• 18484 Citations
  • 76 Scopus h-Index
1985 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2009

Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways

Donoso, M., Cancino, J., Lee, J., Van Kerkhof, P., Retamal, C., Bu, G., Gonzalez, A., Caceres, A. & Marzolo, M. P., Jan 1 2009, In : Molecular biology of the cell. 20, 1, p. 481-497 17 p.

Research output: Contribution to journalArticle

42 Scopus citations

Receptor-associated protein interacts with amyloid-β peptide and promotes its cellular uptake

Kanekiyo, T. & Bu, G., Nov 27 2009, In : Journal of Biological Chemistry. 284, 48, p. 33352-33359 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
2008

Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes

Lee, J., Retamal, C., Cuitiño, L., Caruano-Yzermans, A., Shin, J. E., Van Kerkhof, P., Marzolo, M. P. & Bu, G., Apr 25 2008, In : Journal of Biological Chemistry. 283, 17, p. 11501-11508 8 p.

Research output: Contribution to journalArticle

110 Scopus citations

Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: Implication for breast cancer osteolytic bone metastases

Bu, G., Lu, W., Liu, C. C., Selander, K., Yoneda, T., Hall, C., Keller, E. T. & Li, Y., Sep 1 2008, In : International Journal of Cancer. 123, 5, p. 1034-1042 9 p.

Research output: Contribution to journalArticle

78 Scopus citations

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

Cirrito, J. R., Kang, J. E., Lee, J., Stewart, F. R., Verges, D. K., Silverio, L. M., Bu, G., Mennerick, S. & Holtzman, D. M., Apr 10 2008, In : Neuron. 58, 1, p. 42-51 10 p.

Research output: Contribution to journalArticle

408 Scopus citations

Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2

Doray, B., Knisely, J. M., Wartman, L., Bu, G. & Kornfeld, S., Aug 25 2008, In : Traffic. 9, 9, p. 1551-1562 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein

Parkyn, C. J., Vermeulen, E. G. M., Mootoosamy, R. C., Sunyach, C., Jacobsen, C., Oxvig, C., Moestrup, S., Liu, Q., Bu, G., Jen, A. & Morris, R. J., Mar 15 2008, In : Journal of cell science. 121, 6, p. 773-783 11 p.

Research output: Contribution to journalArticle

82 Scopus citations

The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid β peptides in an in vitro model of the blood-brain barrier cells

Yamada, K., Hashimoto, T., Yabuki, C., Nagae, Y., Tachikawa, M., Strickland, D. K., Liu, Q., Bu, G., Basak, J. M., Holtzman, D. M., Ohtsuki, S., Terasaki, T. & Iwatsubo, T., Dec 12 2008, In : Journal of Biological Chemistry. 283, 50, p. 34554-34562 9 p.

Research output: Contribution to journalArticle

78 Scopus citations

tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis

Hu, K., Lin, L., Tan, X., Yang, J., Bu, G., Mars, W. M. & Liu, Y., Mar 1 2008, In : Journal of the American Society of Nephrology. 19, 3, p. 503-514 12 p.

Research output: Contribution to journalArticle

44 Scopus citations
2007

A complete NMR spectral assignment of the conserved region of the MESD protein, MESD(12-155)

Chen, J., Bu, G. & Wang, J., Jul 1 2007, In : Biomolecular NMR Assignments. 1, 1, p. 3-5 3 p.

Research output: Contribution to journalArticle

A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression

Yuseff, M. I., Farfan, P., Bu, G. & Marzolo, M. P., Sep 1 2007, In : Traffic. 8, 9, p. 1215-1230 16 p.

Research output: Contribution to journalArticle

35 Scopus citations

Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1

Liu, Q., Zerbinatti, C. V., Zhang, J., Hoe, H. S., Wang, B., Cole, S. L., Herz, J., Muglia, L. & Bu, G., Oct 4 2007, In : Neuron. 56, 1, p. 66-78 13 p.

Research output: Contribution to journalArticle

255 Scopus citations

ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

Fuentealba, R. A., Barría, M. I., Lee, J., Cam, J., Araya, C., Escudero, C. A., Inestrosa, N. C., Bronfman, F. C., Bu, G. & Marzolo, M. P., Aug 13 2007, In : Molecular neurodegeneration. 2, 1, 14.

