Harold Robert (Bob) III Bergen

2020

Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease

Tischer, A., Brehm, M. A., Machha, V. R., Moon-Tasson, L., Benson, L. M., Nelton, K. J., Leger, R. R., Obser, T., Martinez-Vargas, M., Whitten, S. T., Chen, D., Pruthi, R. K., Bergen, H. R., Cruz, M. A., Schneppenheim, R. & Auton, M., Jan 17 2020, In: Journal of Molecular Biology. 432, 2, p. 305-323 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2017

Aggregation of full-length immunoglobulin light chains from systemic light chain amyloidosis (AL) patients is remodeled by epigallocatechin-3-gallate

Andrich, K., Hegenbart, U., Kimmich, C., Kedia, N., Bergen, H. R., Schönland, S., Wanker, E. & Bieschke, J., Feb 10 2017, In: Journal of Biological Chemistry. 292, 6, p. 2328-2344 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Mitochondrial integrity and function in the progression of early pressure overload–induced left ventricular remodeling

Chaanine, A. H., Nair, K. S., Bergen, R. H., Klaus, K., Guenzel, A. J., Hajjar, R. J. & Redfield, M. M., 2017, In: Journal of the American Heart Association. 6, 6, e005869.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Phosphatidylserine stimulates ceramide 1-phosphate (C1P) intermembrane transfer by C1P transfer proteins

Zhai, X., Gao, Y. G., Mishra, S. K., Simanshu, D. K., Boldyrev, I. A., Benson, L. M., Bergen, H. R., Malinina, L., Mundy, J., Molotkovsky, J. G., Patel, D. J. & Brown, R. E., Feb 10 2017, In: Journal of Biological Chemistry. 292, 6, p. 2531-2541 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2016

Altered skeletal muscle mitochondrial proteome as the basis of disruption of mitochondrial function in diabetic mice

Zabielski, P., Lanza, I. R., Gopala, S., Heppelmann, C. J. H., Bergen, H. R., Dasari, S. & Nair, K. S., Mar 2016, In: Diabetes. 65, 3, p. 561-573 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Clonotypic light chain peptides identified for monitoring minimal residual disease in multiple myeloma without bone marrow aspiration

Robert Bergen, H., Dasari, S., Dispenzieri, A., Mills, J. R., Ramirez-Alvarado, M., Tschumper, R. C., Jelinek, D. F., Barnidge, D. R. & Murray, D. L., Jan 2016, In: Clinical chemistry. 62, 1, p. 243-251 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

Schafer, M. J., Atkinson, E. J., Vanderboom, P. M., Kotajarvi, B., White, T. A., Moore, M. M., Bruce, C. J., Greason, K. L., Suri, R. M., Khosla, S., Miller, J. D., Bergen, H. R. & LeBrasseur, N. K., Jun 14 2016, In: Cell Metabolism. 23, 6, p. 1207-1215 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

115 Scopus citations

Release of skeletal muscle peptide fragments identifies individual proteins degraded during insulin deprivation in type 1 diabetic humans and mice

Robinson, M. M., Dasari, S., Karakelides, H., Bergen, H. R. & Nair, K. S., Sep 1 2016, In: American Journal of Physiology - Endocrinology and Metabolism. 311, 3, p. E628-E637

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2015

Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging

Johnson, M. L., Irving, B. A., Lanza, I. R., Vendelbo, M. H., Konopka, A. R., Robinson, M. M., Henderson, G. C., Klaus, K. A., Morse, D. M., Heppelmann, C., Bergen, H. R., Dasari, S., Schimke, J. M., Jakaitis, D. R. & Nair, K. S., Nov 2015, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 70, 11, p. 1386-1393 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Inflammation and the depot-specific secretome of human preadipocytes

Zhu, Y., Tchkonia, T., Stout, M. B., Giorgadze, N., Wang, L., Li, P. W., Heppelmann, C. J., Bouloumié, A., Jensen, M. D., Robert Bergen, H. & Kirkland, J. L., May 1 2015, In: Obesity. 23, 5, p. 989-999 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: Insights using a new mass spectrometry-based assay

Bergen, H. R., Farr, J. N., Vanderboom, P. M., Atkinson, E. J., White, T. A., Singh, R. J., Khosla, S. & LeBrasseur, N. K., Jul 15 2015, In: Skeletal Muscle. 5, 1, 21.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

2014

Preclinical evaluation of the supercritical extract of azadirachta indica (neem) leaves in vitro and in vivo on inhibition of prostate cancer tumor growth

Wu, Q., Kohli, M., Bergen, H. R., Cheville, J. C., Karnes, R. J., Cao, H., Young, C. Y. F., Tindall, D. J., McNiven, M. A. & Donkena, K. V., May 2014, In: Molecular cancer therapeutics. 13, 5, p. 1067-1077 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Subfractionation, characterization, and in-depth proteomic analysis of glomerular membrane vesicles in human urine

Hogan, M. C., Johnson, K. L., Zenka, R. M., Cristine Charlesworth, M., Madden, B. J., Mahoney, D. W., Oberg, A. L., Huang, B. Q., Leontovich, A. A., Nesbitt, L. L., Bakeberg, J. L., McCormick, D. J., Robert Bergen, H. & Ward, C. J., May 2014, In: Kidney international. 85, 5, p. 1225-1237 13 p.

