Research output

Research output per year 1991 2011 2012 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 539 Article
• 26 Review article
• 23 Comment/debate
• 9 Letter
• 4 More
  • 3 Editorial
  • 1 Chapter

Research output per year

Research output per year

Search results

• Article

  The BRCA2 c.68-7T > A variant is not pathogenic: A model for clinical calibration of spliceogenicity

  kConFab/AOCS Investigators, May 2018, In: Human mutation. 39, 5, p. 729-741 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Calibration 100%
  • Exons 40%
  • Protein Isoforms 39%
  • Neoplasms 23%
  • Causality 22%
  13 Scopus citations

• The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

  Tavtigian, S. V., Simard, J., Rommens, J., Couch, F., Shattuck-Eidens, D., Neuhausen, S., Merajver, S., Thorlacius, S., Offit, K., Stoppa-Lyonnet, D., Belanger, C., Bell, R., Berry, S., Bogden, R., Chen, Q., Davis, T., Dumont, M., Frye, C., Hattier, T., Jammulapati, S., & 31 othersJanecki, T., Jiang, P., Kehrer, R., Leblanc, J. F., Mitchell, J. T., McArthur-Morrison, J., Nguyen, K., Peng, Y., Samson, C., Schroeder, M., Snyder, S. C., Steele, L., Stringfellow, M., Stroup, C., Swedlund, B., Swensen, J., Teng, D., Thomas, A., Tran, T., Tran, T., Tranchant, M., Weaver-Feldhaus, J., Wong, A. K. C., Shizuya, H., Eyfjord, J. E., Cannon-Albright, L., Labrie, F., Skolnick, M. H., Weber, B., Kamb, A. & Goldgar, D. E., Mar 1996, In: Nature Genetics. 12, 3, p. 333-337 5 p.

  Research output: Contribution to journal › Article › peer-review

  • BRCA2 Gene 100%
  • Chromosomes 55%
  • Mutation 39%
  • BRCA2 Protein 38%
  • Male Breast Neoplasms 33%
  681 Scopus citations

• The Contribution of Germline Predisposition Gene Mutations to Clinical Subtypes of Invasive Breast Cancer from a Clinical Genetic Testing Cohort

  Hu, C., Polley, E. C., Yadav, S., Lilyquist, J., Shimelis, H., Na, J., Hart, S. N., Goldgar, D. E., Shah, S., Pesaran, T., Dolinsky, J. S., Laduca, H. & Couch, F. J., Dec 1 2020, In: Journal of the National Cancer Institute. 112, 12, p. 1231-1241 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genetic Testing 100%
  • Estrogen Receptors 80%
  • Breast Neoplasms 61%
  • Mutation 54%
  • Genes 38%
  14 Scopus citations

• The contribution of pathogenic variants in breast cancer susceptibility genes to familial breast cancer risk

  Slavin, T. P., Maxwell, K. N., Lilyquist, J., Vijai, J., Neuhausen, S. L., Hart, S. N., Ravichandran, V., Thomas, T., Maria, A., Villano, D., Schrader, K. A., Moore, R., Hu, C., Wubbenhorst, B., Wenz, B. M., D’andrea, K., Robson, M. E., Peterlongo, P., Bonanni, B., Ford, J. M., & 7 othersGarber, J. E., Domchek, S. M., Szabo, C., Offit, K., Nathanson, K. L., Weitzel, J. N. & Couch, F. J., Jun 9 2017, In: npj Breast Cancer. 3, 1, 22.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Familial Breast Cancer 100%
  • Neoplasm Genes 75%
  • Breast Neoplasms 44%
  • Mutation 38%
  • Odds Ratio 17%

• The contributions of breast density and common genetic variation to breast cancer risk

  Vachon, C. M., Pankratz, V. S., Scott, C. G., Haeberle, L., Ziv, E., Jensen, M. R., Brandt, K. R., Whaley, D. H., Olson, J. E., Heusinger, K., Hack, C. C., Jud, S. M., Beckmann, M. W., Schulz-Wendtland, R., Tice, J. A., Norman, A. D., Cunningham, J. M., Purrington, K. S., Easton, D. F., Sellers, T. A., & 3 othersKerlikowske, K., Fasching, P. A. & Couch, F. J., May 1 2015, In: Journal of the National Cancer Institute. 107, 5

  Research output: Contribution to journal › Article › peer-review

  • Breast Density 100%
  • Genetic Variation 70%
  • Breast Neoplasms 46%
  • Data Systems 15%
  • Area Under Curve 14%
  110 Scopus citations

• The exon 13 duplication in the BRCA1 gene is a founder mutation present in geographicaly diverse populations

