Haidong M Dong, MD, PhD

  • 14379 Citations
  • 48 Scopus h-Index
1992 …2020

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2020

ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance

Orme, J. J., Jazieh, K. A., Xie, T., Harrington, S., Liu, X., Ball, M., Madden, B., Charlesworth, M. C., Azam, T. U., Lucien, F., Wootla, B., Li, Y., Villasboas, J. C., Mansfield, A. S., Dronca, R. S. & Dong, H., Jan 1 2020, In : OncoImmunology. 9, 1, 1744980.

Research output: Contribution to journalArticle

Open Access

Bidirectional signals of PD-L1 in T cells that fraternize with cancer cells

Johnson, R. M. G., Wen, T. & Dong, H., Apr 1 2020, In : Nature immunology. 21, 4, p. 365-366 2 p.

Research output: Contribution to journalArticle

Regulation of sister chromatid cohesion by nuclear PD-L1

Yu, J., Qin, B., Moyer, A. M., Nowsheen, S., Tu, X., Dong, H., Boughey, J. C., Goetz, M. P., Weinshilboum, R., Lou, Z. & Wang, L., Jan 1 2020, (Accepted/In press) In : Cell Research.

Research output: Contribution to journalArticle

Open Access

Tumor Mutational Burden From Tumor-Only Sequencing Compared With Germline Subtraction From Paired Tumor and Normal Specimens

Parikh, K., Huether, R., White, K., Hoskinson, D., Beaubier, N., Dong, H., Adjei, A. A. & Mansfield, A. S., Feb 5 2020, In : JAMA Network Open. 3, 2, p. e200202

Research output: Contribution to journalArticle

Open Access
2019

BRAF V600E-induced, tumor intrinsic PD-L1 can regulate chemotherapy-induced apoptosis in human colon cancer cells and in tumor xenografts

Feng, D., Qin, B., Pal, K., Sun, L., Dutta, S., Dong, H., Liu, X., Mukhopadhyay, D., Huang, S. & Sinicrope, F. A., Jan 1 2019, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

3 Scopus citations

Circulating levels of PD-L1 and Galectin-9 are associated with patient survival in surgically treated Hepatocellular Carcinoma independent of their intra-tumoral expression levels

Sideras, K., de Man, R. A., Harrington, S. M., Polak, W. G., Zhou, G., Schutz, H. M., Pedroza-Gonzalez, A., Biermann, K., Mancham, S., Hansen, B. E., Bart Takkenberg, R., van Vuuren, A. J., Pan, Q., Ijzermans, J. N. M., Sleijfer, S., Sprengers, D., Dong, H. M., Kwekkeboom, J. & Bruno, M. J., Dec 1 2019, In : Scientific reports. 9, 1, 10677.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Concordance of PD-1 and PD-L1 (B7-H1) in paired primary and metastatic clear cell renal cell carcinoma

Eckel-Passow, J. E., Ho, T. H., Serie, D. J., Cheville, J. C., Houston Thompson, R., Costello, B. A., Dong, H., Kwon, E. D., Leibovich, B. C. & Parker, A. S., Jan 1 2019, (Accepted/In press) In : Cancer medicine.

Research output: Contribution to journalArticle

Open Access

Neoantigenic Potential of Complex Chromosomal Rearrangements in Mesothelioma

Mansfield, A., Peikert, T. D., Smadbeck, J., Udell, J. B. M., Garcia-Rivera, E., Elsbernd, L., Erskine, C. L., Van Keulen, V. P., Kosari, F., Murphy, S. J., Ren, H., Serla, V. V., Schaefer Klein, J. L., Karagouga, G., Harris, F. R., Sosa, C., Johnson, S. H., Nevala, W., Markovic, S. N., Bungum, A. O. & 6 others, Edell, E., Dong, H. M., Cheville, J., Aubry, M. C., Jen, J. & Vasmatzis, G., Feb 1 2019, In : Journal of Thoracic Oncology. 14, 2, p. 276-287 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Tu, X., Qin, B., Zhang, Y., Zhang, C., Kahila, M., Nowsheen, S., Yin, P., Yuan, J., Pei, H., Li, H., Yu, J., Song, Z., Zhou, Q., Zhao, F., Liu, J., Zhang, C., Dong, H. M., Mutter, R. & Lou, Z., Jun 20 2019, In : Molecular Cell. 74, 6, p. 1215-1226.e4

