• 2431 Citations
  • 22 Scopus h-Index
20062019
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Research Output 2006 2019

  • 2431 Citations
  • 22 Scopus h-Index
  • 50 Article
  • 2 Review article
  • 1 Chapter
2019
1 Citation (Scopus)

A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of 165,000 high-risk patients

LaDuca, H., Polley, E., Yussuf, A., Hoang, L., Gutierrez, S., Hart, S., Yadav, S., Hu, C., Na, J., Goldgar, D. E., Fulk, K., Smith, L. P., Horton, C., Profato, J., Pesaran, T., Gau, C. L., Pronold, M., Davis, B. T., Chao, E. C., Couch, F. J. & 1 others, Dolinsky, J. S., Jan 1 2019, (Accepted/In press) In : Genetics in Medicine.

Research output: Contribution to journalArticle

Open Access
Neoplasm Genes
Genetic Testing
Hereditary Nonpolyposis Colorectal Neoplasms
Neoplasms
Melanoma

Decreasing treatment of asymptomatic bacteriuria: An interprofessional approach to antibiotic stewardship

Narayanan, P., Knoph, K., Chen, N. X., McCoy, C. P., Devalapalli, A. P., Schoonover, K., Schuetz, A. N., Estes, L., Polley, E., Kashiwagi, D. & Virk, A., Jan 1 2019, In : Journal of Clinical Outcomes Management. 26, 4, p. 169-174 6 p.

Research output: Contribution to journalArticle

Bacteriuria
Anti-Bacterial Agents
Internal Medicine
Urine
Medical Order Entry Systems
1 Citation (Scopus)

Gene expression differences between matched pairs of ovarian cancer patient tumors and patient-derived xenografts

Liu, Y., Chanana, P., Davila, J. I., Hou, X., Zanfagnin, V., McGehee, C. D., Goode, E. L., Polley, E., Haluska, P., Weroha, S. J. & Wang, C., Dec 1 2019, In : Scientific reports. 9, 1, 6314.

Research output: Contribution to journalArticle

Open Access
Heterografts
Ovarian Neoplasms
Gene Expression
Neoplasms
Tissue Donors

HIV elite control is associated with reduced TRAILshort expression

Paim, A. C., Cummins, N. W., Natesampillai, S., Garcia-Rivera, E., Kogan, N., Neogi, U., Sönnerborg, A., Sperk, M., Bren, G. D., Deeks, S., Polley, E. & Badley, A. D., Sep 1 2019, In : AIDS. 33, 11, p. 1757-1763 7 p.

Research output: Contribution to journalArticle

HIV-1
HIV
Blood Cells
Cell Death
HIV Infections
1 Citation (Scopus)

Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

Vachon, C. M., Scott, C. G., Tamimi, R. M., Thompson, D. J., Fasching, P. A., Stone, J., Southey, M. C., Winham, S. J., Lindström, S., Lilyquist, J., Giles, G. G., Milne, R. L., MacInnis, R. J., Baglietto, L., Li, J., Czene, K., Bolla, M. K., Wang, Q., Dennis, J., Haeberle, L. & 16 others, Eriksson, M., Kraft, P., Luben, R., Wareham, N., Olson, J. E., Norman, A., Polley, E., Maskarinec, G., Le Marchand, L., Haiman, C. A., Hopper, J. L., Couch, F. J., Easton, D. F., Hall, P., Chatterjee, N. & Garcia-Closas, M., May 22 2019, In : Breast Cancer Research. 21, 1, 68.

Research output: Contribution to journalArticle

Open Access
Body Mass Index
Breast Neoplasms
Odds Ratio
Single Nucleotide Polymorphism
Breast Density
40 Citations (Scopus)

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

NBCS Collaborators, ABCTB Investigators & kConFab/AOCS Investigators, Jan 3 2019, In : American Journal of Human Genetics. 104, 1, p. 21-34 14 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Estrogen Receptors
Prospective Studies
Single Nucleotide Polymorphism
Genome
1 Citation (Scopus)

Risk of Different Cancers Among First-degree Relatives of Pancreatic Cancer Patients: Influence of Probands' Susceptibility Gene Mutation Status

