• 6142 Citations
  • 39 Scopus h-Index
1980 …2019

Research output per year

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Research Output

  • 6142 Citations
  • 39 Scopus h-Index
  • 98 Article
  • 5 Review article
  • 2 Editorial
  • 1 Comment/debate
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Article

Adventitial delivery of lentivirus-shRNA-ADAMTS-1 reduces venous stenosis formation in arteriovenous fistula

Torres, E. C. N., Yang, B., Janardhanan, R., Brahmbhatt, A., Leof, E., Mukhopadhyay, D. & Misra, S., Apr 14 2014, In : PloS one. 9, 4, e94510.

Research output: Contribution to journalArticle

15 Scopus citations

Adventitial transduction of lentivirus-shRNA-VEGF-A in arteriovenous fistula reduces venous stenosis formation

Yang, B., Janardhanan, R., Vohra, P., Greene, E. L., Bhattacharya, S., Withers, S., Roy, B., Nieves Torres, E. C., Mandrekar, J., Leof, E. B., Mukhopadhyay, D. & Misra, S., Feb 2014, In : Kidney international. 85, 2, p. 289-306 18 p.

Research output: Contribution to journalArticle

32 Scopus citations

Analysis of Pneumocystis carinii introns

Thomas, C. F., Leof, E. B. & Limper, A. H., Nov 1 1999, In : Infection and Immunity. 67, 11, p. 6157-6160 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

An association between type Iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization

Xiong, X., Xu, Q., Huang, Y., Singh, R. D., Anderson, R., Leof, E., Hu, J. & Ling, K., Jan 1 2012, In : Molecular biology of the cell. 23, 1, p. 87-98 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

A non-Smad mechanism of fibroblast activation by transforming growth factor-β via c-Abl and Egr-1: Selective modulation by imatinib mesylate

Bhattacharyya, S., Ishida, W., Wu, M., Wilkes, M., Mori, Y., Hinchcliff, M., Leof, E. & Varga, J., Mar 12 2009, In : Oncogene. 28, 10, p. 1285-1297 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

A unique element in the cytoplasmic tail of the type II transforming growth factor-β receptor controls basolateral delivery

Murphy, S. J., Shapira, K. E., Henis, Y. I. & Leof, E. B., Oct 1 2007, In : Molecular biology of the cell. 18, 10, p. 3788-3799 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

B7-1 drives TGF-β stimulated pancreatic carcinoma cell migration and expression of EMT target genes

Kang, J. H., Jung, M. Y. & Leof, E. B., Jan 1 2019, In : PloS one. 14, 9, e0222083.

Research output: Contribution to journalArticle

Open Access

Basolateral delivery of the type i transforming growth factor beta receptor is mediated by a dominant-acting cytoplasmic motif

Yin, X., Kang, J. H., Andrianifahanana, M., Wang, Y., Jung, M. Y., Hernandez, D. M. & Leof, E. B., Oct 1 2017, In : Molecular Biology of the Cell. 28, 20, p. 2701-2711 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis

Wang, Y., Cao, Y., Yamada, S., Thirunavukkarasu, M., Nin, V., Joshi, M., Rishi, M. T., Bhattacharya, S., Camacho-Pereira, J., Sharma, A. K., Shameer, K., Kocher, J-P., Sanchez, J. A., Wang, E., Hoeppner, L. H., Dutta, S. K., Leof, E. B., Shah, V., Claffey, K. P., Chini, E. N. & 4 others, Simons, M., Terzic, A., Maulik, N. & Mukhopadhyay, D., Jun 27 2015, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 6, p. 1401-1412 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Cell cycle-dependent inhibition of p34(cdc2) synthesis by transforming growth factor β1 in cycling epithelial cells

Eblen, S. T., Fautsch, M. P., Burnette, R. J., Joshi, P. & Leof, E. B., Jan 1 1994, In : Cell Growth and Differentiation. 5, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Cell Density Sensing Alters TGF-β Signaling in a Cell-Type-Specific Manner, Independent from Hippo Pathway Activation

Nallet-Staub, F., Yin, X., Gilbert, C., Marsaud, V., BenMimoun, S., Javelaud, D., Leof, E. B. & Mauviel, A., Mar 9 2015, In : Developmental Cell. 32, 5, p. 640-651 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Cell-penetrating peptides selectively targeting SMAD3 inhibit profibrotic TGF-β signaling

Kang, J. H., Jung, M. Y., Yin, X., Andrianifahanana, M., Hernandez, D. M. & Leof, E. B., Jun 30 2017, In : Journal of Clinical Investigation. 127, 7, p. 2541-2554 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3

Wilkes, M. C., Murphy, S. J., Garamszegi, N. & Leof, E. B., Dec 1 2003, In : Molecular and cellular biology. 23, 23, p. 8878-8889 12 p.

