Elaine C Wirrell, MD

  • 7195 Citations
  • 48 Scopus h-Index
1991 …2020

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2020

Extinguishing Febrile Infection-Related Epilepsy Syndrome: Pipe Dream or Reality?

Payne, E. T., Koh, S. & Wirrell, E. C., Apr 1 2020, In : Seminars in Neurology. 40, 2, p. 263-272 10 p.

Research output: Contribution to journalArticle

Fenfluramine for Treatment-Resistant Seizures in Patients with Dravet Syndrome Receiving Stiripentol-Inclusive Regimens: A Randomized Clinical Trial

Nabbout, R., Mistry, A., Zuberi, S., Villeneuve, N., Gil-Nagel, A., Sanchez-Carpintero, R., Stephani, U., Laux, L., Wirrell, E., Knupp, K., Chiron, C., Farfel, G., Galer, B. S., Morrison, G., Lock, M., Agarwal, A. & Auvin, S., Mar 2020, In : JAMA neurology. 77, 3, p. 300-308 9 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2019

Immediate outcomes in early life epilepsy: A contemporary account

Berg, A. T., Wusthoff, C., Shellhaas, R. A., Loddenkemper, T., Grinspan, Z. M., Saneto, R. P., Knupp, K. G., Patel, A., Sullivan, J. E., Kossoff, E. H., Chu, C. J., Massey, S., Valencia, I., Keator, C., Wirrell, E. C., Coryell, J., Millichap, J. J. & Gaillard, W. D., Aug 2019, In : Epilepsy and Behavior. 97, p. 44-50 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Seizure Rescue Medication Use among US Pediatric Epilepsy Providers: A Survey of the Pediatric Epilepsy Research Consortium

Wallace, A., Wirrell, E. & Payne, E., Sep 2019, In : Journal of Pediatrics. 212, p. 111-116 6 p.

Research output: Contribution to journalArticle

The Ketogenic and Modified Atkins Diet Therapy for Children With Refractory Epilepsy of Genetic Etiology

Jagadish, S., Payne, E. T., Wong-Kisiel, L., Nickels, K. C., Eckert, S. & Wirrell, E. C., Jan 1 2019, In : Pediatric Neurology.

Research output: Contribution to journalArticle

2 Scopus citations
2018

A Novel Phenotype in a Previously Described Epilepsy—Aphasia Disorder

Fine, A. L., Wong-Kisiel, L. & Wirrell, E. C., Jul 1 2018, In : Seminars in Pediatric Neurology. 26, p. 21-24 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Comparative effectiveness of levetiracetam vs phenobarbital for infantile epilepsy

Grinspan, Z. M., Shellhaas, R. A., Coryell, J., Sullivan, J. E., Wirrell, E. C., Mytinger, J. R., Gaillard, W. D., Kossoff, E. H., Valencia, I., Knupp, K. G., Wusthoff, C., Keator, C., Ryan, N., Loddenkemper, T., Chu, C. J., Novotny, E. J., Millichap, J. & Berg, A. T., Apr 2018, In : JAMA Pediatrics. 172, 4, p. 352-360 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Correction to: Treatment Strategies for Dravet Syndrome (CNS Drugs, (2018), 32, 4, (335-350), 10.1007/s40263-018-0511-y)

Knupp, K. G. & Wirrell, E. C., Jan 1 2018, (Accepted/In press) In : CNS Drugs.

Research output: Contribution to journalArticle

2 Scopus citations

De Novo DNM1L Variant in a Teenager With Progressive Paroxysmal Dystonia and Lethal Super-refractory Myoclonic Status Epilepticus

Ryan, C. S., Fine, A. L., Cohen, A. L., Schiltz, B. M., Renaud, D. L., Wirrell, E. C., Patterson, M. C., Boczek, N. J., Liu, R., Babovic-Vuksanovic, D., Chan, D. C. & Payne, E. T., Jan 1 2018, (Accepted/In press) In : Journal of Child Neurology.