Antwi, S., Fagan, S. E., Chaffee, K. G., Bamlet, W. R., Hu, C., Polley, E., Hart, S., Shimelis, H., Lilyquist, J., Gnanaolivu, R. D., Mc Williams, R. R., Oberg, A. L., Couch, F. J. & Petersen, G. M., Mar 1 2019, In : Journal of the National Cancer Institute. 111, 3, p. 264-271 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Mutation
Genes
Confidence Intervals
Neoplasms
Radiotherapy
Breast Neoplasms
Survival
Hormones
Therapeutics
2018
51 Citations (Scopus)

Association between inherited germline mutations in cancer predisposition genes and risk of pancreatic cancer

Hu, C., Hart, S., Polley, E., Gnanaolivu, R., Shimelis, H., Lee, K. Y., Lilyquist, J., Na, J., Moore, R., Antwi, S., Bamlet, W. R., Chaffee, K. G., DiCarlo, J., Wu, Z., Samara, R., Kasi, P. M., Mc Williams, R. R., Petersen, G. M. & Couch, F. J., Jun 19 2018, In : JAMA - Journal of the American Medical Association. 319, 23, p. 2401-2409 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Neoplasm Genes
Pancreatic Neoplasms
Odds Ratio
Exome
3 Citations (Scopus)

Cancer susceptibility gene mutations in type I and II endometrial cancer

Long, B., Lilyquist, J., Weaver, A., Hu, C., Gnanaolivu, R., Lee, K. Y., Hart, S., Polley, E., Bakkum-Gamez, J. N., Couch, F. J. & Dowdy, S. C., Jan 1 2018, (Accepted/In press) In : Gynecologic Oncology.

Research output: Contribution to journalArticle

Neoplasm Genes
Endometrial Neoplasms
Mutation
Uterine Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms
2 Citations (Scopus)

Characterizing Potentially Preventable Admissions: A Mixed Methods Study of Rates, Associated Factors, Outcomes, and Physician Decision-Making

Daniels, L. M., Sorita, A., Kashiwagi, D. T., Okubo, M., Small, E., Polley, E. & Sawatsky, A. P., Jan 16 2018, (Accepted/In press) In : Journal of General Internal Medicine. p. 1-8 8 p.

Research output: Contribution to journalArticle

Decision Making
Physicians
Emergency Medicine
Medicine
Outpatients
4 Citations (Scopus)

Comprehensive annotation of BRCA1 and BRCA2 missense variants by functionally validated sequence-based computational prediction models

Hart, S., Hoskin, T., Shimelis, H., Moore, R. M., Feng, B., Thomas, A., Lindor, N. M., Polley, E., Goldgar, D. E., Iversen, E., Monteiro, A. N. A., Suman, V. J. & Couch, F. J., Jun 8 2018, (Accepted/In press) In : Genetics in Medicine. p. 1-10 10 p.

Research output: Contribution to journalArticle

Politics
Computer Simulation
Area Under Curve
BRCA2 Protein
Confidence Intervals
21 Citations (Scopus)

Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis

Glatz, M., Jo, J. H., Kennedy, E. A., Polley, E., Segre, J. A., Simpson, E. L. & Kong, H. H., Feb 1 2018, In : PLoS One. 13, 2, e0192443.

Research output: Contribution to journalArticle

Emollients
atopic dermatitis
Streptococcus salivarius
Atopic Dermatitis
Skin
2 Citations (Scopus)

HIV protease-generated Casp8p41, when bound and inactivated by Bcl2, is degraded by the proteasome

Natesampillai, S., Cummins, N. W., Nie, Z., Sampath, R., Baker, J. V., Henry, K., Pinzone, M., O'Doherty, U., Polley, E., Bren, G. D., Katzmann, D. J. & Badley, A. D., Jul 1 2018, In : Journal of Virology. 92, 13, e00037-18.