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

2013

ANO5-muscular dystrophy: Clinical, pathological and molecular findings

Liewluck, T., Winder, T. L., Dimberg, E. L., Crum, B. A., Heppelmann, C. J., Wang, Y., Bergen, H. R. & Milone, M., Oct 2013, In: European Journal of Neurology. 20, 10, p. 1383-1389 7 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

The regulation of apoptosis by the downstream regulatory element antagonist modulator/potassium channel interacting protein 3 (DREAM/KChIP3) through interactions with hexokinase I

Craig, T. A., Ramachandran, P. L., Bergen, H. R., Podratz, J. L., Windebank, A. J. & Kumar, R., Apr 19 2013, In: Biochemical and Biophysical Research Communications. 433, 4, p. 508-512 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2012

Candidate serum biomarkers for prostate adenocarcinoma identified by mRNA differences in prostate tissue and verified with protein measurements in tissue and blood

Klee, E. W., Bondar, O. P., Goodmanson, M. K., Dyer, R. B., Erdogan, S., Bergstralh, E. J., Bergen, H. R., Sebo, T. J. & Klee, G. G., Mar 2012, In: Clinical chemistry. 58, 3, p. 599-609 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis

Lanza, I. R., Zabielski, P., Klaus, K. A., Morse, D. M., Heppelmann, C. J., Bergen, H. R., Dasari, S., Walrand, S., Short, K. R., Johnson, M. L., Robinson, M. M., Schimke, J. M., Jakaitis, D. R., Asmann, Y. W., Sun, Z. & Nair, K. S., Dec 5 2012, In: Cell Metabolism. 16, 6, p. 777-788 12 p.

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function

Ramachandran, P. L., Craig, T. A., Atanasova, E. A., Cui, G., Owen, B. A., Bergen, H. R., Mer, G. & Kumar, R., Nov 16 2012, In: Journal of Biological Chemistry. 287, 47, p. 39439-39448 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

The sclerostin-bone protein interactome

Devarajan-Ketha, H., Craig, T. A., Madden, B. J., Robert Bergen, H. & Kumar, R., Jan 13 2012, In: Biochemical and Biophysical Research Communications. 417, 2, p. 830-835 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

2011

Mass spectrometric-based proteomic analysis of amyloid neuropathy type in nerve tissue

Klein, C. J., Vrana, J. A., Theis, J. D., Dyck, P. J., Dyck, P. J. B., Spinner, R. J., Mauermann, M. L., Bergen, H. R., Zeldenrust, S. R. & Dogan, A., Feb 2011, In: Archives of neurology. 68, 2, p. 195-199 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

90 Scopus citations

Relative quantification: Characterization of bias, variability and fold changes in mass spectrometry data from iTRAQ-labeled peptides

Mahoney, D. W., Therneau, T. M., Heppelmann, C. J., Higgins, L., Benson, L. M., Zenka, R. M., Jagtap, P., Nelsestuen, G. L., Bergen, H. R. & Oberg, A. L., Sep 2 2011, In: Journal of Proteome Research. 10, 9, p. 4325-4333 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Simultaneous phenotyping and quantification of α-1-antitrypsin by liquid chromatography-tandem mass spectrometry

Chen, Y., Snyder, M. R., Zhu, Y., Tostrud, L. J., Benson, L. M., Katzmann, J. A. & Bergen, H. R., Aug 2011, In: Clinical chemistry. 57, 8, p. 1161-1168 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2010

Bi-linear regression for ¹⁸O quantification: Modeling across the elution profile

Eckel-Passow, J. E., Mahoney, D. W., Oberg, A. L., Zenka, R. M., Johnson, K. L., Nair, K. S., Kudva, Y. C., Bergen, H. R. & Therneau, T. M., 2010, In: Journal of Proteomics and Bioinformatics. 3, 12, p. 323-329 7 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Structural determination and tryptophan fluorescence of heterokaryon incompatibility C2 protein (HET-C2), a fungal glycolipid transfer protein (GLTP), provide novel insights into glycolipid specificity and membrane interaction by the GLTP fold

Kenoth, R., Simanshu, D. K., Kamlekar, R. K., Pike, H. M., Molotkovsky, J. G., Benson, L. M., Bergen, H. R., Prendergast, F. G., Malinina, L., Venyaminov, S. Y., Patel, D. J. & Brown, R. E., Apr 23 2010, In: Journal of Biological Chemistry. 285, 17, p. 13066-13078 13 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

2009

An insight into high-resolution mass-spectrometry data

Eckel-Passow, J. E., Oberg, A. L., Therneau, T. M. & Bergen, H. R., Jul 2009, In: Biostatistics. 10, 3, p. 481-500 20 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens

Vrana, J. A., Gamez, J. D., Madden, B. J., Theis, J. D., Bergen, H. R. & Dogan, A., Dec 3 2009, In: Blood. 114, 24, p. 4957-4959 3 p.

