• 5896 Citations
  • 38 Scopus h-Index
19992021
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Research Output 1999 2019

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Article
2019

Detection of DNA damage response in nonalcoholic fatty liver disease via p53-binding protein 1 nuclear expression

Akazawa, Y., Nakashima, R., Matsuda, K., Okamaoto, K., Hirano, R., Kawasaki, H., Miuma, S., Miyaaki, H., Malhi, H. M., Abiru, S., Itoh, M., Kondo, H., Fukuoka, J., Nakao, K. & Nakashima, M., Jan 1 2019, In : Modern Pathology.

Research output: Contribution to journalArticle

DNA Damage
Carrier Proteins
Hepatocytes
Double-Stranded DNA Breaks
Nonesterified Fatty Acids
4 Citations (Scopus)

Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis

Maiers, J. & Malhi, H. M., Jan 1 2019, In : Seminars in Liver Disease. 39, 2, p. 235-248 14 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Metabolic Diseases
Liver Diseases
Fibrosis
Liver

Hepatology Highlights

Mousa, O., Malhi, H. M., Schwartz, R. E., Kulai, T. B., Trivedi, H. D., Lau, D. T. Y., Shen, N. T., Brown, R. S., Hirsova, P., Xu, X., Nicholls, H. T., Pisa, J. F., Tafesh, Z. H., Fortune, B. E., Gupta, V., Kostallari, E., Russo, N. & Jesudian, A. B., Mar 1 2019, In : Hepatology (Baltimore, Md.). 69, 3, p. 927-930 4 p.

Research output: Contribution to journalArticle

Gastroenterology
1 Citation (Scopus)

Hepatology Highlights

Suri, J. S., Ezaz, G., Lau, D. T. Y., Kulai, T. B., Malhi, H. M., Tafesh, Z. H., Fortune, B., Rosenblatt, R., Brown, R. S., Pisa, J. F., Russo, N., Hirsova, P., Schwartz, R. E., Obaidullah Aseem, S., Jalan-Sakrikar, N. & Gupta, V., Jun 1 2019, In : Hepatology (Baltimore, Md.). 69, 6, p. 2311-2314 4 p.

Research output: Contribution to journalArticle

Gastroenterology

Hepatology Highlights

Russo, N., Jesudian, A., Shen, N. T., Brown, R. S., Sugiyama, A., Nicholls, H. T., Pisa, J. F., Krisko, T. I., Rosenblatt, R., Tafesh, Z. H., Fortune, B. E., Mousa, O., Malhi, H. M., Schwartz, R. E., Gupta, V., Kulai, T. B. & Malhi, H., Jan 1 2019, In : Hepatology (Baltimore, Md.). 69, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

Gastroenterology

Hepatology Highlights

Russo, N., Brown, R. S., Shah, S. L., Krisko, T. I., Krumm, C. S., Nicholls, H. T., Mousa, O., Malhi, H. M., Schwartz, R. E., Lominadze, Z., Rosenblatt, R., Fortune, B. E., Pisa, J. F., Jesudian, A. B., Gupta, V. & Tafesh, Z. H., Feb 1 2019, In : Hepatology. 69, 2, p. 469-472 4 p.

Research output: Contribution to journalArticle

Gastroenterology

Hepatology Highlights

Trivedi, H. D., Lau, D. T. Y., Kulai, T. B., Malhi, H. M., Schwartz, R. E., Pisa, J. F., Brown, R. S., Russo, N., Nair, K. M., Roccaro, G., Hirsova, P., Gupta, V., Xu, X., Krisko, T. & Kostallari, E., May 1 2019, In : Hepatology (Baltimore, Md.). 69, 5, p. 1849-1851 3 p.

Research output: Contribution to journalArticle

Gastroenterology

Hepatology Highlights

Nair, K. M., Vora, R. S., Mousa, O. Y., Malhi, H. M., Schwartz, R. E., Pisa, J. F., Brown, R. S., Trivedi, H. D., Lau, D. T. Y., Shen, N., Shenoy, A., Maiers, J., Kostallari, E., Hirsova, P., Russo, N. & Kulai, T. B., Apr 1 2019, In : Hepatology (Baltimore, Md.). 69, 4, p. 1365-1368 4 p.