Research output: Contribution to journalArticle

HIV Protease
proteasome endopeptidase complex
Proteasome Endopeptidase Complex
cell death
Cell Death
8 Citations (Scopus)

Interaction between the microbiome and TP53 in human lung cancer

Greathouse, K. L., White, J. R., Vargas, A. J., Bliskovsky, V. V., Beck, J. A., von Muhlinen, N., Polley, E., Bowman, E. D., Khan, M. A., Robles, A. I., Cooks, T., Ryan, B. M., Padgett, N., Dzutsev, A. H., Trinchieri, G., Pineda, M. A., Bilke, S., Meltzer, P. S., Hokenstad, A. N., Stickrod, T. M. & 13 others, Walther-Antonio, M., Earl, J. P., Mell, J. C., Krol, J. E., Balashov, S. V., Bhat, A. S., Ehrlich, G. D., Valm, A., Deming, C., Conlan, S., Oh, J., Segre, J. A. & Harris, C. C., Aug 24 2018, In : Genome Biology. 19, 1, 123.

Research output: Contribution to journalArticle

Microbiota
lung neoplasms
cancer
Lung Neoplasms
neoplasms
5 Citations (Scopus)

The NCI transcriptional pharmacodynamics workbench: A tool to examine dynamic expression profiling of therapeutic response in the NCI-60 cell line panel

Monks, A., Zhao, Y., Hose, C., Hamed, H., Krushkal, J., Fang, J., Sonkin, D., Palmisano, A., Polley, E., Fogli, L. K., Konate, M. M., Miller, S. B., Simpson, M. A., Voth, A. R., Li, M. C., Harris, E., Wu, X., Connelly, J. W., Rapisarda, A., Teicher, B. A. & 2 others, Simon, R. & Doroshow, J. H., Dec 15 2018, In : Cancer Research. 78, 24, p. 6807-6817 11 p.

Research output: Contribution to journalArticle

Cell Line
Pharmaceutical Preparations
Gene Expression
Antineoplastic Agents
Neoplasms
37 Citations (Scopus)

Triple-negative breast cancer risk genes identified by multigene hereditary cancer panel testing

Shimelis, H., LaDuca, H., Hu, C., Hart, S., Na, J., Thomas, A., Akinhanmi, M., Moore, R. M., Brauch, H., Cox, A., Eccles, D. M., Ewart-Toland, A., Fasching, P. A., Fostira, F., Garber, J., Godwin, A. K., Konstantopoulou, I., Nevanlinna, H., Sharma, P., Yannoukakos, D. & 9 others, Yao, S., Feng, B. J., Davis, B. T., Lilyquist, J., Pesaran, T., Goldgar, D. E., Polley, E., Dolinsky, J. S. & Couch, F. J., Jan 1 2018, In : Journal of the National Cancer Institute. 110, 8, p. 855-862 8 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Neoplasm Genes
Odds Ratio
Neoplasms
Breast Neoplasms
2017
35 Citations (Scopus)

Analytical Validation of the Next-Generation Sequencing Assay for a Nationwide Signal-Finding Clinical Trial: Molecular Analysis for Therapy Choice Clinical Trial

Lih, C. J., Harrington, R. D., Sims, D. J., Harper, K. N., Bouk, C. H., Datta, V., Yau, J., Singh, R. R., Routbort, M. J., Luthra, R., Patel, K. P., Mantha, G. S., Krishnamurthy, S., Ronski, K., Walther, Z., Finberg, K. E., Canosa, S., Robinson, H., Raymond, A., Le, L. P. & 8 others, McShane, L. M., Polley, E., Conley, B. A., Doroshow, J. H., Iafrate, A. J., Sklar, J. L., Hamilton, S. R. & Williams, P. M., Mar 1 2017, In : Journal of Molecular Diagnostics. 19, 2, p. 313-327 15 p.

Research output: Contribution to journalArticle

Clinical Trials
Precision Medicine
Neoplasms
Gene Amplification
Therapeutics
4 Citations (Scopus)

Association of γH2AX at diagnosis with chemotherapy outcome in patients with breast cancer

Yang, S. X., Polley, E. & Nguyen, D., Jan 1 2017, In : Theranostics. 7, 4, p. 945-951 7 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Drug Therapy
Survival
Neoplasms
Confidence Intervals
138 Citations (Scopus)

Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer

Couch, F. J., Shimelis, H., Hu, C., Hart, S., Polley, E., Na, J., Hallberg, E., Moore, R., Thomas, A., Lilyquist, J., Feng, B., McFarland, R., Pesaran, T., Huether, R., LaDuca, H., Chao, E. C., Goldgar, D. E. & Dolinsky, J. S., Sep 1 2017, In : JAMA oncology. 3, 9, p. 1190-1196 7 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Genes
Genes
Neoplasms
Genetic Testing
34 Citations (Scopus)

