• 6023 Citations
  • 38 Scopus h-Index
19992021

Research output per year

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Research Output

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Article
1999

Liver Repopulation with Hepatocyte Transplantation: New Avenues for Gene and Cell Therapy

Gupta, S., Malhi, H. M., Gagandeep, S. & Novikoff, P., Nov 1999, In : Journal of Gene Medicine. 1, 6, p. 386-392 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Repopulation of the liver with transplanted cells for novel cell and gene therapies

Malhi, H. M. & Gupta, S., 1999, In : Medical Science Monitor. 5, 6, p. 1221-1230 10 p.

Research output: Contribution to journalArticle

2000

Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver

Gupta, S., Rajvanshi, P., Malhi, H. M., Slehria, S., Sokhi, R. P., Vasa, S. R. G., Dabeva, M., Shafritz, D. A. & Kerr, A., 2000, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 279, 4 42-4

Research output: Contribution to journalArticle

45 Scopus citations

K(ATP) channels regulate mitogenically induced proliferation in primary rat hepatocytes and human liver cell lines: Implications for liver growth control and potential therapeutic targeting

Malhi, H. M., Irani, A. N., Rajvanshi, P., Suadicani, S. O., Spray, D. C., McDonald, T. V. & Gupta, S., Aug 25 2000, In : Journal of Biological Chemistry. 275, 34, p. 26050-26057 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Re-Engineering the Liver with Natural Biomaterials

Gupta, S., Malhi, H. M. & Gorla, G. R., Dec 2000, In : Yonsei Medical Journal. 41, 6, p. 814-824 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

The application of a lentiviral vector for gene transfer in fetal human hepatocytes

Zahler, M. H., Irani, A., Malhi, H. M., Reutens, A. T., Albanese, C., Bouzahzah, B., Joyce, D., Gupta, S. & Pestell, R. G., May 2000, In : Journal of Gene Medicine. 2, 3, p. 186-193 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
2001

Correction of liver disease following transplantation of normal rat hepatocytes into Long-Evans Cinnamon rats modeling Wilson's disease

Irani, A. N., Malhi, H. M., Slehria, S., Gorla, G. R., Volenberg, I., Schilsky, M. L. & Gupta, S., 2001, In : Molecular Therapy. 3, 3, p. 302-309 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

Hepatocyte transplantation: New horizons and challenges

Malhi, H. M. & Gupta, S., 2001, In : Journal of Hepato-Biliary-Pancreatic Surgery. 8, 1, p. 40-50 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Polyploidy associated with oxidative injury attenuates proliferative potential of cells

Gorla, G. R., Malhi, H. M. & Gupta, S., 2001, In : Journal of Cell Science. 114, 16, p. 2943-2951 9 p.

Research output: Contribution to journalArticle

103 Scopus citations
2002

99mTc-mebrofenin scintigraphy for evaluating liver disease in a rat model of Wilson's disease

Malhi, H. M., Bhargava, K. K., Afriyie, M. O., Volenberg, I., Schilsky, M. L., Palestro, C. J. & Gupta, S., 2002, In : Journal of Nuclear Medicine. 43, 2, p. 246-252 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cell transplantation after oxidative hepatic preconditioning with radiation and ischemia-reperfusion leads to extensive liver repopulation

Malhi, H. M., Gorla, G. R., Irani, A. N., Annamaneni, P. & Gupta, S., Oct 1 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 20, p. 13114-13119 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Cyclophosphamide disrupts hepatic sinusoidal endothelium and improves transplanted cell engraftment in rat liver

Malhi, H. M., Annamaneni, P., Slehria, S., Joseph, B., Bhargava, K. K., Palestro, C. J., Novikoff, P. M. & Gupta, S., 2002, In : Hepatology. 36, 1, p. 112-121 10 p.

Research output: Contribution to journalArticle

76 Scopus citations

Early cell transplantation in LEC rats modeling Wilson's disease eliminates hepatic copper with reversal of liver disease

Malhi, H. M., Irani, A. N., Volenberg, I., Schilsky, M. L. & Gupta, S., 2002, In : Gastroenterology. 122, 2, p. 438-447 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Enzymatically labeled chromosomal probes for in situ identification of human cells in xenogeneic transplant models

Cho, J. J., Malhi, H. M., Wang, R., Joseph, B., Ludlow, J. W., Susick, R. & Gupta, S., Sep 2002, In : Nature Medicine. 8, 9, p. 1033-1036 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature hepatocytes

Malhi, H. M., Irani, A. N., Gagandeep, S. & Gupta, S., Jul 1 2002, In : Journal of Cell Science. 115, 13, p. 2679-2688 10 p.

Research output: Contribution to journalArticle

165 Scopus citations

Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver

Joseph, B., Malhi, H. M., Bhargava, K. K., Palestro, C. J., McCuskey, R. S. & Gupta, S., Nov 1 2002, In : Gastroenterology. 123, 5, p. 1677-1685 9 p.