Research output: Contribution to journalArticle

53 Scopus citations

Lipoprotein receptor-related protein-1 mediates amyloid-β-mediated cell death of cerebrovascular cells

Wilhelmus, M. M. M., Otte-Höller, I., Van Triel, J. J. J., Veerhuis, R., Maat-Schieman, M. L. C., Bu, G., De Waal, R. M. W. & Verbeek, M. M., Dec 2007, In : American Journal of Pathology. 171, 6, p. 1989-1999 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells

Chen, S., Bu, G., Takei, Y., Sakamoto, K., Ikematsu, S., Muramatsu, T. & Kadomatsu, K., Nov 15 2007, In : Journal of cell science. 120, 22, p. 4009-4015 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Slow endocytosis of the LDL receptor-related protein 1B: Implications for a novel cytoplasmic tail conformation

Knisely, J. M., Li, Y., Griffith, J. M., Geuze, H. J., Schwartz, A. L. & Bu, G., Sep 10 2007, In : Experimental Cell Research. 313, 15, p. 3298-3307 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

The γ/σ1 and α/σ2 hemicomplexes of clathrin adaptors AP-1 and AP-2 Harbor the dileucine recognition site

Doray, B., Lee, I., Knisely, J., Bu, G. & Kornfeld, S., May 1 2007, In : Molecular biology of the cell. 18, 5, p. 1887-1896 10 p.

Research output: Contribution to journalArticle

114 Scopus citations
2006

Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Aβ42 accumulation in amyloid model mice

Zerbinatti, C. V., Wahrle, S. E., Kim, H., Cam, J. A., Bales, K., Paul, S. M., Holtzman, D. M. & Bu, G., Nov 24 2006, In : Journal of Biological Chemistry. 281, 47, p. 36180-36186 7 p.

Research output: Contribution to journalArticle

104 Scopus citations

Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice

Lisi, S., Botta, R., Pinchera, A., Collins, A. B., Refetoff, S., Arvan, P., Bu, G., Grasso, L., Marshansky, V., Bechoua, S., Hurtado-Lorenzo, A., Marcocci, C., Brown, D., McCluskey, R. T. & Marinò, M., Apr 1 2006, In : American Journal of Physiology - Cell Physiology. 290, 4, p. C1160-C1167

Research output: Contribution to journalArticle

11 Scopus citations

Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd

Li, Y., Lu, W., He, X. & Bu, G., Oct 2 2006, In : FEBS Letters. 580, 22, p. 5423-5428 6 p.

Research output: Contribution to journalArticle

19 Scopus citations
83 Scopus citations

Recent advances in basic neurosciences and brain disease: From synapses to behavior

Bi, G. Q., Bolshakov, V., Bu, G., Cahill, C. M., Chen, Z. F., Collingridge, G. L., Cooper, R. L., Coorssen, J. R., El-Husseini, A., Galhardo, V., Gan, W. B., Gu, J., Inoue, K., Isaac, J., Iwata, K., Jia, Z., Kaang, B. K., Kawamata, M., Kida, S., Klann, E. & 24 others, Kohno, T., Li, M., Li, X. J., MacDonald, J. F., Nader, K., Nguyen, P. V., Oh, U., Ren, K., Roder, J. C., Salter, M. W., Song, W., Sugita, S., Tang, S. J., Tao, Y., Tian, Y. T., Woo, N., Woodin, M. A., Yan, Z., Yoshimura, M., Xu, M., Xu, Z. C., Zhang, X., Zhen, M. & Zhuo, M., 2006, In : Molecular Pain. 2, 38.

Research output: Contribution to journalArticle

4 Scopus citations

Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein

Ladu, M. J., Stine, W. B., Narita, M., Getz, G. S., Reardon, C. A. & Bu, G., Jan 17 2006, In : Biochemistry. 45, 2, p. 381-390 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2005

ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its rafts' association

Cuitino, L., Matute, R., Retamal, C., Bu, G., Inestrosa, N. C. & Marzolo, M. P., Sep 1 2005, In : Traffic. 6, 9, p. 820-838 19 p.