Clinical activity of the γ-secretase inhibitor PF-03084014 in adults with desmoid tumors (aggressive fibromatosis)

Kummar, S., Coyne, G. O. S., Do, K. T., Turkbey, B., Meltzer, P. S., Polley, E., Choyke, P. L., Meehan, R., Vilimas, R., Horneffer, Y., Juwara, L., Lih, A., Choudhary, A., Mitchell, S. A., Helman, L. J., Doroshow, J. H. & Chen, A. P., May 10 2017, In : Journal of Clinical Oncology. 35, 14, p. 1561-1569 9 p.

Research output: Contribution to journalArticle

Aggressive Fibromatosis
Amyloid Precursor Protein Secretases
Neoplasms
Connective Tissue Cells
Germ-Line Mutation
24 Citations (Scopus)

Frequency of mutations in a large series of clinically ascertained ovarian cancer cases tested on multi-gene panels compared to reference controls

Lilyquist, J., LaDuca, H., Polley, E., Davis, B. T., Shimelis, H., Hu, C., Hart, S., Dolinsky, J. S., Couch, F. J. & Goldgar, D. E., Nov 1 2017, In : Gynecologic Oncology. 147, 2, p. 375-380 6 p.

Research output: Contribution to journalArticle

Mutation Rate
Ovarian Neoplasms
Genes
Exome
Neoplasm Genes
7 Citations (Scopus)

Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells

Liu, H., Antony, S., Roy, K., Juhasz, A., Wu, Y., Lu, J., Meitzler, J. L., Jiang, G., Polley, E. & Doroshow, J. H., Jan 1 2017, In : Oncotarget. 8, 24, p. 38113-38135 23 p.

Research output: Contribution to journalArticle

Interleukin-13
Interleukin-4
Colonic Neoplasms
Type II Interleukin-4 Receptors
Reactive Oxygen Species
4 Citations (Scopus)

OpenGeneMed: a portable, flexible and customizable informatics hub for the coordination of next-generation sequencing studies in support of precision medicine trials

Palmisano, A., Zhao, Y., Li, M. C., Polley, E. & Simon, R. M., Sep 1 2017, In : Briefings in Bioinformatics. 18, 5, p. 723-734 12 p.

Research output: Contribution to journalArticle

Precision Medicine
Informatics
Medicine
Pipelines
Oncology
10 Citations (Scopus)

Societal challenges of precision medicine: Bringing order to chaos

the IBCD-Faculty, Oct 1 2017, In : European Journal of Cancer. 84, p. 325-334 10 p.

Research output: Contribution to journalArticle

Precision Medicine
Biomarkers
Biomedical Engineering
Belgium
Drug Delivery Systems
28 Citations (Scopus)

The National Cancer Institute ALMANAC: A comprehensive screening resource for the detection of anticancer drug pairs with enhanced therapeutic activity

Holbeck, S. L., Camalier, R., Crowell, J. A., Govindharajulu, J. P., Hollingshead, M., Anderson, L. W., Polley, E., Rubinstein, L., Srivastava, A., Wilsker, D., Collins, J. M. & Doroshow, J. H., Jul 1 2017, In : Cancer Research. 77, 13, p. 3564-3576 13 p.

Research output: Contribution to journalArticle

National Cancer Institute (U.S.)
Pharmaceutical Preparations
Neoplasms
Therapeutics
Clinical Trials, Phase I
2016
25 Citations (Scopus)

Analytical Validation and Application of a Targeted Next-Generation Sequencing Mutation-Detection Assay for Use in Treatment Assignment in the NCI-MPACT Trial

Lih, C. J., Sims, D. J., Harrington, R. D., Polley, E., Zhao, Y., Mehaffey, M. G., Forbes, T. D., Das, B., Walsh, W. D., Datta, V., Harper, K. N., Bouk, C. H., Rubinstein, L. V., Simon, R. M., Conley, B. A., Chen, A. P., Kummar, S., Doroshow, J. H. & Williams, P. M., Jan 1 2016, In : Journal of Molecular Diagnostics. 18, 1, p. 51-67 17 p.

