Haidong M Dong, MD, PhD

  • 14322 Citations
  • 48 Scopus h-Index
1992 …2020

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2010

B7-H1 expression in vestibular schwannomas

Archibald, D. J., Neff, B. A., Voss, S. G., Splinter, P. L., Driscoll, C. L. W., Link, M. J., Dong, H. & Kwon, E. D., Aug 1 2010, In : Otology and Neurotology. 31, 6, p. 991-997 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

B7-H1 expression on old CD8+ T cells negatively regulates the activation of immune responses in aged animals

Mirza, N., Duque, M. A., Dominguez, A. L., Schrum, A. G., Dong, H. & Lustgarten, J., May 15 2010, In : Journal of Immunology. 184, 10, p. 5466-5474 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by down-regulating microRNA-513

Gong, A. Y., Zhou, R., Hu, G., Liu, J., Sosnowska, D., Drescher, K. M., Dong, H. & Chen, X. M., Jan 1 2010, In : Journal of Infectious Diseases. 201, 1, p. 160-169 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2009

B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders

Wilcox, R. A., Feldman, A. L., Wada, D. A., Yang, Z. Z., Comfere, N. I., Dong, H., Kwon, E. D., Novak, A. J., Markovic, S. N., Pittelkow, M. R., Witzig, T. E. & Ansell, S. M., Nov 20 2009, In : Blood. 114, 10, p. 2149-2158 10 p.

Research output: Contribution to journalArticle

139 Scopus citations

MicroRNA-513 regulates B7-H1 translation and is involved in IFN-γ-induced B7-H1 expression in cholangiocytes

Gong, A. Y., Zhou, R., Hu, G., Li, X., Splinter, P. L., O'Hara, S. P., LaRusso, N. F., Soukup, G. A., Dong, H. & Chen, X. M., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1325-1333 9 p.

Research output: Contribution to journalArticle

131 Scopus citations

TLR3-stimulated dendritic cells up-regulate B7-H1 expression and influence the magnitude of CD8 T cell responses to tumor vaccination

Pulko, V., Liu, X., Krco, C. J., Harris, K. J., Frigola, X., Kwon, E. D. & Dong, H., Sep 15 2009, In : Journal of Immunology. 183, 6, p. 3634-3641 8 p.

Research output: Contribution to journalArticle

61 Scopus citations
2008

Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma

Crispen, P. L., Sheinin, Y., Roth, T. J., Lohse, C. M., Kuntz, S. M., Frigola, X., Houston Thompson, R., Boorjian, S. A., Dong, H., Leibovich, B. C., Blute, M. L. & Kwon, E. D., Aug 15 2008, In : Clinical Cancer Research. 14, 16, p. 5150-5157 8 p.

Research output: Contribution to journalArticle

166 Scopus citations
2007

Implications of B7-H1 expression in clear cell carcinoma of the kidney for prognostication and therapy

Thompson, R. H., Dong, H. & Kwon, E. D., Jan 15 2007, In : Clinical Cancer Research. 13, 2 II, p. 709s-714s

Research output: Contribution to journalArticle

142 Scopus citations

PD-1 is expressed by tumor-infiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma

Thompson, R. H., Dong, H., Lohse, C. M., Leibovich, B. C., Blute, M. L., Cheville, J. C. & Kwon, E. D., Mar 15 2007, In : Clinical Cancer Research. 13, 6, p. 1757-1761 5 p.

Research output: Contribution to journalArticle

371 Scopus citations

PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: Associations with localized stage progression

Inman, B. A., Sebo, T. J., Frigola, X., Dong, H., Bergstralh, E. J., Frank, I., Fradet, Y., Lacombe, L. & Kwon, E. D., Apr 15 2007, In : Cancer. 109, 8, p. 1499-1505 7 p.

Research output: Contribution to journalArticle

264 Scopus citations

Survivin and B7-H1 are collaborative predictors of survival and represent potential therapeutic targets for patients with renal cell carcinoma

Krambeck, A. E., Dong, H., Thompson, R. H., Kuntz, S. M., Lohse, C. M., Leibovich, B. C., Blute, M. L., Sebo, T. J., Cheville, J. C., Parker, A. S. & Kwon, E. D., Mar 15 2007, In : Clinical Cancer Research. 13, 6, p. 1749-1756 8 p.