Research output: Contribution to journalArticle

7 Scopus citations

Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression

Jin, X., Ding, D., Yan, Y., Li, H., Wang, B., Ma, L., Ye, Z., Ma, T., Wu, Q., Rodrigues, D. N., Kohli, M., Jimenez, R., Wang, L., Goodrich, D. W., de Bono, J., Dong, H., Wu, H., Zhu, R. & Huang, H., Jan 3 2019, In : Molecular Cell. 73, 1, p. 22-35.e6

Research output: Contribution to journalArticle

21 Scopus citations

Prospective Immunophenotyping of CD8+ T Cells and Associated Clinical Outcomes of Patients With Oligometastatic Prostate Cancer Treated With Metastasis-Directed SBRT

Evans, J. D., Morris, L. K., Zhang, H., Cao, S., Liu, X., Mara, K. C., Stish, B. J., Davis, B. J., Mansfield, A., Dronca, R. S., Iott, M. J., Kwon, E. D., Foote, R. L., Olivier, K. R., Dong, H. M. & Park, S. S., Jan 1 2019, In : International Journal of Radiation Oncology Biology Physics. 103, 1, p. 229-240 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Reverse signaling via PD-L1 supports malignant cell growth and survival in classical Hodgkin lymphoma

Jalali, S., Price-Troska, T., Bothun, C., Villasboas Bisneto, J. J. C. ., Kim, H. J., Yang, Z. Z., Novak, A. J., Dong, H. M. & Ansell, S. M., Mar 1 2019, In : Blood cancer journal. 9, 3, 22.

Research output: Contribution to journalArticle

6 Scopus citations

Sex Differences in Tolerability to Anti-Programmed Cell Death Protein 1 Therapy in Patients with Metastatic Melanoma and Non-Small Cell Lung Cancer: Are We All Equal?

Duma, N., Abdel-Ghani, A., Yadav, S., Hoversten, K. P., Reed, C. T., Sitek, A. N., Enninga, E. A. L., Paludo, J., Aguilera, J. V., Leventakos, K., Lou, Y., Kottschade, L. A., Dong, H. M., Mansfield, A., Manochakian, R., Adjei, A. & Dronca, R. S., Jan 1 2019, In : Oncologist.

Research output: Contribution to journalArticle

6 Scopus citations

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., Ye, Z., Beckermann, K. E., Wu, Y., Jenkins, J. W., Siska, P. J., Vincent, B. G., Prakash, Y. S., Peikert, T., Edelson, B. T., Taneja, R., Kaplan, M. H., Rathmell, J. C., Dong, H., Hitosugi, T. & 1 others, Sun, J., Sep 17 2019, In : Immunity. 51, 3, p. 491-507.e7

Research output: Contribution to journalArticle

8 Scopus citations
2018

Bim is an independent prognostic marker in intrahepatic cholangiocarcinoma

Zhang, H., Jenkins, S. M., Lee, C. T., Harrington, S. M., Liu, Z., Dong, H. M. & Zhang, L., Aug 1 2018, In : Human Pathology. 78, p. 97-105 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Contraction of T cell richness in lung cancer brain metastases

Mansfield, A., Ren, H., Sutor, S., Sarangi, V., Nair, A., Davila, J., Elsbernd, L. R., Udell, J. B., Dronca, R. S., Park, S. S., Markovic, S. N., Sun, Z. D., Halling, K. C., Nevala, W. K., Aubry, M. C., Dong, H. M. & Jen, J., Dec 1 2018, In : Scientific Reports. 8, 1, 2171.