Research output: Contribution to journalArticle

Gastroenterology

Hepatology Highlights

Hirsova, P., Malhi, H. M., Russo, N., Shah, P. A., Trivedi, H., Lau, D. T. Y., Pisa, J. F., Wu, A., Shen, N., Jesudian, A., Tafesh, Z. H., Fortune, B. E., Hilscher, M., Jalan-Sakrikar, N. & Mousa, O., Aug 1 2019, In : Hepatology (Baltimore, Md.). 70, 2, p. 455-458 4 p.

Research output: Contribution to journalArticle

Gastroenterology

Hepatology Highlights

Mousa, O. Y., Malhi, H. M., Russo, N., Jesudian, A., Pisa, J. F., Kulai, T. B., Maiers, J., Kostallari, E., Jalan-Sakrikar, N., Tafesh, Z. H., Fortune, B. E., Yang, L., Lau, D. T. Y., Nair, K. & Wedd, J., Jul 1 2019, In : Hepatology (Baltimore, Md.). 70, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

Gastroenterology
4 Citations (Scopus)
Elasticity Imaging Techniques
Magnetic Resonance Imaging
Liver
Fats
Linear Models
3 Citations (Scopus)

Transforming growth factor (TGF) cross-talk with the unfolded protein response is critical for hepatic stellate cell activation

Liu, Z., Li, C., Kang, N., Malhi, H. M., Shah, V. & Maiers, J., Jan 1 2019, In : Journal of Biological Chemistry. 294, 9, p. 3137-3151 15 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Hepatic Stellate Cells
Transforming Growth Factors
Chemical activation
CCAAT-Enhancer-Binding Proteins
2018
1 Citation (Scopus)

Deletion of endoplasmic reticulum stress-responsive co-chaperone p58IPK protects mice from diet-induced steatohepatitis

Bandla, H., Dasgupta, D., Mauer, A. S., Nozickova, B., Kumar, S., Hirsova, P., Graham, R. & Malhi, H. M., Jan 1 2018, (Accepted/In press) In : Hepatology Research.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Fatty Liver
Endoplasmic Reticulum
Phosphotransferases
Diet
2 Citations (Scopus)

Hepatocyte-Derived Lipotoxic Extracellular Vesicle Sphingosine 1-Phosphate Induces Macrophage Chemotaxis

Liao, C. Y., Song, M. J., Gao, Y., Mauer, A. S., Revzin, A. & Malhi, H. M., Jan 1 2018, In : Frontiers in Immunology. 9, 1 p.

Research output: Contribution to journalArticle

Chemotaxis
Hepatocytes
Macrophages
Lysosphingolipid Receptors
Palmitates

Hepatology Highlights

Shen, N. T., Brown, R. S., Imai, N., Krisko, T. I., Alves-Bezerra, M., Nicholls, H. T., Kulai, T. B., Schwartz, R. E., Tafesh, Z. H., Jesudian, A., Rosenblatt, R., Fortune, B. E., Pisa, J. F., Mousa, O., Malhi, H. M. & Gupta, V., Dec 1 2018, In : Hepatology. 68, 6, p. 2049-2052 4 p.

Research output: Contribution to journalArticle

Gastroenterology
2 Citations (Scopus)

Hypothyroidism is associated with worse outcomes of hepatocellular carcinoma patients after liver transplantation

Zhang, N., Jin, W., Zhou, S., Yang, J. D., Harmsen, W. S., Giama, N. H., Wongjarupong, N., Heimbach, J. K., Watt, K. D., Malhi, H. M., Therneau, T. M. & Roberts, L. R., Jan 1 2018, (Accepted/In press) In : Cancer Medicine.