Research output: Contribution to journalArticle

81 Scopus citations

Targeting molecular and cellular inhibitory mechanisms for improvement of antitumor memory responses reactivated by tumor cell vaccine

Webster, W. S., Thompson, R. H., Harris, K. J., Frigola, X., Kuntz, S., Inman, B. A. & Dong, H., Sep 1 2007, In : Journal of Immunology. 179, 5, p. 2860-2869 10 p.

Research output: Contribution to journalArticle

Open Access
54 Scopus citations

Tumor-infiltrating Foxp3-CD4+CD25+ T cells predict poor survival in renal cell carcinoma

Siddiqui, S. A., Frigola, X., Bonne-Annee, S., Mercader, M., Kuntz, S. M., Krambeck, A. E., Sengupta, S., Dong, H., Cheville, J. C., Lohse, C. M., Krco, C. J., Webster, W. S., Leibovich, B. C., Blute, M. L., Knutson, K. L. & Kwon, E. D., Apr 1 2007, In : Clinical Cancer Research. 13, 7, p. 2075-2081 7 p.

Research output: Contribution to journalArticle

131 Scopus citations
2006

B7-H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival

Krambeck, A. E., Thompson, R. H., Dong, H., Lohse, C. M., Park, E. S., Kuntz, S. M., Leibovich, B. C., Blute, M. L., Cheville, J. C. & Kwon, E. D., Jul 4 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 27, p. 10391-10396 6 p.

Research output: Contribution to journalArticle

235 Scopus citations

Human bone marrow: A reservoir for "enhanced effector memory" CD8+ T cells with potent recall function

Zhang, X., Dong, H., Lin, W., Voss, S., Hinkley, L., Westergren, M., Tian, G., Berry, D., Lewellen, D., Vile, R. G., Chen, L., Farber, D. L. & Strome, S. E., Nov 15 2006, In : Journal of Immunology. 177, 10, p. 6730-6737 8 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Mononuclear cell infiltration in clear-cell renal cell carcinoma independently predicts patient survival

Webster, W. S., Lohse, C. M., Thompson, R. H., Dong, H., Frigola, X., Dicks, D. L., Sengupta, S., Frank, I., Leibovich, B. C., Blute, M. L., Cheville, J. C. & Kwon, E. D., Jul 1 2006, In : Cancer. 107, 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up

Thompson, R. H., Kuntz, S. M., Leibovich, B. C., Dong, H., Lohse, C. M., Webster, W. S., Sengupta, S., Frank, I., Parker, A. S., Zincke, H., Blute, M. L., Sebo, T. J., Cheville, J. C. & Kwon, E. D., Apr 1 2006, In : Cancer research. 66, 7, p. 3381-3385 5 p.

Research output: Contribution to journalArticle

610 Scopus citations
2005

B7-H1 glycoprotein blockade: A novel strategy to enhance immunotherapy in patients with renal cell carcinoma

Thompson, R. H., Webster, W. S., Cheville, J. C., Lohse, C. M., Dong, H., Leibovich, B. C., Kuntz, S. M., Sengupta, S., Kwon, E. D. & Blute, M. L., Nov 1 2005, In : Urology. 66, 5 SUPPL., p. 10-14 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity

Hirano, F., Kaneko, K., Tamura, H., Dong, H., Wang, S., Ichikawa, M., Rietz, C., Flies, D. B., Lau, J. S., Zhu, G., Tamada, K. & Chen, L., Feb 1 2005, In : Cancer research. 65, 3, p. 1089-1096 8 p.

Research output: Contribution to journalArticle

655 Scopus citations

Costimulatory molecule B7-H1 in primary and metastatic clear cell renal cell carcinoma

Thompson, R. H., Gillett, M. D., Cheville, J. C., Lohse, C. M., Dong, H., Webster, W. S., Chen, L., Zincke, H., Blute, M. L., Leibovich, B. C. & Kwon, E. D., Nov 15 2005, In : Cancer. 104, 10, p. 2084-2091 8 p.