Research output: Contribution to journalArticle

4 Scopus citations

Effect of cannabidiol on drop seizures in the lennox–gastaut syndrome

for the GWPCARE3 Study Group, May 17 2018, In : New England Journal of Medicine. 378, 20, p. 1888-1897 10 p.

Research output: Contribution to journalArticle

178 Scopus citations

How do we diagnose and treat epilepsy with myoclonic-atonic seizures (Doose syndrome)? Results of the Pediatric Epilepsy Research Consortium survey

for the Pediatric Epilepsy Research Consortium, Aug 2018, In : Epilepsy Research. 144, p. 14-19 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Impact of Prior Authorization of Antiepileptic Drugs in Children With Epilepsy

Wirrell, E. C., Vanderwiel, A. J., Nickels, L., Vanderwiel, S. L. & Nickels, K. C., Jan 1 2018, (Accepted/In press) In : Pediatric Neurology.

Research output: Contribution to journalArticle

2 Scopus citations

Jeavons Syndrome: Clinical Features and Response to Treatment

Smith, K. M., Youssef, P. E., Wirrell, E. C., Nickels, K. C., Payne, E. T., Britton, J. W., Shin, C., Cascino, G. D., Patterson, M. C. & Wong-Kisiel, L., Jan 1 2018, (Accepted/In press) In : Pediatric Neurology.

Research output: Contribution to journalArticle

3 Scopus citations

Ketogenic Diet Therapy in Infants: Efficacy and Tolerability

Wirrell, E. C., Eckert, S., Wong-Kisiel, L., Payne, E. & Nickels, K. C., Jan 1 2018, (Accepted/In press) In : Pediatric Neurology.

Research output: Contribution to journalArticle

5 Scopus citations

LGI1 and CASPR2 neurological autoimmunity in children

López-Chiriboga, A. S., Klein, C., Zekeridou, A., McKeon, A., Dubey, D., Flanagan, E. P., Lennon, V. A., Tillema, J. M., Wirrell, E. C., Patterson, M. C., Gadoth, A., Aaen, J. G., Brenton, J. N., Bui, J. D., Moen, A., Otten, C., Piquet, A. & Pittock, S. J., Sep 2018, In : Annals of neurology. 84, 3, p. 473-480 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Neuroimaging of early life epilepsy

Coryell, J., Gaillard, W. D., Shellhaas, R. A., Grinspan, Z. M., Wirrell, E. C., Knupp, K. G., Wusthoff, C. J., Keator, C., Sullivan, J. E., Loddenkemper, T., Patel, A., Chu, C. J., Massey, S., Novotny, E. J., Saneto, R. P. & Berg, A. T., Sep 2018, In : Pediatrics. 142, 3, e20180672.

Research output: Contribution to journalArticle

2 Scopus citations

Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group

The Charlie Foundation, Matthew's Friends & the Practice Committee of the Child Neurology Society, Jan 1 2018, In : Epilepsia Open. 3, 2, p. 175-192 18 p.

Research output: Contribution to journalArticle

Open Access
84 Scopus citations

Systematic review of the screening, diagnosis, and management of ADHD in children with epilepsy. Consensus paper of the Task Force on Comorbidities of the ILAE Pediatric Commission

Auvin, S., Wirrell, E., Donald, K. A., Berl, M., Hartmann, H., Valente, K. D., Van Bogaert, P., Cross, J. H., Osawa, M., Kanemura, H., Aihara, M., Guerreiro, M. M., Samia, P., Vinayan, K. P., Smith, M. L., Carmant, L., Kerr, M., Hermann, B., Dunn, D. & Wilmshurst, J. M., Oct 2018, In : Epilepsia. 59, 10, p. 1867-1880 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Treatment Strategies for Dravet Syndrome

Knupp, K. G. & Wirrell, E. C., Mar 28 2018, (Accepted/In press) In : CNS Drugs. p. 1-16 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

Why west? Comparisons of clinical, genetic and molecular features of infants with and without spasms

