• 2189 Citations
  • 26 Scopus h-Index
1990 …2019

Research output per year

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Research Output

  • 2189 Citations
  • 26 Scopus h-Index
  • 59 Article
  • 1 Chapter
  • 1 Review article
2019

Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition

Raeeszadeh-Sarmazdeh, M., Greene, K. A., Sankaran, B., Downey, G. P., Radisky, D. C. & Radisky, E. S., Jan 1 2019, In : Journal of Biological Chemistry. 294, 24, p. 9476-9488 13 p.

Research output: Contribution to journalArticle

Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin

Cohen, I., Coban, M., Shahar, A., Sankaran, B., Hockla, A., Lacham, S., Caulfield, T., Radisky, E. S. & Papo, N., Jan 1 2019, In : Journal of Biological Chemistry. 294, 13, p. 5105-5120 16 p.

Research output: Contribution to journalArticle

3 Scopus citations

Novel pathogenic PRSS1 variant p.Glu190Lys in a case of chronic pancreatitis

Jancsó, Z., Oracz, G., Kujko, A. A., Kolodziejczyk, E., Radisky, E. S., Rygiel, A. M. & Sahin-Tóth, M., Jan 1 2019, In : Frontiers in Genetics. 10, FEB, 46.

Research output: Contribution to journalArticle

Open Access

PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma

Ma, H., Hockla, A., Mehner, C., Coban, M., Papo, N., Radisky, D. C. & Radisky, E. S., Dec 1 2019, In : Scientific reports. 9, 1, 1844.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering

Sananes, A., Cohen, I., Shahar, A., Hockla, A., De Vita, E., Miller, A. K., Radisky, E. S. & Papo, N., Jan 1 2018, In : Journal of Biological Chemistry. 293, 33, p. 12663-12680 18 p.

Research output: Contribution to journalArticle

3 Scopus citations

Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell

Arkadash, V., Radisky, E. S. & Papo, N., Aug 10 2018, In : Oncotarget. 9, 62, p. 32036-32053 18 p.

Research output: Contribution to journalArticle

2 Scopus citations
5 Scopus citations

Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases

Cohen, I., Naftaly, S., Ben-Zeev, E., Hockla, A., Radisky, E. S. & Papo, N., Apr 16 2018, In : Biochemical Journal. 475, 7, p. 1335-1352 18 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017
22 Scopus citations

Small molecule inhibitors of mesotrypsin from a structurebased docking screen

Kayode, O., Huang, Z., Soares, A. S., Caulfield, T., Dong, Z., Bode, A. M. & Radisky, E. S., May 1 2017, In : PLoS One. 12, 5, e0176694.

Research output: Contribution to journalArticle

2 Scopus citations

Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer

Radisky, E. S., Raeeszadeh-Sarmazdeh, M. & Radisky, D. C., 2017, (Accepted/In press) In : Journal of Cellular Biochemistry.

Research output: Contribution to journalArticle

27 Scopus citations
2016

An acrobatic substrate metamorphosis reveals a requirement for substrate conformational dynamics in trypsin proteolysis

Kayode, O., Wang, R., Pendlebury, D. F., Cohen, I., Henin, R. D., Hockla, A., Soares, A. S., Papo, N., Caulfield, T. & Radisky, E. S., Dec 16 2016, In : Journal of Biological Chemistry. 291, 51, p. 26304-26319 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy

Cohen, I., Kayode, O., Hockla, A., Sankaran, B., Radisky, D. C., Radisky, E. S. & Papo, N., May 15 2016, In : Biochemical Journal. 473, 10, p. 1329-1341 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

MYC is a crucial mediator of TGFβ-induced invasion in basal breast cancer

Cichon, M. A., Moruzzi, M. E., Shqau, T. A., Miller, E., Mehner, C., Ethier, S. P., Copland, J. A. III., Radisky, E. S. & Radisky, D. C., Jun 15 2016, In : Cancer Research. 76, 12, p. 3520-3530 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Matrix metalloproteinases as breast cancer drivers and therapeutic targets

Radisky, E. S. & Radisky, D. C., Jun 1 2015, In : Frontiers in Bioscience - Landmark. 20, 7, p. 1144-1163 20 p.

Research output: Contribution to journalArticle

45 Scopus citations
2014
17 Scopus citations

Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma

Mehner, C., Miller, E., Khauv, D., Nassar, A., Oberg, A. L., Bamlet, W. R., Zhang, L., Waldmann, J., Radisky, E. S., Crawford, H. C. & Radisky, D. C., Oct 1 2014, In : Molecular Cancer Research. 12, 10, p. 1430-1439 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

Mehner, C., Hockla, A., Miller, E., Ran, S., Radisky, D. C. & Radisky, E. S., 2014, In : Oncotarget. 5, 9, p. 2736-2749 14 p.

