• 1185 Citations
  • 16 Scopus h-Index
20012020

Research output per year

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Research Output

  • 1185 Citations
  • 16 Scopus h-Index
  • 55 Article
  • 2 Letter
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Article
2001

A novel γ-secretase assay based on detection of the putative C-terminal fragment-γ of amyloid β protein precursor

Pinnix, I., Musunuru, U., Tun, H., Sridharan, A., Golde, T., Eckman, C., Ziani-Cherif, C., Onstead, L. & Sambamurti, K., Jan 5 2001, In : Journal of Biological Chemistry. 276, 1, p. 481-487 7 p.

Research output: Contribution to journalArticle

125 Scopus citations
2002

Lipid rafts play an important role in Aβ biogenesis by regulating the β-secretase pathway

Tun, H., Marlow, L., Pinnix, I., Kinsey, R. & Sambamurti, K., Jan 1 2002, In : Journal of Molecular Neuroscience. 19, 1-2, p. 31-35 5 p.

Research output: Contribution to journalArticle

77 Scopus citations
2004
3 Scopus citations
2005

Etanercept therapy for late-onset idiopathic pneumonia syndrome after nonmyeloablative allogeneic hematopoietic stem cell transplantation

Tun, H. W., Wallace, K. H., Grinton, S. F., Khoor, A. & Burger, C. D., Dec 1 2005, In : Transplantation proceedings. 37, 10, p. 4492-4496 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
2007

Efficacy of conventional cytogenetics and FISH for EGR1 to detect deletion 5q in hematological disorders and to assess response to treatment with Lenalidomide

Zou, Y. S., Fink, S. R., Stockero, K. J., Paternoster, S. F., Smoley, S. A., Tun, H. W., Reeder, C. B., Tefferi, A. & Dewald, G. W., Sep 2007, In : Leukemia Research. 31, 9, p. 1185-1189 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
2008

Pathway analysis of primary central nervous system lymphoma

Tun, H. W., Personett, D., Baskerville, K. A., Menke, D. M., Jaeckle, K. A., Kreinest, P., Edenfield, B., Zubair, A. C., O'Neill, B. P., Lai, W. R., Park, P. J. & McKinney, M., Mar 15 2008, In : Blood. 111, 6, p. 3200-3210 11 p.

Research output: Contribution to journalArticle

115 Scopus citations
14 Scopus citations
2009

The physician-patient relationship and quality of life: Lessons from chronic lymphocytic leukemia

Shanafelt, T. D., Bowen, D. A., Venkat, C., Slager, S. L., Zent, C. S., Kay, N. E., Reinalda, M., Tun, H., Sloan, J. A. & Call, T. G., Feb 1 2009, In : Leukemia Research. 33, 2, p. 263-270 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2010

Loss of type III transforming growth factor-Β receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma

Cooper, S. J., Zou, H., Legrand, S. N., Marlow, L. A., Von Roemeling, C. A., Radisky, D. C., Wu, K. J., Hempel, N., Margulis, V., Tun, H. W., Blobe, G. C., Wood, C. G. & Copland, J. A., May 20 2010, In : Oncogene. 29, 20, p. 2905-2915 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Pathway signature and cellular differentiation in clear cell renal cell carcinoma

Tun, H. W., Marlow, L. A., von Roemeling, C. A., Cooper, S. J., Kreinest, P., Wu, K., Luxon, B. A., Sinha, M., Anastasiadis, P. Z. & Copland, J. A., Sep 17 2010, In : PloS one. 5, 5, e10696.

Research output: Contribution to journalArticle

108 Scopus citations

Selective central nervous system tropism of primary central nervous system lymphoma

Jiang, L., Marlow, L. A., Cooper, S. J., Roemeling, C. V., Menke, D. M., Copland, J. A. & Tun, H. W., Dec 1 2010, In : International Journal of Clinical and Experimental Pathology. 3, 8, p. 763-767 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Use of rituximab for periocular and intraocular mucosa-associated lymphoid tissue lymphoma

Shetty, R. K., Adams, B. H., Tun, H. W., Runyan, B. R., Menke, D. M. & Broderick, D. F., Apr 1 2010, In : Ocular Immunology and Inflammation. 18, 2, p. 110-112 3 p.