Research output: Contribution to journalArticle

National Cancer Institute (U.S.)
Nucleotides
Mutation
Neoplasms
Therapeutics
21 Citations (Scopus)

Bromodomain and hedgehog pathway targets in small cell lung cancer

Kaur, G., Reinhart, R. A., Monks, A., Evans, D., Morris, J., Polley, E. & Teicher, B. A., Jan 1 2016, In : Cancer Letters. 371, 2, p. 225-239 15 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Topotecan
Etoposide
HhAntag691
Pharmaceutical Preparations
101 Citations (Scopus)

Comprehensive characterization of the Published Kinase Inhibitor Set

Elkins, J. M., Fedele, V., Szklarz, M., Abdul Azeez, K. R., Salah, E., Mikolajczyk, J., Romanov, S., Sepetov, N., Huang, X. P., Roth, B. L., Al Haj Zen, A., Fourches, D., Muratov, E., Tropsha, A., Morris, J., Teicher, B. A., Kunkel, M., Polley, E., Lackey, K. E., Atkinson, F. L. & 8 others, Overington, J. P., Bamborough, P., Müller, S., Price, D. J., Willson, T. M., Drewry, D. H., Knapp, S. & Zuercher, W. J., Jan 1 2016, In : Nature Biotechnology. 34, 1, p. 95-103 9 p.

Research output: Contribution to journalArticle

Assays
Phosphotransferases
Proteins
Adenosinetriphosphate
Cell proliferation
27 Citations (Scopus)

Diverse Human Skin Fungal Communities in Children Converge in Adulthood

NISC Comparative Sequencing Program, Dec 1 2016, In : Journal of Investigative Dermatology. 136, 12, p. 2356-2363 8 p.

Research output: Contribution to journalArticle

Skin
Malassezia
Fungi
Puberty
Tinea
86 Citations (Scopus)

New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer

Yang, S. X., Polley, E. & Lipkowitz, S., Apr 1 2016, In : Cancer Treatment Reviews. 45, p. 87-96 10 p.

Research output: Contribution to journalArticle

Critical Pathways
Phosphatidylinositol 3-Kinases
Breast Neoplasms
Precision Medicine
Mutation
17 Citations (Scopus)

Plasmid-Based Materials as Multiplex Quality Controls and Calibrators for Clinical Next-Generation Sequencing Assays

Sims, D. J., Harrington, R. D., Polley, E., Forbes, T. D., Mehaffey, M. G., McGregor, P. M., Camalier, C. E., Harper, K. N., Bouk, C. H., Das, B., Conley, B. A., Doroshow, J. H., Williams, P. M. & Lih, C. J., May 1 2016, In : Journal of Molecular Diagnostics. 18, 3, p. 336-349 14 p.

Research output: Contribution to journalArticle

Quality Control
Plasmids
Paraffin
Formaldehyde
HapMap Project
1 Citation (Scopus)

RefCNV: Identification of gene-based copy number variants using whole exome sequencing

Chang, L. C., Das, B., Lih, C. J., Si, H., Camalier, C. E., McGregor, P. M. & Polley, E., Apr 27 2016, In : Cancer Informatics. 15, p. 65-71 7 p.

Research output: Contribution to journalArticle

Exome
Gene Dosage
Exons
DNA Copy Number Variations
Genome
44 Citations (Scopus)

Small Cell Lung Cancer Screen of Oncology Drugs, Investigational Agents, and Gene and microRNA Expression

Polley, E., Kunkel, M., Evans, D., Silvers, T., Delosh, R., Laudeman, J., Ogle, C., Reinhart, R., Selby, M., Connelly, J., Harris, E., Fer, N., Sonkin, D., Kaur, G., Monks, A., Malik, S., Morris, J. & Teicher, B. A., Oct 1 2016, In : Journal of the National Cancer Institute. 108, 10, djw122.

Research output: Contribution to journalArticle

Investigational Drugs
Small Cell Lung Carcinoma
MicroRNAs
Gene Expression
Etoposide
1 Citation (Scopus)

Testing the Relative Performance of Data Adaptive Prediction Algorithms: A Generalized Test of Conditional Risk Differences

Goldstein, B. A., Polley, E., Briggs, F. B. S., Van Der Laan, M. J. & Hubbard, A., May 1 2016, In : International Journal of Biostatistics. 12, 1, p. 117-129 13 p.