Research output: Contribution to journalArticle

140 Scopus citations

Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia

Tamura, H., Dan, K., Tamada, K., Nakamura, K., Shioi, Y., Hyodo, H., Wang, S. D., Dong, H., Chen, L. & Ogata, K., Aug 15 2005, In : Clinical Cancer Research. 11, 16, p. 5708-5717 10 p.

Research output: Contribution to journalArticle

73 Scopus citations
2004

Augmentation of T cell levels and responses induced by androgen deprivation

Roden, A. C., Moser, M. T., Tri, S. D., Mercader, M., Kuntz, S. M., Dong, H., Hurwitz, A. A., McKean, D. J., Celis, E., Leibovich, B. C., Allison, J. P. & Kwon, E. D., Nov 15 2004, In : Journal of Immunology. 173, 10, p. 6098-6108 11 p.

Research output: Contribution to journalArticle

Open Access
170 Scopus citations

B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes

Dong, H., Zhu, G., Tamada, K., Flies, D. B., Van Deursen, J. M. A. & Chen, L., Mar 1 2004, In : Immunity. 20, 3, p. 327-336 10 p.

Research output: Contribution to journalArticle

284 Scopus citations

B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells

Luo, L., Chapoval, A. I., Flies, D. B., Zhu, G., Hirano, F., Wang, S., Lau, J. S., Dong, H., Tamada, K., Flies, A. S., Liu, Y. & Chen, L., Nov 1 2004, In : Journal of Immunology. 173, 9, p. 5445-5450 6 p.

Research output: Contribution to journalArticle

Open Access
126 Scopus citations

Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target

Thompson, R. H., Gillett, M. D., Cheville, J. C., Lohse, C. M., Dong, H., Webster, W. S., Krejci, K. G., Lobo, J. R., Sengupta, S., Chen, L., Zincke, H., Blute, M. L., Strome, S. E., Leibovich, B. C. & Kwon, E. D., Dec 7 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 49, p. 17174-17179 6 p.

Research output: Contribution to journalArticle

574 Scopus citations
2003

B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma

Strome, S. E., Dong, H., Tamura, H., Voss, S. G., Flies, D. B., Tamada, K., Salomao, D., Cheville, J., Hirano, F., Lin, W., Kasperbauer, J. L., Ballman, K. V. & Chen, L., Oct 1 2003, In : Cancer research. 63, 19, p. 6501-6505 5 p.

Research output: Contribution to journalArticle

380 Scopus citations

B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression

Trabattoni, D., Saresella, M., Biasin, M., Boasso, A., Piacentini, L., Ferrante, P., Dong, H., Maserati, R., Shearer, G. M., Chen, L. & Clerici, M., Apr 1 2003, In : Blood. 101, 7, p. 2514-2520 7 p.

Research output: Contribution to journalArticle

140 Scopus citations

Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity

Curiel, T. J., Wei, S., Dong, H., Alvarez, X., Cheng, P., Mottram, P., Krzysiek, R., Knutson, K. L., Daniel, B., Zimmermann, M. C., David, O., Burow, M., Gordon, A., Dhurandhar, N., Myers, L., Berggren, R., Hemminki, A., Alvarez, R. D., Emilie, D., Curiel, D. T. & 2 others, Chen, L. & Zou, W., May 1 2003, In : Nature Medicine. 9, 5, p. 562-567 6 p.

Research output: Contribution to journalArticle

827 Scopus citations

Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis

Dong, H., Strome, S. E., Matteson, E. L., Moder, K. G., Flies, D. B., Zhu, G., Tamura, H., Driscoll, C. L. W. & Chen, L., Feb 2003, In : Journal of Clinical Investigation. 111, 3, p. 363-370 8 p.

Research output: Contribution to journalArticle

Open Access
141 Scopus citations

Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction

Wang, S., Bajorath, J., Flies, D. B., Dong, H., Honjo, T. & Chen, L., May 5 2003, In : Journal of Experimental Medicine. 197, 9, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

237 Scopus citations

Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells

Radhakrishnan, S., Nguyen, L. T., Ciric, B., Ure, D. R., Zhou, B., Tamada, K., Dong, H., Tseng, S. Y., Shin, T., Pardoll, D. M., Chen, L., Kyle, R. A., Rodriguez, M. & Pease, L. R., Feb 15 2003, In : Journal of Immunology. 170, 4, p. 1830-1838 9 p.