Berg, A. T., Chakravorty, S., Koh, S., Grinspan, Z. M., Shellhaas, R. A., Saneto, R. P., Wirrell, E. C., Coryell, J., Chu, C. J., Mytinger, J. R., Gaillard, W. D., Valencia, I., Knupp, K. G., Loddenkemper, T., Sullivan, J. E., Poduri, A., Millichap, J. J., Keator, C., Wusthoff, C., Ryan, N. & 2 others, Dobyns, W. B. & Hegde, M., Mar 2018, In : PloS one. 13, 3, e0193599.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Cognitive and Social Outcomes of Epileptic Encephalopathies

Nickels, K. C. & Wirrell, E. C., Nov 1 2017, In : Seminars in Pediatric Neurology. 24, 4, p. 264-275 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Early-life epilepsies and the emerging role of genetic testing

Berg, A. T., Coryell, J., Saneto, R. P., Grinspan, Z. M., Alexander, J. J., Kekis, M., Sullivan, J. E., Wirrell, E. C., Shellhaas, R. A., Mytinger, J. R., Gaillard, W. D., Kossoff, E. H., Valencia, I., Knupp, K. G., Wusthoff, C., Keator, C., Dobyns, W. B., Ryan, N., Loddenkemper, T., Chu, C. J. & 2 others, Novotny, E. J. & Koh, S., Sep 2017, In : JAMA Pediatrics. 171, 9, p. 863-871 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Epidemiology and Outcomes of Arterial Ischemic Stroke in Children: The Canadian Pediatric Ischemic Stroke Registry

deVeber, G. A., Kirton, A., Booth, F. A., Yager, J. Y., Wirrell, E. C., Wood, E., Shevell, M., Surmava, A. M., McCusker, P., Massicotte, M. P., MacGregor, D., MacDonald, E. A., Meaney, B., Levin, S., Lemieux, B. G., Jardine, L., Humphreys, P., David, M., Chan, A. K. C., Buckley, D. J. & 1 others, Bjornson, B. H., Apr 1 2017, In : Pediatric Neurology. 69, p. 58-70 13 p.

Research output: Contribution to journalArticle

49 Scopus citations

EpiNet as a way of involving more physicians and patients in epilepsy research: Validation study and accreditation process

the EpiNet Study Group, Mar 1 2017, In : Epilepsia Open. 2, 1, p. 20-31 12 p.

Research output: Contribution to journalArticle

Open Access

Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus

Shellhaas, R. A., Berg, A. T., Grinspan, Z. M., Wusthoff, C. J., Millichap, J. J., Loddenkemper, T., Coryell, J., Saneto, R. P., Chu, C. J., Joshi, S. M., Sullivan, J. E., Knupp, K. G., Kossoff, E. H., Keator, C., Wirrell, E. C., Mytinger, J. R., Valencia, I., Massey, S. & Gaillard, W. D., Oct 2017, In : Pediatric Neurology. 75, p. 73-79 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Not all SCN1A epileptic encephalopathies are Dravet syndrome

Sadleir, L. G., Mountier, E. I., Gill, D., Davis, S., Joshi, C., Devile, C., Kurian, M. A., Mandelstam, S., Wirrell, E., Nickels, K. C., Murali, H. R., Carvill, G., Myers, C. T., Mefford, H. C. & Scheffer, I. E., Sep 5 2017, In : Neurology. 89, 10, p. 1035-1042 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Optimizing the Diagnosis and Management of Dravet Syndrome: Recommendations From a North American Consensus Panel

Wirrell, E. C., Laux, L., Donner, E., Jette, N., Knupp, K., Meskis, M. A., Miller, I., Sullivan, J., Welborn, M. & Berg, A. T., Mar 1 2017, In : Pediatric Neurology. 68, p. 18-34.e3

Research output: Contribution to journalArticle

56 Scopus citations

Predictive models in the diagnosis and treatment of autoimmune epilepsy

Dubey, D., Singh, J., Britton, J. W., Pittock, S. J., Flanagan, E., Lennon, V. A., Tillema, J-M., Wirrell, E. C., Shin, C., So, E., Cascino, G. D., Wingerchuk, D. M., Hoerth, M. T., Shih, J. J., Nickels, K. C. & McKeon, A., 2017, (Accepted/In press) In : Epilepsia.