Research output: Contribution to journalArticle

102 Scopus citations

Characterization of a mitogen-activated protein kinase from Pneumocystis carinii

Thomas, C. F., Kottom, T. J., Leof, E. B. & Limper, A. H., Jul 1 1998, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 275, 1 19-1, p. L193-L199

Research output: Contribution to journalArticle

24 Scopus citations
1 Scopus citations

Characterization of the Pneumocystis carinii cyclin-dependent kinase life cycle regulatory system

Limper, A. H., Thomas, J., Mubarak, K. K., Gustafson, M. P., Kottom, T. J. & Leof, E. B., Nov 1 1997, In : Journal of Eukaryotic Microbiology. 44, 6, p. 32S

Research output: Contribution to journalArticle

3 Scopus citations
43 Scopus citations

Cholera toxin potentiates the action of competence factors in BALB/c-3T3 cells

Wharton, W., Leof, E. B. & Pledger, W. J., Jan 1 1980, In : Journal of Cell Biology. 87, 2 II, p. No. CC017

Research output: Contribution to journalArticle

Cloning and characterization of the suc1 cell cycle control gene from Pneumocystis carinii

Mubarak, K. K., Thomas, C. F., Leof, E. B. & Limper, A. H., Oct 1 1998, In : Chest. 114, 4 SUPPL., p. 273S

Research output: Contribution to journalArticle

Conditional binding to and cell cycle-regulated inhibition of cyclin- dependent kinase complexes by p27(Kip1)

Eblen, S. T., Fautsch, M. P., Anders, R. A. & Leof, E. B., Jan 1 1995, In : Cell Growth and Differentiation. 6, 8, p. 915-925 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

CorMatrix Wrapped Around the Adventitia of the Arteriovenous Fistula Outflow Vein Attenuates Venous Neointimal Hyperplasia

Yang, B., Kilari, S., Brahmbhatt, A., McCall, D. L., Torres, E. N., Leof, E. B., Mukhopadhyay, D. & Misra, S., Dec 1 2017, In : Scientific Reports. 7, 1, 14298.

Research output: Contribution to journalArticle

3 Scopus citations

Cyclic AMP potentiates down regulation of epidermal growth factor receptors by platelet-derived growth factor

Leof, E. B., Olashaw, N. E., Pledger, W. J. & O'Keefe, E. J., Nov 16 1982, In : Biochemical and Biophysical Research Communications. 109, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
24 Scopus citations

Differential regulation of p34cdc2 and p33cdk2 by transforming growth factor‐β1 in murine mammary epithelial cells

Fautsch, M. P., Eblen, S. T., Anders, R. A., Burnette, R. J. & Leof, E. B., Aug 1995, In : Journal of cellular biochemistry. 58, 4, p. 517-526 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Differential requirement for type I and type II transforming growth factor β receptor kinase activity in ligand-mediated receptor endocytosis

Anders, R. A., Doré, J. J. E., Arline, S. L., Garamszegi, N. & Leof, E. B., Sep 4 1998, In : Journal of Biological Chemistry. 273, 36, p. 23118-23125 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Differential sensitivity of fibroblasts to epidermal growth factor is related to cyclic AMP concentration

Olashaw, N. E., Leof, E. B., O'Keefe, E. J. & Pledger, W. J., Mar 1984, In : Journal of Cellular Physiology. 118, 3, p. 291-297 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Differential trafficking of transforming growth factor-β receptors and ligand in polarized epithelial cells

Murphy, S. J., Doré, J. J. E., Edens, M., Coffey, R. J., Barnard, J. A., Mitchell, H., Wilkes, M. & Leof, E. B., Jun 1 2004, In : Molecular biology of the cell. 15, 6, p. 2853-2862 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Dissociation of p34cdc2 Complex Formation from Phosphorylation and Histone H1 Kinase Activity

Eblen, S. T., Eblen, S. T., Fautsch, M. P., Burnette, R. J., Leof, E. B., Snyder, M. & Leof, E. B., May 1 1995, In : Cancer research. 55, 9, p. 1994-2000 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Distinct endocytic responses of heteromeric and homomeric transforming growth factor β receptors

Anders, R. A., Arline, S. L., Doré, J. J. E. & Leof, E. B., Jan 1 1997, In : Molecular biology of the cell. 8, 11, p. 2133-2143 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Distinct pathways regulate transforming growth factor β1‐stimulated proto‐oncogene and extracellular matrix gene expression

Howe, P. H., Cunningham, M. R. & Leof, E. B., Jan 1990, In : Journal of Cellular Physiology. 142, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-β

Rahimi, R. A., Andrianifahanana, M., Wilkes, M. C., Edens, M., Kottom, T. J., Blenis, J. & Leof, E. B., Jan 1 2009, In : Cancer research. 69, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

66 Scopus citations

Elevated intracellular concentrations of cyclic AMP inhibited serum‐stimulated, density‐arrested BALB/c‐3T3 cells in mid G1

Leof, E. B., Wharton, W., O'Keefe, E. & Pledger, W. J., 1982, In : Journal of cellular biochemistry. 19, 1, p. 93-103 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells

Leof, E. B., Wharton, W., Van Wyk, J. J. & Pledger, W. J., Sep 1982, In : Experimental Cell Research. 141, 1, p. 107-115 9 p.