Research output: Contribution to journalArticle

102 Scopus citations
2003

Metal-catalyzed oxidation of extracellular matrix components perturbs hepatocyte survival with activation of intracellular signaling pathways

Giri, R. K., Malhi, H. M., Joseph, B., Kandimalla, J. & Gupta, S., Dec 1 2003, In : Experimental Cell Research. 291, 2, p. 451-462 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Sestamibi is a substrate for MDR1 and MDR2 P-glycoprotein genes

Joseph, B., Bhargava, K. K., Malhi, H. M., Schilsky, M. L., Jain, D., Palestro, C. J. & Gupta, S., Jul 1 2003, In : European Journal of Nuclear Medicine and Molecular Imaging. 30, 7, p. 1024-1031 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential

Wege, H., Le, H. T., Chui, M. S., Liu, L., Wu, J., Giri, R., Malhi, H. M., Sappal, B. S., Kumaran, V., Gupta, S. & Zern, M. A., Feb 1 2003, In : Gastroenterology. 124, 2, p. 432-444 13 p.

Research output: Contribution to journalArticle

151 Scopus citations
2004

Warfarin and celecoxib interaction in the setting of cytochrome P450 (CYP2C9) polymorphism with bleeding complication

Malhi, H. M., Atac, B., Daly, A. K. & Gupta, S., Feb 2004, In : Postgraduate Medical Journal. 80, 940, p. 107-109 3 p.

Research output: Contribution to journalArticle

27 Scopus citations
2006

Apoptosis and necrosis in the liver: A tale of two deaths?

Malhi, H. M., Gores, G. J. & Lemasters, J. J., Feb 2006, In : Hepatology. 43, 2 SUPPL. 1

Research output: Contribution to journalArticle

522 Scopus citations

Cancer therapy: Back to metabolism

Malhi, H. M. & Gores, G. J., Aug 2006, In : Cancer Biology and Therapy. 5, 8, p. 986-987 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cholangiocarcinoma: Modern advances in understanding a deadly old disease

Malhi, H. M. & Gores, G. J., Dec 2006, In : Journal of Hepatology. 45, 6, p. 856-867 12 p.

Research output: Contribution to journalArticle

202 Scopus citations

Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis

Malhi, H. M., Bronk, S. F., Werneburg, N. W. & Gores, G. J., Apr 28 2006, In : Journal of Biological Chemistry. 281, 17, p. 12093-12101 9 p.

Research output: Contribution to journalArticle

465 Scopus citations

Review article: The modern diagnosis and therapy of cholangiocarcinoma

Malhi, H. M. & Gores, G. J., May 2006, In : Alimentary Pharmacology and Therapeutics. 23, 9, p. 1287-1296 10 p.

Research output: Contribution to journalArticle

81 Scopus citations

TRAIL resistance results in cancer progression: A TRAIL to perdition?

Malhi, H. M. & Gores, G. J., Nov 30 2006, In : Oncogene. 25, 56, p. 7333-7335 3 p.

Research output: Contribution to journalArticle

64 Scopus citations
2007

Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity

Malhi, H. M., Barreyro, F. J., Isomoto, H., Bronk, S. F. & Gores, G. J., Aug 2007, In : Gut. 56, 8, p. 1124-1131 8 p.

Research output: Contribution to journalArticle

155 Scopus citations

TRAILs and tribulation

Malhi, H. M., Nov 2007, In : Hepatology. 46, 5, p. 1320-1322 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis

Barreyro, F. J., Kobayashi, S., Bronk, S. F., Werneburg, N. W., Malhi, H. M. & Gores, G. J., Sep 14 2007, In : Journal of Biological Chemistry. 282, 37, p. 27141-27154 14 p.

Research output: Contribution to journalArticle

149 Scopus citations
2008

Cellular and Molecular Mechanisms of Liver Injury

Malhi, H. M. & Gores, G. J., May 2008, In : Gastroenterology. 134, 6, p. 1641-1654 14 p.

Research output: Contribution to journalArticle

348 Scopus citations

Development of cell therapy strategies to overcome copper toxicity in the LEC rat model of Wilson disease

Malhi, H. M., Joseph, B., Schilsky, M. L. & Gupta, S., Mar 2008, In : Regenerative Medicine. 3, 2, p. 165-173 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease

Malhi, H. M. & Gores, G. J., Nov 2008, In : Seminars in Liver Disease. 28, 4, p. 360-369 10 p.

Research output: Contribution to journalArticle

349 Scopus citations
2010

Hepatocyte death: A clear and present danger

Malhi, H. M., Guicciardi, M. E. & Gores, G. J., Jul 2010, In : Physiological Reviews. 90, 3, p. 1165-1194 30 p.

Research output: Contribution to journalArticle

278 Scopus citations
2011

Endoplasmic reticulum stress in liver disease

Malhi, H. M. & Kaufman, R. J., Apr 2011, In : Journal of Hepatology. 54, 4, p. 795-809 15 p.

Research output: Contribution to journalArticle

623 Scopus citations
2013

Apoptosis and necrosis in the liver

Guicciardi, M. E., Malhi, H. M., Mott, J. L. & Gores, G. J., 2013, In : Comprehensive Physiology. 3, 2, p. 977-1010 34 p.

