Elizabeth Jacobsen, PhD

  • 13400 E. Shea Blvd, MCCRB 2-217

    85259 Scottsdale

    United States

  • 1454 Citations
  • 20 Scopus h-Index
20002020

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Research Output

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Article
2020

Image Analysis of Eosinophil Peroxidase Immunohistochemistry for Diagnosis of Eosinophilic Esophagitis

Wright, B. L., Doyle, A. D., Shim, K. P., Pai, R. K., Barshow, S. M., Horsley-Silva, J. L., Luo, H., Rank, M. A., Jacobsen, E. A., Katzka, D. A., Kita, H. & Dellon, E. S., 2020, (Accepted/In press) In : Digestive diseases and sciences.

Research output: Contribution to journalArticle

M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis

Lee, S. H., Chaves, M. M., Kamenyeva, O., Gazzinelli-Guimaraes, P. H., Kang, B., Pessenda, G., Passelli, K., Tacchini-Cottier, F., Kabat, J., Jacobsen, E. A., Nutman, T. B. & Sacks, D. L., 2020, In : Science Immunology. 5, 46, eaaz4415.

Research output: Contribution to journalArticle

2019

Eosinophil-derived IL-13 promotes emphysema

Doyle, A. D., Mukherjee, M., LeSuer, W. E., Bittner, T. B., Pasha, S. M., Frere, J. J., Neely, J. L., Kloeber, J. A., Shim, K. P., Ochkur, S. I., Ho, T., Svenningsen, S., Wright, B. L., Rank, M. A., Lee, J. J., Nair, P. & Jacobsen, E. A., May 1 2019, In : The European respiratory journal. 53, 5

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Eosinophil peroxidase, GATA3, and T-bet as tissue biomarkers in chronic rhinosinusitis

Lal, D., Wright, B. L., Shim, K. P., Zarka, M. A., Lee, J. J., Chang, Y. H., Ochkur, S. I., Divekar, R., Doyle, A. D., Jacobsen, E. A., Kita, H. & Rank, M. A., Jun 2019, In : Journal of Allergy and Clinical Immunology. 143, 6, p. 2284-2287.e6

Research output: Contribution to journalArticle

1 Scopus citations

Eosinophils downregulate lung alloimmunity by decreasing TCR signal transduction

Onyema, O. O., Guo, Y., Mahgoub, B., Wang, Q., Manafi, A., Mei, Z., Banerjee, A., Li, D., Stoler, M. H., Zaidi, M. T., Schrum, A. G., Kreisel, D., Gelman, A. E., Jacobsen, E. A. & Krupnick, A. S., Jun 6 2019, In : JCI Insight. 4, 11, e128241.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Intravital imaging allows real-time characterization of tissue resident eosinophils

Chojnacki, A., Wojcik, K., Petri, B., Aulakh, G., Jacobsen, E. A., LeSuer, W. E., Colarusso, P. & Patel, K. D., Dec 1 2019, In : Communications Biology. 2, 1, 181.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Baseline gastrointestinal eosinophilia is common in oral immunotherapy subjects with IgE-mediated peanut allergy

Wright, B. L., Fernandez-Becker, N. Q., Kambham, N., Purington, N., Tupa, D., Zhang, W., Rank, M. A., Kita, H., Shim, K. P., Bunning, B. J., Doyle, A. D., Jacobsen, E. A., Boyd, S. D., Tsai, M., Maecker, H., Manohar, M., Galli, S. J., Nadeau, K. C. & Chinthrajah, R. S., Nov 22 2018, In : Frontiers in immunology. 9, NOV, 2624.

Research output: Contribution to journalArticle

10 Scopus citations

Increased GATA-3 and T-bet expression in eosinophilic esophagitis versus gastroesophageal reflux disease

Wright, B. L., Nguyen, N., Shim, K. P., Masterson, J. C., Jacobsen, E. A., Ochkur, S. I., Lee, J. J. & Furuta, G. T., May 2018, In : Journal of Allergy and Clinical Immunology. 141, 5, p. 1919-1921.e5

Research output: Contribution to journalArticle

2 Scopus citations

Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease

Abdala-Valencia, H., Coden, M. E., Chiarella, S. E., Jacobsen, E., Bochner, B. S., Lee, J. J. & Berdnikovs, S., Jan 1 2018, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

26 Scopus citations

Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice

Willetts, L., Felix, L. C., Jacobsen, E. A., Puttagunta, L., Condjella, R. M., Zellner, K. R., Ochkur, S. I., Kim, J. D., Luo, H., Lee, N. A., Lee, J. J., Moqbel, R. & Lacy, P., Dec 1 2018, In : Communications Biology. 1, 1, 83.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2017

Frontline science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation

Ochkur, S. I., Doyle, A. D., Jacobsen, E., LeSuer, W. E., Li, W., Protheroe, C. A., Zellner, K. R., Colbert, D., Shen, H. H. H., Irvin, C. G., Lee, J. J. & Lee, N. A., Sep 1 2017, In : Journal of Leukocyte Biology. 102, 3, p. 589-599 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Lung pathologies in a chronic inflammation mouse model are independent of eosinophil degranulation

Jacobsen, E. A., Ochkur, S. I., Doyle, A. D., LeSuer, W. E., Li, W., Protheroe, C. A., Colbert, D., Zellner, K. R., Shen, H. H., Irvin, C. G., Lee, J. J. & Lee, N. A., May 15 2017, In : American journal of respiratory and critical care medicine. 195, 10, p. 1321-1332 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Sputum autoantibodies in patients with severe eosinophilic asthma

