• 18484 Citations
  • 76 Scopus h-Index
1985 …2020

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Article

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone far LDL receptor-related protein

Bu, G., Geuze, H. J., Strous, G. J. & Schwartz, A. L., Jan 1 1995, In : EMBO Journal. 14, 10, p. 2269-2280 12 p.

Research output: Contribution to journalArticle

260 Scopus citations

39-kD protein inhibits tissue-type plasminogen activator clearance in vivo

Warshawsky, I., Bu, G. & Schwartz, A. L., 1993, In : Journal of Clinical Investigation. 92, 2, p. 937-944 8 p.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations

5-HT3 antagonist ondansetron increases apoE secretion by modulating the LXR-ABCA1 pathway

Shinohara, M., Shinohara, M., Zhao, J., Fu, Y., Liu, C. C., Kanekiyo, T. & Bu, G., Mar 2 2019, In : International journal of molecular sciences. 20, 6, 1488.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

ABCA7 deficiency accelerates amyloid-βgeneration and alzheimer’s neuronal pathology

Sakae, N., Liu, C. C., Shinohara, M., Frisch-Daiello, J., Ma, L., Yamazaki, Y., Tachibana, M., Younkin, L., Kurti, A., Carrasquillo, M. M., Zou, F., Sevlever, D., Bisceglio, G., Gan, M., Fol, R., Knight, P., Wang, M., Han, X., Fryer, J. D., Fitzgerald, M. L. & 4 others, Ohyagi, Y., Younkin, S. G., Bu, G. & Kanekiyo, T., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain

Aikawa, T., Ren, Y., Yamazaki, Y., Tachibana, M., Johnson, M. R., Anderson, C. T., Martens, Y. A., Holm, M. L., Asmann, Y. W., Saito, T., Saido, T. C., Fitzgerald, M. L., Bu, G. & Kanekiyo, T., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 47, p. 23790-23796 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II

Zhao, S., Li, Z., Zhang, M., Zhang, L., Zheng, H., Ning, J., Wang, Y., Wang, F., Zhang, X., Gan, H., Wang, Y., Zhang, X., Luo, H., Bu, G., Xu, H., Yao, Y. & Zhang, Y. W., Jul 1 2019, In : Experimental and Molecular Medicine. 51, 7, 84.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

A complete NMR spectral assignment of the conserved region of the MESD protein, MESD(12-155)

Chen, J., Bu, G. & Wang, J., Jul 1 2007, In : Biomolecular NMR Assignments. 1, 1, p. 3-5 3 p.

Research output: Contribution to journalArticle

A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression

Yuseff, M. I., Farfan, P., Bu, G. & Marzolo, M. P., Sep 1 2007, In : Traffic. 8, 9, p. 1215-1230 16 p.

Research output: Contribution to journalArticle

35 Scopus citations

Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes

Lee, J., Retamal, C., Cuitiño, L., Caruano-Yzermans, A., Shin, J. E., Van Kerkhof, P., Marzolo, M. P. & Bu, G., Apr 25 2008, In : Journal of Biological Chemistry. 283, 17, p. 11501-11508 8 p.

Research output: Contribution to journalArticle

110 Scopus citations

Adenosine analogs inhibit the guanine-7-methylation of mRNA cap structures

Oxenrider, K. A., Bu, G. & Sitz, T. O., Feb 1 1993, In : FEBS Letters. 316, 3, p. 273-277 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways

Zhao, N., Ren, Y., Yamazaki, Y., Qiao, W., Li, F., Felton, L. M., Mahmoudiandehkordi, S., Kueider-Paisley, A., Sonoustoun, B., Arnold, M., Shue, F., Zheng, J., Attrebi, O. N., Martens, Y. A., Li, Z., Bastea, L., Meneses, A. D., Chen, K., Thompson, J. W., St John-Williams, L. & 12 others, Tachibana, M., Aikawa, T., Oue, H., Job, L., Yamazaki, A., Liu, C. C., Storz, P., Asmann, Y. W., Ertekin-Taner, N., Kanekiyo, T., Kaddurah-Daouk, R. & Bu, G., Jun 3 2020, In : Neuron. 106, 5, p. 727-742.e6

Research output: Contribution to journalArticle

1 Scopus citations

Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid

Chen, Y., Huang, X., Zhang, Y. W., Rockenstein, E., Bu, G., Golde, T. E., Masliah, E. & Xu, H., Aug 15 2012, In : Journal of Neuroscience. 32, 33, p. 11390-11395 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model

Hettinger, J. C., Lee, H., Bu, G., Holtzman, D. M. & Cirrito, J. R., May 15 2018, In : Molecular neurodegeneration. 13, 1, 22.

