• 18444 Citations
  • 75 Scopus h-Index
1985 …2020

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Article
2002

Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutants

Li, Y., Lu, W., Schwartz, A. L. & Bu, G., Apr 16 2002, In : Biochemistry. 41, 15, p. 4921-4928 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Tissue factor pathway inhibitor induces expression of JUNB and GADD45B mRNAs

Shirotani-Ikejima, H., Kokame, K., Hamuro, T., Bu, G., Kato, H. & Miyata, T., Dec 1 2002, In : Biochemical and Biophysical Research Communications. 299, 5, p. 847-852 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
2001

Apolipoprotein E and apolipoprotein E receptors modulate Aβ-induced glial neuroinflammatory responses

LaDu, M. J., Shah, J. A., Reardon, C. A., Getz, G. S., Bu, G., Hu, J., Guo, L. & Van Eldik, L. J., Oct 9 2001, In : Neurochemistry International. 39, 5-6, p. 427-434 8 p.

Research output: Contribution to journalArticle

91 Scopus citations

Bimonthly update. Genetics and molecular biology.

Zerbinatti, C. & Bu, G., Feb 2001, In : Current opinion in lipidology. 12, 1, p. 77-79 3 p.

Research output: Contribution to journalArticle

Differential Functions of Members of the Low Density Lipoprotein Receptor Family Suggested by their Distinct Endocytosis Rates

Li, Y., Lu, W., Marzolo, M. P. & Bu, G., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 18000-18006 7 p.

Research output: Contribution to journalArticle

120 Scopus citations

Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein

Obermoeller-McCormick, L. M., Li, Y., Osaka, H., FitzGerald, D. J., Schwartz, A. L. & Bu, G., Apr 17 2001, In : Journal of cell science. 114, 5, p. 899-908 10 p.

Research output: Contribution to journalArticle

98 Scopus citations

High Affinity Binding of Receptor-associated Protein to Heparin and Low Density Lipoprotein Receptor-related Protein Requires Similar Basic Amino Acid Sequence Motifs

Melman, L., Cao, Z. F., Rennke, S., Marzolo, M. P., Wardell, M. R. & Bu, G., Aug 3 2001, In : Journal of Biological Chemistry. 276, 31, p. 29338-29346 9 p.

Research output: Contribution to journalArticle

25 Scopus citations
62 Scopus citations

Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins

Van Kerkhof, P., Alves dos Santos, C. M., Sachse, M., Klumperman, J., Bu, G. & Strous, G. J., Jan 1 2001, In : Molecular biology of the cell. 12, 8, p. 2556-2566 11 p.

Research output: Contribution to journalArticle

90 Scopus citations

The Putative Tumor Suppressor LRP1B, a Novel Member of the Low Density Lipoprotein (LDL) Receptor Family, Exhibits Both Overlapping and Distinct Properties with the LDL Receptor-related Protein

Liu, C. X., Li, Y., Obermoeller-McCormick, L. M., Schwartz, A. L. & Bu, G., Aug 3 2001, In : Journal of Biological Chemistry. 276, 31, p. 28889-28896 8 p.

Research output: Contribution to journalArticle

84 Scopus citations
2000

Apolipoprotein E receptors mediate the effects of β-amyloid on astrocyte cultures

Ladu, M. J., Shah, J. A., Reardon, C. A., Getz, G. S., Bu, G., Hu, J., Guo, L. & Van Eldik, L. J., Oct 27 2000, In : Journal of Biological Chemistry. 275, 43, p. 33974-33980 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

Expression of α2-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells

Marzolo, M. P., Von Bernhardi, R., Bu, G. & Inestrosa, N. C., May 1 2000, In : Journal of Neuroscience Research. 60, 3, p. 401-411 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

Lipoproteins in the central nervous system

Ladu, M. J., Reardon, C., Van Eldik, L., Fagan, A. M., Bu, G., Holtzman, D. & Getz, G. S., Jan 1 2000, In : Annals of the New York Academy of Sciences. 903, p. 167-175 9 p.

Research output: Contribution to journalArticle

155 Scopus citations

Role of tissue plasminogen activator receptor LRP in hippocampal long- term potentiation

Zhuo, M., Holtzman, D. M., Li, Y., Osaka, H., DeMaro, J., Jacquin, M. & Bu, G., Jan 15 2000, In : Journal of Neuroscience. 20, 2, p. 542-549 8 p.

Research output: Contribution to journalArticle

Open Access
234 Scopus citations

The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein

Li, Y., Marzolo, M. P., Van Kerkhof, P., Strous, G. J. & Bu, G., Jun 2 2000, In : Journal of Biological Chemistry. 275, 22, p. 17187-17194 8 p.

Research output: Contribution to journalArticle

180 Scopus citations

Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands

Liu, Y., Jones, M., Hingtgen, C. M., Bu, G., Laribee, N., Tanzi, R. E., Moir, R. D., Nath, A. & He, J. J., Dec 1 2000, In : Nature Medicine. 6, 12, p. 1380-1387 8 p.

