Haidong M Dong, MD, PhD

  • 14765 Citations
  • 48 Scopus h-Index
1992 …2020

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ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance

Orme, J. J., Jazieh, K. A., Xie, T., Harrington, S., Liu, X., Ball, M., Madden, B., Charlesworth, M. C., Azam, T. U., Lucien, F., Wootla, B., Li, Y., Villasboas, J. C., Mansfield, A. S., Dronca, R. S. & Dong, H., Jan 1 2020, In : OncoImmunology. 9, 1, 1744980.

Research output: Contribution to journalArticle

Open Access

Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas

Zhou, G., Sprengers, D., Boor, P. P. C., Doukas, M., Schutz, H., Mancham, S., Pedroza-Gonzalez, A., Polak, W. G., de Jonge, J., Gaspersz, M., Dong, H. M., Thielemans, K., Pan, Q., IJzermans, J. N. M., Bruno, M. J. & Kwekkeboom, J., Oct 1 2017, In : Gastroenterology. 153, 4, p. 1107-1119.e10

Research output: Contribution to journalArticle

96 Scopus citations

Apoptosis as a mechanism of lectin-dependent monocyte-mediated cytotoxicity

Dong, H. D., Kimoto, Y., Takai, S. I. & Taguchi, T., Jan 1 1996, In : Immunological Investigations. 25, 1-2, p. 65-78 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Apoptosis of tumor cells in lectin-dependent lymphokine-activated killer cell-mediated cytotoxicity

Dong, H., Xing, R. & Guo, L., Dec 1 1995, In : Chinese Journal of Oncology. 17, 4, p. 245-248 4 p.

Research output: Contribution to journalArticle

Augmentation of T cell levels and responses induced by androgen deprivation

Roden, A. C., Moser, M. T., Tri, S. D., Mercader, M., Kuntz, S. M., Dong, H., Hurwitz, A. A., McKean, D. J., Celis, E., Leibovich, B. C., Allison, J. P. & Kwon, E. D., Nov 15 2004, In : Journal of Immunology. 173, 10, p. 6098-6108 11 p.

Research output: Contribution to journalArticle

Open Access
173 Scopus citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

Dong, H., Zhu, G., Tamada, K. & Chen, L., Dec 1 1999, In : Nature Medicine. 5, 12, p. 1365-1369 5 p.

Research output: Contribution to journalArticle

1507 Scopus citations

B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders

Wilcox, R. A., Feldman, A. L., Wada, D. A., Yang, Z. Z., Comfere, N. I., Dong, H., Kwon, E. D., Novak, A. J., Markovic, S. N., Pittelkow, M. R., Witzig, T. E. & Ansell, S. M., 2009, In : Blood. 114, 10, p. 2149-2158 10 p.

Research output: Contribution to journalArticle

141 Scopus citations

B7-H1 antibodies lose antitumor activity due to activation of p38 MAPK that leads to apoptosis of tumor-reactive CD8+T cells

Liu, X., Wu, X., Cao, S., Harrington, S. M., Yin, P., Mansfield, A. & Dong, H. M., Nov 8 2016, In : Scientific Reports. 6, 36722.

Research output: Contribution to journalArticle

11 Scopus citations

B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma

Strome, S. E., Dong, H., Tamura, H., Voss, S. G., Flies, D. B., Tamada, K., Salomao, D., Cheville, J., Hirano, F., Lin, W., Kasperbauer, J. L., Ballman, K. V. & Chen, L., Oct 1 2003, In : Cancer research. 63, 19, p. 6501-6505 5 p.

Research output: Contribution to journalArticle

390 Scopus citations

B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function

Tamura, H., Dong, H., Zhu, G., Sica, G. L., Flies, D. B., Tamada, K. & Chen, L., Mar 15 2001, In : Blood. 97, 6, p. 1809-1816 8 p.

Research output: Contribution to journalArticle

181 Scopus citations

B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes

Dong, H., Zhu, G., Tamada, K., Flies, D. B., Van Deursen, J. M. A. & Chen, L., Mar 1 2004, In : Immunity. 20, 3, p. 327-336 10 p.

Research output: Contribution to journalArticle

288 Scopus citations

B7-H1 expressed by activated CD8 T cells is essential for their survival

Pulko, V., Harris, K. J., Liu, X., Gibbons, R. M., Harrington, S. M., Krco, C. J., Kwon, E. D. & Dong, H., Dec 1 2011, In : Journal of Immunology. 187, 11, p. 5606-5614 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis

Mansfield, A. S., Roden, A. C., Peikert, T., Sheinin, Y. M., Harrington, S. M., Krco, C. J., Dong, H. & Kwon, E. D., Jul 2014, In : Journal of Thoracic Oncology. 9, 7, p. 1036-1040 5 p.