Research output: Contribution to journalArticle

4 Scopus citations

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

Zhong, L., Wang, Z., Wang, D., Wang, Z., Martens, Y. A., Wu, L., Xu, Y., Wang, K., Li, J., Huang, R., Can, D., Xu, H., Bu, G. & Chen, X. F., Mar 27 2018, In : Molecular neurodegeneration. 13, 1, 15.

Research output: Contribution to journalArticle

30 Scopus citations

Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1

Liu, Q., Zerbinatti, C. V., Zhang, J., Hoe, H. S., Wang, B., Cole, S. L., Herz, J., Muglia, L. & Bu, G., Oct 4 2007, In : Neuron. 56, 1, p. 66-78 13 p.

Research output: Contribution to journalArticle

255 Scopus citations

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

Hu, X., Crick, S. L., Bu, G., Frieden, C., Pappu, R. V. & Lee, J. M., Dec 1 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 48, p. 20324-20329 6 p.

Research output: Contribution to journalArticle

242 Scopus citations

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations

Youmans, K. L., Leung, S., Zhang, J., Maus, E., Baysac, K., Bu, G., Vassar, R., Yu, C. & LaDu, M. J., Mar 15 2011, In : Journal of Neuroscience Methods. 196, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide

Moulder, K. L., Narita, M., Chang, L. K., Bu, G. & Johnson, E. M., Feb 24 1999, In : Journal of neurochemistry. 72, 3, p. 1069-1080 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

APOE «4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

Dickson, D. W., Heckman, M. G., Murray, M. E., Soto, A. I., Walton, R. L., Diehl, N. N., Van Gerpen, J. A., Uitti, R. J., Wszolek, Z. K., Ertekin-Taner, N., Knopman, D. S., Petersen, R. C., Graff-Radford, N. R., Boeve, B. F., Bu, G., Ferman, T. J. & Ross, O. A., Sep 18 2018, In : Neurology. 91, 12, p. E1182-E1195

Research output: Contribution to journalArticle

24 Scopus citations
1 Scopus citations

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch-Daiello, J. L., Han, X., Fryer, J. D. & Bu, G. D., 2016, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

36 Scopus citations

ApoE4 Accelerates Early Seeding of Amyloid Pathology

Liu, C-C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C. W. & Bu, G. D., Dec 6 2017, In : Neuron. 96, 5, p. 1024-1032.e3

Research output: Contribution to journalArticle

72 Scopus citations

APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

Zhao, N., Attrebi, O. N., Ren, Y., Qiao, W., Sonustun, B., Martens, Y. A., Meneses, A. D., Li, F., Shue, F., Zheng, J., van Ingelgom, A. J., Davis, M. D., Kurti, A., Knight, J. A., Linares, C., Chen, Y., Delenclos, M., Liu, C. C., Fryer, J. D., Asmann, Y. W. & 4 others, McLean, P. J., Dickson, D. W., Ross, O. A. & Bu, G., Feb 5 2020, In : Science translational medicine. 12, 529, eaay1809.

Research output: Contribution to journalArticle

7 Scopus citations

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

Tachibana, M., Holm, M. L., Liu, C. C., Shinohara, M., Aikawa, T., Oue, H., Yamazaki, Y., Martens, Y. A., Murray, M. E., Sullivan, P. M., Weyer, K., Glerup, S., Dickson, D. W., Bu, G. & Kanekiyo, T., Mar 2019, In : Journal of Clinical Investigation. 129, 3, p. 1272-1277 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of alzheimer disease

Youmans, K. L., Tai, L. M., Nwabuisi-Heath, E., Jungbauer, L., Kanekiyo, T., Gan, M., Kim, J., Eimer, W. A., Estus, S., Rebeck, G. W., Weeber, E. J., Bu, G., Yu, C. & LaDu, M. J., Dec 7 2012, In : Journal of Biological Chemistry. 287, 50, p. 41774-41786 13 p.