  Mazoyer, S., Leary, J., Kirk, J., Fleischmann, E., Wagner, T., Claes, K., Messiaen, L., Foulkes, W., Desrochers, M., Simard, J., Phelan, C. M., Kwan, E., Narod, S. A., Vahteristo, P., Nevanlinna, H., Durando, X., Bignon, Y. J., Peyrat, J. P., Bonnardel, C., Sinilnikova, O. M., & 66 othersPuget, N., Lenoir, G. M., Audoynaud, C., Goldgar, D., Maugard, C., Caux, V., Gad, S., Stoppa-Lyonnet, D., Noguès, C., Lidereau, R., Machavoine, C., Bressac-De Paillerets, B., Kuschel, B., Betz, B., Niederacher, D., Beckmann, M. W., Hamann, U., Gayther, S. A., Ponder, B. A. P., Robinson, M., Taylor, G. R., Bishop, T., Catteau, A., Solomon, E., Cohen, B., Steel, M., Collins, N., Stratton, M., Van Der Looij, M., Oláh, E., Miller, N. J., Barton, D. E., Sverdlov, R. S., Friedman, E., Radice, P., Montagna, M., Sensi, E., Caligo, M., Van Eijk, R., Devilee, P., Van Der Luijt, R., Heimdal, K., Møller, P., Borg, Å., Diez, O., Cortes, J., Domenech, M., Baiget, M., Osorio, A., Benítez, J., Maillet, P., Sappino, A. P., Özdag, H., Özçelik, T., Ozturk, M., Rohlfs, E. M., Boyd, J., McDermott, D., Offit, K., Unger, M., Nathanson, K., Weber, B. L., Sellers, T. A., Hampton, E., Couch, F. J. & Neuhausen, S., 2000, In: American journal of human genetics. 67, 1, p. 207-212 6 p.

  Research output: Contribution to journal › Article › peer-review

  • BRCA1 Gene 100%
  • Belgium 85%
  • Ovarian Neoplasms 66%
  • Canada 66%
  • Exons 61%
  80 Scopus citations

• The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

  KConFab, ABCTB Investigators & GEMO Study Collaborators, Dec 1 2019, In: npj Breast Cancer. 5, 1, 38.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms 100%
  • Breast Neoplasms 52%
  • olaparib 42%
  • Chromosome Fragility 24%
  • diepoxybutane 23%
  9 Scopus citations

• The germline MLH1 K618A variant and susceptibility to lynch syndrome-associated tumors

  Medeiros, F., Lindor, N. M., Couch, F. J. & Highsmith, W. E., May 2012, In: Journal of Molecular Diagnostics. 14, 3, p. 264-273 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • Gene Frequency 55%
  • Neoplasms 24%
  • Mutation 21%
  • Neoplasm Genes 20%
  7 Scopus citations

• The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

  Goetz, M. P., Knox, S. K., Suman, V. J., Rae, J. M., Safgren, S. L., Ames, M. M., Visscher, D. W., Reynolds, C., Couch, F. J., Lingle, W. L., Weinshilboum, R. M., Fritcher, E. G. B., Nibbe, A. M., Desta, Z., Nguyen, A., Flockhart, D. A., Perez, E. A. & Ingle, J. N., Jan 1 2007, In: Breast Cancer Research and Treatment. 101, 1, p. 113-121 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytochrome P-450 CYP2D6 100%
  • Tamoxifen 84%
  • Cytochrome P-450 CYP2D6 Inhibitors 66%
  • 4-hydroxy-N-desmethyltamoxifen 27%
  • Genetic Variation 23%
  485 Scopus citations

• The influence of mammogram acquisition on the mammographic density and breast cancer association in the mayo mammography health study cohort

  Olson, J. E., Sellers, T. A., Scott, C. G., Schueler, B. A., Brandt, K. R., Serie, D. J., Jensen, M. R., Wu, F. F., Morton, M. J., Heine, J. J., Couch, F. J., Pankratz, V. S. & Vachon, C. M., Nov 15 2012, In: Breast Cancer Research. 14, 6, R147.