Research output: Contribution to journalArticle

7 Scopus citations
2011

Molecular analysis of intravascular large B-cell lymphoma with neoangiogenesis

Saurel, C. A., Personett, D. A., Edenfield, B. H., Solberg, L. A., Jiang, L., Menke, D. M. & Tun, H. W., Jan 1 2011, In : British journal of haematology. 152, 2, p. 234-236 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Plasmacytoma-like posttransplant lymphoproliferative disorder following orthotopic liver transplantation: A case report

Vishnu, P., Jiang, L., Cortese, C., Menke, D. M. & Tun, H. W., Sep 1 2011, In : Transplantation proceedings. 43, 7, p. 2806-2809 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
2012

Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: A paradigm shift that impacts current therapeutic strategies

Marlow, L. A., von Roemeling, C. A., Cooper, S. J., Zhang, Y., Rohl, S. D., Arora, S., Gonzales, I. M., Azorsa, D. O., Reddi, H. V., Tun, H. W., Dö ppler, H. R., Storz, P., Smallridge, R. C. & Copland, J. A., Dec 1 2012, In : Journal of cell science. 125, 18, p. 4253-4263 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Hypoxia negatively regulates heparan sulfatase 2 expression in renal cancer cell lines

Khurana, A., Tun, H. W., Marlow, L., Copland, J. A., Dredge, K. & Shridhar, V., Jul 1 2012, In : Molecular Carcinogenesis. 51, 7, p. 565-575 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Pharmacokinetics of Agelastatin A in the central nervous system

Li, Z., Kamon, T., Personett, D. A., Caulfield, T., Copland, J. A., Yoshimitsu, T. & Tun, H. W., Feb 1 2012, In : MedChemComm. 3, 2, p. 233-237 5 p.

Research output: Contribution to journalArticle

11 Scopus citations
4 Scopus citations

Primary central nervous system B cell lymphoma with features intermediate between diffuse large B cell lymphoma and burkitt lymphoma

Jiang, L., Li, Z., Finn, L. E., Personnet, D. A., Edenfield, B., Foran, J. M., Jaeckle, K. A., Reimer, R., Menke, D. M., Ketterling, R. P. & Tun, H. W., Feb 13 2012, In : International Journal of Clinical and Experimental Pathology. 5, 1, p. 72-76 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Reexpression of tumor suppressor, sFRP1, leads to antitumor synergy of combined HDAC and methyltransferase inhibitors in chemoresistant cancers

Cooper, S. J., Von Roemeling, C. A., Kang, K. H., Marlow, L. A., Grebe, S. K., Menefee, M. E., Tun, H. W., Colon-Otero, G., Perez, E. A. & Copland, J. A., Oct 1 2012, In : Molecular cancer therapeutics. 11, 10, p. 2105-2115 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
2013

An integrated approach to the discovery of potent agelastatin A analogues for brain tumors: Chemical synthesis and biological, physicochemical and CNS pharmacokinetic analyses

Li, Z., Shigeoka, D., Caulfield, T. R., Kawachi, T., Qiu, Y., Kamon, T., Arai, M., Tun, H. W. & Yoshimitsu, T., Jul 1 2013, In : MedChemComm. 4, 7, p. 1093-1098 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

A phase I/II trial of reduced intensity allogeneic hematopoietic cell transplant for hematologic malignancies using cladribine, thiotepa and rabbit antithymocyte globulin

Larsen, J. T., Hogan, W. J., Micallef, I. N., Dispenzieri, A., Gertz, M. A., Inwards, D. J., Tun, H. W., Roy, V., Geyer, S. M., Allred, J. B., Wu, W. D., Ansell, S. M., Elliott, M. A., Tefferi, A., Porrata, L. F., Gastineau, D. A., Lacy, M. Q. & Litzow, M. R., Aug 1 2013, In : Leukemia and Lymphoma. 54, 8, p. 1713-1718 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

CD47 and osteopontin expression in diffuse large B-cell lymphoma with nodal and intravascular involvement

Starr, J. S., Jiang, L., Li, Z., Qiu, Y., Menke, D. M. & Tun, H. W., Oct 1 2013, In : Clinical Lymphoma, Myeloma and Leukemia. 13, 5, p. 597-601 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Combined plasma exchange and platelet transfusion in immune-mediated thrombocytopenic emergencies

Finn, L. & Tun, H., Dec 1 2013, In : Transfusion and Apheresis Science. 49, 3, p. 661-664 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Long-term repair of T-cell synapse activity in a phase II trial of chemoimmunotherapy followed by lenalidomide consolidation in previously untreated chronic lymphocytic leukemia (CLL)

Shanafelt, T. D., Ramsay, A. G., Zent, C. S., Leis, J. F., Tun, H. W., Call, T. G., LaPlant, B., Bowen, D., Pettinger, A., Jelinek, D. F., Hanson, C. A. & Kay, N. E., May 16 2013, In : Blood. 121, 20, p. 4137-4141 5 p.