Research output: Contribution to journalArticle

Hypothyroidism
Liver Transplantation
Hepatocellular Carcinoma
Survival
Recurrence
429 Citations (Scopus)

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G. K., Ayre, D. C., Bach, J. M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N. N., Baxter, A. A., Bebawy, M., Beckham, C. & 362 others, Bedina Zavec, A., Benmoussa, A., Berardi, A. C., Bergese, P., Bielska, E., Blenkiron, C., Bobis-Wozowicz, S., Boilard, E., Boireau, W., Bongiovanni, A., Borràs, F. E., Bosch, S., Boulanger, C. M., Breakefield, X., Breglio, A. M., Brennan, M., Brigstock, D. R., Brisson, A., Broekman, M. L. D., Bromberg, J. F., Bryl-Górecka, P., Buch, S., Buck, A. H., Burger, D., Busatto, S., Buschmann, D., Bussolati, B., Buzás, E. I., Byrd, J. B., Camussi, G., Carter, D. R. F., Caruso, S., Chamley, L. W., Chang, Y. T., Chaudhuri, A. D., Chen, C., Chen, S., Cheng, L., Chin, A. R., Clayton, A., Clerici, S. P., Cocks, A., Cocucci, E., Coffey, R. J., Cordeiro-da-Silva, A., Couch, Y., Coumans, F. A. W., Coyle, B., Crescitelli, R., Criado, M. F., D’Souza-Schorey, C., Das, S., de Candia, P., De Santana, E. F., De Wever, O., del Portillo, H. A., Demaret, T., Deville, S., Devitt, A., Dhondt, B., Di Vizio, D., Dieterich, L. C., Dolo, V., Dominguez Rubio, A. P., Dominici, M., Dourado, M. R., Driedonks, T. A. P., Duarte, F. V., Duncan, H. M., Eichenberger, R. M., Ekström, K., EL Andaloussi, S., Elie-Caille, C., Erdbrügger, U., Falcón-Pérez, J. M., Fatima, F., Fish, J. E., Flores-Bellver, M., Försönits, A., Frelet-Barrand, A., Fricke, F., Fuhrmann, G., Gabrielsson, S., Gámez-Valero, A., Gardiner, C., Gärtner, K., Gaudin, R., Gho, Y. S., Giebel, B., Gilbert, C., Gimona, M., Giusti, I., Goberdhan, D. C. I., Görgens, A., Gorski, S. M., Greening, D. W., Gross, J. C., Gualerzi, A., Gupta, G. N., Gustafson, D., Handberg, A., Haraszti, R. A., Harrison, P., Hegyesi, H., Hendrix, A., Hill, A. F., Hochberg, F. H., Hoffmann, K. F., Holder, B., Holthofer, H., Hosseinkhani, B., Hu, G., Huang, Y., Huber, V., Hunt, S., Ibrahim, A. G. E., Ikezu, T., Inal, J. M., Isin, M., Ivanova, A., Jackson, H. K., Jacobsen, S., Jay, S. M., Jayachandran, M., Jenster, G., Jiang, L., Johnson, S. M., Jones, J. C., Jong, A., Jovanovic-Talisman, T., Jung, S., Kalluri, R., Kano, S. I., Kaur, S., Kawamura, Y., Keller, E. T., Khamari, D., Khomyakova, E., Khvorova, A., Kierulf, P., Kim, K. P., Kislinger, T., Klingeborn, M., Klinke, D. J., Kornek, M., Kosanović, M. M., Kovács, Á. F., Krämer-Albers, E. M., Krasemann, S., Krause, M., Kurochkin, I. V., Kusuma, G. D., Kuypers, S., Laitinen, S., Langevin, S. M., Languino, L. R., Lannigan, J., Lässer, C., Laurent, L. C., Lavieu, G., Lázaro-Ibáñez, E., Le