Research output: Contribution to journalArticle

145 Scopus citations

C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis

Malhi, H. M., Kropp, E. M., Clavo, V. F., Kobrossi, C. R., Han, J., Mauer, A. S., Yong, J. & Kaufman, R. J., Jun 28 2013, In : Journal of Biological Chemistry. 288, 26, p. 18624-18642 19 p.

Research output: Contribution to journalArticle

49 Scopus citations

ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice

Han, J., Murthy, R., Wood, B., Song, B., Wang, S., Sun, B., Malhi, H. M. & Kaufman, R. J., Apr 2013, In : Diabetologia. 56, 4, p. 911-924 14 p.

Research output: Contribution to journalArticle

60 Scopus citations

Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure

Fisher, J. E., McKenzie, T. J., Lillegard, J. B., Yu, Y., Juskewitch, J. E., Nedredal, G. I., Brunn, G. J., Yi, E. S., Malhi, H. M., Smyrk, T. C. & Nyberg, S., Mar 2013, In : Journal of Surgical Research. 180, 1, p. 147-155 9 p.

Research output: Contribution to journalArticle

41 Scopus citations
2014

Mmu-miR-615-3p regulates lipoapoptosis by inhibiting C/EBP homologous protein

Miyamoto, Y., Mauer, A. S., Kumar, S., Mott, J. L. & Malhi, H. M., Oct 14 2014, In : PLoS One. 9, 10, e109637.

Research output: Contribution to journalArticle

18 Scopus citations
2015

Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame

Ibrahim, S. C., Hirsova, P., Malhi, H. M. & Gores, G. J., Dec 1 2015, (Accepted/In press) In : Digestive Diseases and Sciences. p. 1-12 12 p.

Research output: Contribution to journalArticle

72 Scopus citations

Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes

Ibrahim, S. C., Hirsova, P., Tomita, K., Bronk, S. F., Werneburg, N. W., Harrison, S. A., Goodfellow, V. S., Malhi, H. M. & Gores, G. J., 2015, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

57 Scopus citations

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells

Hassler, J. R., Scheuner, D. L., Wang, S., Han, J., Kodali, V. K., Li, P., Nguyen, J., George, J. S., Davis, C., Wu, S. P., Bai, Y., Sartor, M., Cavalcoli, J., Malhi, H. M., Baudouin, G., Zhang, Y., Yates, J. R., Itkin-Ansari, P., Volkmann, N. & Kaufman, R. J., Oct 1 2015, In : PLoS Biology. 13, 10, p. e1002277

Research output: Contribution to journalArticle

46 Scopus citations

TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess

Idrissova, L., Malhi, H. M., Werneburg, N. W., LeBrasseur, N. K., Bronk, S. F., Fingas, C., Tchkonia, T., Pirtskhalava, T., White, T. A., Stout, M. B., Hirsova, P., Krishnan, A., Liedtke, C., Trautwein, C., Finnberg, N., El-Deiry, W. S., Kirkland, J. L. & Gores, G. J., May 1 2015, In : Journal of Hepatology. 62, 5, p. 1156-1163 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
2016

Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

Verma, V. K., Li, H., Wang, R., Hirsova, P., Mushref, M., Liu, Y., Cao, S., Contreras, P. C., Malhi, H. M., Kamath, P. S., Gores, G. J. & Shah, V., Mar 1 2016, In : Journal of Hepatology. 64, 3, p. 651-660 10 p.

Research output: Contribution to journalArticle

71 Scopus citations

Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1 α -dependent manner

Kakazu, E., Mauer, A. S., Yin, M. & Malhi, H. M., Feb 1 2016, In : Journal of Lipid Research. 57, 2, p. 233-245 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles from Hepatocytes

Hirsova, P., Ibrahim, S. C., Krishnan, A., Verma, V. K., Bronk, S. F., Werneburg, N. W., Charlton, M. R., Shah, V., Malhi, H. M. & Gores, G. J., Apr 1 2016, In : Gastroenterology. 150, 4, p. 956-967 12 p.

Research output: Contribution to journalArticle

112 Scopus citations
12 Scopus citations

The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice

Maiers, J., Kostallari, E., Mushref, M., deAssuncao, T. M., Li, H., Jalan-Sakrikar, N., Huebert, R. C., Cao, S., Malhi, H. M. & Shah, V., 2016, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

18 Scopus citations
2017

A Molecular Signature of Murine NASH: A Step Closer to a Human Predictive Biomarker?

Ibrahim, S. C. & Malhi, H. M., Jan 1 2017, (Accepted/In press) In : CMGH.

Research output: Contribution to journalArticle

Distinguishing between hepatic inflammation and fibrosis with MR elastography

Yin, M., Glaser, K. J., Manduca, A., Mounajjed, T., Malhi, H. M., Simonetto, D., Wang, R., Yang, L., Mao, S. A., Glorioso, J. M., Elgilani, F. M., Ward, C. J., Harris, P. C., Nyberg, S., Shah, V. & Ehman, R. L., Sep 1 2017, In : Radiology. 284, 3, p. 694-705 12 p.

Research output: Contribution to journalArticle

34 Scopus citations