  Research output: Contribution to journal › Article › peer-review

  • Breast Density 100%
  • Mammography 77%
  • Cohort Studies 49%
  • Breast Neoplasms 46%
  • Health 35%
  35 Scopus citations

• The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers

  Laitman, Y., Kuchenbaecker, K. B., Rantala, J., Hogervorst, F., Peock, S., Godwin, A. K., Arason, A., Kirchhoff, T., Offit, K., Isaacs, C., Schmutzler, R. K., Wappenschmidt, B., Nevanlinna, H., Chen, X., Chenevix-Trench, G., Healey, S., Couch, F., Peterlongo, P., Radice, P., Nathanson, K. L., & 9 othersCaligo, M. A., Neuhausen, S. L., Ganz, P., Sinilnikova, O. M., McGuffog, L., Easton, D. F., Antoniou, A. C., Wolf, I. & Friedman, E., Apr 2012, In: Breast Cancer Research and Treatment. 132, 3, p. 1119-1126 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Mutation 100%
  • Breast Neoplasms 82%
  • Ovarian Neoplasms 73%
  • Neoplasms 57%
  • Alleles 23%
  9 Scopus citations

• The landscape of somatic genetic alterations in breast cancers from atm germline mutation carriers

  Weigelt, B., Bi, R., Kumar, R., Blecua, P., Mandelker, D. L., Geyer, F. C., Pareja, F., James, P. A., Couch, F. J., Eccles, D. M., Blows, F., Pharoah, P., Li, A., Selenica, P., Lim, R. S., Jayakumaran, G., Waddell, N., Shen, R., Norton, L., Wen, H. Y., & 5 othersPowell, S. N., Riaz, N., Robson, M. E., Reis-Filho, J. S. & Chenevix-Trench, G., Sep 1 2018, In: Journal of the National Cancer Institute. 110, 9, p. 1030-1034 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ataxia Telangiectasia 100%
  • Germ-Line Mutation 88%
  • Breast Neoplasms 50%
  • Ataxia-Telangiectasia Variant 30%
  • Whole Exome Sequencing 18%
  49 Scopus citations

• The oncoarray consortium: A network for understanding the genetic architecture of common cancers

  Amos, C. I., Dennis, J., Wang, Z., Byun, J., Schumacher, F. R., Gayther, S. A., Casey, G., Hunter, D. J., Sellers, T. A., Gruber, S. B., Dunning, A. M., Michailidou, K., Fachal, L., Doheny, K., Spurdle, A. B., Li, Y., Xiao, X., Romm, J., Pugh, E., Coetzee, G. A., & 73 othersHazelett, D. J., Bojesen, S. E., Caga-Anan, C., Haiman, C. A., Kamal, A., Luccarini, C., Tessier, D., Vincent, D., Bacot, F., Van Den Berg, D. J., Nelson, S., Demetriades, S., Goldgar, D. E., Couch, F. J., Forman, J. L., Giles, G. G., Conti, D. V., Bickeboller, H., Risch, A., Waldenberger, M., Bruske-Hohlfeld, I., Hicks, B. D., Ling, H., McGuffog, L., Lee, A., Kuchenbaecker, K., Soucy, P., Manz, J., Cunningham, J. M., Butterbach, K., Kote-Jarai, Z., Kraft, P., FitzGerald, L., Lindstrom, S., Adams, M., McKay, J. D., Phelan, C. M., Benlloch, S., Kelemen, L. E., Brennan, P., Riggan, M., O'Mara, T. A., Shen, H., Shi, Y., Thompson, D. J., Goodman, M. T., Nielsen, S. F., Berchuck, A., Laboissiere, S., Schmit, S. L., Shelford, T., Edlund, C. K., Taylor, J. A., Field, J. K., Park, S. K., Offit, K., Thomassen, M., Schmutzler, R., Ottini, L., Hung, R. J., Marchini, J., Olama, A. A. A., Peters, U., Eeles, R. A., Seldin, M. F., Gillanders, E., Seminara, D., Antoniou, A. C., Pharoah, P. D. P., Chenevix-Trench, G., Chanock, S. J., Simard, J. & Easton, D. F., Jan 2017, In: Cancer Epidemiology Biomarkers and Prevention. 26, 1, p. 126-135 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Single Nucleotide Polymorphism 100%
  • Quality Control 77%
  • Neoplasms 64%
  • Pharmacogenetics 45%
  • Genetic Models 44%
  149 Scopus citations

• The Oncogenic STP Axis Promotes Triple-Negative Breast Cancer via Degradation of the REST Tumor Suppressor

  Karlin, K. L., Mondal, G., Hartman, J. K., Tyagi, S., Kurley, S. J., Bland, C. S., Hsu, T. Y. T., Renwick, A., Fang, J. E., Migliaccio, I., Callaway, C., Nair, A., Dominguez-Vidana, R., Nguyen, D. X., Osborne, C. K., Schiff, R., Yu-Lee, L. Y., Jung, S. Y., Edwards, D. P., Hilsenbeck, S. G., & 5 othersRosen, J. M., Zhang, X. H. F., Shaw, C. A., Couch, F. J. & Westbrook, T. F., Nov 20 2014, In: Cell reports. 9, 4, p. 1318-1332 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Oncogenic 100%
  • Triple Negative Breast Neoplasms 86%
  • Tumor Suppressor Protein 56%
  • Protein 29%
  • Neoplasms 23%
  13 Scopus citations

