• 18484 Citations
  • 76 Scopus h-Index
1985 …2020

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Article
2014

Sorting nexin 17 regulates ApoER2 recycling and reelin signaling

Sotelo, P., Farfán, P., Benitez, M. L., Bu, G. & Marzolo, M. P., Apr 4 2014, In : PloS one. 9, 4, e93672.

Research output: Contribution to journalArticle

22 Scopus citations

Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity

Wang, X., Huang, T., Zhao, Y., Zheng, Q., Thompson, R. C., Bu, G., Zhang, Y. W., Hong, W. & Xu, H., Jan 1 2014, In : Cell reports. 9, 3, p. 1023-1033 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls

Martínez-Morillo, E., Hansson, O., Atagi, Y., Bu, G., Minthon, L., Diamandis, E. P. & Nielsen, H. M., May 2014, In : Acta neuropathologica. 127, 5, p. 633-643 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

Tyrosine-based signal mediates lrp6 receptor endocytosis and desensitization of wnt/β-catenin pathway signaling

Liu, C. C., Kanekiyo, T., Roth, B. & Bu, G., Oct 3 2014, In : Journal of Biological Chemistry. 289, 40, p. 27562-27570 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

α2A adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction

Chena, Y., Penga, Y., Chea, P., Gannona, M., Liua, Y., Lib, L., Bu, G., Van Groena, T., Jiaod, K. & Wanga, Q., Dec 2 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 48, p. 17296-17301 6 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations
2013

ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

Verghese, P. B., Castellano, J. M., Garai, K., Wang, Y., Jiang, H., Shah, A., Bu, G., Frieden, C. & Holtzman, D. M., May 7 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 19, p. E1807-E1816

Research output: Contribution to journalArticle

246 Scopus citations

A Sorting Nexin 17-Binding Domain Within the LRP1 Cytoplasmic Tail Mediates Receptor Recycling Through the Basolateral Sorting Endosome

Farfán, P., Lee, J., Larios, J., Sotelo, P., Bu, G. & Marzolo, M. P., Jul 1 2013, In : Traffic. 14, 7, p. 823-838 16 p.

Research output: Contribution to journalArticle

22 Scopus citations
33 Scopus citations

Ferritin light chain interacts with PEN-2 and affects γ-secretase activity

Li, X., Liu, Y., Zheng, Q., Yao, G., Cheng, P., Bu, G., Xu, H. & Zhang, Y. W., Aug 26 2013, In : Neuroscience Letters. 548, p. 90-94 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and alzheimer disease in a transgenic mouse model and human samples

Tai, L. M., Bilousova, T., Jungbauer, L., Roeske, S. K., Youmans, K. L., Yu, C., Poon, W. W., Cornwell, L. B., Miller, C. A., Vinters, H. V., Van Eldik, L. J., Fardo, D. W., Estus, S., Bu, G., Gylys, K. H. & LaDu, M. J., Feb 22 2013, In : Journal of Biological Chemistry. 288, 8, p. 5914-5926 13 p.

Research output: Contribution to journalArticle

91 Scopus citations

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome

Wang, X., Zhao, Y., Zhang, X., Badie, H., Zhou, Y., Mu, Y., Loo, L. S., Cai, L., Thompson, R. C., Yang, B., Chen, Y., Johnson, P. F., Wu, C., Bu, G., Mobley, W. C., Zhang, D., Gage, F. H., Ranscht, B., Zhang, Y. W., Lipton, S. A. & 2 others, Hong, W. & Xu, H., Apr 1 2013, In : Nature Medicine. 19, 4, p. 473-480 8 p.

Research output: Contribution to journalArticle

128 Scopus citations

Neuronal clearance of amyloid-β by endocytic receptor LRP1

Kanekiyo, T., Cirrito, J. R., Liu, C. C., Shinohara, M., Li, J., Schuler, D. R., Shinohara, M., Holtzman, D. M. & Bu, G., Dec 9 2013, In : Journal of Neuroscience. 33, 49, p. 19276-19283 8 p.