Research output: Contribution to journalArticle

21 Scopus citations

CX3CR1 identifies PD-1 therapy-responsive CD8+ T cells that withstand chemotherapy during cancer chemoimmunotherapy

Yan, Y., Cao, S., Liu, X., Harrington, S. M., Bindeman, W. E., Adjei, A. A., Jang, J. S., Jen, J., Li, Y., Chanana, P., Mansfield, A. S., Park, S. S., Markovic, S. N., Dronca, R. S. & Dong, H., Apr 19 2018, In : JCI insight. 3, 8

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

Chen, G., Huang, A. C., Zhang, W., Zhang, G., Wu, M., Xu, W., Yu, Z., Yang, J., Wang, B., Sun, H., Xia, H., Man, Q., Zhong, W., Antelo, L. F., Wu, B., Xiong, X., Liu, X., Guan, L., Li, T., Liu, S. & 19 others, Yang, R., Lu, Y., Dong, L., McGettigan, S., Somasundaram, R., Radhakrishnan, R., Mills, G., Lu, Y., Kim, J., Chen, Y. H., Dong, H., Zhao, Y., Karakousis, G. C., Mitchell, T. C., Schuchter, L. M., Herlyn, M., Wherry, E. J., Xu, X. & Guo, W., Aug 16 2018, In : Nature. 560, 7718, p. 382-386 5 p.

Research output: Contribution to journalArticle

290 Scopus citations
3 Scopus citations

PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression

Tang, H., Liang, Y., Anders, R. A., Taube, J. M., Qiu, X., Mulgaonkar, A., Liu, X., Harrington, S. M., Guo, J., Xin, Y., Xiong, Y., Nham, K., Silvers, W., Hao, G., Sun, X., Chen, M., Hannan, R., Qiao, J., Dong, H. M., Peng, H. & 1 others, Fu, Y. X., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 580-588 9 p.

Research output: Contribution to journalArticle

102 Scopus citations

Prevalent homozygous deletions of type i interferon and defensin genes in human cancers associate with immunotherapy resistance

Ye, Z., Dong, H. M., Li, Y., Ma, T., Huang, H., Leong, H. S., Eckel-Passow, J. E., Kocher, J-P., Liang, H. & Wang, L., Jul 15 2018, In : Clinical Cancer Research. 24, 14, p. 3299-3308 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy

Wu, X., Li, Y., Liu, X., Chen, C., Harrington, S. M., Cao, S., Xie, T., Orzechowski, A., Pham, T., Mansfield, A., Yan, Y., Kwon, E. D., Wang, L. M., Ling, K. & Dong, H. M., Dec 1 2018, In : Heliyon. 4, 12, e01039.

Research output: Contribution to journalArticle

3 Scopus citations

Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance

Liang, Y., Tang, H., Guo, J., Qiu, X., Yang, Z., Ren, Z., Sun, Z., Bian, Y., Xu, L., Xu, H., Shen, J., Han, Y., Dong, H. M., Peng, H. & Fu, Y. X., Dec 1 2018, In : Nature Communications. 9, 1, 4586.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas

Zhou, G., Sprengers, D., Boor, P. P. C., Doukas, M., Schutz, H., Mancham, S., Pedroza-Gonzalez, A., Polak, W. G., de Jonge, J., Gaspersz, M., Dong, H. M., Thielemans, K., Pan, Q., IJzermans, J. N. M., Bruno, M. J. & Kwekkeboom, J., Oct 1 2017, In : Gastroenterology. 153, 4, p. 1107-1119.e10

Research output: Contribution to journalArticle

86 Scopus citations

B7-H1 influences the accumulation of virus-specific tissue resident memory T cells in the central nervous system

Pavelko, K. D., Bell, M. P., Harrington, S. M. & Dong, H. M., Nov 9 2017, In : Frontiers in Immunology. 8, NOV, 1532.

Research output: Contribution to journalArticle

11 Scopus citations

Immune checkpoint molecules soluble program death ligand 1 and galectin-9 are increased in pregnancy

Enninga, E. A. L., Harrington, S. M., Creedon, D. J., Ruano, R., Markovic, S. N., Dong, H. M. & Dronca, R. S., Jan 1 2017, (Accepted/In press) In : American Journal of Reproductive Immunology.

