• 2160 Citations
  • 26 Scopus h-Index
1990 …2019
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Research Output 1990 2019

  • 2160 Citations
  • 26 Scopus h-Index
  • 59 Article
  • 1 Chapter
  • 1 Review article
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Article
2019

Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition

Raeeszadeh-Sarmazdeh, M., Greene, K. A., Sankaran, B., Downey, G. P., Radisky, D. C. & Radisky, E. S., Jan 1 2019, In : Journal of Biological Chemistry. 294, 24, p. 9476-9488 13 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-1
Tissue Inhibitor of Metalloproteinases
Metalloproteases
Matrix Metalloproteinases
Matrix Metalloproteinase 3
3 Citations (Scopus)

Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin

Cohen, I., Coban, M., Shahar, A., Sankaran, B., Hockla, A., Lacham, S., Caulfield, T., Radisky, E. S. & Papo, N., Jan 1 2019, In : Journal of Biological Chemistry. 294, 13, p. 5105-5120 16 p.

Research output: Contribution to journalArticle

Proteolysis
Serine Proteinase Inhibitors
Human Engineering
Disulfides
Peptide Hydrolases

Novel pathogenic PRSS1 variant p.Glu190Lys in a case of chronic pancreatitis

Jancsó, Z., Oracz, G., Kujko, A. A., Kolodziejczyk, E., Radisky, E. S., Rygiel, A. M. & Sahin-Tóth, M., Jan 1 2019, In : Frontiers in Genetics. 10, FEB, 46.

Research output: Contribution to journalArticle

Open Access
Trypsinogen
Chronic Pancreatitis
trypsinogen activation peptide
Mutation
Enzyme Precursors
1 Citation (Scopus)

PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma

Ma, H., Hockla, A., Mehner, C., Coban, M., Papo, N., Radisky, D. C. & Radisky, E. S., Dec 1 2019, In : Scientific reports. 9, 1, 1844.

Research output: Contribution to journalArticle

Open Access
Kallikreins
Peptide Hydrolases
Growth
Neoplasms
Serine Proteases
2018
3 Citations (Scopus)

A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering

Sananes, A., Cohen, I., Shahar, A., Hockla, A., De Vita, E., Miller, A. K., Radisky, E. S. & Papo, N., Jan 1 2018, In : Journal of Biological Chemistry. 293, 33, p. 12663-12680 18 p.

Research output: Contribution to journalArticle

Proteolysis
Kallikreins
Peptide Hydrolases
Neoplasms
Protease Inhibitors
2 Citations (Scopus)

Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell

Arkadash, V., Radisky, E. S. & Papo, N., Aug 10 2018, In : Oncotarget. 9, 62, p. 32036-32053 18 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-2
Peptide Hydrolases
Matrix Metalloproteinase Inhibitors
MCF-7 Cells
Sequence Homology
5 Citations (Scopus)

Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14

Shirian, J., Arkadash, V., Cohen, I., Sapir, T., Radisky, E. S., Papo, N. & Shifman, J. M., Jan 1 2018, (Accepted/In press) In : FEBS Letters.

Research output: Contribution to journalArticle

Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases
Yeast
Yeasts
Technology
2 Citations (Scopus)

Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

Naftaly, S., Cohen, I., Shahar, A., Hockla, A., Radisky, E. S. & Papo, N., Dec 1 2018, In : Nature Communications. 9, 1, 3935.

Research output: Contribution to journalArticle

sequencing
Amyloid beta-Protein Precursor
inhibitors
Screening
screening
3 Citations (Scopus)

Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases

Cohen, I., Naftaly, S., Ben-Zeev, E., Hockla, A., Radisky, E. S. & Papo, N., Apr 16 2018, In : Biochemical Journal. 475, 7, p. 1335-1352 18 p.