Research output: Contribution to journalArticle

126 Scopus citations

B7-H1 expression in vestibular schwannomas

Archibald, D. J., Neff, B. A., Voss, S. G., Splinter, P. L., Driscoll, C. L. W., Link, M. J., Dong, H. & Kwon, E. D., Aug 1 2010, In : Otology and Neurotology. 31, 6, p. 991-997 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

B7-H1 expression on old CD8+ T cells negatively regulates the activation of immune responses in aged animals

Mirza, N., Duque, M. A., Dominguez, A. L., Schrum, A. G., Dong, H. & Lustgarten, J., May 15 2010, In : Journal of Immunology. 184, 10, p. 5466-5474 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

B7-H1 glycoprotein blockade: A novel strategy to enhance immunotherapy in patients with renal cell carcinoma

Thompson, R. H., Webster, W. S., Cheville, J. C., Lohse, C. M., Dong, H., Leibovich, B. C., Kuntz, S. M., Sengupta, S., Kwon, E. D. & Blute, M. L., Nov 1 2005, In : Urology. 66, 5 SUPPL., p. 10-14 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

B7-H1 influences the accumulation of virus-specific tissue resident memory T cells in the central nervous system

Pavelko, K. D., Bell, M. P., Harrington, S. M. & Dong, H., Nov 9 2017, In : Frontiers in immunology. 8, NOV, 1532.

Research output: Contribution to journalArticle

11 Scopus citations

B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression

Trabattoni, D., Saresella, M., Biasin, M., Boasso, A., Piacentini, L., Ferrante, P., Dong, H., Maserati, R., Shearer, G. M., Chen, L. & Clerici, M., Apr 1 2003, In : Blood. 101, 7, p. 2514-2520 7 p.

Research output: Contribution to journalArticle

141 Scopus citations

B7-H1 limits the entry of effector CD8+ T cells to the memory pool by upregulating bim

Gibbons, R. M., Liu, X., Pulko, V., Harrington, S. M., Krco, C. J., Kwon, E. D. & Dong, H., Dec 1 2012, In : OncoImmunology. 1, 7, p. 1061-1073 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

B7-H1 signaling is integrated during CD8+ T cell priming and restrains effector differentiation

Gibbons, R. M., Liu, X., Harrington, S. M., Krco, C. J., Kwon, E. D. & Dong, H., Aug 2014, In : Cancer Immunology, Immunotherapy. 63, 8, p. 859-867 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

Chapoval, A. I., Ni, J., Lau, J. S., Wilcox, R. A., Flies, D. B., Liu, D., Dong, H., Sica, G. L., Zhu, G., Tamada, K. & Chen, L., Mar 1 2001, In : Nature immunology. 2, 3, p. 269-274 6 p.

Research output: Contribution to journalArticle

559 Scopus citations

B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells

Luo, L., Chapoval, A. I., Flies, D. B., Zhu, G., Hirano, F., Wang, S., Lau, J. S., Dong, H., Tamada, K., Flies, A. S., Liu, Y. & Chen, L., Nov 1 2004, In : Journal of Immunology. 173, 9, p. 5445-5450 6 p.

Research output: Contribution to journalArticle

Open Access
128 Scopus citations

B7-H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival

Krambeck, A. E., Thompson, R. H., Dong, H., Lohse, C. M., Park, E. S., Kuntz, S. M., Leibovich, B. C., Blute, M. L., Cheville, J. C. & Kwon, E. D., Jul 4 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 27, p. 10391-10396 6 p.

Research output: Contribution to journalArticle

240 Scopus citations

Bidirectional signals of PD-L1 in T cells that fraternize with cancer cells

Johnson, R. M. G., Wen, T. & Dong, H., Apr 1 2020, In : Nature immunology. 21, 4, p. 365-366 2 p.

Research output: Contribution to journalArticle

Bim is an independent prognostic marker in intrahepatic cholangiocarcinoma

Zhang, H., Jenkins, S. M., Lee, C. T., Harrington, S. M., Liu, Z., Dong, H. M. & Zhang, L., Aug 1 2018, In : Human Pathology. 78, p. 97-105 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity

Hirano, F., Kaneko, K., Tamura, H., Dong, H., Wang, S., Ichikawa, M., Rietz, C., Flies, D. B., Lau, J. S., Zhu, G., Tamada, K. & Chen, L., Feb 1 2005, In : Cancer research. 65, 3, p. 1089-1096 8 p.