Research output: Contribution to journalArticle

18 Scopus citations

PD-L1 interacts with CD80 to regulate graft-versusleukemia activity of donor CD8+ T cells

Ni, X., Song, Q., Cassady, K., Deng, R., Jin, H., Zhang, M., Dong, H. M., Forman, S., Martin, P. J., Chen, Y. Z., Wang, J. & Zeng, D., May 1 2017, In : Journal of Clinical Investigation. 127, 5, p. 1960-1977 18 p.

Research output: Contribution to journalArticle

27 Scopus citations

Pembrolizumab in patients with CLL and Richter transformation or with relapsed CLL

Ding, W. D., LaPlant, B. R., Call, T. G., Parikh, S. A., Leis, J. F., He, R., Shanafelt, T. D., Sinha, S., Le-Rademacher, J., Feldman, A. L., Habermann, T. M., Witzig, T. E., Wiseman, G. A., Lin, Y., Asmus, E., Nowakowski, G. S., Conte, M. J., Bowen, D. A., Aitken, C. N., Van Dyke, D. L. & 15 others, Greipp, P. T., Liu, X., Wu, X., Zhang, H., Secreto, C. R., Tian, S., Braggio, E. D., Wellik, L. E., Micallef, I., Viswanatha, D. S., Yan, H. D., Chanan Khan, A. A., Kay, N. E., Dong, H. M. & Ansell, S. M., Jun 29 2017, In : Blood. 129, 26, p. 3419-3427 9 p.

Research output: Contribution to journalArticle

113 Scopus citations

Temporal and spatial heterogeneity of programmed cell death 1-Ligand 1 expression in malignant mesothelioma

Terra, S. B. S. P., Mansfield, A., Dong, H. M., Peikert, T. D. & Roden, A., Aug 19 2017, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

13 Scopus citations

Type Iγ phosphatidylinositol phosphate kinase regulates PD-L1 expression by activating NF-κB

Xue, J., Chen, C., Qi, M., Huang, Y., Wang, L., Gao, Y., Dong, H. & Ling, K., Jan 1 2017, In : Oncotarget. 8, 26, p. 42414-42427 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Undifferentiated Pancreatic Carcinomas Display Enrichment for Frequency and Extent of PD-L1 Expression by Tumor Cells

Lehrke, H. D., Graham, R., Mc Williams, R. R., Lam-Himlin, D. M., Smyrk, T. C., Jenkins, S., Dong, H. M. & Zhang, L., Nov 2 2017, In : American Journal of Clinical Pathology. 148, 5, p. 441-449 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

B7-H1 antibodies lose antitumor activity due to activation of p38 MAPK that leads to apoptosis of tumor-reactive CD8+T cells

Liu, X., Wu, X., Cao, S., Harrington, S. M., Yin, P., Mansfield, A. & Dong, H. M., Nov 8 2016, In : Scientific Reports. 6, 36722.

Research output: Contribution to journalArticle

11 Scopus citations

CpG-induced antitumor immunity requires IL-12 in expansion of effector cells and down-regulation of PD-1

Yin, P., Liu, X., Mansfield, A. S., Harrington, S. M., Li, Y., Yan, Y. & Dong, H., Jan 1 2016, In : Oncotarget. 7, 43, p. 70223-70231 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
16 Scopus citations

PD-1 blunts the function of ovarian tumor-infiltrating dendritic cells by inactivating NF-κB

Karyampudi, L., Lamichhane, P., Krempski, J., Kalli, K. R., Behrens, M. D., Vargas, D. M., Hartmann, L. C., Janco, J. M. T., Dong, H. M., Hedin, K. E., Dietz, A. B., Goode, E. L. & Knutson, K. L., Jan 15 2016, In : Cancer Research. 76, 2, p. 239-250 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
3 Scopus citations
121 Scopus citations
2015

Immunomodulatory antibody therapy of Cancer: The closer, the better

Dronca, R. S. & Dong, H. M., Mar 1 2015, In : Clinical Cancer Research. 21, 5, p. 944-946 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Immunotherapy in Prostate Cancer

Sobol, I., Thompson, R. H., Dong, H. M., Krco, C. & Kwon, E. D., Jun 1 2015, In : Current Urology Reports. 16, 6, p. 1-5 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

PD-1 restrains radiotherapy-induced abscopal effect

Park, S. S., Dong, H. M., Liu, X., Harrington, S. M., Krco, C. J., Grams, M. P., Mansfield, A., Furutani, K. M., Olivier, K. R. & Kwon, E. D., Jun 1 2015, In : Cancer immunology research. 3, 6, p. 610-619 10 p.