Research output: Contribution to journalArticle

31 Scopus citations

The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium

the Pediatric Epilepsy Research Consortium, Dec 2017, In : Epilepsia. 58, 12, p. 2098-2103 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2016

A microRNA-328 binding site in PAX6 is associated with centrotemporal spikes of rolandic epilepsy

Panjwani, N., Wilson, M. D., Addis, L., Crosbie, J., Wirrell, E. C., Auvin, S., Caraballo, R. H., Kinali, M., McCormick, D., Oren, C., Taylor, J., Trounce, J., Clarke, T., Akman, C. I., Kugler, S. L., Mandelbaum, D. E., McGoldrick, P., Wolf, S. M., Arnold, P., Schachar, R. & 2 others, Pal, D. K. & Strug, L. J., Jul 1 2016, In : Annals of Clinical and Translational Neurology. p. 512-522 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Do Patients Require Inpatient Admission to Receive Adrenocorticotropic Hormone (ACTH)? A Survey of US-Based Prescribers

Joshi, C., Berg, A. T. & Wirrell, E. C., Feb 1 2016, In : Journal of Child Neurology. 31, 2, p. 164-169 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Febrile infection-related epilepsy syndrome treated with anakinra

Kenney-Jung, D. L., Vezzani, A., Kahoud, R. J., LaFrance-Corey, R. G., Ho, M. L., Muskardin, T. W., Wirrell, E. C., Howe, C. L. & Payne, E. T., Dec 1 2016, In : Annals of Neurology. 80, 6, p. 939-945 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Focal photoparoxysmal response in the Heidenhain variant of CJD: Hidden from view!

Feyissa, A., Wirrell, E. C., Jones, D. T., Young, N. P. & Britton, J. W., Apr 26 2016, In : Neurology. 86, 17, p. 1647-1648 2 p.

Research output: Contribution to journalArticle

Mortality in Dravet syndrome

Cooper, M. S., Mcintosh, A., Crompton, D. E., McMahon, J. M., Schneider, A., Farrell, K., Ganesan, V., Gill, D., Kivity, S., Lerman-Sagie, T., McLellan, A., Pelekanos, J., Ramesh, V., Sadleir, L., Wirrell, E. C. & Scheffer, I. E., Dec 1 2016, In : Epilepsy Research. 128, p. 43-47 5 p.

Research output: Contribution to journalArticle

68 Scopus citations

Patient and caregiver view on seizure detection devices: A survey study

Tovar Quiroga, D. F., Britton, J. W. & Wirrell, E. C., Oct 1 2016, In : Seizure. 41, p. 179-181 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

Prevalence and Risk Factors of Peri-ictal Autonomic Changes in Children With Temporal Lobe Seizures

Whealy, M., Wirrell, E. C., Wong-Kisiel, L., Nickels, K. C. & Payne, E. T., Jul 18 2016, (Accepted/In press) In : Pediatric Neurology.

Research output: Contribution to journalArticle

5 Scopus citations

Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort

the Pediatric Epilepsy Research Consortium, Nov 1 2016, In : Epilepsia. 57, 11, p. 1834-1842 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Response to treatment in a prospective national infantile spasms cohort

Knupp, K. G., Coryell, J., Nickels, K. C., Ryan, N., Leister, E., Loddenkemper, T., Grinspan, Z., Hartman, A. L., Kossoff, E. H., Gaillard, W. D., Mytinger, J. R., Joshi, S., Shellhaas, R. A., Sullivan, J., Dlugos, D., Hamikawa, L., Berg, A. T., Millichap, J., Nordli, D. R. & Wirrell, E., Mar 1 2016, In : Annals of neurology. 79, 3, p. 475-484 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

Routine vs extended outpatient EEG for the detection of interictal epileptiform discharges

Burkholder, D. B., Britton, J. W., Rajasekaran, V., Fabris, R. R., Cherian, P. J., Kelly-Williams, K. M., So, E. L., Nickels, K. C., Wong-Kisiel, L., Lagerlund, T. D., Cascino, G. D., Worrell, G. A. & Wirrell, E. C., Apr 19 2016, In : Neurology. 86, 16, p. 1524-1530 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Understanding Death in Children With Epilepsy

Donner, E. J., Camfield, P., Brooks, L., Buchhalter, J., Camfield, C., Loddenkemper, T. & Wirrell, E. C., Oct 4 2016, (Accepted/In press) In : Pediatric Neurology.