Research output: Contribution to journalArticle

66 Scopus citations

Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models

Li, Z., Qiu, Y., Personett, D., Huang, P., Edenfield, B., Katz, J., Babusis, D., Tang, Y., Shirely, M. A., Moghaddam, M. F., Copland, J. A. & Tun, H. W., Aug 5 2013, In : PloS one. 8, 8, e71754.

Research output: Contribution to journalArticle

37 Scopus citations

Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma

Von Roemeling, C. A., Marlow, L. A., Wei, J. J., Cooper, S. J., Caulfield, T. R., Wu, K., Tan, W. W., Tun, H. W. & Copland, J. A., May 1 2013, In : Clinical Cancer Research. 19, 9, p. 2368-2380 13 p.

Research output: Contribution to journalArticle

102 Scopus citations
2014

Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration

von Roemeling, C. A., Marlow, L. A., Radisky, D. C., Rohl, A., Larsen, H. E., Wei, J., Sasinowska, H., Zhu, H., Drake, R., Sasinowski, M., Tun, H. W. & Copland, J. A., 2014, In : Oncotarget. 5, 14, p. 5320-5334 15 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4

Von Roemeling, C. A., Radisky, D. C., Marlow, L. A., Cooper, S. J., Grebe, S. K., Anastasiadis, P. Z., Tun, H. W. & Copland, J. A., Sep 1 2014, In : Cancer research. 74, 17, p. 4796-4810 15 p.

Research output: Contribution to journalArticle

54 Scopus citations
2015

Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target

Von Roemeling, C. A., Marlow, L. A., Pinkerton, A. B., Crist, A., Miller, J., Tun, H. W., Smallridge, R. C. & Copland, J. A. III., May 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 5, p. E697-E709

Research output: Contribution to journalArticle

44 Scopus citations

A case of exuberant cutaneous lymphomagenesis in the setting of chronic patch mycosis fungoides

Sluzevich, J. C., Tun, H. W., Jacks, D. S. & Jiang, L., 2015, In : JAAD Case Reports. 1, 1, p. 46-48 3 p.

Research output: Contribution to journalArticle

Excellent outcome of immunomodulation or Bruton’s tyrosine kinase inhibition in highly refractory primary cutaneous diffuse large B-cell lymphoma, leg type

Gupta, E., Accurso, J., Sluzevich, J., Menke, D. M. & Tun, H. W., Dec 29 2015, In : Rare Tumors. 7, 4, p. 164-166 3 p., 6067.

Research output: Contribution to journalArticle

14 Scopus citations
11 Scopus citations

S100A8 is a novel therapeutic target for anaplastic thyroid carcinoma

Reeb, A. N., Li, W., Sewell, W., Marlow, L. A., Tun, H. W., Smallridge, R. C., Copland, J. A. III., Spradling, K., Chernock, R. & Lin, R. Y., Feb 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 2, p. E232-E242

Research output: Contribution to journalArticle

18 Scopus citations

T-cell/histiocyte-rich large B-cell lymphoma presenting as a primary central nervous system lymphoma

Advani, P., Starr, J., Swaika, A., Jiang, L., Qiu, Y., Li, Z. & Tun, H. W., Dec 29 2015, In : Rare Tumors. 7, 4, p. 160-162 3 p., 6084.

Research output: Contribution to journalArticle

1 Scopus citations

The mTORC1 inhibitor everolimus has antitumor activity in vitro and produces tumor responses in patients with relapsed T-cell lymphoma

Witzig, T. E., Reeder, C., Han, J. J., LaPlant, B., Stenson, M., Tun, H. W., Macon, W., Ansell, S. M., Habermann, T. M., Inwards, D. J., Micallef, I., Johnston, P. B., Porrata, L. F., Colgan, J. P., Markovic, S. N., Nowakowski, G. S. & Gupta, M., Jul 16 2015, In : Blood. 126, 3, p. 328-335 8 p.

Research output: Contribution to journalArticle

52 Scopus citations
2016

Osteopontin is a multi-faceted pro-tumorigenic driver for central nervous system lymphoma

Yushi, Q., Li, Z., Von Roemeling, C. A., Doeppler, H., Marlow, L. A., Kim, Y. S. B., Radisky, D. C., Storz, P., Copland, J. A. III. & Tun, H. W., May 31 2016, In : Oncotarget. 7, 22, p. 32156-32171 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Surface modification of nanoparticles enables selective evasion of phagocytic clearance by distinct macrophage phenotypes

Qie, Y., Yuan, H., Von Roemeling, C. A., Chen, Y., Liu, X., Shih, K. D., Knight, J. A., Tun, H. W., Wharen, R. E., Jiang, W. & Kim, Y. S. B., May 19 2016, In : Scientific Reports. 6, 26269.