Research output: Contribution to journalArticle

231 Scopus citations

Epidermal growth factor (EGF) is required only during the traverse of early G1 in PDGF stimulated density-arrested BALB/c-3T3 cells

Leof, E. B., Van Wyk, J. J., O'Keefe, E. J. & Pledger, W. J., Aug 1983, In : Experimental Cell Research. 147, 1, p. 202-208 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Epidermal growth factor and somatomedin C control G1 progression of competent BALB/c-3T3 cells: Somatomedin C regulates commitment to DNA synthesis

Leof, E. B., Wharton, W., Van Wyk, J. J. & Pledger, W. J., Jan 1 1980, In : Journal of Cell Biology. 87, 2 II, p. No. CC018

Research output: Contribution to journalArticle

3 Scopus citations

ERBB receptor activation is required for profibrotic responses to transforming growth factor β

Andrianifahanana, M., Wilkes, M. C., Repellin, C. E., Edens, M., Kottom, T. J., Rahimi, R. A. & Leof, E. B., Oct 1 2010, In : Cancer research. 70, 19, p. 7421-7430 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Erbin and the NF2 Tumor Suppressor Merlin Cooperatively Regulate Cell-Type-Specific Activation of PAK2 by TGF-β

Wilkes, M. C., Repellin, C. E., Hong, M., Bracamonte, M., Penheiter, S. G., Borg, J. P. & Leof, E. B., Mar 17 2009, In : Developmental Cell. 16, 3, p. 433-444 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Fatty acid synthase is required for profibrotic TGF-b signaling

Jung, M. Y., Kang, J. H., Hernandez, D. M., Yin, X., Andrianifahanana, M., Wang, Y., Gonzalez-Guerrico, A., Limper, A. H., Lupu, R. & Leof, E. B., Jul 1 2018, In : FASEB Journal. 32, 7, p. 3803-3815 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

FKBP12 is a negative regulator of transforming growth factor-β receptor internalization

Yao, D., Doré, J. J. E. & Leof, E. B., Apr 28 2000, In : Journal of Biological Chemistry. 275, 17, p. 13149-13154 6 p.

Research output: Contribution to journalArticle

49 Scopus citations

Growth Factors and Cancer

Leof, E. B., Moses, H. L., Goustin, A. S. & Shipley, G. D., Jun 1 1986, In : Cancer research. 46, 3, p. 1015-1029 15 p.

Research output: Contribution to journalArticle

764 Scopus citations

Heteromeric and homomeric transforming growth factor-β receptors show distinct signaling and endocytic responses in epithelial cells

Doré, J. J. E., Edens, M., Garamszegi, N. & Leof, E. B., Nov 27 1999, In : Journal of Biological Chemistry. 273, 48, p. 31770-31777 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Histologic studies of the intraocular toxicity of imatinib mesylate in rabbits

Kitzmann, A. S., Baratz, K. H., Mohney, B. G., Pulido, J. S., Cameron, J. D., Lee, E. S. & Leof, E. B., May 2008, In : Eye. 22, 5, p. 712-714 3 p.

Research output: Contribution to journalArticle

7 Scopus citations
1 Scopus citations
35 Scopus citations

Identification of a cell division cycle (cdc2) homologue in Pneumocystis carinii

Thomas, C. F., Gustafson, M., Vuk-Pavlovic, Z., Leof, E. B. & Limper, A. H., Sep 1 1996, In : Journal of Eukaryotic Microbiology. 43, 5, p. 11S

Research output: Contribution to journalArticle

6 Scopus citations

Imatinib mesylate blocks a non-Smad TGF-β pathway and reduces renal fibrogenesis in vivo

Wang, S., Wilkes, M. C., Leof, E. B. & Hirschberg, R., Jan 1 2005, In : FASEB Journal. 19, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

200 Scopus citations

Imatinib mesylate causes genome-wide transcriptional changes in systemic sclerosis fibroblasts in vitro

Hinchcliff, M., Huang, C. C., Ishida, W., Fang, F., Lee, J., Jafari, N., Wilkes, M., Bhattacharyya, S., Leof, E. & Varga, J., May 1 2012, In : Clinical and experimental rheumatology. 30, SUPPL.71, p. S86-S96

Research output: Contribution to journalArticle

7 Scopus citations

Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis

Daniels, C. E., Wilkes, M. C., Edens, M., Kottom, T. J., Murphy, S. J., Limper, A. H. & Leof, E. B., Nov 1 2004, In : Journal of Clinical Investigation. 114, 9, p. 1308-1316 9 p.

Research output: Contribution to journalArticle

459 Scopus citations

Increases in cyclic AMP potentiate competence formation in BALB/c‐3T3 cells

Wharton, W., Leof, E. B., Olashaw, N., Earp, H. S. & Pledger, W. J., May 1982, In : Journal of Cellular Physiology. 111, 2, p. 201-206 6 p.

Research output: Contribution to journalArticle

31 Scopus citations