Research output: Contribution to journalArticle

311 Scopus citations
1999

Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide

Moulder, K. L., Narita, M., Chang, L. K., Bu, G. & Johnson, E. M., Feb 24 1999, In : Journal of neurochemistry. 72, 3, p. 1069-1080 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Down-regulation of monocyte tissue factor mediated by tissue factor pathway inhibitor and the low density lipoprotein receptor-related protein

Hamik, A., Setiadi, H., Bu, G., McEver, R. P. & Morrissey, J. H., Feb 19 1999, In : Journal of Biological Chemistry. 274, 8, p. 4962-4969 8 p.

Research output: Contribution to journalArticle

75 Scopus citations
25 Scopus citations
1998

Ca2+ and receptor-associated protein are independently required for proper folding and disulfide bond formation of the low density lipoprotein receptor-related protein

Obermoeller, L. M., Ghen, Z., Schwartz, A. L. & Bu, G., Aug 28 1998, In : Journal of Biological Chemistry. 273, 35, p. 22374-22381 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury

Fagan, A. M., Murphy, B. A., Patel, S. N., Kilbridge, J. F., Mobley, W. C., Bu, G. & Holtzman, D. M., Jun 1998, In : Experimental Neurology. 151, 2, p. 314-325 12 p.

Research output: Contribution to journalArticle

101 Scopus citations

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: Astrocyte-specific expression and differing biological effects of astrocyte- secreted apoE3 and apoE4 lipoproteins

Sun, Y., Wu, S., Bu, G., Onifade, M. K., Patel, S. N., LaDu, M. J., Fagan, A. M. & Holtzman, D. M., May 1 1998, In : Journal of Neuroscience. 18, 9, p. 3261-3272 12 p.

Research output: Contribution to journalArticle

186 Scopus citations

Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein

Bu, G., Sun, Y., Schwartz, A. L. & Holtzman, D. M., May 22 1998, In : Journal of Biological Chemistry. 273, 21, p. 13359-13365 7 p.

Research output: Contribution to journalArticle

58 Scopus citations

The domain structure of human receptor-associated protein. Protease sensitivity and guanidine HCl denaturation

Rall, S. C., Ye, P., Bu, G. & Wardell, M. R., Sep 11 1998, In : Journal of Biological Chemistry. 273, 37, p. 24152-24157 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
1997

Differential functions of triplicated repeats suggest two independent roles for the receptor-associated protein as a molecular chaperone

Obermoeller, L. M., Warshawsky, I., Wardell, M. R. & Bu, G., Apr 18 1997, In : Journal of Biological Chemistry. 272, 16, p. 10761-10768 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP)

Bu, G., Rennke, S. & Geuze, H. J., Jan 1 1997, In : Journal of cell science. 110, 1, p. 65-73 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

High density lipoprotein decreases β-amyloid toxicity in cortical cell culture

Farhangrazi, Z. S., Ying, H., Bu, G., Dugan, L. L., Fagan, A. M., Choi, D. W. & Holtzman, D. M., Jan 1 1997, In : NeuroReport. 8, 5, p. 1127-1130 4 p.

Research output: Contribution to journalArticle

25 Scopus citations

Low density lipoprotein receptor-related protein modulates the expression of tissue-type plasminogen activator in human colon fibroblasts

Hardy, M. M., Feder, J., Wolfe, R. A. & Bu, G., Mar 7 1997, In : Journal of Biological Chemistry. 272, 10, p. 6812-6817 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development

Narita, M., Bu, G., Holtzman, D. M. & Schwartz, A. L., Feb 1997, In : Journal of neurochemistry. 68, 2, p. 587-595 9 p.

Research output: Contribution to journalArticle

91 Scopus citations

α2-macroglobulin complexes with and mediates the endocytosis of β- amyloid peptide via cell surface low-density lipoprotein receptor-related protein

Narita, M., Holtzman, D. M., Schwartz, A. L. & Bu, G., Nov 1997, In : Journal of neurochemistry. 69, 5, p. 1904-1911 8 p.

Research output: Contribution to journalArticle

225 Scopus citations
1996

Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein

Fagan, A. M., Bu, G., Sun, Y., Daugherty, A. & Holtzman, D. M., 1996, In : Journal of Biological Chemistry. 271, 47, p. 30121-30125 5 p.

Research output: Contribution to journalArticle

181 Scopus citations

Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein

Bu, G. & Rennke, S., Sep 25 1996, In : Journal of Biological Chemistry. 271, 36, p. 22218-22224 7 p.

Research output: Contribution to journalArticle

148 Scopus citations
1995

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone far LDL receptor-related protein

Bu, G., Geuze, H. J., Strous, G. J. & Schwartz, A. L., Jan 1 1995, In : EMBO Journal. 14, 10, p. 2269-2280 12 p.

