T., Kemp, P. J., Pabelick, C. M., Prakash, Y. S. & Riccardi, D., Apr 22 2015, In : Science translational medicine. 7, 284, p. 284ra58

Research output: Contribution to journalArticle

68 Scopus citations
184 Scopus citations

CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge

Guedes, A. G. P., Paulin, J., Rivero-Nava, L., Kita, H., Lund, F. E. & Kannan, M. S., Dec 1 2006, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 291, 6, p. L1286-L1293

Research output: Contribution to journalArticle

47 Scopus citations

CD66b regulates adhesion and activation of human eosinophils

Yoon, J., Terada, A. & Kita, H., Dec 15 2007, In : Journal of Immunology. 179, 12, p. 8454-8462 9 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J. F., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature communications. 8, 14532.

Research output: Contribution to journalArticle

307 Scopus citations

Cellular stress response to varicella-zoster virus infection of human skin includes highly elevated interleukin-6 expression

Jarosinski, K. W., Carpenter, J. E., Buckingham, E. M., Jackson, W., Knudtson, K., Moffat, J. F., Kita, H. & Grose, C., 2018, In : Open Forum Infectious Diseases. 5, 6

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Childhood asthma and human leukocyte antigen type

Juhn, Y. J., Kita, H., Lee, L. A., Smith, R. W., Bagniewski, S. M., Weaver, A. L., Pankratz, V. S., Jacobson, R. M. & Poland, G. A., Jan 1 2007, In : Tissue Antigens. 69, 1, p. 38-46 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Childhood asthma and measles vaccine response

Juhn, Y. J., Kita, H., Lee, L. A., Swanson, R. J., Smith, R., Bagniewski, S. M., Weaver, A. L., Pankratz, V. S., Jacobson, R. M. & Poland, G. A., Oct 2006, In : Annals of Allergy, Asthma and Immunology. 97, 4, p. 469-476 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Chronic rhinosinusitis: An enhanced immune response to ubiquitous airborne fungi

Shin, S. H., Ponikau, J. U., Sherris, D. A., Congdon, D., Frigas, E., Homburger, H. A., Swanson, M. C., Gleich, G. J. & Kita, H., Dec 1 2004, In : Journal of Allergy and Clinical Immunology. 114, 6, p. 1369-1375 7 p.

Research output: Contribution to journalArticle

217 Scopus citations

Cigarette smoke-induced oxidative stress suppresses generation of dendritic cell IL-12 and IL-23 through ERK-dependent pathways

Kroening, P. R., Barnes, T. W., Pease, L., Limper, A., Kita, H. & Vassallo, R., Jul 15 2008, In : Journal of Immunology. 181, 2, p. 1536-1547 12 p.

Research output: Contribution to journalArticle

Open Access
67 Scopus citations