Research output: Contribution to journalArticle

54 Scopus citations
2017

Compounds, compositions, and methods of agelastatin alkaloids: patent evaluation of WO2015042239 (A1)

Yoshimitsu, T. & Tun, H. W., Feb 1 2017, In : Expert Opinion on Therapeutic Patents. 27, 2, p. 113-119 7 p.

Research output: Contribution to journalArticle

Hairy cell lymphoma: A potentially under-recognized entity

Hammond, W. A., Swaika, A., Menke, D. & Tun, H. W., Mar 28 2017, In : Rare Tumors. 9, 1, p. 1-3 3 p., 6518.

Research output: Contribution to journalArticle

3 Scopus citations

Mantle cell lymphoma with a novel t(11;12)(q13;p11.2): a proposed alternative mechanism of CCND1 up-regulation

Menke, J. R., Vasmatzis, G., Murphy, S., Yang, L., Menke, D. M., Tun, H. W., King, R., Smoley, S. A., Ketterling, R. P. & Sukov, W. R., Jun 1 2017, In : Human Pathology. 64, p. 207-212 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

von Roemeling, C. A., Caulfield, T. R., Marlow, L., Bok, I., Wen, J., Miller, J. L., Hughes, R., Hazlehurst, L., Pinkerton, A. B., Radisky, D. C., Tun, H. W., Kim, Y. S. B., Lane, A. L. & Copland, J. A., Jan 1 2018, In : Oncotarget. 9, 1, p. 3-20 18 p.

Research output: Contribution to journalArticle

7 Scopus citations

Allogeneic hematopoietic cell transplant for relapsed-refractory, marginal zone lymphoma: a single-center experience

Dholaria, B. R., Hammond, W. A., Roy, V., Sher, T., Vishnu, P., Soyano, A., Finn, L. E. & Tun, H., Mar 23 2018, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-4 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Combined alkylation and histone deacetylase inhibition with EDO-S101 has significant therapeutic activity against brain tumors in preclinical models

Qiu, Y., Li, Z., Copland, J. A., Mehrling, T. & Tun, H. W., Jun 15 2018, In : Oncotarget. 9, 46, p. 28155-28164 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacokinetics-based clinical management of acquired von willebrand syndrome: A case report

Baldeo, C. M., Rivera, C. E., Tun, H. W. & Vishnu, P., Jan 19 2018, In : Journal of Blood Medicine. 9, p. 9-13 5 p.

Research output: Contribution to journalArticle

Phase 1 study of pomalidomide and dexamethasone for relapsed/refractory primary CNS or vitreoretinal lymphoma

Tun, H. W., Johnston, P. B., DeAngelis, L. M., Atherton, P. J., Pederson, L. D., Koenig, P. A., Reeder, C. B., Padula Omuro, A. M., Schiff, D., O'Neill, B., Pulido, J., Jaeckle, K. A., Grommes, C. & Witzig, T. E., Nov 22 2018, In : Blood. 132, 21, p. 2240-2248 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Primary histiocytic sarcoma of the central nervous system: A case report with platelet derived growth factor receptor mutation and PD-L1/PD-L2 expression and literature review

May, J. M., Waddle, M. R., Miller, D. H., Stross, W. C., Kaleem, T. A., May, B. C., Miller, R. C., Jiang, L., Strong, G. W., Trifiletti, D., Chaichana, K. L., Reimer, R., Tun, H. W. & Peterson, J. L., Sep 5 2018, In : Radiation Oncology. 13, 1, 167.

Research output: Contribution to journalArticle

2 Scopus citations
2019

A randomized trial of three novel regimens for recurrent acute myeloid leukemia demonstrates the continuing challenge of treating this difficult disease

Litzow, M. R., Wang, X. V., Carroll, M. P., Karp, J. E., Ketterling, R. P., Zhang, Y., Kaufmann, S. H., Lazarus, H. M., Luger, S. M., Paietta, E. M., Pratz, K. W., Tun, H. W., Altman, J. K., Broun, E. R., Rybka, W. B., Rowe, J. M. & Tallman, M. S., Jan 2019, In : American journal of hematology. 94, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Autologous Stem Cell Transplantation in Central Nervous System Lymphoma: A Multicenter Retrospective Series and a Review of the Literature

Dholaria, B. R., Kumar, A., Azzuqua, A. G., Nishihori, T., Kharfan-Dabaja, M. A., Tun, H. W. & Ayala, E., Jan 1 2019, In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

1 Scopus citations