• 2283 Citations
  • 26 Scopus h-Index
1990 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Kojima, Y., Machida, Y., Palani, S., Caulfield, T. R., Radisky, E. S., Kaufmann, S. H. & Machida, Y. J., Dec 1 2020, In : Nature communications. 11, 1, 1318.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Mirolysin structures open a window on gum disease

Radisky, E. S., Jan 1 2020, In : IUCrJ. 7, p. 3-4 2 p.

Research output: Contribution to journalComment/debate

Open Access

Quantitative mapping of binding specificity landscapes for homologous targets by using a high-throughput method

Aharon, L., Aharoni, S. L., Radisky, E. S. & Papo, N., May 2020, In : Biochemical Journal. 477, 9, p. 1701-1719 19 p.

Research output: Contribution to journalArticle

Open Access

Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H

Gui, F., Zhang, Y., Wan, J., Zhan, X., Yao, Y., Li, Y., Haddock, A. N., Shi, J., Guo, J., Chen, J., Zhu, X., Edenfield, B. H., Zhuang, L., Hu, C., Wang, Y., Mukhopadhyay, D., Radisky, E. S., Zhang, L., Lugea, A., Pandol, S. J. & 2 others, Bi, Y. & Ji, B., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 189-202 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition

Raeeszadeh-Sarmazdeh, M., Greene, K. A., Sankaran, B., Downey, G. P., Radisky, D. C. & Radisky, E. S., Jun 14 2019, In : Journal of Biological Chemistry. 294, 24, p. 9476-9488 13 p.

Research output: Contribution to journalArticle

Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin

Cohen, I., Coban, M., Shahar, A., Sankaran, B., Hockla, A., Lacham, S., Caulfield, T. R., Radisky, E. S. & Papo, N., Mar 29 2019, In : Journal of Biological Chemistry. 294, 13, p. 5105-5120 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Novel pathogenic PRSS1 variant p.Glu190Lys in a case of chronic pancreatitis

Jancsó, Z., Oracz, G., Kujko, A. A., Kolodziejczyk, E., Radisky, E. S., Rygiel, A. M. & Sahin-Tóth, M., 2019, In : Frontiers in Genetics. 10, FEB, 46.

Research output: Contribution to journalArticle

Open Access

PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma

Ma, H., Hockla, A., Mehner, C., Coban, M., Papo, N., Radisky, D. C. & Radisky, E. S., Dec 1 2019, In : Scientific reports. 9, 1, 1844.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering

Sananes, A., Cohen, I., Shahar, A., Hockla, A., De Vita, E., Miller, A. K., Radisky, E. S. & Papo, N., Jan 1 2018, In : Journal of Biological Chemistry. 293, 33, p. 12663-12680 18 p.

Research output: Contribution to journalArticle

3 Scopus citations

Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell

Arkadash, V., Radisky, E. S. & Papo, N., Aug 10 2018, In : Oncotarget. 9, 62, p. 32036-32053 18 p.

Research output: Contribution to journalArticle

3 Scopus citations

Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14

Shirian, J., Arkadash, V., Cohen, I., Sapir, T., Radisky, E. S., Papo, N. & Shifman, J. M., Jan 1 2018, (Accepted/In press) In : FEBS Letters.

Research output: Contribution to journalArticle

6 Scopus citations

Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

Naftaly, S., Cohen, I., Shahar, A., Hockla, A., Radisky, E. S. & Papo, N., Dec 1 2018, In : Nature Communications. 9, 1, 3935.

Research output: Contribution to journalArticle

3 Scopus citations

Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases

Cohen, I., Naftaly, S., Ben-Zeev, E., Hockla, A., Radisky, E. S. & Papo, N., Apr 16 2018, In : Biochemical Journal. 475, 7, p. 1335-1352 18 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Development of high affinity and high specificity inhibitors of matrix metalloproteinase 14 through computational design and directed evolution

Arkadash, V., Yosef, G., Shirian, J., Cohen, I., Horev, Y., Grossman, M., Sagi, I., Radisky, E. S., Shifman, J. M. & Papo, N., Feb 24 2017, In : Journal of Biological Chemistry. 292, 8, p. 3481-3495 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

EGFR as a prognostic biomarker and therapeutic target in ovarian cancer: Evaluation of patient cohort and literature review

Mehner, C., Oberg, A. L., Goergen, K. M., Kalli, K. R., Maurer, M. J., Nassar, A., Goode, E. L., Keeney, G., Jatoi, A., Radisky, D. C. & Radisky, E. S., May 1 2017, In : Genes and Cancer. 8, 5-6, p. 589-599 11 p.