Research output: Contribution to journalArticle

669 Scopus citations

Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity

Curiel, T. J., Wei, S., Dong, H., Alvarez, X., Cheng, P., Mottram, P., Krzysiek, R., Knutson, K. L., Daniel, B., Zimmermann, M. C., David, O., Burow, M., Gordon, A., Dhurandhar, N., Myers, L., Berggren, R., Hemminki, A., Alvarez, R. D., Emilie, D., Curiel, D. T. & 2 others, Chen, L. & Zou, W., May 1 2003, In : Nature Medicine. 9, 5, p. 562-567 6 p.

Research output: Contribution to journalArticle

843 Scopus citations

BRAF V600E-induced, tumor intrinsic PD-L1 can regulate chemotherapy-induced apoptosis in human colon cancer cells and in tumor xenografts

Feng, D., Qin, B., Pal, K., Sun, L., Dutta, S., Dong, H., Liu, X., Mukhopadhyay, D., Huang, S. & Sinicrope, F. A., Jan 1 2019, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

6 Scopus citations

Chemo-immunotherapy combination after PD-1 inhibitor failure improves clinical outcomes in metastatic melanoma patients

Vera Aguilera, J., Paludo, J., McWilliams, R. R., Zhang, H., Li, Y., Kumar, A. B., Failing, J., Kottschade, L. A., Block, M. S., Markovic, S. N., Dong, H., Dronca, R. S. & Yan, Y., 2020, (Accepted/In press) In : Melanoma research. p. 364-375 12 p.

Research output: Contribution to journalArticle

Open Access

Circulating levels of PD-L1 and Galectin-9 are associated with patient survival in surgically treated Hepatocellular Carcinoma independent of their intra-tumoral expression levels

Sideras, K., de Man, R. A., Harrington, S. M., Polak, W. G., Zhou, G., Schutz, H. M., Pedroza-Gonzalez, A., Biermann, K., Mancham, S., Hansen, B. E., Bart Takkenberg, R., van Vuuren, A. J., Pan, Q., Ijzermans, J. N. M., Sleijfer, S., Sprengers, D., Dong, H., Kwekkeboom, J. & Bruno, M. J., Dec 1 2019, In : Scientific reports. 9, 1, 10677.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Concordance of PD-1 and PD-L1 (B7-H1) in paired primary and metastatic clear cell renal cell carcinoma

Eckel-Passow, J. E., Ho, T. H., Serie, D. J., Cheville, J. C., Houston Thompson, R., Costello, B. A., Dong, H., Kwon, E. D., Leibovich, B. C. & Parker, A. S., Jan 1 2019, (Accepted/In press) In : Cancer medicine.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Contraction of T cell richness in lung cancer brain metastases

Mansfield, A., Ren, H., Sutor, S., Sarangi, V., Nair, A., Davila, J., Elsbernd, L. R., Udell, J. B., Dronca, R. S., Park, S. S., Markovic, S. N., Sun, Z. D., Halling, K. C., Nevala, W. K., Aubry, M. C., Dong, H. M. & Jen, J., Dec 1 2018, In : Scientific Reports. 8, 1, 2171.

Research output: Contribution to journalArticle

24 Scopus citations

Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis

Dong, H., Strome, S. E., Matteson, E. L., Moder, K. G., Flies, D. B., Zhu, G., Tamura, H., Driscoll, C. L. W. & Chen, L., Feb 2003, In : Journal of Clinical Investigation. 111, 3, p. 363-370 8 p.

Research output: Contribution to journalArticle

Open Access
142 Scopus citations

Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS

Wang, S., Zhu, G., Chapoval, A. I., Dong, H., Tamada, K., Ni, J. & Chen, L., Oct 15 2000, In : Blood. 96, 8, p. 2808-2813 6 p.

Research output: Contribution to journalArticle

214 Scopus citations

Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target

Thompson, R. H., Gillett, M. D., Cheville, J. C., Lohse, C. M., Dong, H., Webster, W. S., Krejci, K. G., Lobo, J. R., Sengupta, S., Chen, L., Zincke, H., Blute, M. L., Strome, S. E., Leibovich, B. C. & Kwon, E. D., Dec 7 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 49, p. 17174-17179 6 p.

Research output: Contribution to journalArticle

587 Scopus citations

Costimulatory molecule B7-H1 in primary and metastatic clear cell renal cell carcinoma

Thompson, R. H., Gillett, M. D., Cheville, J. C., Lohse, C. M., Dong, H., Webster, W. S., Chen, L., Zincke, H., Blute, M. L., Leibovich, B. C. & Kwon, E. D., Nov 15 2005, In : Cancer. 104, 10, p. 2084-2091 8 p.

