Fergus J Couch, PhD

Chair, Division of Experimental Pathology

  • 40432 Citations
  • 91 Scopus h-Index
1991 …2021

Research output per year

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Research Output

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Review article
2020

Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: Best practices in functional analysis for clinical annotation

Monteiro, A. N., Bouwman, P., Kousholt, A. N., Eccles, D. M., Millot, G. A., Masson, J. Y., Schmidt, M. K., Sharan, S. K., Scully, R., Wiesmüller, L., Couch, F. & Vreeswijk, M. P. G., Jan 1 2020, (Accepted/In press) In : Journal of medical genetics. 106368.

Research output: Contribution to journalReview article

2019

Hereditary Cancer Syndromes—A Primer on Diagnosis and Management: Part 1: Breast-Ovarian Cancer Syndromes

Samadder, N. J., Giridhar, K., Baffy, N., Riegert-Johnson, D. & Couch, F. J., Jun 1 2019, In : Mayo Clinic proceedings. 94, 6, p. 1084-1098 15 p.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations

Hereditary Cancer Syndromes—A Primer on Diagnosis and Management, Part 2: Gastrointestinal Cancer Syndromes

Samadder, N. J., Baffy, N., Giridhar, K., Couch, F. J. & Riegert-Johnson, D., Jun 1 2019, In : Mayo Clinic proceedings. 94, 6, p. 1099-1116 18 p.

Research output: Contribution to journalReview article

2 Scopus citations
2018

Cardiovascular Concerns in BRCA1 and BRCA2 Mutation Carriers

Gast, K. C., Viscuse, P. V., Nowsheen, S., Haddad, T. C., Mutter, R., Wahner Hendrickson, A. E., Couch, F. J. & Ruddy, K. J., Feb 1 2018, In : Current Treatment Options in Cardiovascular Medicine. 20, 2, 18.

Research output: Contribution to journalReview article

3 Scopus citations
2016

Counselling framework for moderate-penetrance cancer-susceptibility mutations

Tung, N., Domchek, S. M., Stadler, Z., Nathanson, K. L., Couch, F. J., Garber, J. E., Offit, K. & Robson, M. E., Sep 1 2016, In : Nature Reviews Clinical Oncology. 13, 9, p. 581-588 8 p.

Research output: Contribution to journalReview article

133 Scopus citations

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

KConFab investigators, Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Consortium of Modifiers of BRCA1 and BRCA2, Australian Ovarian Cancer Study Group, Australian Ovarian Cancer Study Group, Australian Ovarian Cancer Study Group & GEMO Study Collaborators, May 1 2016, In : Gynecologic oncology. 141, 2, p. 386-401 16 p.

Research output: Contribution to journalReview article

8 Scopus citations
2014

Functional assays for analysis of variants of uncertain significance in BRCA2

Guidugli, L., Carreira, A., Caputo, S. M., Ehlen, A., Galli, A., Monteiro, A. N. A., Neuhausen, S. L., Hansen, T. V. O., Couch, F. J. & Vreeswijk, M. P. G., Feb 1 2014, In : Human mutation. 35, 2, p. 151-164 14 p.

Research output: Contribution to journalReview article

47 Scopus citations

Two decades after BRCA: Setting paradigms in personalized cancer care and prevention

Couch, F. J., Nathanson, K. L. & Offit, K., Jan 1 2014, In : Science. 343, 6178, p. 1466-1470 5 p.

Research output: Contribution to journalReview article

178 Scopus citations
2013

Genetic susceptibility to triple-negative breast cancer

Stevens, K. N., Vachon, C. M. & Couch, F. J., Apr 1 2013, In : Cancer research. 73, 7, p. 2025-2030 6 p.

Research output: Contribution to journalReview article

105 Scopus citations
2012

A guide for functional analysis of BRCA1 variants of uncertain significance

Millot, G. A., Carvalho, M. A., Caputo, S. M., Vreeswijk, M. P. G., Brown, M. A., Webb, M., Rouleau, E., Neuhausen, S. L., Hansen, T. V. O., Galli, A., Brandão, R. D., Blok, M. J., Velkova, A., Couch, F. J. & Monteiro, A. N. A., Nov 1 2012, In : Human mutation. 33, 11, p. 1526-1537 12 p.

Research output: Contribution to journalReview article

80 Scopus citations

A review of a multifactorial probability-based model for classification of BRCA1 and BRCA2 variants of uncertain significance (VUS)

Lindor, N. M., Guidugli, L., Wang, X., Vallée, M. P., Monteiro, A. N. A., Tavtigian, S., Goldgar, D. E. & Couch, F. J., Jan 1 2012, In : Human mutation. 33, 1, p. 8-21 14 p.