Research output: Contribution to journalArticle

260 Scopus citations

Binding and endocytosis of 39 kDa protein by mdbk cells

Vettenranta, K., Bu, G. & Schwartz, A. L., Aug 1995, In : Journal of Cellular Physiology. 164, 2, p. 441-447 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

Holtzman, D. M., Pitas, R. E., Kilbridge, J., Nathan, B., Mahley, R. W., Bu, G. & Schwartz, A. L., Oct 10 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 21, p. 9480-9484 5 p.

Research output: Contribution to journalArticle

315 Scopus citations

Sites Within the 39-kDa Protein Important for Regulating Ligand Binding to the Low-Density Lipoprotein Receptor-Related Protein

Warshawsky, I., Bu, G. & Schwartz, A. L., Jan 1 1995, In : Biochemistry. 34, 10, p. 3404-3415 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo

Warshawsky, I., Bu, G., Mast, A., Saffitz, J. E., Broze, G. J. & Schwartz, A. L., Apr 1995, In : Journal of Clinical Investigation. 95, 4, p. 1773-1781 9 p.

Research output: Contribution to journalArticle

Open Access
65 Scopus citations

Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo

Narita, M., Bu, G., Olins, G. M., Higuchi, D. A., Herz, J., Broze, G. J. & Schwartz, A. L., Jan 1 1995, In : Journal of Biological Chemistry. 270, 42, p. 24800-24804 5 p.

Research output: Contribution to journalArticle

74 Scopus citations

Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo

Narita, M., Bu, G., Herz, J. & Schwarte, A. L., Aug 1995, In : Journal of Clinical Investigation. 96, 2, p. 1164-1168 5 p.

Research output: Contribution to journalArticle

Open Access
71 Scopus citations
1994

Binding analysis of amino-terminal and carboxyl-terminal regions of the 39-kDa protein to the low density lipoprotein receptor-related protein

Warshawsky, I., Bu, G. & Schwartz, A. L., Feb 4 1994, In : Journal of Biological Chemistry. 269, 5, p. 3325-3330 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons

Bu, G., Maksymovitch, E. A., Nerbonne, J. M. & Schwartz, A. L., Jul 15 1994, In : Journal of Biological Chemistry. 269, 28, p. 18521-18528 8 p.

Research output: Contribution to journalArticle

192 Scopus citations
3 Scopus citations

LRP and the Receptor‐Mediated Endocytosis of Plasminogen Activators

WARSHAWSKY, ILKA., BU, GUOJUN. & SCHWARTZ, ALAN. L., Sep 1994, In : Annals of the New York Academy of Sciences. 737, 1, p. 70-87 18 p.

Research output: Contribution to journalArticle

6 Scopus citations

Receptor-Mediated Endocytosis of Plasminogen Activators

Bu, G., Morton, P. A. & Schwartz, A. L., Jan 1 1994, In : Advances in Molecular and Cell Biology. 8, C, p. 87-131 45 p.

Research output: Contribution to journalArticle

Subcellular localization and endocytic function of low density lipoprotein receptor-related protein in human glioblastoma cells

Bu, G., Maksymovitch, E. A., Geuze, H. & Schwartz, A. L., Nov 25 1994, In : Journal of Biological Chemistry. 269, 47, p. 29874-29882 9 p.

Research output: Contribution to journalArticle

122 Scopus citations
1993

39-kD protein inhibits tissue-type plasminogen activator clearance in vivo

Warshawsky, I., Bu, G. & Schwartz, A. L., 1993, In : Journal of Clinical Investigation. 92, 2, p. 937-944 8 p.

Research output: Contribution to journalArticle

Open Access
57 Scopus citations

Adenosine analogs inhibit the guanine-7-methylation of mRNA cap structures

Oxenrider, K. A., Bu, G. & Sitz, T. O., Feb 1 1993, In : FEBS Letters. 316, 3, p. 273-277 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification of domains on the 39-kDa protein that inhibit the binding of ligands to the low density lipoprotein receptor-related protein

Warshawsky, I., Bu, G. & Schwartz, A. L., Jan 1 1993, In : Journal of Biological Chemistry. 268, 29, p. 22046-22054 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Interaction of a 39 kDa protein with the low-density-lipoprotein-receptor-related protein (LRP) on rat hepatoma cells

Iadonato, S. P., Bu, G., Maksymovitch, E. A. & Schwartz, A. L., Jan 1 1993, In : Biochemical Journal. 296, 3, p. 867-875 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Receptor-mediated endocytosis of tissue-type plasminogen activator by low density lipoprotein receptor-related protein on human hepatoma HepG2 cells

Bu, G., Maksymovitch, E. A. & Schwartz, A. L., Jan 1 1993, In : Journal of Biological Chemistry. 268, 17, p. 13002-13009 8 p.

Research output: Contribution to journalArticle

81 Scopus citations