Research output: Contribution to journalArticle

168 Scopus citations

Stem cells for murine interstitial cells of Cajal suppress cellular immunity and colitis via prostaglandin E<inf>2</inf> secretion

Dave, M., Hayashi, Y., Gajdos, G. B., Smyrk, T. C., Svingen, P. A., Kvasha, S. M., Lorincz, A., Dong, H. M., Faubion, W. A. & Ordog, T., May 1 2015, In : Gastroenterology. 148, 5, p. 978-990 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Synergy of cancer immunotherapy and radiotherapy

Mansfield, A., Park, S. S. & Dong, H. M., 2015, In : Aging. 7, 3, p. 144-145 2 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis

Mansfield, A. S., Roden, A. C., Peikert, T., Sheinin, Y. M., Harrington, S. M., Krco, C. J., Dong, H. & Kwon, E. D., Jul 2014, In : Journal of Thoracic Oncology. 9, 7, p. 1036-1040 5 p.

Research output: Contribution to journalArticle

125 Scopus citations

B7-H1 signaling is integrated during CD8+ T cell priming and restrains effector differentiation

Gibbons, R. M., Liu, X., Harrington, S. M., Krco, C. J., Kwon, E. D. & Dong, H., Aug 2014, In : Cancer Immunology, Immunotherapy. 63, 8, p. 859-867 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Endogenous tumor-reactive CD8+ T cells are differentiated effector cells expressing high levels of CD11a and PD-1 but are unable to control tumor growth

Liu, X., Gibbons, R. M., Harrington, S. M., Krco, C. J., Markovic, S. N., Kwon, E. D. & Dong, H., Jun 1 2013, In : OncoImmunology. 2, 6, e23972.

Research output: Contribution to journalArticle

20 Scopus citations

Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma

Tamura, H., Ishibashi, M., Yamashita, T., Tanosaki, S., Okuyama, N., Kondo, A., Hyodo, H., Shinya, E., Takahashi, H., Dong, H., Tamada, K., Chen, L., Dan, K. & Ogata, K., Feb 1 2013, In : Leukemia. 27, 2, p. 464-472 9 p.

Research output: Contribution to journalArticle

122 Scopus citations
2012

B7-H1 limits the entry of effector CD8+ T cells to the memory pool by upregulating bim

Gibbons, R. M., Liu, X., Pulko, V., Harrington, S. M., Krco, C. J., Kwon, E. D. & Dong, H., Dec 1 2012, In : OncoImmunology. 1, 7, p. 1061-1073 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
2011

B7-H1 expressed by activated CD8 T cells is essential for their survival

Pulko, V., Harris, K. J., Liu, X., Gibbons, R. M., Harrington, S. M., Krco, C. J., Kwon, E. D. & Dong, H., Dec 1 2011, In : Journal of Immunology. 187, 11, p. 5606-5614 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Identification of a soluble form of B7-H1 that retains immunosuppressive activity and is associated with aggressive renal cell carcinoma

Frigola, X., Inman, B. A., Lohse, C. M., Krco, C. J., Cheville, J. C., Thompson, R. H., Leibovich, B., Blute, M. L., Dong, H. & Kwon, E. D., Apr 1 2011, In : Clinical Cancer Research. 17, 7, p. 1915-1923 9 p.

Research output: Contribution to journalArticle

151 Scopus citations

Tumor-infiltrating programmed death receptor-1+ dendritic cells mediate immune suppression in ovarian cancer

Krempski, J., Karyampudi, L., Behrens, M. D., Erskine, C. L., Hartmann, L., Dong, H., Goode, E. L., Kalli, K. R. & Knutson, K. L., Jun 15 2011, In : Journal of Immunology. 186, 12, p. 6905-6913 9 p.

Research output: Contribution to journalArticle

119 Scopus citations