• 6135 Citations
  • 39 Scopus h-Index
1980 …2019

Research output per year

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Research Output

  • 6135 Citations
  • 39 Scopus h-Index
  • 106 Article
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Article

Adventitial delivery of lentivirus-shRNA-ADAMTS-1 reduces venous stenosis formation in arteriovenous fistula

Torres, E. C. N., Yang, B., Janardhanan, R., Brahmbhatt, A., Leof, E. B., Mukhopadhyay, D. & Misra, S., 2014, In : PLoS One. 9, 4, p. e94510

Research output: Contribution to journalArticle

15 Scopus citations

Adventitial transduction of lentivirus-shRNA-VEGF-A in arteriovenous fistula reduces venous stenosis formation

Yang, B., Janardhanan, R., Vohra, P., Greene, E. L., Bhattacharya, S., Withers, S., Roy, B., Nieves Torres, E. C., Mandrekar, J., Leof, E. B., Mukhopadhyay, D. & Misra, S., Feb 2014, In : Kidney International. 85, 2, p. 289-306 18 p.

Research output: Contribution to journalArticle

32 Scopus citations

Analysis of Pneumocystis carinii introns

Thomas, C. F., Leof, E. B. & Limper, A. H., Nov 1999, In : Infection and Immunity. 67, 11, p. 6157-6160 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

An association between type Iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization

Xiong, X., Xu, Q., Huang, Y., Singh, R. D., Anderson, R., Leof, E. B., Hu, J. & Ling, K., Jan 1 2012, In : Molecular Biology of the Cell. 23, 1, p. 87-98 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

A non-Smad mechanism of fibroblast activation by transforming growth factor-β via c-Abl and Egr-1: Selective modulation by imatinib mesylate

Bhattacharyya, S., Ishida, W., Wu, M., Wilkes, M., Mori, Y., Hinchcliff, M., Leof, E. B. & Varga, J., Mar 12 2009, In : Oncogene. 28, 10, p. 1285-1297 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

A unique element in the cytoplasmic tail of the type II transforming growth factor-β receptor controls basolateral delivery

Murphy, S. J., Shapira, K. E., Henis, Y. I. & Leof, E. B., Oct 2007, In : Molecular Biology of the Cell. 18, 10, p. 3788-3799 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

B7-1 drives TGF-β stimulated pancreatic carcinoma cell migration and expression of EMT target genes

Kang, J. H., Jung, M. Y. & Leof, E. B., Jan 1 2019, In : PloS one. 14, 9, e0222083.

Research output: Contribution to journalArticle

Open Access

Basolateral delivery of the type i transforming growth factor beta receptor is mediated by a dominant-acting cytoplasmic motif

Yin, X., Kang, J. H., Andrianifahanana, M., Wang, Y., Jung, M. Y., Hernandez, D. M. & Leof, E. B., Oct 1 2017, In : Molecular Biology of the Cell. 28, 20, p. 2701-2711 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis

Wang, Y., Cao, Y., Yamada, S., Thirunavukkarasu, M., Nin, V., Joshi, M., Rishi, M. T., Bhattacharya, S., Camacho-Pereira, J., Sharma, A. K., Shameer, K., Kocher, J-P., Sanchez, J. A., Wang, E., Hoeppner, L. H., Dutta, S. K., Leof, E. B., Shah, V., Claffey, K. P., Chini, E. N. & 4 others, Simons, M., Terzic, A., Maulik, N. & Mukhopadhyay, D., Jun 27 2015, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 6, p. 1401-1412 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Cell cycle-dependent inhibition of p34(cdc2) synthesis by transforming growth factor β1 in cycling epithelial cells

Eblen, S. T., Fautsch, M. P., Burnette, R. J., Joshi, P. & Leof, E. B., 1994, In : Cell Growth and Differentiation. 5, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Cell Density Sensing Alters TGF-β Signaling in a Cell-Type-Specific Manner, Independent from Hippo Pathway Activation

Nallet-Staub, F., Yin, X., Gilbert, C., Marsaud, V., BenMimoun, S., Javelaud, D., Leof, E. B. & Mauviel, A., Mar 9 2015, In : Developmental Cell. 32, 5, p. 640-651 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Cell-penetrating peptides selectively targeting SMAD3 inhibit profibrotic TGF-β signaling

Kang, J. H., Jung, M. Y., Yin, X., Andrianifahanana, M., Hernandez, D. M. & Leof, E. B., Jun 30 2017, In : Journal of Clinical Investigation. 127, 7, p. 2541-2554 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3

Wilkes, M. C., Murphy, S. J., Garamszegi, N. & Leof, E. B., Dec 2003, In : Molecular and Cellular Biology. 23, 23, p. 8878-8889 12 p.