Research output: Contribution to journalArticle

53 Scopus citations

Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease

Green, P. S., Bales, K., Paul, S. & Bu, G., Jun 1 2005, In : Endocrinology. 146, 6, p. 2774-2781 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Independent and cooperative roles of N-glycans and molecular chaperones in the folding and disulfide bond formation of the low-density lipoprotein (LDL) receptor-related protein

McCormick, L. M., Urade, R., Arakaki, Y., Schwartz, A. L. & Bu, G., Apr 19 2005, In : Biochemistry. 44, 15, p. 5794-5803 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

LRP1B functions as a receptor for Pseudomonas exotoxin

Pastrana, D. V., Hanson, A. J., Knisely, J., Bu, G. & FitzGerald, D. J., Sep 25 2005, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1741, 3, p. 234-239 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding

Li, Y., Chen, J., Lu, W., McCormick, L. M., Wang, J. & Bu, G., Nov 15 2005, In : Journal of cell science. 118, 22, p. 5305-5314 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the β-amyloid precursor protein

Cam, J. A., Zerbinatti, C. V., Li, Y. & Bu, G., Apr 15 2005, In : Journal of Biological Chemistry. 280, 15, p. 15464-15470 7 p.

Research output: Contribution to journalArticle

72 Scopus citations

Sorting nexin 17 facilitates LRP recycling in the early endosome

Van Kerkhof, P., Lee, J., McCormick, L., Tetrault, E., Lu, W., Schoenfish, M., Oorschot, V., Strous, G. J., Klumperman, J. & Bu, G., Aug 17 2005, In : EMBO Journal. 24, 16, p. 2851-2861 11 p.

Research output: Contribution to journalArticle

101 Scopus citations

Striking differences of LDL receptor-related protein 1B expression in mouse and human

Li, Y., Lu, W. & Bu, G., Aug 5 2005, In : Biochemical and Biophysical Research Communications. 333, 3, p. 868-873 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice

Fryer, J. D., DeMattos, R. B., McCormick, L. M., O'Dell, M. A., Spinner, M. L., Bales, K. R., Paul, S. M., Sullivan, P. M., Parsadanian, M., Bu, G. & Holtzman, D. M., Jul 8 2005, In : Journal of Biological Chemistry. 280, 27, p. 25754-25759 6 p.

Research output: Contribution to journalArticle

97 Scopus citations

Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis

Benchenane, K., Berezowski, V., Ali, C., Fernández-Monreal, M., López-Atalaya, J. P., Brillault, J., Chuquet, J., Nouvelot, A., MacKenzie, E. T., Bu, G., Cecchelli, R., Touzani, O. & Vivien, D., May 3 2005, In : Circulation. 111, 17, p. 2241-2249 9 p.

Research output: Contribution to journalArticle

144 Scopus citations

Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation

Wu, L. J., Toyoda, H., Zhao, M. G., Lee, Y. S., Tang, J., Ko, S. W., Yong, H. J., Shum, F. W. F., Zerbinatti, C. V., Bu, G., Wei, F., Xu, T. L., Muglia, L. J., Chen, Z. F., Auberson, Y. P., Kaang, B. K. & Zhuo, M., Nov 30 2005, In : Journal of Neuroscience. 25, 48, p. 11107-11116 10 p.

Research output: Contribution to journalArticle

179 Scopus citations
2004

Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway

Li, Y., Lu, W., Schwartz, A. L. & Bu, G., Jun 1 2004, In : Journal of Lipid Research. 45, 6, p. 1084-1091 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier

Pan, W., Kastin, A. J., Zankel, T. C., van Kerkhof, P., Terasaki, T. & Bu, G., Oct 1 2004, In : Journal of cell science. 117, 21, p. 5071-5078 8 p.

Research output: Contribution to journalArticle

109 Scopus citations

Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

Zerbinatti, C. V., Wozniak, D. F., Cirrito, J., Cam, J. A., Osaka, H., Bales, K. R., Zhuo, M., Paul, S. M., Holtzman, D. M. & Bu, G., Jan 27 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 4, p. 1075-1080 6 p.