Research output: Contribution to journalReview article

90 Scopus citations
2011

Common variants in ZNF365 are associated with both mammographic density and breast cancer risk

Lindström, S., Vachon, C. M., Li, J., Varghese, J., Thompson, D., Warren, R., Brown, J., Leyland, J., Audley, T., Wareham, N. J., Loos, R. J. F., Paterson, A. D., Rommens, J., Waggott, D., Martin, L. J., Scott, C. G., Pankratz, V. S., Hankinson, S. E., Hazra, A., Hunter, D. J. & 15 others, Hopper, J. L., Southey, M. C., Chanock, S. J., Dos Santos Silva, I., Liu, J., Eriksson, L., Couch, F. J., Stone, J., Apicella, C., Czene, K., Kraft, P., Hall, P., Easton, D. F., Boyd, N. F. & Tamimi, R. M., Mar 1 2011, In : Nature Genetics. 43, 3, p. 185-187 3 p.

Research output: Contribution to journalReview article

89 Scopus citations
2008

Assessment of functional effects of unclassified genetic variants

Couch, F. J., Rasmussen, L. J., Hofstra, R., Monteiro, A. N. A., Greenblatt, M. S. & De Wind, N., Nov 1 2008, In : Human mutation. 29, 11, p. 1314-1326 13 p.

Research output: Contribution to journalReview article

77 Scopus citations
2007

Functional assays for BRCA1 and BRCA2

Carvalho, M. A., Couch, F. J. & Monteiro, A. N. A., Jan 1 2007, In : International Journal of Biochemistry and Cell Biology. 39, 2, p. 298-310 13 p.

Research output: Contribution to journalReview article

40 Scopus citations
2006

Cancer risk assessment at the atomic level

Monteiro, A. N. A. & Couch, F. J., Feb 15 2006, In : Cancer research. 66, 4, p. 1897-1899 3 p.

Research output: Contribution to journalReview article

13 Scopus citations

Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers: An update

Gronwald, J., Tung, N., Foulkes, W. D., Offit, K., Gershoni, R., Daly, M., Kim-Sing, C., Olsson, H., Ainsworth, P., Eisen, A., Saal, H., Friedman, E., Olopade, O., Osborne, M., Weitzel, J., Lynch, H., Ghadirian, P., Lubinski, J., Sun, P., Narod, S. A. & 20 others, Gilchrist, D., Weber, B., Rebbeck, T., Isaacs, C., Neuhausen, S., Garber, J., Karlan, B., Fishman, D., Merajver, S., McKinnon, W., Wood, M., Evans, G., Moller, P., Pasini, B., Sweet, K., Eng, C., Rennert, G., Couch, F., McLennan, J. & Provencher, D., May 1 2006, In : International Journal of Cancer. 118, 9, p. 2281-2284 4 p.

Research output: Contribution to journalReview article

213 Scopus citations
2004

Genetic epidemiology of BRCA1

Couch, F. J., Jun 2004, In : Cancer Biology and Therapy. 3, 6, p. 509-514 6 p.

Research output: Contribution to journalReview article

Open Access
20 Scopus citations

The role of Tbx2 and Tbx3 in mammary development and tumorigenesis

Rowley, M., Grothey, E. & Couch, F. J., Apr 1 2004, In : Journal of Mammary Gland Biology and Neoplasia. 9, 2, p. 109-118 10 p.

Research output: Contribution to journalReview article

75 Scopus citations
2003

The 17q23 amplicon and breast cancer

Sinclair, C. S., Rowley, M., Naderi, A. & Couch, F. J., Apr 1 2003, In : Breast Cancer Research and Treatment. 78, 3, p. 313-322 10 p.

Research output: Contribution to journalReview article

108 Scopus citations
2002

BRCA2 and pancreatic cancer

Naderi, A. & Couch, F. J., Dec 1 2002, In : International Journal of Gastrointestinal Cancer. 31, 1-3, p. 99-106 8 p.

Research output: Contribution to journalReview article

38 Scopus citations
1996

Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families

Tonin, P., Weber, B., Offit, K., Couch, F., Rebbeck, T. R., Neuhausen, S., Godwin, A. K., Daly, M., Wagner-Costalos, J., Berman, D., Grana, G., Fox, E., Kane, M. F., Kolodner, R. D., Krainer, M., Haber, D. A., Struewing, J. P., Warner, E. & Rosen, B., Nov 19 1996, In : Nature Medicine. 2, 11, p. 1179-1183 5 p.

Research output: Contribution to journalReview article

262 Scopus citations