Research output: Contribution to journalArticle

Risk Difference
Testing
Prediction
Cross-validation
Gene
2015
35 Citations (Scopus)

Application of molecular profiling in clinical trials for advanced metastatic cancers

Kummar, S., Williams, P. M., Lih, C. J., Polley, E., Chen, A. P., Rubinstein, L. V., Zhao, Y., Simon, R. M., Conley, B. A. & Doroshow, J. H., Jan 1 2015, In : Journal of the National Cancer Institute. 107, 4

Research output: Contribution to journalArticle

Clinical Trials
Precision Medicine
Neoplasms
Mutation
Messenger RNA
15 Citations (Scopus)

Genemed: An informatics hub for the coordination of next-generation sequencing studies that support precision oncology clinical trials

Zhao, Y., Polley, E., Li, M. C., Lih, C. J., Palmisano, A., Sims, D. J., Rubinstein, L. V., Conley, B. A., Chen, A. P., Williams, P. M., Kummar, S., Doroshow, J. H. & Simon, R. M., Mar 19 2015, In : Cancer Informatics. 14, p. 45-55 11 p.

Research output: Contribution to journalArticle

Informatics
Clinical Trials
Neoplasms
Mutation
Therapeutics
15 Citations (Scopus)

Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors

Do, K., Speranza, G., Chang, L. C., Polley, E., Bishop, R., Zhu, W., Trepel, J. B., Lee, S., Lee, M. J., Kinders, R. J., Phillips, L., Collins, J., Lyons, J., Jeong, W., Antony, R., Chen, A. P., Neckers, L., Doroshow, J. H. & Kummar, S., Aug 1 2015, In : Investigational New Drugs. 33, 4, p. 921-930 10 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Appointments and Schedules
Neoplasms
Pharmacokinetics
Biopsy
15 Citations (Scopus)

Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression

Teicher, B. A., Polley, E., Kunkel, M., Evans, D., Silvers, T., Delosh, R., Laudeman, J., Ogle, C., Reinhart, R., Selby, M., Connelly, J., Harris, E., Monks, A. & Morris, J., Nov 1 2015, In : Molecular Cancer Therapeutics. 14, 11, p. 2452-2462 11 p.

Research output: Contribution to journalArticle

Investigational Drugs
MicroRNAs
Sarcoma
Gene Expression
Cell Line
2014
1 Citation (Scopus)

Two-stage adaptive cutoff design for building and validating a prognostic biomarker signature

Polley, M-Y., Polley, E., Huang, E. P., Freidlin, B. & Simon, R., Jan 1 2014, In : Statistics in Medicine. 33, 29, p. 5097-5110 14 p.

Research output: Contribution to journalArticle

Two-stage Design
Adaptive Design
Biomarkers
Signature
Lymphoma, Large B-Cell, Diffuse
2013
121 Citations (Scopus)

Cediranib for metastatic alveolar soft part sarcoma

Kummar, S., Allen, D., Monks, A., Polley, E., Hose, C. D., Ivy, S. P., Turkbey, I. B., Lawrence, S., Kinders, R. J., Choyke, P., Simon, R., Steinberg, S. M., Doroshow, J. H. & Helman, L., Jun 20 2013, In : Journal of Clinical Oncology. 31, 18, p. 2296-2302 7 p.

Research output: Contribution to journalArticle

Alveolar Soft Part Sarcoma
Vascular Endothelial Growth Factor Receptor
Neoplasms
Biopsy
cediranib
15 Citations (Scopus)

Clinical trials for precision oncology using next-generation sequencing

Simon, R. & Polley, E., Jul 1 2013, In : Personalized Medicine. 10, 5, p. 485-495 11 p.

Research output: Contribution to journalReview article

Clinical Trials
Neoplasms
Medical Oncology
Genomics
Pharmaceutical Preparations
13 Citations (Scopus)

Exploring large weight deletion and the ability to balance confounders when using inverse probability of treatment weighting in the presence of rare treatment decisions

Kilpatrick, R. D., Gilbertson, D., Brookhart, M. A., Polley, E., Rothman, K. J. & Bradbury, B. D., Feb 1 2013, In : Pharmacoepidemiology and Drug Safety. 22, 2, p. 111-121 11 p.