Lay, S., Lee, M. S., Lee, Y. X. F., Lemos, D. S., Lenassi, M., Leszczynska, A., Li, I. T. S., Liao, K., Libregts, S. F., Ligeti, E., Lim, R., Lim, S. K., Linē, A., Linnemannstöns, K., Llorente, A., Lombard, C. A., Lorenowicz, M. J., Lörincz, Á. M., Lötvall, J., Lovett, J., Lowry, M. C., Loyer, X., Lu, Q., Lukomska, B., Lunavat, T. R., Maas, S. L. N., Malhi, H. M., Marcilla, A., Mariani, J., Mariscal, J., Martens-Uzunova, E. S., Martin-Jaular, L., Martinez, M. C., Martins, V. R., Mathieu, M., Mathivanan, S., Maugeri, M., McGinnis, L. K., McVey, M. J., Meckes, D. G., Meehan, K. L., Mertens, I., Minciacchi, V. R., Möller, A., Møller Jørgensen, M., Morales-Kastresana, A., Morhayim, J., Mullier, F., Muraca, M., Musante, L., Mussack, V., Muth, D. C., Myburgh, K. H., Najrana, T., Nawaz, M., Nazarenko, I., Nejsum, P., Neri, C., Neri, T., Nieuwland, R., Nimrichter, L., Nolan, J. P., Nolte-’t Hoen, E. N. M., Noren Hooten, N., O’Driscoll, L., O’Grady, T., O’Loghlen, A., Ochiya, T., Olivier, M., Ortiz, A., Ortiz, L. A., Osteikoetxea, X., Ostegaard, O., Ostrowski, M., Park, J., Pegtel, D. M., Peinado, H., Perut, F., Pfaffl, M. W., Phinney, D. G., Pieters, B. C. H., Pink, R. C., Pisetsky, D. S., Pogge von Strandmann, E., Polakovicova, I., Poon, I. K. H., Powell, B. H., Prada, I., Pulliam, L., Quesenberry, P., Radeghieri, A., Raffai, R. L., Raimondo, S., Rak, J., Ramirez, M. I., Raposo, G., Rayyan, M. S., Regev-Rudzki, N., Ricklefs, F. L., Robbins, P. D., Roberts, D. D., Rodrigues, S. C., Rohde, E., Rome, S., Rouschop, K. M. A., Rughetti, A., Russell, A. E., Saá, P., Sahoo, S., Salas-Huenuleo, E., Sánchez, C., Saugstad, J. A., Saul, M. J., Schiffelers, R. M., Schneider, R., Schøyen, T. H., Scott, A., Shahaj, E., Sharma, S., Shatnyeva, O., Shekari, F., Shelke, G. V., Shetty, A. K., Shiba, K., Siljander, P. R. M., Silva, A. M., Skowronek, A., Snyder, O. L., Soares, R. P., Sódar, B. W., Soekmadji, C., Sotillo, J., Stahl, P. D., Stoorvogel, W., Stott, S. L., Strasser, E. F., Swift, S., Tahara, H., Tewari, M., Timms, K., Tiwari, S., Tixeira, R., Tkach, M., Toh, W. S., Tomasini, R., Torrecilhas, A. C., Tosar, J. P., Toxavidis, V., Urbanelli, L., Vader, P., van Balkom, B. W. M., van der Grein, S. G., Van Deun, J., van Herwijnen, M. J. C., Van Keuren-Jensen, K., van Niel, G., van Royen, M. E., van Wijnen, A. J., Vasconcelos, M. H., Vechetti, I. J., Veit, T. D., Vella, L. J., Velot, É., Verweij, F. J., Vestad, B., Viñas, J. L., Visnovitz, T., Vukman, K. V., Wahlgren, J., Watson, D. C., Wauben, M. H. M., Weaver, A., Webber, J. P., Weber, V., Wehman, A. M., Weiss, D. J., Welsh, J. A., Wendt, S., Wheelock, A. M., Wiener, Z., Witte, L., Wolfram, J., Xagorari, A., Xander, P., Xu, J., Yan, X., Yáñez-Mó, M., Yin, H., Yuana, Y., Zappulli, V., Zarubova, J., Žėkas, V., Zhang, J. Y., Zhao, Z., Zheng, L., Zheutlin, A. R., Zickler, A. M., Zimmermann, P., Zivkovic, A. M., Zocco, D. & Zuba-Surma, E. K., Jan 1 2018, In : Journal of Extracellular Vesicles. 7, 1, 1535750.