Research output: Contribution to journal › Article › peer-review

540 Scopus citations

Discovery of naturally processed and HLA-presented class I peptides from vaccinia virus infection using mass spectrometry for vaccine development

Johnson, K. L., Ovsyannikova, I. G., Mason, C. J., Bergen, H. R. & Poland, G. A., Dec 10 2009, In: Vaccine. 28, 1, p. 38-47 10 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Extensive fractionation and identification of proteins within nasal lavage fluids from allergic rhinitis and asthmatic chronic rhinosinusitis patients

Benson, L. M., Mason, C. J., Friedman, O., Kita, H., Bergen, H. R. & Plager, D. A., Jan 2009, In: Journal of Separation Science. 32, 1, p. 44-56 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Glomeruli of Dense Deposit Disease contain components of the alternative and terminal complement pathway

Sethi, S., Gamez, J. D., Vrana, J. A., Theis, J. D., Bergen, H. R., Zipfel, P. F., Dogan, A. & Smith, R. J. H., May 2009, In: Kidney international. 75, 9, p. 952-960 9 p.

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Glycolipid acquisition by human glycolipid transfer protein dramatically alters intrinsic tryptophan fluorescence: Insights into glycolipid binding affinity

Zhai, X., Malakhova, M. L., Pike, H. M., Benson, L. M., Bergen, H. R., Sugár, I. P., Malinina, L., Patel, D. J. & Brown, R. E., May 15 2009, In: Journal of Biological Chemistry. 284, 20, p. 13620-13628 9 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Severe osteogenesis imperfecta in cyclophilin B-deficient mice

Choi, J. W., Sutor, S. L., Lindquist, L., Evans, G. L., Madden, B. J., Bergen, H. R., Hefferan, T. E., Yaszemski, M. J. & Bram, R. J., Dec 2009, In: PLoS genetics. 5, 12, e1000750.

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Transthyretin mass determination for detection of transthyretin familial amyloid.

O'Brien, J. F. & Bergen, H. R., 2009, In: Methods in molecular biology (Clifton, N.J.). 492, p. 353-365 13 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2008

Immunoglobulin derived depositions in the nervous system: Novel mass spectrometry application for protein characterization in formalin-fixed tissues

Rodriguez, F. J., Gamez, J. D., Vrana, J. A., Theis, J. D., Giannini, C., Scheithauer, B. W., Parisi, J. E., Lucchinetti, C. F., Pendlebury, W. W., Bergen, H. R. & Dogan, A., Oct 2008, In: Laboratory Investigation. 88, 10, p. 1024-1037 14 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Statistical analysis of relative labeled mass spectrometry data from complex samples using ANOVA

Oberg, A. L., Mahoney, D. W., Eckel-Passow, J. E., Malone, C. J., Wolfinger, R. D., Hill, E. G., Cooper, L. T., Onuma, O. K., Spiro, C., Therneau, T. M. & Bergen, H. R., Jan 2008, In: Journal of Proteome Research. 7, 1, p. 225-233 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

125 Scopus citations

2007

A method for automatically interpreting mass spectra of ¹⁸O-labeled isotopic clusters

Mason, C. J., Therneau, T. M., Eckel-Passow, J. E., Johnson, K. L., Oberg, A. L., Olson, J. E., Nair, K. S., Muddiman, D. C. & Bergen, H. R., Feb 2007, In: Molecular and Cellular Proteomics. 6, 2, p. 305-318 14 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

A simple method to remove contaminating salt from IPG strips prior to IEF

Heppelmann, C. J., Benson, L. M. & Bergen, H. R., Nov 2007, In: ELECTROPHORESIS. 28, 21, p. 3988-3991 4 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Detection of hypo-N-glycosylation using mass spectrometry of transferrin.

