Eugenia D Trushina, PhD

  • 1799 Citations
  • 18 Scopus h-Index
20032019
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Research Output 2003 2019

  • 1799 Citations
  • 18 Scopus h-Index
  • 25 Article
  • 3 Chapter
  • 3 Review article
  • 1 Comment/debate
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Article
2019
2 Citations (Scopus)

A comprehensive protocol for multiplatform metabolomics analysis in patient-derived skin fibroblasts

Wilkins, J., Sakrikar, D., Petterson, X. M., Lanza, I. R. & Trushina, E. D., Jun 1 2019, In : Metabolomics. 15, 6, 83.

Research output: Contribution to journalArticle

Metabolomics
Fibroblasts
Metabolites
Skin
Mass Spectrometry
Open Access
Alzheimer Disease
Brain
Precision Medicine
Systems Biology
Cerebrospinal Fluid
2018
6 Citations (Scopus)

Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane

Zhang, L., Trushin, S., Christensen, T. A., Tripathi, U., Hong, C., Geroux, R. E., Howell, K. G., Poduslo, J. F. & Trushina, E. D., Jun 1 2018, In : Neurobiology of Disease. 114, p. 1-16 16 p.

Research output: Contribution to journalArticle

Amyloid beta-Peptides
Cell Membrane
Peptides
Alzheimer Disease
Mitochondrial Dynamics
2017
12 Citations (Scopus)

Cisplatin induces mitochondrial deficits in Drosophila larval segmental nerve

Podratz, J. L., Lee, H., Knorr, P., Koehler, S., Forsythe, S., Lambrecht, K., Arias, S., Schmidt, K., Steinhoff, G., Yudintsev, G., Yang, A., Trushina, E. D. & Windebank, A. J., Jan 1 2017, In : Neurobiology of Disease. 97, p. 60-69 10 p.

Research output: Contribution to journalArticle

Cisplatin
Drosophila
Larva
Mitochondrial DNA
Mitochondrial Dynamics
2016
37 Citations (Scopus)

A hippo and fibroblast growth factor receptor autocrine pathway in cholangiocarcinoma

Rizvi, S., Yamada, D., Hirsova, P., Bronk, S. F., Werneburg, N. W., Krishnan, A., Salim, W., Zhang, L., Trushina, E. D., Truty, M. & Gores, G. J., Apr 8 2016, In : Journal of Biological Chemistry. 291, 15, p. 8031-8047 17 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Cholangiocarcinoma
Proteins
Nuclear Proteins
Cells
47 Citations (Scopus)

Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease

Zhang, L., Trushin, S., Christensen, T. A., Bachmeier, B. V., Gateno, B., Schroeder, A., Yao, J., Itoh, K., Sesaki, H., Poon, W. W., Gylys, K. H., Patterson, E. R., Parisi, J. E., Diaz Brinton, R., Salisbury, J. L. & Trushina, E. D., Jan 5 2016, In : Scientific Reports. 6, 18725.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Alzheimer Disease
Mitochondria
Brain
Organelles
21 Citations (Scopus)

Alzheimer disease research in the 21st century: Past and current failures, new perspectives and funding priorities

Pistollato, F., Ohayon, E. L., Lam, A., Langley, G. R., Novak, T. J., Pamies, D., Perry, G., Trushina, E. D., Williams, R. S. B., Roher, A. E., Hartung, T., Harnad, S., Barnard, N., Morris, M. C., Lai, M. C., Merkley, R. & Charukeshi Chandrasekera, P., 2016, In : Oncotarget. 7, 26, p. 38999-39016 18 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Research
Ethics
Life Style
Epidemiologic Studies
2015
22 Citations (Scopus)

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Zhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P., Pinto, M., Jin, L. W., Prasain, K., Nguyen, T. D. T., Yamazaki, Y., Kanekiyo, T., Bu, G. D., Gateno, B., Chang, K. O., Nath, K. A., Nemutlu, E., Dzeja, P. P., Pang, Y-P., Hua, D. H. & Trushina, E. D., Apr 1 2015, In : EBioMedicine. 2, 4, p. 294-305 12 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Animals
Animal Models
Modulation
Glycogen Synthase Kinase 3
70 Citations (Scopus)

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

Yue, M., Hinkle, K. M., Davies, P., Trushina, E. D., Fiesel, F., Christenson, T. A., Schroeder, A. S., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S. J., Beevers, J. E., Milnerwood, A. J., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D. W., Farrer, M. J. & Melrose, H. L., Jun 1 2015, In : Neurobiology of Disease. 78, p. 172-195 24 p.

Research output: Contribution to journalArticle

Mutation
Dopamine
Phosphotransferases
Mitochondrial Dynamics
Microdialysis
31 Citations (Scopus)

White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease

Klosinski, L. P., Yao, J., Yin, F., Fonteh, A. N., Harrington, M. G., Christensen, T. A., Trushina, E. D. & Brinton, R. D., Dec 1 2015, In : EBioMedicine. 2, 12, p. 1888-1904 17 p.