Research output: Contribution to journalReview article

12 Scopus citations

Small molecule inhibitors of mesotrypsin from a structurebased docking screen

Kayode, O., Huang, Z., Soares, A. S., Caulfield, T. R., Dong, Z., Bode, A. M. & Radisky, E. S., May 2017, In : PloS one. 12, 5, e0176694.

Research output: Contribution to journalArticle

2 Scopus citations

Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer

Radisky, E. S., Raeeszadeh-Sarmazdeh, M. & Radisky, D. C., 2017, (Accepted/In press) In : Journal of Cellular Biochemistry.

Research output: Contribution to journalArticle

31 Scopus citations
2016

An acrobatic substrate metamorphosis reveals a requirement for substrate conformational dynamics in trypsin proteolysis

Kayode, O., Wang, R., Pendlebury, D. F., Cohen, I., Henin, R. D., Hockla, A., Soares, A. S., Papo, N., Caulfield, T. R. & Radisky, E. S., Dec 16 2016, In : Journal of Biological Chemistry. 291, 51, p. 26304-26319 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy

Cohen, I., Kayode, O., Hockla, A., Sankaran, B., Radisky, D. C., Radisky, E. S. & Papo, N., May 15 2016, In : Biochemical Journal. 473, 10, p. 1329-1341 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

MYC is a crucial mediator of TGFβ-induced invasion in basal breast cancer

Cichon, M. A., Moruzzi, M. E., Shqau, T. A., Miller, E., Mehner, C., Ethier, S. P., Copland, J. A. III., Radisky, E. S. & Radisky, D. C., Jun 15 2016, In : Cancer Research. 76, 12, p. 3520-3530 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Matrix metalloproteinases as breast cancer drivers and therapeutic targets

Radisky, E. S. & Radisky, D. C., Jun 1 2015, In : Frontiers in Bioscience - Landmark. 20, 7, p. 1144-1163 20 p.

Research output: Contribution to journalReview article

53 Scopus citations

Mesotrypsin has evolved four unique residues to cleave trypsin inhibitors as substrates

Alloy, A. P., Kayode, O., Wang, R., Hockla, A., Soares, A. S. & Radisky, E. S., Aug 28 2015, In : Journal of Biological Chemistry. 290, 35, p. 21523-21535 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers

Mehner, C., Oberg, A. L., Kalli, K. R., Nassar, A., Hockla, A., Pendlebury, D., Cichon, M. A., Goergen, K. M., Maurer, M. J., Goode, E. L., Keeney, G. L., Jatoi, A., Sahin-Tóth, M., Copland, J. A., Radisky, D. C. & Radisky, E. S., 2015, In : Oncotarget. 6, 34, p. 35737-35754 18 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Sequence and conformational specificity in substrate recognition: Several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin

Pendlebury, D., Wang, R., Henin, R. D., Hockla, A., Soares, A. S., Madden, B. J., Kazanov, M. D. & Radisky, E. S., Nov 21 2014, In : Journal of Biological Chemistry. 289, 47, p. 32783-32797 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma

Mehner, C., Miller, E., Khauv, D., Nassar, A., Oberg, A. L., Bamlet, W. R., Zhang, L., Waldmann, J., Radisky, E. S., Crawford, H. C. & Radisky, D. C., Oct 1 2014, In : Molecular Cancer Research. 12, 10, p. 1430-1439 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

Mehner, C., Hockla, A., Miller, E., Ran, S., Radisky, D. C. & Radisky, E. S., 2014, In : Oncotarget. 5, 9, p. 2736-2749 14 p.

Research output: Contribution to journalArticle

Open Access
156 Scopus citations

Tyrosine sulfation of human trypsin steers S2′ subsite selectivity towards basic amino acids

Szabó, A., Salameh, M. A., Ludwig, M., Radisky, E. S. & Sahin-Tóth, M., Jul 10 2014, In : PloS one. 9, 7, e102063.

Research output: Contribution to journalArticle

5 Scopus citations

Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation

Szabó, A., Radisky, E. S. & Sahin-Tóth, M., Feb 21 2014, In : Journal of Biological Chemistry. 289, 8, p. 4753-4761 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Biochemical and structural insights into mesotrypsin: An unusual human trypsin

Salameh, M. A. & Radisky, E. S., Sep 23 2013, In : International Journal of Biochemistry and Molecular Biology. 4, 3, p. 129-139 11 p.

Research output: Contribution to journalReview article

14 Scopus citations

Human Trypsins

Chen, J. M., Radisky, E. S. & Férec, C., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 3. p. 2600-2609 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation

Batra, J., Szabó, A., Caulfield, T. R., Soares, A. S., Sahin-Tóth, M. & Radisky, E. S., Apr 5 2013, In : Journal of Biological Chemistry. 288, 14, p. 9848-9859 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes

Batra, J., Soares, A. S., Mehner, C. & Radisky, E. S., Sep 20 2013, In : PloS one. 8, 9, e75836.