• The predictive ability of the 313 variant–based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant

  GEMO Study Collaborators, EMBRACE Collaborators, OCGN Investigators, HEBON Investigators & KConFab investigators, Sep 2021, In: Genetics in Medicine. 23, 9, p. 1726-1737 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Aptitude 100%
  • Breast Neoplasms 93%
  • Heterozygote 71%
  • Estrogen Receptors 37%
  • Confidence Intervals 15%

• The prevalence of BRCA2 mutations in familial pancreatic cancer

  Couch, F. J., Johnson, M. R., Rabe, K. G., Brune, K., De Andrade, M., Goggins, M., Rothenmund, H., Gallinger, S., Klein, A., Petersen, G. M. & Hruban, R. H., Feb 2007, In: Cancer Epidemiology Biomarkers and Prevention. 16, 2, p. 342-346 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Neoplasms 100%
  • Mutation 59%
  • Ovarian Neoplasms 24%
  • BRCA2 Gene 18%
  • Breast Neoplasms 16%
  205 Scopus citations

• The risks of cancer in older women with BRCA pathogenic variants: How far have we come?

  Metcalfe, K. A., Gronwald, J., Tung, N. M., McCuaig, J. M., Eisen, A., Elser, C., Foulkes, W. D., Neuhausen, S. L., Senter, L., Moller, P., Bordeleau, L., Fruscio, R., Velsher, L., Zakalik, D., Olopade, O. I., Eng, C., Pal, T., Cullinane, C. A., Couch, F. J., Kotsopoulos, J., & 3 othersSun, P., Lubinski, J. & Narod, S. A., 2022, (Accepted/In press) In: Cancer.

  Research output: Contribution to journal › Article › peer-review

  • Neoplasms 100%
  • Salpingo-oophorectomy 44%
  • Mastectomy 38%
  • Breast 26%

• The role of genetic breast cancer susceptibility variants as prognostic factors

  Fasching, P. A., Pharoah, P. D. P., Cox, A., Nevanlinna, H., Bojesen, S. E., Karn, T., Broeks, A., Van Leeuwen, F. E., Van't Veer, L. J., Udo, R., Dunning, A. M., Greco, D., Aittomäki, K., Blomqvist, C., Shah, M., Nordestgaard, B. G., Flyger, H., Hopper, J. L., Southey, M. C., Apicella, C., & 78 othersGarcia-Closas, M., Sherman, M., Lissowska, J., Seynaeve, C., Huijts, P. E. A., Tollenaar, R. A. E. M., Ziogas, A., Ekici, A. B., Rauh, C., Mannermaa, A., Kataja, V., Kosma, V. M., Hartikainen, J. M., Andrulis, I. L., Ozcelik, H., Mulligan, A. M., Glendon, G., Hall, P., Czene, K., Liu, J., Chang-Claude, J., Wang-Gohrke, S., Eilber, U., Nickels, S., Dörk, T., Schiekel, M., Bremer, M., Park-Simon, T. W., Giles, G. G., Severi, G., Baglietto, L., Hooning, M. J., Martens, J. W. M., Jager, A., Kriege, M., Lindblom, A., Margolin, S., Couch, F. J., Stevens, K. N., Olson, J. E., Kosel, M., Cross, S. S., Balasubramanian, S. P., Reed, M. W. R., Miron, A., John, E. M., Winqvist, R., Pylkäs, K., Jukkola-Vuorinen, A., Kauppila, S., Burwinkel, B., Marme, F., Schneeweiss, A., Sohn, C., Chenevix-Trench, G., Lambrechts, D., Dieudonne, A. S., Hatse, S., Van Limbergen, E., Benitez, J., Milne, R. L., Zamora, M. P., Pérez, J. I. A., Bonanni, B., Peissel, B., Loris, B., Peterlongo, P., Rajaraman, P., Schonfeld, S. J., Anton-Culver, H., Devilee, P., Beckmann, M. W., Slamon, D. J., Phillips, K. A., Figueroa, J. D., Humphreys, M. K., Easton, D. F. & Schmidt, M. K., Sep 2012, In: Human molecular genetics. 21, 17, p. 3926-3939 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Single Nucleotide Polymorphism 100%
  • Breast Neoplasms 76%
  • Survival 59%
  • Genome-Wide Association Study 37%
  • Gene Expression 14%
  67 Scopus citations