Research output: Contribution to journalArticle

Ketone Bodies
Brain
Alzheimer Disease
Aging of materials
Lipids
2014
77 Citations (Scopus)

Developing novel blood-based biomarkers for Alzheimer's disease

Snyder, H. M., Carrillo, M. C., Grodstein, F., Henriksen, K., Jeromin, A., Lovestone, S., Mielke, M. M., O'Bryant, S., Sarasa, M., Sjøgren, M., Soares, H., Teeling, J., Trushina, E. D., Ward, M., West, T., Bain, L. J., Shineman, D. W., Weiner, M. & Fillit, H. M., Jan 2014, In : Alzheimer's and Dementia. 10, 1, p. 109-114 6 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Biomarkers
Drug Discovery
Research
Disease Progression
13 Citations (Scopus)

Loss of caveolin-1 expression in knock-in mouse model of huntington's disease suppresses pathophysiology in vivo

Trushina, E. D., Canaria, C. A., Lee, D. Y. & McMurray, C. T., Jan 2014, In : Human Molecular Genetics. 23, 1, p. 129-144 16 p., ddt406.

Research output: Contribution to journalArticle

Caveolin 1
Huntington Disease
Mutant Proteins
Cholesterol
Neurons
84 Citations (Scopus)
Metabolomics
Alzheimer Disease
Mitochondrial Diseases
Neurobehavioral Manifestations
Aptitude
2013
45 Citations (Scopus)

Bortezomib alters microtubule polymerization and axonal transport in rat dorsal root ganglion neurons

Staff, N. P., Podratz, J. L., Grassner, L., Bader, M., Paz, J., Knight, A. M., Loprinzi, C. L., Trushina, E. D. & Windebank, A. J., Dec 2013, In : NeuroToxicology. 39, p. 124-131 8 p.

Research output: Contribution to journalArticle

Axonal Transport
Spinal Ganglia
Microtubules
Polymerization
Neurons

From metabolic pathways to biomarkers: Where are we now with metabolomics in Alzheimers disease

Trushina, E. D., Sep 2013, In : Future Neurology. 8, 5, p. 491-494 4 p.

Research output: Contribution to journalArticle

Metabolomics
Metabolic Networks and Pathways
Cerebrospinal Fluid
Alzheimer Disease
Biomarkers
182 Citations (Scopus)
Cerebrospinal fluid
Metabolomics
metabolomics
cerebrospinal fluid
Alzheimer disease
2012
5 Citations (Scopus)

Comprehensive method for culturing embryonic dorsal root ganglion neurons for Seahorse Extracellular Flux XF24 analysis

Lange, M., Zeng, Y., Knight, A., Windebank, A. J. & Trushina, E. D., 2012, In : Frontiers in Neurology. 3 DEC, Article 175.

Research output: Contribution to journalArticle

Smegmamorpha
Spinal Ganglia
Neurons
Mitochondrial Dynamics
Peripheral Nervous System Diseases
143 Citations (Scopus)

Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial alzheimer's disease

Trushina, E. D., Nemutlu, E., Zhang, S., Christensen, T., Camp, J., Mesa, J., Siddiqui, A., Tamura, Y., Sesaki, H., Wengenack, T. M., Dzeja, P. P. & Poduslo, J. F., Feb 29 2012, In : PLoS One. 7, 2, e32737.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Metabolomics
metabolomics
Alzheimer disease
Alzheimer Disease
2009
8 Citations (Scopus)
Pyrones
Corpus Striatum
Mutant Proteins
Huntington Disease
Phenotype
2007
280 Citations (Scopus)

Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases

Trushina, E. D. & McMurray, C. T., Apr 14 2007, In : Neuroscience. 145, 4, p. 1233-1248 16 p.

Research output: Contribution to journalArticle

Huntington Disease
Neurodegenerative Diseases
Oxidative Stress
Friedreich Ataxia
Xeroderma Pigmentosum
2006
72 Citations (Scopus)

Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo

Trushina, E. D., Singh, R. D., Dyer, R. B., Cao, S., Shah, V., Parton, R. G., Pagano, R. E. & McMurray, C. T., Dec 15 2006, In : Human Molecular Genetics. 15, 24, p. 3578-3591 14 p.

Research output: Contribution to journalArticle

Clathrin
Caveolin 1
Endocytosis
Cholesterol
Neurons
56 Citations (Scopus)

Neurological abnormalities in caveolin-1 knock out mice

Trushina, E. D., Du Charme, J., Parisi, J. E. & McMurray, C. T., Sep 15 2006, In : Behavioural Brain Research. 172, 1, p. 24-32 9 p.

Research output: Contribution to journalArticle

Caveolin 1
Knockout Mice
Phenotype
Muscle Weakness
Brain
2004
359 Citations (Scopus)

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

Trushina, E. D., Dyer, R. B., Badger, J. D., Ure, D., Eide, L., Tran, D. D., Vrieze, B. T., Legendre-Guillemin, V., McPherson, P. S., Mandavilli, B. S., Van Houten, B., Zeitlin, S., Mc Niven, M. A., Aebersold, R., Hayden, M., Parisi, J. E., Seeberg, E., Dragatsis, I., Doyle, K., Bender, A. & 2 others, Chacko, C. & McMurray, C. T., Sep 2004, In : Molecular and Cellular Biology. 24, 18, p. 8195-8209 15 p.

Research output: Contribution to journalArticle

Neurons
Genetically Modified Animals
Huntington Disease
Invertebrates
Mammals
2003
67 Citations (Scopus)

Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease

Trushina, E. D., Heldebrant, M. P., Terzic, C. M., Bortolon, R., Kovtun, I. V., Badger, J. D., Terzic, A., Estévez, A., Windebank, A. J., Dyer, R. B., Yao, J. & McMurray, C. T., Oct 14 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 21, p. 12171-12176 6 p.

Research output: Contribution to journalArticle

Poisons
Huntington Disease
Microtubules
Proteolysis
Time-Lapse Imaging