Research output: Contribution to journalArticle

102 Scopus citations
24 Scopus citations
1 Scopus citations

Characterization of the Pneumocystis carinii cyclin-dependent kinase life cycle regulatory system

Limper, A. H., Thomas C.F., J., Mubarak, K. K., Gustafson, M., Kottom, T. J. & Leof, E. B., Nov 1997, In : Journal of Eukaryotic Microbiology. 44, 6

Research output: Contribution to journalArticle

3 Scopus citations
43 Scopus citations

Cholera toxin potentiates the action of competence factors in BALB/c-3T3 cells

Wharton, W., Leof, E. B. & Pledger, W. J., 1980, In : Journal of Cell Biology. 87, 2 II

Research output: Contribution to journalArticle

Cloning and characterization of the suc1 cell cycle control gene from Pneumocystis carinii

Mubarak, K. K., Thomas, C. F., Leof, E. B. & Limper, A. H., Oct 1998, In : Chest. 114, 4 SUPPL.

Research output: Contribution to journalArticle

Conditional binding to and cell cycle-regulated inhibition of cyclin- dependent kinase complexes by p27(Kip1)

Eblen, S. T., Fautsch, M. P., Anders, R. A. & Leof, E. B., 1995, In : Cell Growth and Differentiation. 6, 8, p. 915-925 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

CorMatrix Wrapped Around the Adventitia of the Arteriovenous Fistula Outflow Vein Attenuates Venous Neointimal Hyperplasia

Yang, B., Kilari, S., Brahmbhatt, A., McCall, D. L., Torres, E. N., Leof, E. B., Mukhopadhyay, D. & Misra, S., Dec 1 2017, In : Scientific Reports. 7, 1, 14298.

Research output: Contribution to journalArticle

3 Scopus citations

Cyclic AMP potentiates down regulation of epidermal growth factor receptors by platelet-derived growth factor

Leof, E. B., Olashaw, N. E., Pledger, W. J. & O'Keefe, E. J., Nov 16 1982, In : Biochemical and Biophysical Research Communications. 109, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
24 Scopus citations

Differential regulation of p34(cdc2) and p33(cdk2) by transforming growth factor-β1 in murine mammary epithelial cells

Fautsch, M. P., Eblen, S. T., Anders, R. A., Burnette, R. J. & Leof, E. B., 1995, In : Journal of Cellular Biochemistry. 58, 4, p. 517-526 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Differential requirement for type I and type II transforming growth factor β receptor kinase activity in ligand-mediated receptor endocytosis

Anders, R. A., Doré, J. J. E., Arline, S. L., Garamszegi, N. & Leof, E. B., Sep 4 1998, In : Journal of Biological Chemistry. 273, 36, p. 23118-23125 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Differential sensitivity of fibroblasts to epidermal growth factor is related to cyclic AMP concentration

Olashaw, N. E., Leof, E. B., O'Keefe, E. J. & Pledger, W. J., 1984, In : Journal of Cellular Physiology. 118, 3, p. 291-297 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Differential trafficking of transforming growth factor-β receptors and ligand in polarized epithelial cells

Murphy, S. J., Doré, J. J. E., Edens, M., Coffey, R. J., Barnard, J. A., Mitchell, H., Wilkes, M. & Leof, E. B., Jun 2004, In : Molecular Biology of the Cell. 15, 6, p. 2853-2862 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Dissociation of p34cdc2 complex formation from phosphorylation and histone H1 kinase activity

Eblen, S. T., Fautsch, M. P., Fautsch, M. P., Snyder, M. & Leof, E. B., May 1 1995, In : Cancer Research. 55, 9, p. 1994-2000 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Distinct endocytic responses of heteromeric and homomeric transforming growth factor β receptors

Anders, R. A., Arline, S. L., Doré, J. J. E. & Leof, E. B., 1997, In : Molecular Biology of the Cell. 8, 11, p. 2133-2143 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Distinct pathways regulate transforming growth factor β1-stimulated proto-oncogene and extracellular matrix gene expression

Howe, P. H., Cunningham, M. R. & Leof, E. B., 1990, In : Journal of Cellular Physiology. 142, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-β

Rahimi, R. A., Andrianifahanana, M., Wilkes, M. C., Edens, M., Kottom, T. J., Blenis, J. & Leof, E. B., Jan 1 2009, In : Cancer Research. 69, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

66 Scopus citations

Elevated intracellular concentrations of cyclic AMP inhibited serum-stimulated, density-arrested BALB/c-3T3 cells in mid G1

Leof, E. B., Wharton, W., O'Keefe, E. & Pledger, W. J., 1982, In : Journal of Cellular Biochemistry. 19, 1, p. 93-103 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells

Leof, E. B., Wharton, W., Van Wyk, J. J. & Pledger, W. J., 1982, In : Experimental Cell Research. 141, 1, p. 107-115 9 p.