Research output: Contribution to journalArticle

Serine Proteases
Screening
Tuning
Peptide Hydrolases
Proteins
2017
21 Citations (Scopus)

Development of high affinity and high specificity inhibitors of matrix metalloproteinase 14 through computational design and directed evolution

Arkadash, V., Yosef, G., Shirian, J., Cohen, I., Horev, Y., Grossman, M., Sagi, I., Radisky, E. S., Shifman, J. M. & Papo, N., Feb 24 2017, In : Journal of Biological Chemistry. 292, 8, p. 3481-3495 15 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 14
Matrix Metalloproteinases
Matrix Metalloproteinase Inhibitors
Protein Engineering
Proteins
2 Citations (Scopus)

Small molecule inhibitors of mesotrypsin from a structurebased docking screen

Kayode, O., Huang, Z., Soares, A. S., Caulfield, T., Dong, Z., Bode, A. M. & Radisky, E. S., May 1 2017, In : PLoS One. 12, 5, e0176694.

Research output: Contribution to journalArticle

Diminazene
diminazene
crystal structure
Crystal structure
Trypsin
27 Citations (Scopus)

Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer

Radisky, E. S., Raeeszadeh-Sarmazdeh, M. & Radisky, D. C., 2017, (Accepted/In press) In : Journal of Cellular Biochemistry.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Breast Neoplasms
Tissue Inhibitor of Metalloproteinases
Therapeutics
Tumors
2016
11 Citations (Scopus)

An acrobatic substrate metamorphosis reveals a requirement for substrate conformational dynamics in trypsin proteolysis

Kayode, O., Wang, R., Pendlebury, D. F., Cohen, I., Henin, R. D., Hockla, A., Soares, A. S., Papo, N., Caulfield, T. & Radisky, E. S., Dec 16 2016, In : Journal of Biological Chemistry. 291, 51, p. 26304-26319 16 p.

Research output: Contribution to journalArticle

Proteolysis
Catalysis
Trypsin
Substrates
Enzymes
19 Citations (Scopus)

Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy

Cohen, I., Kayode, O., Hockla, A., Sankaran, B., Radisky, D. C., Radisky, E. S. & Papo, N., May 15 2016, In : Biochemical Journal. 473, 10, p. 1329-1341 13 p.

Research output: Contribution to journalArticle

Protein Engineering
Tumors
Neoplasms
Screening
Proteins
6 Citations (Scopus)

MYC is a crucial mediator of TGFβ-induced invasion in basal breast cancer

Cichon, M. A., Moruzzi, M. E., Shqau, T. A., Miller, E., Mehner, C., Ethier, S. P., Copland, J. A. III., Radisky, E. S. & Radisky, D. C., Jun 15 2016, In : Cancer Research. 76, 12, p. 3520-3530 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Autocrine Communication
Paracrine Communication
Breast
2015
42 Citations (Scopus)

Matrix metalloproteinases as breast cancer drivers and therapeutic targets

Radisky, E. S. & Radisky, D. C., Jun 1 2015, In : Frontiers in Bioscience - Landmark. 20, 7, p. 1144-1163 20 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Breast Neoplasms
Therapeutics
Tumors
Tumor Microenvironment
13 Citations (Scopus)

Mesotrypsin has evolved four unique residues to cleave trypsin inhibitors as substrates

Alloy, A. P., Kayode, O., Wang, R., Hockla, A., Soares, A. S. & Radisky, E. S., Aug 28 2015, In : Journal of Biological Chemistry. 290, 35, p. 21523-21535 13 p.

Research output: Contribution to journalArticle

Aprotinin
Trypsin Inhibitors
Trypsin
Amyloid beta-Protein Precursor
Protease Inhibitors
6 Citations (Scopus)

Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers

Mehner, C., Oberg, A. L., Kalli, K. R., Nassar, A., Hockla, A., Pendlebury, D., Cichon, M. A., Goergen, K. M., Maurer, M. J., Goode, E. L., Keeney, G., Jatoi, A., Sahin-Tóth, M., Copland, J. A. III., Radisky, D. C. & Radisky, E. S., 2015, In : Oncotarget. 6, 34, p. 35737-35754 18 p.