Research output: Contribution to journalArticle

127 Scopus citations

The C-Terminal Region Mesd Peptide Mimics Full-Length Mesd and Acts as an Inhibitor of Wnt/β-Catenin Signaling in Cancer Cells

Lin, C., Lu, W., Zhang, W., Londoño-Joshi, A. I., Buchsbaum, D. J., Bu, G. & Li, Y., Feb 28 2013, In : PloS one. 8, 2, e58102.

Research output: Contribution to journalArticle

9 Scopus citations

TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure

Chen, F., Radisky, E. S., Das, P., Batra, J., Hata, T., Hori, T., Baine, A. M. T., Gardner, L., Yue, M. Y., Bu, G., Del Zoppo, G., Patel, T. C. & Nguyen, J. H., Jul 1 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 7, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
2012

Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid

Chen, Y., Huang, X., Zhang, Y. W., Rockenstein, E., Bu, G., Golde, T. E., Masliah, E. & Xu, H., Aug 15 2012, In : Journal of Neuroscience. 32, 33, p. 11390-11395 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of alzheimer disease

Youmans, K. L., Tai, L. M., Nwabuisi-Heath, E., Jungbauer, L., Kanekiyo, T., Gan, M., Kim, J., Eimer, W. A., Estus, S., Rebeck, G. W., Weeber, E. J., Bu, G., Yu, C. & LaDu, M. J., Dec 7 2012, In : Journal of Biological Chemistry. 287, 50, p. 41774-41786 13 p.

Research output: Contribution to journalArticle

121 Scopus citations

Apolipoprotein E and apolipoprotein E receptors: Normal biology and roles in Alzheimer disease

Holtzman, D. M., Herz, J. & Bu, G., Mar 2012, In : Cold Spring Harbor Perspectives in Medicine. 2, 3

Research output: Contribution to journalArticle

367 Scopus citations

Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration

Zhang, H., Zhang, Y. W., Chen, Y., Huang, X., Zhou, F., Wang, W., Xian, B., Zhang, X., Masliah, E., Chen, Q., Han, J. D. J., Bu, G., Reed, J. C., Liao, F. F., Chen, Y. G. & Xu, H., Oct 31 2012, In : Journal of Neuroscience. 32, 44, p. 15565-15576 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms

Li, J., Kanekiyo, T., Shinohara, M., Zhang, Y., LaDu, M. J., Xu, H. & Bu, G., Dec 28 2012, In : Journal of Biological Chemistry. 287, 53, p. 44593-44601 9 p.

Research output: Contribution to journalArticle

99 Scopus citations

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

Youmans, K. L., Tai, L. M., Kanekiyo, T., Stine, W. B., Michon, S. C., Nwabuisi-Heath, E., Manelli, A. M., Fu, Y., Riordan, S., Eimer, W. A., Binder, L., Bu, G., Yu, C., Hartley, D. M. & Ladu, M. J., Mar 19 2012, In : Molecular neurodegeneration. 7, 1, 8.

Research output: Contribution to journalArticle

85 Scopus citations

LRP1-Dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis

Pi, X., Schmitt, C. E., Xie, L., Portbury, A. L., Wu, Y., Lockyer, P., Dyer, L. A., Moser, M., Bu, G., Flynn, E. J., Jin, S. W. & Patterson, C., Aug 17 2012, In : Circulation research. 111, 5, p. 564-574 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Lrp1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β

Kanekiyo, T., Liu, C. C., Shinohara, M., Li, J. & Bu, G., Nov 14 2012, In : Journal of Neuroscience. 32, 46, p. 16458-16465 8 p.