Research output: Contribution to journalArticle

Weights and Measures
Epoetin Alfa
Therapeutics
Mortality
Hemoglobins
2 Citations (Scopus)

Free HIV Antiretroviral Therapy Enhances Adherence among Individuals on Stable Treatment: Implications for Potential Shortfalls in Free Antiretroviral Therapy

Byakika-Tusiime, J., Polley, E., Oyugi, J. H. & Bangsberg, D. R., Sep 5 2013, In : PLoS One. 8, 9, e70375.

Research output: Contribution to journalArticle

HIV
therapeutics
Structural Models
drug therapy
T-cells
170 Citations (Scopus)

The exomes of the NCI-60 panel: A genomic resource for cancer biology and systems pharmacology

Abaan, O. D., Polley, E., Davis, S. R., Zhu, Y. J., Bilke, S., Walker, R. L., Pineda, M., Gindin, Y., Jiang, Y., Reinhold, W. C., Holbeck, S. L., Simon, R. M., Doroshow, J. H., Pommier, Y. & Meltzer, P. S., Jul 15 2013, In : Cancer Research. 73, 14, p. 4372-4382 11 p.

Research output: Contribution to journalArticle

Exome
Systems Biology
Pharmacology
Cell Line
Research
2012
128 Citations (Scopus)

Shifts in human skin and nares microbiota of healthy children and adults

Oh, J., Conlan, S., Polley, E., Segre, J. A. & Kong, H. H., Oct 10 2012, In : Genome Medicine. 4, 10, 77.

Research output: Contribution to journalArticle

Microbiota
Skin
Atopic Dermatitis
Propionibacteriaceae
Streptococcaceae
612 Citations (Scopus)

Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

Kong, H. H., Oh, J., Deming, C., Conlan, S., Grice, E. A., Beatson, M. A., Nomicos, E., Polley, E., Komarow, H. D., Mullikin, J., Thomas, J., Blakesley, R., Young, A., Chu, G., Ramsahoye, C., Lovett, S., Han, J., Legaspi, R., Sison, C., Montemayor, C. & 25 others, Gregory, M., Hargrove, A., Johnson, T., Riebow, N., Schmidt, B., Novotny, B., Gupta, J., Benjamin, B., Brooks, S., Coleman, H., Ho, S. L., Schandler, K., Stantripop, M., Maduro, Q., Bouffard, G., Dekhtyar, M., Guan, X., Masiello, C., Maskeri, B., McDowell, J., Park, M., Vemulapalli, M., Murray, P. R., Turner, M. L. & Segre, J. A., May 1 2012, In : Genome Research. 22, 5, p. 850-859 10 p.

Research output: Contribution to journalArticle

Microbiota
Atopic Dermatitis
Skin
Therapeutics
Disease Progression
2011
27 Citations (Scopus)

AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma

Namiki, T., Tanemura, A., Valencia, J. C., Coelho, S. G., Passeron, T., Kawaguchi, M., Vieira, W. D., Ishikawa, M., Nishijima, W., Izumo, T., Kaneko, Y., Katayama, I., Yamaguchi, Y., Yin, L., Polley, E., Liu, H. D., Kawakami, Y., Eishi, Y., Takahashi, E., Yokozeki, H. & 1 others, Hearing, V. J., Apr 19 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 16, p. 6597-6602 6 p.

Research output: Contribution to journalArticle

Adenylate Kinase
Melanoma
Phosphotransferases
Growth
Neoplasms
65 Citations (Scopus)

Random forests for genetic association studies

Goldstein, B. A., Polley, E. & Briggs, F. B. S., Aug 12 2011, In : Statistical Applications in Genetics and Molecular Biology. 10, 1, 32.

Research output: Contribution to journalReview article

Genetic Association
Random Forest
Genetic Association Studies
Learning algorithms
Learning systems
2009
5 Citations (Scopus)

Selecting optimal treatments based on predictive factors

Polley, E. & van der Laan, M. J., Jan 1 2009, Design and Analysis of Clinical Trials with Time-to-Event Endpoints. CRC Press, p. 441-454 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Therapeutics
Clinical Trials
Oncology
Phase III Clinical Trials
Precision Medicine