Research output: Contribution to journalArticle

Anoikis
Serine Proteinase Inhibitors
Ovarian Neoplasms
Neoplasms
Epidermal Growth Factor Receptor
2014
16 Citations (Scopus)

Sequence and conformational specificity in substrate recognition: Several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin

Pendlebury, D., Wang, R., Henin, R. D., Hockla, A., Soares, A. S., Madden, B. J., Kazanov, M. D. & Radisky, E. S., Nov 21 2014, In : Journal of Biological Chemistry. 289, 47, p. 32783-32797 15 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Substrate Specificity
Protease Inhibitors
E-Selectin
Conformations
23 Citations (Scopus)

Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma

Mehner, C., Miller, E., Khauv, D., Nassar, A., Oberg, A. L., Bamlet, W. R., Zhang, L., Waldmann, J., Radisky, E. S., Crawford, H. C. & Radisky, D. C., Oct 1 2014, In : Molecular Cancer Research. 12, 10, p. 1430-1439 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Neoplasms
Foster Home Care
Tumor Microenvironment
138 Citations (Scopus)

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

Mehner, C., Hockla, A., Miller, E., Ran, S., Radisky, D. C. & Radisky, E. S., 2014, In : Oncotarget. 5, 9, p. 2736-2749 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Matrix Metalloproteinase 9
Neoplasm Metastasis
Neoplasms
Breast Neoplasms
4 Citations (Scopus)

Tyrosine sulfation of human trypsin steers S2′ subsite selectivity towards basic amino acids

Szabó, A., Salameh, M. A., Ludwig, M., Radisky, E. S. & Sahin-Tóth, M., Jul 10 2014, In : PLoS One. 9, 7, e102063.

Research output: Contribution to journalArticle

Basic Amino Acids
Trypsin
trypsin
Tyrosine
tyrosine
4 Citations (Scopus)

Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation

Szabó, A., Radisky, E. S. & Sahin-Tóth, M., Feb 21 2014, In : Journal of Biological Chemistry. 289, 8, p. 4753-4761 9 p.

Research output: Contribution to journalArticle

Enzyme Precursors
Thermodynamics
Trypsin
Thermodynamic stability
Chemical activation
2013
13 Citations (Scopus)

Biochemical and structural insights into mesotrypsin: An unusual human trypsin

Salameh, M. A. & Radisky, E. S., 2013, In : International Journal of Biochemistry and Molecular Biology. 4, 3, p. 129-139 11 p.

Research output: Contribution to journalArticle

Trypsin
Pancreas
Trypsin Inhibitors
Substrates
Substrate Specificity
12 Citations (Scopus)

Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation

Batra, J., Szabó, A., Caulfield, T., Soares, A. S., Sahin-Tóth, M. & Radisky, E. S., Apr 5 2013, In : Journal of Biological Chemistry. 288, 14, p. 9848-9859 12 p.

Research output: Contribution to journalArticle

Enzyme Activation
Static Electricity
Electrostatics
Chemical activation
Substrates
17 Citations (Scopus)

Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes

Batra, J., Soares, A. S., Mehner, C. & Radisky, E. S., Sep 20 2013, In : PLoS One. 8, 9, e75836.

Research output: Contribution to journalArticle

stromelysin 2
Matrix Metalloproteinase 10
Tissue Inhibitor of Metalloproteinases
Tissue Inhibitor of Metalloproteinase-2
Matrix Metalloproteinase Inhibitors
5 Citations (Scopus)

PRSS3/mesotrypsin in prostate cancer progression: Implications for translational medicine

Radisky, E. S., Jul 2013, In : Asian Journal of Andrology. 15, 4, p. 439-440 2 p.

Research output: Contribution to journalArticle

Translational Medical Research
Trypsin Inhibitors
Trypsin
Prostatic Neoplasms
25 Citations (Scopus)

TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure

Chen, F., Radisky, E. S., Das, P., Batra, J., Hata, T., Hori, T., Baine, A. M. T., Gardner, L., Yue, M. Y., Bu, G. D., Del Zoppo, G., Patel, T. C. & Nguyen, J. H., Jul 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 7, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-1
Acute Liver Failure
Blood-Brain Barrier
Permeability
Matrix Metalloproteinase 9
2012
41 Citations (Scopus)
Matrix Metalloproteinase 10
Tissue Inhibitor of Metalloproteinases
Tissue Inhibitor of Metalloproteinase-2
Tissue Inhibitor of Metalloproteinase-1
Matrix Metalloproteinases
55 Citations (Scopus)

Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential

Justilien, V., Regala, R. P., Tseng, I. C., Walsh, M. P., Batra, J., Radisky, E. S., Murray, N. R. & Fields, A. P., Apr 24 2012, In : PLoS One. 7, 4, e35040.