Research output: Contribution to journalArticle

113 Scopus citations
2011

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations

Youmans, K. L., Leung, S., Zhang, J., Maus, E., Baysac, K., Bu, G., Vassar, R., Yu, C. & LaDu, M. J., Mar 15 2011, In : Journal of Neuroscience Methods. 196, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis

Wilhelmus, M. M. M., Bol, J. G. J. M., Van Haastert, E. S., Rozemuller, A. J. M., Bu, G., Drukarch, B. & Hoozemans, J. J. M., Nov 1 2011, In : American Journal of Pathology. 179, 5, p. 2152-2156 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model

Nishitsuji, K., Hosono, T., Nakamura, T., Bu, G. & Michikawa, M., May 20 2011, In : Journal of Biological Chemistry. 286, 20, p. 17536-17542 7 p.

Research output: Contribution to journalArticle

136 Scopus citations

Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-β uptake

Kanekiyo, T., Zhang, J., Liu, Q., Liu, C. C., Zhang, L. & Bu, G., Feb 2 2011, In : Journal of Neuroscience. 31, 5, p. 1644-1651 8 p.

Research output: Contribution to journalArticle

107 Scopus citations

Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system

Liu, Q., Zhang, J., Zerbinatti, C., Zhan, Y., Kolber, B. J., Herz, J., Muglia, L. J. & Bu, G., 2011, In : PLoS biology. 9, 1, e1000575.

Research output: Contribution to journalArticle

50 Scopus citations

Premature ligand-receptor interaction during biosynthesis limits the production of growth factor midkine and its receptor LDL receptor-related protein 1

Sakamoto, K., Bu, G., Chen, S., Takei, Y., Hibi, K., Kodera, Y., McCormick, L. M., Nakao, A., Noda, M., Muramatsu, T. & Kadomatsu, K., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8405-8413 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6

Chen, J., Liu, C. C., Li, Q., Nowak, C., Bu, G. & Wang, J., Mar 9 2011, In : Structure. 19, 3, p. 313-323 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
2010

Dkk1 stabilizes wnt co-receptor LRP6: Implication for Wnt ligand-induced LRP6 down-regulation

Li, Y., Lu, W., King, T. D., Liu, C. C., Bijur, G. N. & Bu, G., 2010, In : PloS one. 5, 6, e11014.

Research output: Contribution to journalArticle

49 Scopus citations

Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Aβ42 uptake and lysosomal trafficking

Fuentealba, R. A., Liu, Q., Zhang, J., Kanekiyo, T., Hu, X., Lee, J. M., Ladu, M. J. & Bu, G., 2010, In : PloS one. 5, 7, e11884.

Research output: Contribution to journalArticle

76 Scopus citations

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

Liu, C. C., Prior, J., Piwnica-Worms, D. & Bu, G., Mar 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 11, p. 5136-5141 6 p.

Research output: Contribution to journalArticle

123 Scopus citations

Mesd is a universal inhibitor of wnt coreceptors lrp5 and lrp6 and blocks wnt/β-catenin signaling in cancer cells

Lu, W., Liu, C. C., Thottassery, J. V., Bu, G. & Li, Y., Jun 8 2010, In : Biochemistry. 49, 22, p. 4635-4643 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4

Jen, A., Parkyn, C. J., Mootoosamy, R. C., Ford, M. J., Warley, A., Liu, Q., Bu, G., Baskakov, I. V., Moestrup, S., McGuinness, L., Emptage, N. & Morris, R. J., Jan 15 2010, In : Journal of cell science. 123, 2, p. 246-255 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration

Liu, Q., Trotter, J., Zhang, J., Peters, M. M., Cheng, H., Bao, J., Han, X., Weeber, E. J. & Bu, G., Dec 15 2010, In : Journal of Neuroscience. 30, 50, p. 17068-17078 11 p.