Research output: Contribution to journalArticle

115 Scopus citations

Is tissue-type plasminogen activator a neuromodulator?

Fernández-Monreal, M., López-Atalaya, J. P., Benchenane, K., Léveillé, F., Cacquevel, M., Plawinski, L., MacKenzie, E. T., Bu, G., Buisson, A. & Vivien, D., Apr 1 2004, In : Molecular and Cellular Neuroscience. 25, 4, p. 594-601 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

Lipoprotein receptor binding, cellular uptake, and lysosomal delivery of fusions between the Receptor-associated Protein (RAP) and α-L-iduronidase or acid α-glucosidase

Prince, W. S., McCormick, L. M., Wendt, D. J., Fitzpatrick, P. A., Schwartz, K. L., Aguilera, A. I., Koppaka, V., Christianson, T. M., Vellard, M. C., Pavloff, N., Lemontt, J. F., Qin, M., Starr, C. M., Bu, G. & Zankel, T. C., Aug 13 2004, In : Journal of Biological Chemistry. 279, 33, p. 35037-35046 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering β-catenin subcellular distribution

Li, Y., Lu, W., He, X., Schwartz, A. L. & Bu, G., Dec 2 2004, In : Oncogene. 23, 56, p. 9129-9135 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

The low density lipoprotein receptor-related protein 1B retains β-amyloid precursor protein at the cell surface and reduces amyloid-β peptide production

Cam, J. A., Zerbinatti, C. V., Knisely, J. M., Hecimovic, S., Li, Y. & Bu, G., Jul 9 2004, In : Journal of Biological Chemistry. 279, 28, p. 29639-29646 8 p.

Research output: Contribution to journalArticle

81 Scopus citations
2003

Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains

Marzolo, M. P., Yuseff, M. I., Retamal, C., Donoso, M., Ezquer, F., Farfán, P., Li, Y. & Bu, G., Apr 1 2003, In : Traffic. 4, 4, p. 273-288 16 p.

Research output: Contribution to journalArticle

68 Scopus citations

Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration

Li, Y., Lu, W. & Bu, G., Dec 4 2003, In : FEBS Letters. 555, 2, p. 346-350 5 p.

Research output: Contribution to journalArticle

35 Scopus citations
2002

Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein

Narita, M., Holtzman, D. M., Fagan, A. M., LaDu, M. J., Yu, L., Han, X., Gross, R. W., Bu, G. & Schwartz, A. L., Nov 1 2002, In : Journal of Biochemistry. 132, 5, p. 743-749 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)

Su, H. P., Nakada-Tsukui, K., Tosello-Trampont, A. C., Li, Y., Bu, G., Henson, P. M. & Ravichandran, K. S., Apr 5 2002, In : Journal of Biological Chemistry. 277, 14, p. 11772-11779 8 p.

Research output: Contribution to journalArticle

182 Scopus citations
145 Scopus citations

Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration

Li, Y., Knisely, J. M., Lu, W., McCormick, L. M., Wang, J., Henkin, J., Schwartz, A. L. & Bu, G., Nov 1 2002, In : Journal of Biological Chemistry. 277, 44, p. 42366-42371 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Low density lipoprotein receptor-related protein mediates apolipoprotein E inhibition of smooth muscle cell migration

Swertfeger, D. K., Bu, G. & Hui, D. Y., Feb 8 2002, In : Journal of Biological Chemistry. 277, 6, p. 4141-4146 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Nuclear targeting by the growth factor midkine

Shibata, Y., Muramatsu, T., Hirai, M., Inui, T., Kimura, T., Saito, H., McCormick, L. M., Bu, G. & Kadomatsu, K., Oct 2002, In : Molecular and cellular biology. 22, 19, p. 6788-6796 9 p.

Research output: Contribution to journalArticle

112 Scopus citations

Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway

Melman, L., Geuze, H. J., Li, Y., McCormick, L. M., Van Kerkhof, P., Strous, G. J., Schwartz, A. L. & Bu, G., Sep 2002, In : Molecular biology of the cell. 13, 9, p. 3325-3335 11 p.

Research output: Contribution to journalArticle

37 Scopus citations