O'Brien, J. F., Lacey, J. M. & Bergen, H. R., Jul 2007, In: Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.]. Chapter 17, p. Unit 17.4

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Erratum: Elevated levels of phosphorylated fibrinogen-α-isoforms and differential expression of other post-translationally modified proteins in the plasma of ovarian cancer patients (Journal of Proteome Research (2006) 5, (3318-3325) DOI:10.1021/pr078005j)

Ogata, Y., Heppelmann, C. J., Charlesworth, M. C., Madden, B. J., Miller, M. N., Kalli, K. R., Cilby, W. A., Bergen, H. R., Saggese, D. A. & Muddiman, D. C., Apr 2007, In: Journal of Proteome Research. 6, 4, p. 1615 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Mass spectrometry and peptide-based vaccine development

Ovsyannikova, I. G., Johnson, K. L., Bergen, H. R. & Poland, G. A., Dec 2007, In: Clinical pharmacology and therapeutics. 82, 6, p. 644-652 9 p.

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1-induced cell transformation

Yao, K., Cho, Y. Y., Bergen, H. R., Madden, B. J., Bu, Y. C., Ma, W. Y., Bode, A. M. & Dong, Z., Sep 15 2007, In: Cancer research. 67, 18, p. 8725-8735 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

RSK2 mediates muscle cell differentiation through regulation of NFAT3

Cho, Y. Y., Yao, K., Bode, A. M., Bergen, H. R., Madden, B. J., Oh, S. M., Ermakova, S., Bong, S. K., Hong, S. C., Shim, J. H. & Dong, Z., Mar 16 2007, In: Journal of Biological Chemistry. 282, 11, p. 8380-8392 13 p.

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

2006

Elevated levels of phosphorylated fibrinogen-α-isoforms and differential expression of other post-translationally modified proteins in the plasma of ovarian cancer patients

Ogata, Y., Hepplmann, C. J., Charlesworth, M. C., Madden, B. J., Miller, M. N., Kalli, K. R., Cilby, W. A., Bergen, H. R., Saggese, D. A. & Muddiman, D. G., Dec 2006, In: Journal of Proteome Research. 5, 12, p. 3318-3325 8 p.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Metal-Binding Properties of Human Centrin-2 Determined by Micro-Electrospray Ionization Mass Spectrometry and UV Spectroscopy

Craig, T. A., Benson, L. M., Bergen, H. R., Venyaminov, S. Y., Salisbury, J. L., Ryan, Z. C., Thompson, J. R., Sperry, J., Gross, M. L. & Kumar, R., Aug 2006, In: Journal of the American Society for Mass Spectrometry. 17, 8, p. 1158-1171 14 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Regression analysis for comparing protein samples with ¹⁶O/ ¹⁸O stable-isotope labeled mass spectrometry

Eckel-Passow, J. E., Oberg, A. L., Therneau, T. M., Mason, C. J., Mahoney, D. W., Johnson, K. L., Olson, J. E. & Bergen, H. R., Nov 15 2006, In: Bioinformatics. 22, 22, p. 2739-2745 7 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

2005

Normalization of relative peptide ratios derived from in-gel digests: Applications to protein variant analysis at the peptide level

Bergen, H. R., Muddiman, D. C., O'Brien, J. F. & Hoyer, J. D., 2005, In: Rapid Communications in Mass Spectrometry. 19, 19, p. 2871-2877 7 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure

Hawkridge, A. M., Heublein, D. M., Bergen, H. R., Cataliotti, A., Burnett, J. C. & Muddiman, D. C., Nov 29 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 48, p. 17442-17447 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

217 Scopus citations

2004

An interactive strategy for the accurate characterization of transthyretin variants using combined proteomic and genomic technologies

Zeldenrust, S. R., Bergen, H. R., Nepomuceno, A. I., Butz, M. L., Snow, D. S., Dyck, P. J., Dyck, P. J. B., Klein, C. J., O’brien, J. F., Thibodeau, S. N. & Muddiman, D. C., Jan 1 2004, Amyloid and Amyloidosis. CRC Press, p. 329-331 3 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Characterization of amyloidogenic immunoglobulin light chains directly from serum by on-line immunoaffinity isolation

Bergen, H. R., Abraham, R. S., Johnson, K. L., Bradwell, A. R. & Naylor, S., Apr 2004, In: Biomedical Chromatography. 18, 3, p. 191-201 11 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Detection of genetic variants of transthyretin by liquid chromatography-dual electrospray ionization Fourier-transform ion-cyclotron-resonance mass spectrometry

Nepomuceno, A. I., Mason, C. J., Muddiman, D. C., Bergen, H. R. & Zeldenrust, S. R., Sep 2004, In: Clinical chemistry. 50, 9, p. 1535-1543 9 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Identification of transthyretin variants by sequential proteomic and genomic analysis

Bergen, H. R., Zeldenrust, S. R., Butz, M. L., Snow, D. S., Dyck, P. J., Dyck, P. J. B., Klein, C. J., O'Brien, J. F., Thibodeau, S. N. & Muddiman, D. C., Sep 2004, In: Clinical chemistry. 50, 9, p. 1544-1552 9 p.

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Harold Robert (Bob) III Bergen, PhD

Research output

Search results