Research output: Contribution to journalArticle

19 Scopus citations

PRSS3/mesotrypsin in prostate cancer progression: Implications for translational medicine

Radisky, E. S., Jul 1 2013, In : Asian Journal of Andrology. 15, 4, p. 439-440 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure

Chen, F., Radisky, E. S., Das, P., Batra, J., Hata, T., Hori, T., Baine, A. M. T., Gardner, L., Yue, M. Y., Bu, G., Del Zoppo, G., Patel, T. C. & Nguyen, J. H., Jul 1 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 7, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
2012
43 Scopus citations

Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential

Justilien, V., Regala, R. P., Tseng, I. C., Walsh, M. P., Batra, J., Radisky, E. S., Murray, N. R. & Fields, A. P., Apr 24 2012, In : PloS one. 7, 4, e35040.

Research output: Contribution to journalArticle

60 Scopus citations

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression

Stallings-Mann, M. L., Waldmann, J., Zhang, Y., Miller, E., Gauthier, M. L., Visscher, D. W., Downey, G. P., Radisky, E. S., Fields, A. P. & Radisky, D. C., Jul 11 2012, In : Science translational medicine. 4, 142, 142ra95.

Research output: Contribution to journalArticle

65 Scopus citations

MYC suppresses cancer metastasis by direct transcriptional silencing of α v and β 3 integrin subunits

Liu, H., Radisky, D. C., Yang, D., Xu, R., Radisky, E. S., Bissell, M. J. & Bishop, J. M., Jun 1 2012, In : Nature Cell Biology. 14, 6, p. 567-574 8 p.

Research output: Contribution to journalArticle

127 Scopus citations

PEGylation Extends Circulation Half-Life While Preserving In Vitro and In Vivo Activity of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1)

Batra, J., Robinson, J., Mehner, C., Hockla, A., Miller, E., Radisky, D. C. & Radisky, E. S., 2012, In : PloS one. 7, 11, e50028.

Research output: Contribution to journalArticle

26 Scopus citations

Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors

Salameh, M. A., Soares, A. S., Alloy, A. & Radisky, E. S., Aug 1 2012, In : Protein Science. 21, 8, p. 1103-1112 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

PRSS3/mesotrypsin is a therapeutic target for metastatic prostate cancer

Hockla, A., Miller, E., Salameh, M. A., Copland, J. A., Radisky, D. C. & Radisky, E. S., Dec 1 2012, In : Molecular Cancer Research. 10, 12, p. 1555-1566 12 p.

Research output: Contribution to journalArticle

29 Scopus citations
2011

High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4′ acidic residues

Szabó, A., Héja, D., Szakács, D., Zboray, K., Kékesi, K. A., Radisky, E. S., Sahin-Tóth, M. & Pál, G., Jun 24 2011, In : Journal of Biological Chemistry. 286, 25, p. 22535-22545 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Identifying the Stroma as a Critical Player in Radiation-Induced Mammary Tumor Development

Cichon, M. A., Radisky, E. S. & Radisky, D. C., May 17 2011, In : Cancer cell. 19, 5, p. 571-572 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations

The P 2′ residue is a key determinant of mesotrypsin specificity: Engineering a high-affinity inhibitor with anticancer activity

Salameh, M. A., Soares, A. S., Hockla, A., Radisky, D. C. & Radisky, E. S., Nov 15 2011, In : Biochemical Journal. 440, 1, p. 95-105 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
2010

Cathepsin D: Regulation in mammary gland remodeling, misregulation in breast cancer

Radisky, E. S., Sep 1 2010, In : Cancer Biology and Therapy. 10, 5, p. 467-470 4 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin

Salameh, M. A., Soares, A. S., Navaneetham, D., Sinha, D., Walsh, P. N. & Radisky, E. S., Nov 19 2010, In : Journal of Biological Chemistry. 285, 47, p. 36884-36896 13 p.

Research output: Contribution to journalArticle

33 Scopus citations
297 Scopus citations

Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109

Hockla, A., Radisky, D. C. & Radisky, E. S., Nov 1 2010, In : Breast Cancer Research and Treatment. 124, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin

Orlichenko, L., Geyer, R., Yanagisawa, M., Khauv, D., Radisky, E. S., Anastasiadis, P. Z. & Radisky, D. C., Jun 18 2010, In : Journal of Biological Chemistry. 285, 25, p. 19153-19161 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin

Salameh, M. A., Robinson, J. L., Navaneetham, D., Sinha, D., Madden, B. J., Walsh, P. N. & Radisky, E. S., Jan 15 2010, In : Journal of Biological Chemistry. 285, 3, p. 1939-1949 11 p.

Research output: Contribution to journalArticle

27 Scopus citations