Research output: Contribution to journalArticle

12 Scopus citations

Usefulness of repeat review of head magnetic resonance images during presurgical epilepsy conferences

Kenney, D. L., Kelly-Williams, K. M., Krecke, K. N., Witte, R. J., Watson, R. E., Kotsenas, A. L., Wirrell, E. C., Nickels, K. C., Wong-Kisiel, L. & So, E., Oct 1 2016, In : Epilepsy Research. 126, p. 106-108 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Acetazolamide for electrical status epilepticus in slow-wave sleep

Fine, A. L., Wirrell, E. C., Wong-Kisiel, L. & Nickels, K. C., Sep 1 2015, In : Epilepsia. 56, 9, p. e134-e138

Research output: Contribution to journalArticle

8 Scopus citations

Does treatment have an impact on incidence and risk factors for autism spectrum disorders in children with infantile spasms?

Bitton, J. Y., Demos, M., Elkouby, K., Connolly, M., Weiss, S. K., Donner, E. J., Whiting, S., Ronen, G. M., Bello-Espinosa, L., Wirrell, E. C., Mohamed, I. S., Dooley, J. M. & Carmant, L., Jun 1 2015, In : Epilepsia. 56, 6, p. 856-863 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

How should children with West syndrome be efficiently and accurately investigated? Results from the National Infantile Spasms Consortium

Wirrell, E. C., Shellhaas, R. A., Joshi, C., Keator, C., Kumar, S. & Mitchell, W. G., Apr 1 2015, In : Epilepsia. 56, 4, p. 617-625 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Predictors of length of stay in children admitted for presurgical evaluation for epilepsy surgery

Sun, P. Y., Wyatt, K., Nickels, K. C., Wong-Kisiel, L., Mandrekar, J. & Wirrell, E. C., Sep 1 2015, In : Pediatric Neurology. 53, 3, p. 207-210 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Repeat resective surgery in complex pediatric refractory epilepsy: Lessons learned

Bower, R. S., Wirrell, E. C., Eckel, L. J., Wong-Kisiel, L., Nickels, K. C. & Wetjen, N. M., Jul 1 2015, In : Journal of Neurosurgery: Pediatrics. 16, 1, p. 94-100 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Seizure Freedom in Children with Pathology-Confirmed Focal Cortical Dysplasia

Mrelashvili, A., Witte, R. J., Wirrell, E. C., Nickels, K. C. & Wong-Kisiel, L., 2015, In : Pediatric Neurology. 53, 6, p. 513-518 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Yield and Predictors of Epilepsy Surgery Candidacy in Children Admitted for Surgical Evaluation

Haque, O. J., Mandrekar, J., Wyatt, K., Nickels, K. C., Wong-Kisiel, L., Wetjen, N. & Wirrell, E. C., Jul 1 2015, In : Pediatric Neurology. 53, 1, p. 58-64 7 p., 8635.

Research output: Contribution to journalArticle

2 Scopus citations
2014

Bizarre semiology and medically intractable seizures

Nozile-Firth, K., Wirrell, E. & Giannini, C., Jun 2014, In : Seminars in Pediatric Neurology. 21, 2, p. 154-159 6 p.

Research output: Contribution to journalArticle

Chronic subthreshold subdural cortical stimulation for the treatment of focal epilepsy originating from eloquent cortex

Child, N. D., Stead, M., Wirrell, E. C., Nickels, K. C., Wetjen, N. M., Lee, K. H. & Klassen, B. T., Jan 1 2014, In : Epilepsia. 55, 3, p. e18-e21

Research output: Contribution to journalArticle

25 Scopus citations