Research output: Contribution to journalArticle

142 Scopus citations

CpG-induced antitumor immunity requires IL-12 in expansion of effector cells and down-regulation of PD-1

Yin, P., Liu, X., Mansfield, A. S., Harrington, S. M., Li, Y., Yan, Y. & Dong, H., 2016, In : Oncotarget. 7, 43, p. 70223-70231 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by down-regulating microRNA-513

Gong, A. Y., Zhou, R., Hu, G., Liu, J., Sosnowska, D., Drescher, K. M., Dong, H. & Chen, X. M., Jan 2010, In : Journal of Infectious Diseases. 201, 1, p. 160-169 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

CX3CR1 identifies PD-1 therapy-responsive CD8+ T cells that withstand chemotherapy during cancer chemoimmunotherapy

Yan, Y., Cao, S., Liu, X., Harrington, S. M., Bindeman, W. E., Adjei, A. A., Jang, J. S., Jen, J., Li, Y., Chanana, P., Mansfield, A. S., Park, S. S., Markovic, S. N., Dronca, R. S. & Dong, H., Apr 19 2018, In : JCI Insight. 3, 8

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Endogenous tumor-reactive CD8+ T cells are differentiated effector cells expressing high levels of CD11a and PD-1 but are unable to control tumor growth

Liu, X., Gibbons, R. M., Harrington, S. M., Krco, C. J., Markovic, S. N., Kwon, E. D. & Dong, H., Jun 1 2013, In : OncoImmunology. 2, 6, e23972.

Research output: Contribution to journalArticle

20 Scopus citations

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

Chen, G., Huang, A. C., Zhang, W., Zhang, G., Wu, M., Xu, W., Yu, Z., Yang, J., Wang, B., Sun, H., Xia, H., Man, Q., Zhong, W., Antelo, L. F., Wu, B., Xiong, X., Liu, X., Guan, L., Li, T., Liu, S. & 19 others, Yang, R., Lu, Y., Dong, L., McGettigan, S., Somasundaram, R., Radhakrishnan, R., Mills, G., Lu, Y., Kim, J., Chen, Y. H., Dong, H., Zhao, Y., Karakousis, G. C., Mitchell, T. C., Schuchter, L. M., Herlyn, M., Wherry, E. J., Xu, X. & Guo, W., Aug 16 2018, In : Nature. 560, 7718, p. 382-386 5 p.

Research output: Contribution to journalArticle

343 Scopus citations

Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia

Tamura, H., Dan, K., Tamada, K., Nakamura, K., Shioi, Y., Hyodo, H., Wang, S. D., Dong, H., Chen, L. & Ogata, K., Aug 15 2005, In : Clinical Cancer Research. 11, 16, p. 5708-5717 10 p.

Research output: Contribution to journalArticle

74 Scopus citations
3 Scopus citations

Human bone marrow: A reservoir for "enhanced effector memory" CD8+ T cells with potent recall function

Zhang, X., Dong, H., Lin, W., Voss, S., Hinkley, L., Westergren, M., Tian, G., Berry, D., Lewellen, D., Vile, R. G., Chen, L., Farber, D. L. & Strome, S. E., Nov 15 2006, In : Journal of Immunology. 177, 10, p. 6730-6737 8 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Identification of a soluble form of B7-H1 that retains immunosuppressive activity and is associated with aggressive renal cell carcinoma

Frigola, X., Inman, B. A., Lohse, C. M., Krco, C. J., Cheville, J. C., Thompson, R. H., Leibovich, B., Blute, M. L., Dong, H. & Kwon, E. D., Apr 1 2011, In : Clinical Cancer Research. 17, 7, p. 1915-1923 9 p.

Research output: Contribution to journalArticle

156 Scopus citations

Immune checkpoint molecules soluble program death ligand 1 and galectin-9 are increased in pregnancy

Enninga, E. A. L., Harrington, S. M., Creedon, D. J., Ruano, R., Markovic, S. N., Dong, H. & Dronca, R. S., Jan 1 2017, (Accepted/In press) In : American Journal of Reproductive Immunology.

Research output: Contribution to journalArticle

21 Scopus citations

Immunomodulatory antibody therapy of Cancer: The closer, the better

Dronca, R. S. & Dong, H., Mar 1 2015, In : Clinical Cancer Research. 21, 5, p. 944-946 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Immunotherapy in Prostate Cancer

Sobol, I., Thompson, R. H., Dong, H. M., Krco, C. & Kwon, E. D., Jun 1 2015, In : Current Urology Reports. 16, 6, p. 1-5 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Implications of B7-H1 expression in clear cell carcinoma of the kidney for prognostication and therapy

Thompson, R. H., Dong, H. & Kwon, E. D., Jan 15 2007, In : Clinical Cancer Research. 13, 2 II, p. 709s-714s

Research output: Contribution to journalArticle

143 Scopus citations
16 Scopus citations