Research output: Contribution to journalArticle

Open Access
55 Scopus citations
2002

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., Lennon, V. A., Cells, E. & Chen, L., Aug 26 2002, In : Nature Medicine. 8, 8, p. 793-800 8 p.

Research output: Contribution to journalArticle

2837 Scopus citations
2001

B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function

Tamura, H., Dong, H., Zhu, G., Sica, G. L., Flies, D. B., Tamada, K. & Chen, L., Mar 15 2001, In : Blood. 97, 6, p. 1809-1816 8 p.

Research output: Contribution to journalArticle

181 Scopus citations

B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

Chapoval, A. I., Ni, J., Lau, J. S., Wilcox, R. A., Flies, D. B., Liu, D., Dong, H., Sica, G. L., Zhu, G., Tamada, K. & Chen, L., Mar 1 2001, In : Nature immunology. 2, 3, p. 269-274 6 p.

Research output: Contribution to journalArticle

546 Scopus citations
2000

Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS

Wang, S., Zhu, G., Chapoval, A. I., Dong, H., Tamada, K., Ni, J. & Chen, L., Oct 15 2000, In : Blood. 96, 8, p. 2808-2813 6 p.

Research output: Contribution to journalArticle

212 Scopus citations

The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice

Shinagawa, T., Dong, H. D., Xu, M., Maekawa, T. & Ishii, S., May 15 2000, In : EMBO Journal. 19, 10, p. 2280-2291 12 p.

Research output: Contribution to journalArticle

92 Scopus citations
1999

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

Dong, H., Zhu, G., Tamada, K. & Chen, L., Dec 1 1999, In : Nature Medicine. 5, 12, p. 1365-1369 5 p.

Research output: Contribution to journalArticle

1469 Scopus citations

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

Nomura, T., Khan, M. M., Kaul, S. C., Dong, H. D., Wadhwa, R., Colmenares, C., Kohno, I. & Ishii, S., Feb 15 1999, In : Genes and Development. 13, 4, p. 412-423 12 p.

Research output: Contribution to journalArticle

Open Access
237 Scopus citations
1998

In vitro enhancing effects of thymic dendritic cells on apoptotic cell death of thymocytes

Dong, H., Chen, J. & Chen, W., Jan 1 1998, In : Science in China, Series C: Life Sciences. 41, 1, p. 87-92 6 p.

Research output: Contribution to journalArticle

Membrane molecules in induction of apoptosis of thymocytes by mouse thymic dendritic cells which express Fas ligands

Dong, H., Chen, J. & Chen, W., Jan 1 1998, In : Science in China, Series C: Life Sciences. 41, 2, p. 189-194 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
1996

Apoptosis as a mechanism of lectin-dependent monocyte-mediated cytotoxicity

Dong, H. D., Kimoto, Y., Takai, S. I. & Taguchi, T., Jan 1 1996, In : Immunological Investigations. 25, 1-2, p. 65-78 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

The different effects of two thymic stromal cells on programmed cell death of thymocytes cultured in vitro

Dong, H., Pang, X. & Chen, W., Dec 1 1996, In : Chinese Journal of Microbiology and Immunology. 16, 4, p. 284-288 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
1995

Apoptosis of tumor cells in lectin-dependent lymphokine-activated killer cell-mediated cytotoxicity

Dong, H., Xing, R. & Guo, L., Dec 1 1995, In : Chinese Journal of Oncology. 17, 4, p. 245-248 4 p.

Research output: Contribution to journalArticle

1994

Treatment of malignant diseases using lectin-dependent lymphokine-activated killer cell-mediated cytotoxicity: Experimental research

Kimoto, Y., Lee-Miyamoto, M., Takai, S. I., Dong, H. M. & Taguchi, T., 1994, In : Japanese Journal of Clinical Immunology. 17, 3, p. 188-198 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
1992
2 Scopus citations