Research output: Contribution to journalArticle

Guidelines
Exosomes
Cell-Derived Microparticles
Extracellular Vesicles
Checklist
2 Citations (Scopus)

StAR-related lipid transfer domain 11 (STARD11)-mediated ceramide transport mediates extracellular vesicle biogenesis

Fukushima, M., Dasgupta, D., Mauer, A. S., Kakazu, E., Nakao, K. & Malhi, H. M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 39, p. 15277-15289 13 p.

Research output: Contribution to journalArticle

Ceramides
Lipids
Palmitates
Exosomes
Multivesicular Bodies
2017

A Molecular Signature of Murine NASH: A Step Closer to a Human Predictive Biomarker?

Ibrahim, S. C. & Malhi, H. M., Jan 1 2017, (Accepted/In press) In : CMGH.

Research output: Contribution to journalArticle

Biomarkers
33 Citations (Scopus)

Distinguishing between hepatic inflammation and fibrosis with MR elastography

Yin, M., Glaser, K. J., Manduca, A., Mounajjed, T., Malhi, H. M., Simonetto, D., Wang, R., Yang, L., Mao, S. A., Glorioso, J. M., Elgilani, F. M., Ward, C. J., Harris, P. C., Nyberg, S., Shah, V. & Ehman, R. L., Sep 1 2017, In : Radiology. 284, 3, p. 694-705 12 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Fibrosis
Inflammation
Liver
Portal Hypertension
38 Citations (Scopus)

Gastrointestinal Complications of Obesity

Camilleri, M., Malhi, H. M. & Acosta, A., May 1 2017, In : Gastroenterology. 152, 7, p. 1656-1670 15 p.

Research output: Contribution to journalArticle

Obesity
Gallstones
Colonic Diseases
Peptic Esophagitis
Barrett Esophagus
1 Citation (Scopus)

Green tea consumption: A potential chemopreventive measure for hepatocellular carcinoma?

Yang, J. D. & Malhi, H. M., Jan 1 2017, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Chemoprevention
Tea
Liver Neoplasms
Hepatocellular Carcinoma
19 Citations (Scopus)
Liver
Macrophages
Inflammation
Chemotaxis
Myeloid Cells
5 Citations (Scopus)

Lipopolysaccharide downregulates macrophage-derived IL-22 to modulate alcohol-induced hepatocyte cell death

Liu, Y., Verma, V. K., Malhi, H. M., Gores, G. J., Kamath, P. S., Sanyal, A., Chalasani, N., Gao, B. & Shah, V., Sep 5 2017, In : American Journal of Physiology - Cell Physiology. 313, 3, p. C305-C313

Research output: Contribution to journalArticle

Lipopolysaccharides
Hepatocytes
Cell Death
Down-Regulation
Macrophages
41 Citations (Scopus)

Sarcopenia in hiding: The risk and consequence of underestimating muscle dysfunction in nonalcoholic steatohepatitis

Bhanji, R. A., Narayanan, P., Allen, A., Malhi, H. M. & Watt, K. D., 2017, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Sarcopenia
Muscles
Insulin Resistance
Skeletal Muscle
Fibrosis
2016
68 Citations (Scopus)

Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

Verma, V. K., Li, H., Wang, R., Hirsova, P., Mushref, M., Liu, Y., Cao, S., Contreras, P. C., Malhi, H. M., Kamath, P. S., Gores, G. J. & Shah, V., Mar 1 2016, In : Journal of Hepatology. 64, 3, p. 651-660 10 p.

Research output: Contribution to journalArticle

CD40 Ligand
Macrophage Activation
Caspases
Hepatocytes
Alcohols
58 Citations (Scopus)

Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1 α -dependent manner

Kakazu, E., Mauer, A. S., Yin, M. & Malhi, H. M., Feb 1 2016, In : Journal of Lipid Research. 57, 2, p. 233-245 13 p.

Research output: Contribution to journalArticle

Macrophages
Palmitates
Ceramides
Inositol
Hepatocytes
108 Citations (Scopus)

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles from Hepatocytes

Hirsova, P., Ibrahim, S. C., Krishnan, A., Verma, V. K., Bronk, S. F., Werneburg, N. W., Charlton, M. R., Shah, V., Malhi, H. M. & Gores, G. J., Apr 1 2016, In : Gastroenterology. 150, 4, p. 956-967 12 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand Receptors
Hepatocytes
Lipids
rho-Associated Kinases
Macrophages
12 Citations (Scopus)
Survival
Graft Survival
Liver Transplantation
Patient Selection
Length of Stay
18 Citations (Scopus)

The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice

Maiers, J., Kostallari, E., Mushref, M., deAssuncao, T. M., Li, H., Jalan-Sakrikar, N., Huebert, R. C., Cao, S., Malhi, H. M. & Shah, V., 2016, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Unfolded Protein Response
Hepatic Stellate Cells
Collagen
Procollagen
Endoplasmic Reticulum
2015
72 Citations (Scopus)

Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame

Ibrahim, S. C., Hirsova, P., Malhi, H. M. & Gores, G. J., Dec 1 2015, (Accepted/In press) In : Digestive Diseases and Sciences. p. 1-12 12 p.