Research output: Contribution to journalArticle

stromelysin 2
Matrix Metalloproteinase 10
Neoplastic Stem Cells
lung neoplasms
Stem cells
61 Citations (Scopus)

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression

Stallings-Mann, M. L., Waldmann, J., Zhang, Y., Miller, E., Gauthier, M. L., Visscher, D. W., Downey, G. P., Radisky, E. S., Fields, A. P. & Radisky, D. C., Jul 11 2012, In : Science Translational Medicine. 4, 142, 142ra95.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Matrix Metalloproteinases
Lung Neoplasms
Transgenic Mice
Epithelial Cells
121 Citations (Scopus)

MYC suppresses cancer metastasis by direct transcriptional silencing of α v and β 3 integrin subunits

Liu, H., Radisky, D. C., Yang, D., Xu, R., Radisky, E. S., Bissell, M. J. & Bishop, J. M., Jun 2012, In : Nature Cell Biology. 14, 6, p. 567-574 8 p.

Research output: Contribution to journalArticle

Integrins
Neoplasm Metastasis
Breast Neoplasms
Neoplasms
Oncogenes
25 Citations (Scopus)

PEGylation Extends Circulation Half-Life While Preserving In Vitro and In Vivo Activity of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1)

Batra, J., Robinson, J., Mehner, C., Hockla, A., Miller, E., Radisky, D. C. & Radisky, E. S., 2012, In : PLoS One. 7, 11, e50028.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-1
metalloproteinases
half life
Half-Life
Tissue Inhibitor of Metalloproteinases
12 Citations (Scopus)

Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors

Salameh, M. A., Soares, A. S., Alloy, A. & Radisky, E. S., Aug 2012, In : Protein Science. 21, 8, p. 1103-1112 10 p.

Research output: Contribution to journalArticle

Protease Inhibitors
Trypsin
Hydrogen
Hydrogen bonds
Aprotinin
28 Citations (Scopus)

PRSS3/mesotrypsin is a therapeutic target for metastatic prostate cancer

Hockla, A., Miller, E., Salameh, M. A., Copland, J. A. III., Radisky, D. C. & Radisky, E. S., Dec 2012, In : Molecular Cancer Research. 10, 12, p. 1555-1566 12 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Trypsin
Therapeutics
Neoplasm Metastasis
Phenotype
2011
22 Citations (Scopus)

High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4′ acidic residues

Szabó, A., Héja, D., Szakács, D., Zboray, K., Kékesi, K. A., Radisky, E. S., Sahin-Tóth, M. & Pál, G., Jun 24 2011, In : Journal of Biological Chemistry. 286, 25, p. 22535-22545 11 p.

Research output: Contribution to journalArticle

Bacteriophages
Display devices
Proteins
Viperidae
Pancreatic Elastase
1 Citation (Scopus)

Identifying the Stroma as a Critical Player in Radiation-Induced Mammary Tumor Development

Cichon, M. A., Radisky, E. S. & Radisky, D. C., May 17 2011, In : Cancer Cell. 19, 5, p. 571-572 2 p.

Research output: Contribution to journalArticle

Radiation
Breast Neoplasms
Transforming Growth Factors
Estrogen Receptors
Neoplasms
26 Citations (Scopus)

The P 2′ residue is a key determinant of mesotrypsin specificity: Engineering a high-affinity inhibitor with anticancer activity

Salameh, M. A., Soares, A. S., Hockla, A., Radisky, D. C. & Radisky, E. S., Nov 15 2011, In : Biochemical Journal. 440, 1, p. 95-105 11 p.

Research output: Contribution to journalArticle

Aprotinin
Trypsin Inhibitors
Protease Inhibitors
Protein Engineering
Mutagenesis
2010
3 Citations (Scopus)

Cathepsin D: Regulation in mammary gland remodeling, misregulation in breast cancer

Radisky, E. S., Sep 1 2010, In : Cancer Biology and Therapy. 10, 5, p. 467-470 4 p.