Research output: Contribution to journalArticle

121 Scopus citations

ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

Verghese, P. B., Castellano, J. M., Garai, K., Wang, Y., Jiang, H., Shah, A., Bu, G., Frieden, C. & Holtzman, D. M., May 7 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 19, p. E1807-E1816

Research output: Contribution to journalArticle

246 Scopus citations

ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

Fuentealba, R. A., Barría, M. I., Lee, J., Cam, J., Araya, C., Escudero, C. A., Inestrosa, N. C., Bronfman, F. C., Bu, G. & Marzolo, M. P., Aug 13 2007, In : Molecular neurodegeneration. 2, 1, 14.

Research output: Contribution to journalArticle

53 Scopus citations

ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its rafts' association

Cuitino, L., Matute, R., Retamal, C., Bu, G., Inestrosa, N. C. & Marzolo, M. P., Sep 1 2005, In : Traffic. 6, 9, p. 820-838 19 p.

Research output: Contribution to journalArticle

53 Scopus citations

ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease

Medway, C. W., Abdul-Hay, S., Mims, T., Ma, L., Bisceglio, G., Zou, F., Pankratz, S., Sando, S. B., Aasly, J. O., Barcikowska, M., Siuda, J., Wszolek, Z. K., Ross, O. A., Carrasquillo, M., Dickson, D. W., Graff-Radford, N., Petersen, R. C., Ertekin-Taner, N., Morgan, K., Bu, G. & 1 others, Younkin, S. G., Mar 10 2014, In : Molecular neurodegeneration. 9, 1, 11.

Research output: Contribution to journalArticle

20 Scopus citations

APOE ε2 is associated with increased tau pathology in primary tauopathy

Zhao, N., Liu, C. C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff-Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R., Murray, M. E., Koga, S. & 3 others, Dickson, D. W., Ross, O. A. & Bu, G., Dec 1 2018, In : Nature communications. 9, 1, 4388.

Research output: Contribution to journalArticle

22 Scopus citations

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

Zhao, J., Davis, M. D., Martens, Y. A., Shinohara, M., Graff Radford, N. R., Younkin, S. G., Wszolek, Z. K., Kanekiyo, T. & Bu, G. D., Jul 15 2017, In : Human Molecular Genetics. 26, 14, p. 2690-2700 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease

Zhao, N., Liu, C-C., Qiao, W. & Bu, G. D., Feb 1 2017, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

86 Scopus citations

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

Zhao, N., Liu, C-C., Van Ingelgom, A. J., Martens, Y. A., Linares, C., Knight, J. A., Painter, M. M., Sullivan, P. M. & Bu, G. D., Sep 27 2017, In : Neuron. 96, 1, p. 115-129 15 p.

Research output: Contribution to journalArticle

73 Scopus citations

Apolipoprotein E and apolipoprotein E receptors: Normal biology and roles in Alzheimer disease

Holtzman, D. M., Herz, J. & Bu, G., Mar 2012, In : Cold Spring Harbor Perspectives in Medicine. 2, 3

Research output: Contribution to journalArticle

367 Scopus citations

Apolipoprotein E and apolipoprotein E receptors modulate Aβ-induced glial neuroinflammatory responses

LaDu, M. J., Shah, J. A., Reardon, C. A., Getz, G. S., Bu, G., Hu, J., Guo, L. & Van Eldik, L. J., Oct 9 2001, In : Neurochemistry International. 39, 5-6, p. 427-434 8 p.

Research output: Contribution to journalArticle

91 Scopus citations

Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Aβ42 accumulation in amyloid model mice

Zerbinatti, C. V., Wahrle, S. E., Kim, H., Cam, J. A., Bales, K., Paul, S. M., Holtzman, D. M. & Bu, G., Nov 24 2006, In : Journal of Biological Chemistry. 281, 47, p. 36180-36186 7 p.