Research output: Contribution to journalArticle

Animal Models
Disease Progression
Investigational Therapies
Non-alcoholic Fatty Liver Disease
Public Health
55 Citations (Scopus)

Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes

Ibrahim, S. C., Hirsova, P., Tomita, K., Bronk, S. F., Werneburg, N. W., Harrison, S. A., Goodfellow, V. S., Malhi, H. M. & Gores, G. J., 2015, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Hepatocytes
Ligands
Lysophosphatidylcholines
Macrophages
Chemotaxis
46 Citations (Scopus)

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells

Hassler, J. R., Scheuner, D. L., Wang, S., Han, J., Kodali, V. K., Li, P., Nguyen, J., George, J. S., Davis, C., Wu, S. P., Bai, Y., Sartor, M., Cavalcoli, J., Malhi, H. M., Baudouin, G., Zhang, Y., Yates, J. R., Itkin-Ansari, P., Volkmann, N. & Kaufman, R. J., Oct 1 2015, In : PLoS Biology. 13, 10, p. e1002277

Research output: Contribution to journalArticle

Cytoprotection
Inositol
Glucose
Messenger RNA
glucose
38 Citations (Scopus)

TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess

Idrissova, L., Malhi, H. M., Werneburg, N. W., LeBrasseur, N. K., Bronk, S. F., Fingas, C., Tchkonia, T., Pirtskhalava, T., White, T. A., Stout, M. B., Hirsova, P., Krishnan, A., Liedtke, C., Trautwein, C., Finnberg, N., El-Deiry, W. S., Kirkland, J. L. & Gores, G. J., May 1 2015, In : Journal of Hepatology. 62, 5, p. 1156-1163 8 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand Receptors
Inflammation
Food
Liver
Adipose Tissue
2014
18 Citations (Scopus)

Mmu-miR-615-3p regulates lipoapoptosis by inhibiting C/EBP homologous protein

Miyamoto, Y., Mauer, A. S., Kumar, S., Mott, J. L. & Malhi, H. M., Oct 14 2014, In : PLoS One. 9, 10, e109637.

Research output: Contribution to journalArticle

Transcription Factor CHOP
Palmitates
palmitates
MicroRNAs
microRNA
2013
144 Citations (Scopus)

Apoptosis and necrosis in the liver

Guicciardi, M. E., Malhi, H. M., Mott, J. L. & Gores, G. J., 2013, In : Comprehensive Physiology. 3, 2, p. 977-1010 34 p.

Research output: Contribution to journalArticle

Apoptosis
Liver
Death Domain Receptors
Cell Death
Liver Diseases
48 Citations (Scopus)

C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis

Malhi, H. M., Kropp, E. M., Clavo, V. F., Kobrossi, C. R., Han, J., Mauer, A. S., Yong, J. & Kaufman, R. J., Jun 28 2013, In : Journal of Biological Chemistry. 288, 26, p. 18624-18642 19 p.

Research output: Contribution to journalArticle

Transcription Factor CHOP
Macrophages
Fatty Liver
Liver
Apoptosis
60 Citations (Scopus)

ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice

Han, J., Murthy, R., Wood, B., Song, B., Wang, S., Sun, B., Malhi, H. M. & Kaufman, R. J., Apr 2013, In : Diabetologia. 56, 4, p. 911-924 14 p.