• The role of KRAS rs61764370 in invasive epithelial ovarian cancer: Implications for clinical testing

  Pharoah, P. D. P., Palmieri, R. T., Ramus, S. J., Gayther, S. A., Andrulis, I. L., Anton-Culver, H., Antonenkova, N., Antoniou, A. C., Goldgar, D., Beattie, M. S., Beckmann, M. W., Birrer, M. J., Bogdanova, N., Bolton, K. L., Brewster, W., Brooks-Wilson, A., Brown, R., Butzow, R., Caldes, T., Caligo, M. A., & 93 othersCampbell, I., Chang-Claude, J., Chen, Y. A., Cook, L. S., Couch, F. J., Cramer, D. W., Cunningham, J. M., Despierre, E., Doherty, J. A., Dörk, T., Dürst, M., Eccles, D. M., Ekici, A. B., Easton, D., Fasching, P. A., De Fazio, A., Fenstermacher, D. A., Flanagan, J. M., Fridley, B. L., Friedman, E., Gao, B., Sinilnikova, O., Gentry-Maharaj, A., Godwin, A. K., Goode, E. L., Goodman, M. T., Gross, J., Hansen, T. V. O., Harnett, P., Rookus, M., Heikkinen, T., Hein, R., Høgdall, C., Høgdall, E., Iversen, E. S., Jakubowska, A., Johnatty, S. E., Karlan, B. Y., Kauff, N. D., Kaye, S. B., Chenevix-Trench, G., Kelemen, L. E., Kiemeney, L. A., Kjaer, S. K., Lambrechts, D., LaPolla, J. P., Lázaro, C., Le, N. D., Leminen, A., Leunen, K., Levine, D. A., Lu, Y., Lundvall, L., Macgregor, S., Marees, T., Massuger, L. F., McLaughlin, J. R., Menon, U., Montagna, M., Moysich, K. B., Narod, S. A., Nathanson, K. L., Nedergaard, L., Ness, R. B., Nevanlinna, H., Nickels, S., Osorio, A., Paul, J., Pearce, C. L., Phelan, C. M., Pike, M. C., Radice, P., Rossing, M. A., Schildkraut, J. M., Sellers, T. A., Singer, C. F., Song, H., Stram, D. O., Sutphen, R., Lindblom, A., Terry, K. L., Tsai, Y. Y., Van Altena, A. M., Vergote, I., Vierkant, R. A., Vitonis, A. F., Walsh, C., Wang-Gohrke, S., Wappenschmidt, B., Wu, A. H., Ziogas, A., Berchuck, A. & Risch, H. A., Jun 1 2011, In: Clinical Cancer Research. 17, 11, p. 3742-3750 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Ovarian Epithelial Carcinoma 100%
  • Ovarian Neoplasms 78%
  • Progression-Free Survival 31%
  • Single Nucleotide Polymorphism 29%
  • Carboplatin 19%
  41 Scopus citations

• The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients

  KConFab investigators, 2015, In: Oncotarget. 6, 10, p. 7390-7407 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Single Nucleotide Polymorphism 100%
  • Adjuvant Chemotherapy 90%
  • Breast Neoplasms 76%
  • Drug Therapy 70%
  • Survival 66%
  12 Scopus citations

• Tissue methylated DNA markers for sporadic pancreatic cancer are strongly associated with familial and genetically predisposed pancreatic cancer

  Majumder, S., Taylor, W. R., Foote, P. H., Gysbers, B. J., Cao, X., Mahoney, D. W., Burger, K. N., Doering, K. A., Graham, R., Couch, F. J., Petersen, G. M. & Kisiel, J. B., 2022, (Accepted/In press) In: Pancreatology.

  Research output: Contribution to journal › Article › peer-review

  • Genetic Markers 100%
  • Pancreatic Neoplasms 90%
  • Adenocarcinoma 74%
  • Germ-Line Mutation 21%
  • Genetic Predisposition to Disease 19%

• TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer

  Fagerholm, R., Khan, S., Schmidt, M. K., García-Closas, M., Heikkilä, P., Saarela, J., Beesley, J., Jamshidi, M., Aittomäki, K., Liu, J., Ali, H. R., Andrulis, I. L., Beckmann, M. W., Behrens, S., Blows, F. M., Brenner, H., Chang-Claude, J., Couch, F. J., Czene, K., Fasching, P. A., & 32 othersFigueroa, J., Floris, G., Glendon, G., Guo, Q., Hll, P., Hallberg, E., Hamann, U., Holleczek, B., Hooning, M. J., Hopper, J. L., Jager, A., Kabisch, M., Keeman, R., Kosma, V. M., Lambrechts, D., Lindblom, A., Mannermaa, A., Margolin, S., Provenzano, E., Shah, M., Southey, M. C., Dennis, J., Lush, M., Michailidou, K., Wang, Q., Bolla, M. K., Dunning, A. M., Easton, D. F., Pharoah, P. D. P., Chenevix-Trench, G., Blomqvist, C. & Nevanlinna, H., 2017, In: Oncotarget. 8, 11, p. 18381-18398 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Single Nucleotide Polymorphism 100%
  • Breast Neoplasms 76%
  • Anthracyclines 67%
  • Survival 66%
  • Estrogen Receptors 55%
  6 Scopus citations