Mukherjee, M., Bulir, D. C., Radford, K., Kjarsgaard, M., Huang, C. M., Jacobsen, E., Ochkur, S. I., Catuneanu, A., Lamothe-Kipnes, H., Mahony, J., Lee, J. J., Lacy, P. & Nair, P. K., Jan 1 2017, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

23 Scopus citations
2015

Differential activation of airway eosinophils induces IL-13-mediated allergic Th2 pulmonary responses in mice

Jacobsen, E., Doyle, A. D., Colbert, D. C., Zellner, K. R., Protheroe, C. A., Lesuer, W. E., Lee, N. A. & Lee, J. J., Sep 1 2015, In : Allergy: European Journal of Allergy and Clinical Immunology. 70, 9, p. 1148-1159 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis

Masterson, J. C., McNamee, E. N., Fillon, S. A., Hosford, L., Harris, R., Fernando, S. D., Jedlicka, P., Iwamoto, R., Jacobsen, E., Protheroe, C., Eltzschig, H. K., Colgan, S. P., Arita, M., Lee, J. J. & Furuta, G. T., Aug 1 2015, In : Gut. 64, 8, p. 1236-1247 12 p.

Research output: Contribution to journalArticle

53 Scopus citations
2014

Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice

Jacobsen, E. A., LeSuer, W. E., Willetts, L., Zellner, K. R., Mazzolini, K., Antonios, N., Beck, B., Protheroe, C., Ochkur, S. I., Colbert, D., Lacy, P., Moqbel, R., Appleton, J., Lee, N. A. & Lee, J. J., Mar 2014, In : Allergy: European Journal of Allergy and Clinical Immunology. 69, 3, p. 315-327 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Predicting response to bacillus Calmette-Guérin (BCG) in patients with carcinoma in situ of the bladder

Nunez-Nateras, R., Castle, E. P., Protheroe, C. A., Stanton, M. L., Ocal, T. I., Ferrigni, E. N., Ochkur, S. I., Jacobsen, E. A., Hou, Y. X., Andrews, P. E., Colby, T. V., Lee, N. A. & Lee, J. J., Jan 2014, In : Urologic Oncology: Seminars and Original Investigations. 32, 1, p. 45.e23-45.e30

Research output: Contribution to journalArticle

33 Scopus citations
2013

Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice

Doyle, A. D., Jacobsen, E. A., Ochkur, S. I., McGarry, M. P., Shim, K. G., Nguyen, D. T. C., Protheroe, C., Colbert, D., Kloeber, J., Neely, J., Shim, K. P., Dyer, K. D., Rosenberg, H. F., Lee, J. J. & Lee, N. A., Aug 1 2013, In : Blood. 122, 5, p. 781-790 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils

Doyle, A. D., Jacobsen, E. A., Ochkur, S. I., Willetts, L., Shim, K., Neely, J., Kloeber, J., LeSuer, W. E., Pero, R. S., Lacy, P., Moqbel, R., Lee, N. A. & Lee, J. J., Jul 1 2013, In : Journal of Leukocyte Biology. 94, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

47 Scopus citations
2011

Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation

Jacobsen, E. A., Zellner, K. R., Colbert, D., Lee, N. A. & Lee, J. J., Dec 1 2011, In : Journal of Immunology. 187, 11, p. 6059-6068 10 p.

Research output: Contribution to journalArticle

77 Scopus citations
2008

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells

Jacobsen, E. A., Ochkur, S. I., Pero, R. S., Taranova, A. G., Protheroe, C. A., Colbert, D. C., Lee, N. A. & Lee, J. J., Mar 17 2008, In : Journal of Experimental Medicine. 205, 3, p. 699-710 12 p.

Research output: Contribution to journalArticle

178 Scopus citations

Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung

Taranova, A. G., Maldonado, D., Vachon, C. M., Jacobsen, E. A., Abdala-Valencia, H., McGarry, M. P., Ochkur, S. I., Protheroe, C. A., Doyle, A., Grant, C. S., Cook-Mills, J., Birnbaumer, L., Lee, N. A. & Lee, J. J., Oct 15 2008, In : Cancer research. 68, 20, p. 8582-8589 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
2007

Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma

Ochkur, S. I., Jacobsen, E. A., Protheroe, C. A., Biechele, T. L., Pero, R. S., McGarry, M. P., Wang, H., O'Neill, K. R., Colbert, D. C., Colby, T. V., Shen, H., Blackburn, M. R., Irvin, C. C., Lee, J. J. & Lee, N. A., Jun 15 2007, In : Journal of Immunology. 178, 12, p. 7879-7889 11 p.

Research output: Contribution to journalArticle

Open Access
117 Scopus citations

Eosinophils: Singularly destructive effector cells or purveyors of immunoregulation?

Jacobsen, E. A., Taranova, A. G., Lee, N. A. & Lee, J. J., Jun 1 2007, In : Journal of Allergy and Clinical Immunology. 119, 6, p. 1313-1320 8 p.

Research output: Contribution to journalArticle

153 Scopus citations
2006

Growth, differentiation, and malignant transformation of pre-B cells mediated by inducible activation of v-Abl oncogene

Jacobsen, E. A., Ananieva, O., Brown, M. L. & Chang, Y., Jun 1 2006, In : Journal of Immunology. 176, 11, p. 6831-6838 8 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations
2004

Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains

Jacobsen, E., Beach, T., Shen, Y., Li, R. & Chang, Y., Sep 10 2004, In : Molecular Brain Research. 128, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

56 Scopus citations