Research output: Contribution to journalArticle

231 Scopus citations

Epidermal growth factor (EGF) is required only during the traverse of early G1 in PDGF stimulated density-arrested BALB/c-3T3 cells

Leof, E. B., Van Wyk, J. J., O'Keefe, E. J. & Pledger, W. J., 1983, In : Experimental Cell Research. 147, 1, p. 202-208 7 p.

Research output: Contribution to journalArticle

66 Scopus citations
3 Scopus citations

ERBB receptor activation is required for profibrotic responses to transforming growth factor β

Andrianifahanana, M., Wilkes, M. C., Repellin, C. E., Edens, M., Kottom, T. J., Rahimi, R. A. & Leof, E. B., Oct 1 2010, In : Cancer Research. 70, 19, p. 7421-7430 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Erbin and the NF2 Tumor Suppressor Merlin Cooperatively Regulate Cell-Type-Specific Activation of PAK2 by TGF-β

Wilkes, M. C., Repellin, C. E., Hong, M., Bracamonte, M., Penheiter, S. G., Borg, J. P. & Leof, E. B., Mar 17 2009, In : Developmental Cell. 16, 3, p. 433-444 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Erratum to Imatinib mesylate causes genome-wide transcriptional changes in systemic sclerosis fibroblasts in vitro [Clin Exp Rheumatol, 30, 2 Suppl. 71, (2012) S86-S96]

Hinchcliff, M., Huang, C. C., Ishida, W., Fang, F., Lee, J., Jafari, N., Wilkes, M., Bhattacharyya, S., Leof, E. B. & Varga, J., 2014, In : Clinical and Experimental Rheumatology. 32, 1, p. 150 1 p.

Research output: Contribution to journalArticle

Fatty acid synthase is required for profibrotic TGF-b signaling

Jung, M. Y., Kang, J. H., Hernandez, D. M., Yin, X., Andrianifahanana, M., Wang, Y., Gonzalez-Guerrico, A., Limper, A. H., Lupu, R. & Leof, E. B., Jul 1 2018, In : FASEB Journal. 32, 7, p. 3803-3815 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Fibrosis, regeneration, and aging: Playing chess with evolution

Torres, V. & Leof, E. B., 2011, In : Journal of the American Society of Nephrology. 22, 8, p. 1393-1395 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

FKBP12 is a negative regulator of transforming growth factor-β receptor internalization

Yao, D., Dore, J. J. J. E. & Leof, E. B., Apr 28 2000, In : Journal of Biological Chemistry. 275, 17, p. 13149-13154 6 p.

Research output: Contribution to journalArticle

49 Scopus citations

Growth factor receptor signalling: Location, location, location

Leof, E. B., Aug 1 2000, In : Trends in Cell Biology. 10, 8, p. 343-348 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Growth factors and cancer

Leof, E. B., Leof, E. B., Shipley, G. D. & Moses, H. L., 1986, In : Cancer Research. 46, 3, p. 1015-1029 15 p.

Research output: Contribution to journalArticle

764 Scopus citations

Heteromeric and homomeric transforming growth factor-β receptors show distinct signaling and endocytic responses in epithelial cells

Dore, J. J. J. E., Edens, M., Garamszegi, N. & Leof, E. B., Nov 27 1999, In : Journal of Biological Chemistry. 273, 48, p. 31770-31777 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Histologic studies of the intraocular toxicity of imatinib mesylate in rabbits

Kitzmann, A. S., Baratz, K., Mohney, B. G., Pulido, J. S., Cameron, J. D., Lee, E. S. & Leof, E. B., May 2008, In : Eye. 22, 5, p. 712-714 3 p.

Research output: Contribution to journalArticle

7 Scopus citations
1 Scopus citations
35 Scopus citations

Identification of a cell division cycle (cdc2) homologue in Pneumocystis carinii

Thomas, C. F., Gustafson, M., Vuk-Pavlovic, Z., Leof, E. B. & Limper, A. H., Sep 1996, In : Journal of Eukaryotic Microbiology. 43, 5

Research output: Contribution to journalArticle

6 Scopus citations

Imatinib mesylate blocks a non-Smad TGF-β pathway and reduces renal fibrogenesis in vivo

Wang, S., Wilkes, M. C., Leof, E. B. & Hirschberg, R., Jan 2005, In : FASEB Journal. 19, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

200 Scopus citations