Research output: Contribution to journalArticle

142 Scopus citations
2013

Biochemical and structural insights into mesotrypsin: An unusual human trypsin

Salameh, M. A. & Radisky, E. S., 2013, In : International Journal of Biochemistry and Molecular Biology. 4, 3, p. 129-139 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation

Batra, J., Szabó, A., Caulfield, T., Soares, A. S., Sahin-Tóth, M. & Radisky, E. S., Apr 5 2013, In : Journal of Biological Chemistry. 288, 14, p. 9848-9859 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
17 Scopus citations

TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure

Chen, F., Radisky, E. S., Das, P., Batra, J., Hata, T., Hori, T., Baine, A. M. T., Gardner, L., Yue, M. Y., Bu, G. D., Del Zoppo, G., Patel, T. C. & Nguyen, J. H., Jul 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 7, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

25 Scopus citations
2012
41 Scopus citations

Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential

Justilien, V., Regala, R. P., Tseng, I. C., Walsh, M. P., Batra, J., Radisky, E. S., Murray, N. R. & Fields, A. P., Apr 24 2012, In : PLoS One. 7, 4, e35040.

Research output: Contribution to journalArticle

57 Scopus citations

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression

Stallings-Mann, M. L., Waldmann, J., Zhang, Y., Miller, E., Gauthier, M. L., Visscher, D. W., Downey, G. P., Radisky, E. S., Fields, A. P. & Radisky, D. C., Jul 11 2012, In : Science Translational Medicine. 4, 142, 142ra95.

Research output: Contribution to journalArticle

64 Scopus citations

MYC suppresses cancer metastasis by direct transcriptional silencing of α v and β 3 integrin subunits

Liu, H., Radisky, D. C., Yang, D., Xu, R., Radisky, E. S., Bissell, M. J. & Bishop, J. M., Jun 2012, In : Nature Cell Biology. 14, 6, p. 567-574 8 p.

Research output: Contribution to journalArticle

121 Scopus citations
25 Scopus citations

PRSS3/mesotrypsin is a therapeutic target for metastatic prostate cancer

Hockla, A., Miller, E., Salameh, M. A., Copland, J. A. III., Radisky, D. C. & Radisky, E. S., Dec 2012, In : Molecular Cancer Research. 10, 12, p. 1555-1566 12 p.

Research output: Contribution to journalArticle

28 Scopus citations
2011
22 Scopus citations

The P 2′ residue is a key determinant of mesotrypsin specificity: Engineering a high-affinity inhibitor with anticancer activity

Salameh, M. A., Soares, A. S., Hockla, A., Radisky, D. C. & Radisky, E. S., Nov 15 2011, In : Biochemical Journal. 440, 1, p. 95-105 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
2010

Cathepsin D: Regulation in mammary gland remodeling, misregulation in breast cancer

Radisky, E. S., Sep 1 2010, In : Cancer Biology and Therapy. 10, 5, p. 467-470 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin

Salameh, M. A., Soares, A. S., Navaneetham, D., Sinha, D., Walsh, P. N. & Radisky, E. S., Nov 19 2010, In : Journal of Biological Chemistry. 285, 47, p. 36884-36896 13 p.

Research output: Contribution to journalArticle

33 Scopus citations
285 Scopus citations

Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109

Hockla, A., Radisky, D. C. & Radisky, E. S., Nov 2010, In : Breast Cancer Research and Treatment. 124, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin

Salameh, M. A., Robinson, J. L., Navaneetham, D., Sinha, D., Madden, B. J., Walsh, P. N. & Radisky, E. S., Jan 15 2010, In : Journal of Biological Chemistry. 285, 3, p. 1939-1949 11 p.

Research output: Contribution to journalArticle

27 Scopus citations
2009

Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function inmammary epithelial morphogenesis

Chen, C. S., Nelson, C. M., Khauv, D., Bennett, S., Radisky, E. S., Hirai, Y., Bissell, M. J. & Radisky, D. C., Mar 13 2009, In : Journal of Biological Chemistry. 284, 11, p. 6877-6884 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
2008

Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin

Salameh, M. A., Soares, A. S., Hockla, A. & Radisky, E. S., Feb 15 2008, In : Journal of Biological Chemistry. 283, 7, p. 4115-4123 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2007
99 Scopus citations
2006

Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates

Radisky, E. S., Lee, J. M., Lu, C. J. K. & Koshland, D. E., May 2 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 18, p. 6835-6840 6 p.

Research output: Contribution to journalArticle

86 Scopus citations