Research output: Contribution to journalArticle

115 Scopus citations

NMR structure note: Solution structure of the core domain of MESD that is essential for proper folding of LRP5/6

Chen, J., Li, Q., Liu, C. C., Zhou, B., Bu, G. & Wang, J., Aug 2010, In : Journal of Biomolecular NMR. 47, 4, p. 283-288 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain

Owen, J. B., Sultana, R., Aluise, C. D., Erickson, M. A., Price, T. O., Bu, G., Banks, W. A. & Butterfield, D. A., Dec 1 2010, In : Free Radical Biology and Medicine. 49, 11, p. 1798-1803 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

TPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3β pathway

Lin, L., Bu, G., Mars, W. M., Reeves, W. B., Tanaka, S. & Hu, K., Oct 2010, In : American Journal of Pathology. 177, 4, p. 1687-1696 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: Implication for breast cancer tumorigenesis

Zhang, J., Li, Y., Liu, Q., Lu, W. & Bu, G., Jan 1 2010, In : Oncogene. 29, 4, p. 539-549 11 p.

Research output: Contribution to journalArticle

63 Scopus citations
2009

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

Hu, X., Crick, S. L., Bu, G., Frieden, C., Pappu, R. V. & Lee, J. M., Dec 1 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 48, p. 20324-20329 6 p.

Research output: Contribution to journalArticle

242 Scopus citations

Cooperative folding and ligand-binding properties of LRP6 β-propeller domains

Liu, C. C., Pearson, C. & Bu, G., May 29 2009, In : Journal of Biological Chemistry. 284, 22, p. 15299-15307 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain

Grear, K. E., Ling, I. F., Simpson, J. F., Furman, J. L., Simmons, C. R., Peterson, S. L., Schmitt, F. A., Markesbery, W. R., Liu, Q., Crook, J. E., Younkin, S. G., Bu, G. & Estus, S., 2009, In : Molecular neurodegeneration. 4, 1, 46.

Research output: Contribution to journalArticle

35 Scopus citations

Interaction of Reelin with amyloid precursor protein promotes neurite outgrowth

Hoe, H. S., Kea, J. L., Carney, R. S. E., Lee, J., Markova, A., Lee, J. Y., Howell, B. W., Hyman, B. T., Pak, D. T. S., Bu, G. & Rebeck, G. W., Jun 10 2009, In : Journal of Neuroscience. 29, 23, p. 7459-7473 15 p.

Research output: Contribution to journalArticle

137 Scopus citations

Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway

Fuentealba, R. A., Liu, Q., Kanekiyo, T., Zhang, J. & Bu, G., Dec 4 2009, In : Journal of Biological Chemistry. 284, 49, p. 34045-34053 9 p.

Research output: Contribution to journalArticle

68 Scopus citations

Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9

Song, H., Li, Y., Lee, J., Schwartz, A. L. & Bu, G., Feb 1 2009, In : Cancer research. 69, 3, p. 879-886 8 p.

Research output: Contribution to journalArticle

117 Scopus citations

LRP1 shedding in human brain: Roles of ADAM10 and ADAM17

Liu, Q., Zhang, J., Tran, H., Verbeek, M. M., Reiss, K., Estus, S. & Bu, G., 2009, In : Molecular neurodegeneration. 4, 1, 17.

Research output: Contribution to journalArticle

61 Scopus citations

Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death

Hayashi, S., Yamamoto, M., Tachibana, K., Ueno, Y., Bu, G. & Fukushima, T., Mar 1 2009, In : Anticancer research. 29, 3, p. 897-906 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Meeting report: 2009 International Conference on Molecular Neurodegeneration May 18-20, 2009, Xiamen, China

Zhang, Y., Owens, L. & Bu, G., Dec 28 2009, In : Molecular neurodegeneration. 4, 1, 43.

Research output: Contribution to journalArticle

56 Scopus citations

Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90α autocrine signaling to promote keratinocyte migration

Woodley, D. T., Fan, J., Cheng, C. F., Li, Y., Chen, M., Bu, G. & Li, W., May 15 2009, In : Journal of cell science. 122, 10, p. 1495-1498 4 p.

Research output: Contribution to journalArticle

43 Scopus citations