• Traceback: A proposed framework to increase identification and genetic counseling of BRCA1 and BRCA2 mutation carriers through family-based outreach

  Samimi, G., Caga-Anan, C. F., Dean, M., Mechanic, L. E., Minasian, L. M., Sherman, M. E., Brody, L. C., Bernardini, M. Q., Lheureux, S., Shaw, P. A., Kwon, J. S., Campbell, I. G., James, P. A., Takenaka, M., Bowtell, D. D., Chenevix-Trench, G., Friedlander, M., Ramus, S. J., Couch, F. J., De Hullu, J. A., & 13 othersHarmsen, M. G., Domchek, S. M., Drapkin, R., Mai, P. L., Feigelson, H. S., Gaudet, M. M., Hurley, K., Robson, M. E., Lacbawan, F., Slavin, T. P., Myers, E. R., Rezende, L. F. & Swisher, E. M., Jul 10 2017, In: Journal of Clinical Oncology. 35, 20, p. 2329-2337 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Genetic Counseling 100%
  • Ovarian Neoplasms 62%
  • Mutation 51%
  • Education 43%
  • Bioethics 31%
  34 Scopus citations

• Transcript identification in the BRCA1 candidate region

  Weber, B. L., Abel, K. J., Couch, F. J., Merajver, S., Castilla, L., Brody, L. C. & Collins, F. S., Feb 1995, In: Breast Cancer Research and Treatment. 33, 2, p. 115-124 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Breast Neoplasms 100%
  • Ovarian Neoplasms 95%
  • Chromosomes, Human, Pair 21 68%
  • Genes 63%
  • Gene Rearrangement 61%
  1 Scopus citations

• Transcriptome-wide association study of breast cancer risk by estrogen-receptor status

  ABCTB Investigators, HEBON Investigators, BCFR Investigators, OCGN Investigators, GEMO Study Collaborators, EMBRACE Collaborators & GC-HBOC Study Collaborators, Jul 1 2020, In: Genetic epidemiology. 44, 5, p. 442-468 27 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Estrogen Receptors 100%
  • Transcriptome 98%
  • Breast Neoplasms 68%
  • Genome-Wide Association Study 41%
  • Neoplasm Genes 28%
  4 Scopus citations

• Transcriptomic and Immunohistochemical Profiling of SLC6A14 in Pancreatic Ductal Adenocarcinoma

  Penheiter, A. R., Erdogan, S., Murphy, S. J., Hart, S. N., Felipe Lima, J., Rakhshan Rohakhtar, F., O'Brien, D. R., Bamlet, W. R., Wuertz, R. E., Smyrk, T. C., Couch, F. J., Vasmatzis, G., Bender, C. E. & Carlson, S. K., 2015, In: BioMed Research International. 2015, 593572.

  Research output: Contribution to journal › Article › peer-review

  • Microarrays 100%
  • Adenocarcinoma 72%
  • Protein 38%
  • Probe 28%
  • Neutral Amino Acid Transport Systems 25%
  17 Scopus citations

• Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation

  Gronwald, J., Glass, K., Rosen, B., Karlan, B., Tung, N., Neuhausen, S. L., Moller, P., Ainsworth, P., Sun, P., Narod, S. A., Lubinski, J., Kotsopoulos, J., Lynch, H. T., Cybulski, C., Kim-Sing, C., Friedman, S., Senter, L., Weitzel, J., Singer, C., Eng, C., & 60 othersMitchell, G., Huzarski, T., McCuaig, J., Eisen, A., Gilchrist, D., Blum, J. L., Zakalik, D., Pal, T., Daly, M., Weber, B., Snyder, C., Fallen, T., Chudley, A., Lunn, J., Donenberg, T., Kurz, R. N., Saal, H., Garber, J., Rennert, G., Sweet, K., Rappaport, C., Lemire, E., Stoppa-Lyonnet, D., Olopade, O. I., Merajver, S., Bordeleau, L., Cullinane, C. A., Friedman, E., McKinnon, W., Wood, M., Rayson, D., Meschino, W., Costalas, J. W., Reilly, R. E., Vadaparampil, S., Offit, K., Kauff, N., Euhus, D., Kwong, A., Isaacs, C., Couch, F., Manoukian, S., Byrski, T., Elser, C., Panchal, S., Armel, S., Demsky, R., Nanda, S., Metcalfe, K., Poll, A., Foulkes, W. D., Robidoux, A., Warner, E., Maehle, L., Evans, G., Pasini, B., Ginsburg, O., Cohen, S., Jakubowska, A. & Little, J., Mar 1 2016, In: Fertility and sterility. 105, 3, p. 781-785 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Infertility 100%
  • Ovarian Neoplasms 98%
  • Fertility 60%
  • Mutation 60%
  • Selective Estrogen Receptor Modulators 28%
  24 Scopus citations