Research output: Contribution to journalArticle

Physiologic Neovascularization
Cathepsin D
Animal Mammary Glands
Protein Transport
Human Mammary Glands
32 Citations (Scopus)

Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin

Salameh, M. A., Soares, A. S., Navaneetham, D., Sinha, D., Walsh, P. N. & Radisky, E. S., Nov 19 2010, In : Journal of Biological Chemistry. 285, 47, p. 36884-36896 13 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Protease Inhibitors
Aprotinin
Scaffolds
Proteolysis
281 Citations (Scopus)
Epithelial-Mesenchymal Transition
Matrix Metalloproteinases
Breast Neoplasms
Human Mammary Glands
Extracellular Matrix
38 Citations (Scopus)

Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109

Hockla, A., Radisky, D. C. & Radisky, E. S., Nov 2010, In : Breast Cancer Research and Treatment. 124, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

Serine Proteases
Breast Neoplasms
CD4-Positive T-Lymphocytes
Serine Proteinase Inhibitors
Growth
24 Citations (Scopus)

The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin

Orlichenko, L., Geyer, R., Yanagisawa, M., Khauv, D., Radisky, E. S., Anastasiadis, P. Z. & Radisky, D. C., Jun 18 2010, In : Journal of Biological Chemistry. 285, 25, p. 19153-19161 9 p.

Research output: Contribution to journalArticle

Tumors
Protein Isoforms
GTP Phosphohydrolases
Amino Acids
Cell Movement
26 Citations (Scopus)

The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin

Salameh, M. A., Robinson, J. L., Navaneetham, D., Sinha, D., Madden, B. J., Walsh, P. N. & Radisky, E. S., Jan 15 2010, In : Journal of Biological Chemistry. 285, 3, p. 1939-1949 11 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Substrates
Protease Inhibitors
Trypsin
Serine Proteases
2009
26 Citations (Scopus)

Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function inmammary epithelial morphogenesis

Chen, C. S., Nelson, C. M., Khauv, D., Bennett, S., Radisky, E. S., Hirai, Y., Bissell, M. J. & Radisky, D. C., Mar 13 2009, In : Journal of Biological Chemistry. 284, 11, p. 6877-6884 8 p.

Research output: Contribution to journalArticle

Syntaxin 1
Morphogenesis
Fusion reactions
Molecules
Breast
2008
38 Citations (Scopus)

Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin

Salameh, M. A., Soares, A. S., Hockla, A. & Radisky, E. S., Feb 15 2008, In : Journal of Biological Chemistry. 283, 7, p. 4115-4123 9 p.

Research output: Contribution to journalArticle

Aprotinin
Trypsin
Substitution reactions
Crystal structure
human PRSS3 protein
2007
99 Citations (Scopus)

Stromal induction of breast cancer: Inflammation and invasion

Radisky, E. S. & Radisky, D. C., Sep 2007, In : Reviews in Endocrine and Metabolic Disorders. 8, 3, p. 279-287 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Inflammation
Neoplasms
Genetically Modified Animals
Tumor Suppressor Genes
2006
86 Citations (Scopus)

Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates

Radisky, E. S., Lee, J. M., Lu, C. J. K. & Koshland, D. E., May 2 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 18, p. 6835-6840 6 p.

Research output: Contribution to journalArticle

Acylation
Serine Proteases
Catalysis
Histidine
Trypsin
2005
32 Citations (Scopus)

Role of the intramolecular hydrogen bond network in the inhibitory power of chymotrypsin inhibitor 2

Radisky, E. S., Lu, C. J. K., Kwan, G. & Koshland, D. E., May 10 2005, In : Biochemistry. 44, 18, p. 6823-6830 8 p.

Research output: Contribution to journalArticle

Proteolysis
Hydrogen
Hydrogen bonds
Subtilisins
Enzyme Stability
2004
37 Citations (Scopus)

Binding, proteolytic, and crystallographic analyses of mutations at the protease - Inhibitor interface of the subtilisin BPN′/chymotrypsin inhibitor 2 complex

Radisky, E. S., Kwan, G., Lu, C. J. K. & Koshland, D. E., Nov 2 2004, In : Biochemistry. 43, 43, p. 13648-13656 9 p.

Research output: Contribution to journalArticle

Subtilisins
Subtilisin
Protease Inhibitors
Mutation
Crystal structure