Research output: Contribution to journalArticle

Transcription Factor CHOP
Adipogenesis
Endoplasmic Reticulum Stress
Adipocytes
3T3-L1 Cells
41 Citations (Scopus)

Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure

Fisher, J. E., McKenzie, T. J., Lillegard, J. B., Yu, Y., Juskewitch, J. E., Nedredal, G. I., Brunn, G. J., Yi, E. S., Malhi, H. M., Smyrk, T. C. & Nyberg, S., Mar 2013, In : Journal of Surgical Research. 180, 1, p. 147-155 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Kupffer Cells
Acute Liver Failure
Acetaminophen
Systemic Inflammatory Response Syndrome
2011
612 Citations (Scopus)

Endoplasmic reticulum stress in liver disease

Malhi, H. M. & Kaufman, R. J., Apr 2011, In : Journal of Hepatology. 54, 4, p. 795-809 15 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Liver Diseases
Unfolded Protein Response
Phosphotransferases
2010
276 Citations (Scopus)

Hepatocyte death: A clear and present danger

Malhi, H. M., Guicciardi, M. E. & Gores, G. J., Jul 2010, In : Physiological Reviews. 90, 3, p. 1165-1194 30 p.

Research output: Contribution to journalArticle

Hepatocytes
Cell Death
Death Domain Receptors
Wounds and Injuries
Necrosis
2008
344 Citations (Scopus)

Cellular and Molecular Mechanisms of Liver Injury

Malhi, H. M. & Gores, G. J., May 2008, In : Gastroenterology. 134, 6, p. 1641-1654 14 p.

Research output: Contribution to journalArticle

Apoptosis
Liver
Wounds and Injuries
Hepatocytes
Liver Diseases
36 Citations (Scopus)

Development of cell therapy strategies to overcome copper toxicity in the LEC rat model of Wilson disease

Malhi, H. M., Joseph, B., Schilsky, M. L. & Gupta, S., Mar 2008, In : Regenerative Medicine. 3, 2, p. 165-173 9 p.

Research output: Contribution to journalArticle

Inbred LEC Rats
Hepatolenticular Degeneration
Cell- and Tissue-Based Therapy
Liver
Toxicity
345 Citations (Scopus)

Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease

Malhi, H. M. & Gores, G. J., Nov 2008, In : Seminars in Liver Disease. 28, 4, p. 360-369 10 p.

Research output: Contribution to journalArticle

Nonesterified Fatty Acids
Apoptosis
Hepatocytes
bcl-2-Associated X Protein
Death Domain Receptors
2007
155 Citations (Scopus)

Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity

Malhi, H. M., Barreyro, F. J., Isomoto, H., Bronk, S. F. & Gores, G. J., Aug 2007, In : Gut. 56, 8, p. 1124-1131 8 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand Receptors
Nonesterified Fatty Acids
Hepatocytes
JNK Mitogen-Activated Protein Kinases
Oleic Acid
2 Citations (Scopus)

TRAILs and tribulation

Malhi, H. M., Nov 2007, In : Hepatology. 46, 5, p. 1320-1322 3 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
Chronic Hepatitis C
Fatty Liver
Antineoplastic Agents
Hepatocytes
149 Citations (Scopus)

Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis

Barreyro, F. J., Kobayashi, S., Bronk, S. F., Werneburg, N. W., Malhi, H. M. & Gores, G. J., Sep 14 2007, In : Journal of Biological Chemistry. 282, 37, p. 27141-27154 14 p.

Research output: Contribution to journalArticle

Nonesterified Fatty Acids
Hepatocytes
Fatty Acids
Protein Phosphatase 2
Phosphoric Monoester Hydrolases
2006
520 Citations (Scopus)

Apoptosis and necrosis in the liver: A tale of two deaths?

Malhi, H. M., Gores, G. J. & Lemasters, J. J., Feb 2006, In : Hepatology. 43, 2 SUPPL. 1

Research output: Contribution to journalArticle

Cell Death
Necrosis
Apoptosis
Liver
Reperfusion
3 Citations (Scopus)

Cancer therapy: Back to metabolism

Malhi, H. M. & Gores, G. J., Aug 2006, In : Cancer Biology and Therapy. 5, 8, p. 986-987 2 p.

Research output: Contribution to journalArticle

4-Butyrolactone
CD95 Antigens
Tumor Suppressor Protein p53
Fatty Acid Synthases
Metabolomics
202 Citations (Scopus)

Cholangiocarcinoma: Modern advances in understanding a deadly old disease

Malhi, H. M. & Gores, G. J., Dec 2006, In : Journal of Hepatology. 45, 6, p. 856-867 12 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Survival
Biliary Tract
Cyclooxygenase 2
Rare Diseases