• Trends in mastectomy rates at the Mayo Clinic Rochester: Effect of surgical year and preoperative magnetic resonance imaging

  Katipamula, R., Degnim, A. C., Hoskin, T., Boughey, J. C., Loprinzi, C., Grant, C. S., Brandt, K. R., Pruthi, S., Chute, C. G., Olson, J. E., Couch, F. J., Ingle, J. N. & Goetz, M. P., Sep 1 2009, In: Journal of Clinical Oncology. 27, 25, p. 4082-4088 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Mastectomy 100%
  • Magnetic Resonance Imaging 60%
  • Odds Ratio 9%
  • Epidemiologic Confounding Factors 8%
  • Breast 5%
  302 Scopus citations

• Triple-negative breast cancer risk genes identified by multigene hereditary cancer panel testing

  Shimelis, H., LaDuca, H., Hu, C., Hart, S. N., Na, J., Thomas, A., Akinhanmi, M., Moore, R. M., Brauch, H., Cox, A., Eccles, D. M., Ewart-Toland, A., Fasching, P. A., Fostira, F., Garber, J., Godwin, A. K., Konstantopoulou, I., Nevanlinna, H., Sharma, P., Yannoukakos, D., & 9 othersYao, S., Feng, B. J., Davis, B. T., Lilyquist, J., Pesaran, T., Goldgar, D. E., Polley, E. C., Dolinsky, J. S. & Couch, F. J., Aug 1 2018, In: Journal of the National Cancer Institute. 110, 8, p. 855-862 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms 100%
  • Neoplasm Genes 89%
  • Odds Ratio 42%
  • Breast Neoplasms 31%
  • Mutation 27%
  106 Scopus citations

• Truncating variants in p53AIP1 disrupting DNA damage-induced apoptosis are associated with prostate cancer risk

  Wang, X., Wang, F., Taniguchi, K., Seelan, R. S., Wang, L., Zarfas, K. E., McDonnell, S. K., Qian, C., Pan, K., Lu, Y., Shridhar, V., Couch, F. J., Tindall, D. J., Beebe-Dimmer, J. L., Cooney, K. A., Isaacs, W. B., Jacobsen, S. J., Schaid, D. J., Thibodeau, S. N. & Liu, W., Nov 1 2006, In: Cancer research. 66, 21, p. 10302-10307 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Apoptosis Regulatory Proteins 100%
  • p53 Genes 93%
  • DNA Damage 73%
  • Prostatic Neoplasms 66%
  • Apoptosis 51%
  10 Scopus citations

• Two distinct mechanisms underlie estrogen-receptor-negative breast cancer susceptibility at the 2p23.2 locus

  Mendoza-Fandiño, G., Lyra, P. C. M., Nepomuceno, T. C., Harro, C. M., Woods, N. T., Li, X., Rangel, L. B., Carvalho, M. A., Couch, F. J. & Monteiro, A. N. A., Apr 2022, In: European Journal of Human Genetics. 30, 4, p. 465-473 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors 100%
  • Nucleic Acid Regulatory Sequences 98%
  • Single Nucleotide Polymorphism 89%
  • Breast Neoplasms 68%
  • Alleles 31%

• Two truncating variants in FANCC and breast cancer risk

  ABCTB Investigators & NBCS Collaborators, Dec 1 2019, In: Scientific reports. 9, 1, 12524.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fanconi Anemia 100%
  • Breast Neoplasms 71%
  • Mutation 31%
  • Genes 30%
  • Neoplasm Genes 20%
  2 Scopus citations

• Use of risk-reducing surgeries in a prospective cohort of 1,499 BRCA1 and BRCA2 mutation carriers