Research output: Contribution to journalArticle

104 Scopus citations

Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis

Wilhelmus, M. M. M., Bol, J. G. J. M., Van Haastert, E. S., Rozemuller, A. J. M., Bu, G., Drukarch, B. & Hoozemans, J. J. M., Nov 1 2011, In : American Journal of Pathology. 179, 5, p. 2152-2156 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Yamazaki, Y., Painter, M. M., Bu, G. D. & Kanekiyo, T., Jun 21 2016, (Accepted/In press) In : CNS Drugs. p. 1-17 17 p.

Research output: Contribution to journalArticle

36 Scopus citations

Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein

Fagan, A. M., Bu, G., Sun, Y., Daugherty, A. & Holtzman, D. M., 1996, In : Journal of Biological Chemistry. 271, 47, p. 30121-30125 5 p.

Research output: Contribution to journalArticle

181 Scopus citations

Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population

Kang, R., Li, P., Wang, T., Li, X., Wei, Z., Zhang, Z., Zhong, L., Cao, L., Heckman, M. G., Zhang, Y. W., Xu, H., Huang, C., Bu, G. D. & Chen, X. F., Jan 28 2016, In : Scientific Reports. 6, 19930.

Research output: Contribution to journalArticle

11 Scopus citations

Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway

Casey, C. S., Atagi, Y., Yamazaki, Y., Shinohara, M., Tachibana, M., Fu, Y., Bu, G. D. & Kanekiyo, T., May 29 2015, In : Journal of Biological Chemistry. 290, 22, p. 14208-14217 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)

Atagi, Y., Liu, C-C., Painter, M. M., Chen, X. F., Verbeeck, C., Zheng, H., Li, X., Rademakers, R. V., Kang, S., Xu, H., Younkin, S. G., Das, P., Fryer, J. D. & Bu, G. D., Oct 23 2015, In : Journal of Biological Chemistry. 290, 43, p. 26043-26050 8 p.

Research output: Contribution to journalArticle

163 Scopus citations

Apolipoprotein e lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

Fu, Y., Zhao, J., Atagi, Y., Nielsen, H. M., Liu, C. C., Zheng, H., Shinohara, M., Kanekiyo, T. & Bu, G., May 5 2016, In : Molecular neurodegeneration. 11, 1, 99.

Research output: Contribution to journalArticle

23 Scopus citations

Apolipoprotein E receptors mediate the effects of β-amyloid on astrocyte cultures

Ladu, M. J., Shah, J. A., Reardon, C. A., Getz, G. S., Bu, G., Hu, J., Guo, L. & Van Eldik, L. J., Oct 27 2000, In : Journal of Biological Chemistry. 275, 43, p. 33974-33980 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model

Nishitsuji, K., Hosono, T., Nakamura, T., Bu, G. & Michikawa, M., May 20 2011, In : Journal of Biological Chemistry. 286, 20, p. 17536-17542 7 p.

Research output: Contribution to journalArticle

136 Scopus citations

Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology

Zhang, C., Shi, Z., Zhang, L., Zhou, Z., Zheng, X., Liu, G., Bu, G., Fraser, P. E., Xu, H. & Zhang, Y. W., 2016, In : Journal of cell science. 129, 5, p. 994-1002 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration

Zhang, H., Zhang, Y. W., Chen, Y., Huang, X., Zhou, F., Wang, W., Xian, B., Zhang, X., Masliah, E., Chen, Q., Han, J. D. J., Bu, G., Reed, J. C., Liao, F. F., Chen, Y. G. & Xu, H., Oct 31 2012, In : Journal of Neuroscience. 32, 44, p. 15565-15576 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

Zhao, Y., Tseng, I. C., Heyser, C. J., Rockenstein, E., Mante, M., Adame, A., Zheng, Q., Huang, T., Wang, X., Arslan, P. E., Chakrabarty, P., Wu, C., Bu, G. D., Mobley, W. C., Zhang, Y. W., St. George-Hyslop, P., Masliah, E., Fraser, P. & Xu, H., Sep 2 2015, In : Neuron. 87, 5, p. 963-975 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

A rapid and cost-effective method for genotyping apolipoprotein e gene polymorphism

Zhong, L., Xie, Y. Z., Cao, T. T., Wang, Z., Wang, T., Li, X., Shen, R. C., Xu, H., Bu, G. & Chen, X. F., Jan 12 2016, In : Molecular neurodegeneration. 11, 1, 2.

Research output: Contribution to journalArticle

18 Scopus citations