  Chai, X., Friebel, T. M., Singer, C. F., Evans, D. G., Lynch, H. T., Isaacs, C., Garber, J. E., Neuhausen, S. L., Matloff, E., Eeles, R., Tung, N., Weitzel, J. N., Couch, F. J., Hulick, P. J., Ganz, P. A., Daly, M. B., Olopade, O. I., Tomlinson, G., Blum, J. L., Domchek, S. M., & 2 othersChen, J. & Rebbeck, T. R., Nov 7 2014, In: Breast Cancer Research and Treatment. 148, 2, p. 397-406 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Salpingo-oophorectomy 100%
  • Mutation 76%
  • Mastectomy 49%
  • Ovarian Neoplasms 11%
  • Genetic Counseling 7%
  36 Scopus citations

• Utilization of gene expression profiling to identify markers of disease recurrence in node-negative breast cancer

  Roche, P. C., Mertens, M. L., Couch, F. J., Ingle, J. N., Leontovich, A. A., Perez, E. A. & Lillie, J., Jan 1 2001, In: Breast Cancer Research and Treatment. 69, 3, 1 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene Expression Profiling 100%
  • Breast Neoplasms 61%
  • Recurrence 55%
  • Genes 26%
  • Subtractive Hybridization Techniques 23%
  2 Scopus citations

• Utilizing Nottingham Prognostic Index in microarray gene expression profiling of breast carcinomas

  Miller, D. V., Leontovich, A. A., Lingle, W. L., Suman, V. J., Mertens, M. L., Lillie, J., Ingalls, K. A., Perez, E. A., Ingle, J. N., Couch, F. J. & Visscher, D. W., Jul 2004, In: Modern Pathology. 17, 7, p. 756-764 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene Expression Profiling 100%
  • Breast Neoplasms 61%
  • Immunohistochemistry 26%
  • Expressed Sequence Tags 24%
  • Genes 23%
  31 Scopus citations

• Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer

  White, K. L., Sellers, T. A., Fridley, B. L., Vierkant, R. A., Phelan, C. M., Tsai, Y. Y., Kalli, K. R., Berchuck, A., Iversen, E. S., Hartmann, L. C., Liebow, M., Armasu, S., Fredericksen, Z., Larson, M. C., Duggan, D., Couch, F. J., Schildkraut, J. M., Cunningham, J. M. & Goode, E. L., Feb 2010, In: Twin Research and Human Genetics. 13, 1, p. 43-56 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Ovarian Epithelial Carcinoma 100%
  • Ovarian Neoplasms 52%
  • Urinary Bladder Neoplasms 27%
  • Single Nucleotide Polymorphism 24%
  • Colorectal Neoplasms 22%
  15 Scopus citations

• Variation in genes required for normal mitosis and risk of breast cancer

  Olson, J. E., Wang, X., Goode, E. L., Pankratz, V. S., Fredericksen, Z. S., Vierkant, R. A., Pharoah, P. D. P., Cerhan, J. R. & Couch, F. J., Jan 2010, In: Breast Cancer Research and Treatment. 119, 2, p. 423-430 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitosis 100%
  • Breast Neoplasms 64%
  • Genes 40%
  • Cell Division 24%
  • Single Nucleotide Polymorphism 21%
  28 Scopus citations

• Von Hippel-Lindau gene product directs cytokinesis: A new tumor suppressor function

  Sinha, S., Mondal, G., Hwang, E. J., Han, D. W., Dutta, S. K., Iyer, S., Karumanchi, S. A., Kim, K. I., Couch, F. J. & Mukhopadhyay, D., Jul 1 2011, In: Journal of cell science. 124, 13, p. 2132-2142 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Renal Cell Carcinoma 79%
  • Polyploidy 52%
  • Lysine 40%
  • Genes 33%
  • Chromosomes 32%
  12 Scopus citations

• Whole-exome sequencing of non-BRCA1/BRCA2 mutation carrier cases at high-risk for hereditary breast/ovarian cancer

  Felicio, P. S., Grasel, R. S., Campacci, N., de Paula, A. E., Galvão, H. C. R., Torrezan, G. T., Sabato, C. S., Fernandes, G. C., Souza, C. P., Michelli, R. D., Andrade, C. E., Barros, B. D. D. F., Matsushita, M. M., Revil, T., Ragoussis, J., Couch, F. J., Hart, S. N., Reis, R. M., Melendez, M. E., Tonin, P. N., & 2 othersCarraro, D. M. & Palmero, E. I., Mar 2021, In: Human mutation. 42, 3, p. 290-299 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Whole Exome Sequencing 100%
  • Ovarian Neoplasms 76%
  • Neoplasm Genes 68%
  • Breast Neoplasms 53%
  • Loss of Heterozygosity 48%
  2 Scopus citations