Debabrata Mukhopadhyay, PhD

  • 14361 Citations
  • 60 Scopus h-Index
1991 …2020
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Research Output 1991 2019

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Article
2005
143 Citations (Scopus)

Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin

Satchi-Fainaro, R., Mamluk, R., Wang, L., Short, S. M., Nagy, J. A., Feng, D., Dvorak, A. M., Dvorak, H. F., Puder, M., Mukhopadhyay, D. & Folkman, J., Mar 2005, In : Cancer Cell. 7, 3, p. 251-261 11 p.

Research output: Contribution to journalArticle

Permeability
Polymers
Vascular Tissue Neoplasms
hydroxypropyl methacrylate
Angiostatins
64 Citations (Scopus)

Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling

Bhattacharya, R., Bang-Decker, M., Hughes, D. A., Mukherjee, P., Shah, V., Mc Niven, M. A. & Mukhopadhyay, D., Oct 2005, In : FASEB Journal. 19, 12, p. 1692-1694 3 p.

Research output: Contribution to journalArticle

vesicular transport proteins
Vesicular Transport Proteins
Dynamin II
guanosine triphosphate
Pathologic Neovascularization
39 Citations (Scopus)

Role of elongin-binding domain of von hippel lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma

Datta, K., Mondal, S., Sinha, S., Li, J., Wang, E., Knebelmann, B., Karumanchi, S. A. & Mukhopadhyay, D., Nov 24 2005, In : Oncogene. 24, 53, p. 7850-7858 9 p.

Research output: Contribution to journalArticle

RNA Stability
Renal Cell Carcinoma
Vascular Endothelial Growth Factor A
Genes
elongin
72 Citations (Scopus)

Vascular endothelial growth factor impairs the functional ability of dendritic cells through Id pathways

Laxmanan, S., Robertson, S. W., Wang, E., Lau, J. S., Briscoe, D. M. & Mukhopadhyay, D., Aug 19 2005, In : Biochemical and Biophysical Research Communications. 334, 1, p. 193-198 6 p.

Research output: Contribution to journalArticle

Dendritic Cells
Vascular Endothelial Growth Factor A
Immunity
Neoplasms
Tumors
177 Citations (Scopus)

VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis

Matsumoto, T., Bohman, S., Dixelius, J., Berge, T., Dimberg, A., Magnusson, P., Wang, L., Wikner, C., Qi, J. H., Wernstedt, C., Wu, J., Bruheim, S., Mugishima, H., Mukhopadhyay, D., Spurkland, A. & Claesson-Welsh, L., Jul 6 2005, In : EMBO Journal. 24, 13, p. 2342-2353 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Vascular Endothelial Growth Factor Receptor
T-cells
Vascular Endothelial Growth Factor Receptor-2
Tumors
2004
69 Citations (Scopus)

Ablation of peripheral dopaminergic nerves stimulates malignant tumor growth by inducing vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis

Basu, S., Sarkar, C., Chakroborty, D., Nagy, J., Mitra, R. B., Dasgupta, P. S. & Mukhopadhyay, D., Aug 15 2004, In : Cancer Research. 64, 16, p. 5551-5555 5 p.

Research output: Contribution to journalArticle

Peripheral Nerves
Vascular Endothelial Growth Factor A
Dopamine
Growth
Neoplasms
10 Citations (Scopus)

CD40-induced transcriptional activation of vascular endothelial growth factor involves a 68-bp region of the promoter containing a CpG island

Lapchak, P. H., Melter, M., Pal, S., Flaxenburg, J. A., Geehan, C., Frank, M. H., Mukhopadhyay, D. & Briscoe, D. M., Sep 2004, In : American Journal of Physiology - Renal Physiology. 287, 3 56-3

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
CD40 Ligand
CpG Islands
Genetic Promoter Regions
Vascular Endothelial Growth Factor A
28 Citations (Scopus)

Complexity in the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-receptors signaling

Mukhopadhyay, D., Zeng, H. & Bhattacharya, R., Sep 2004, In : Molecular and Cellular Biochemistry. 264, 1-2, p. 51-61 11 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor
Vascular Endothelial Growth Factor A
Embryonic Structures
Pathologic Neovascularization
Endothelial cells
77 Citations (Scopus)

Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer

Stephan, S., Datta, K., Wang, E., Li, J., Brekken, R. A., Parangi, S., Thorpe, P. E. & Mukhopadhyay, D., Oct 15 2004, In : Clinical Cancer Research. 10, 20, p. 6993-7000 8 p.

Research output: Contribution to journalArticle

Sirolimus
Pancreatic Neoplasms
Neoplasms
Therapeutics
Cell Proliferation
109 Citations (Scopus)

Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells

Bhattacharya, R., Mukherjee, P., Xiong, Z., Atala, A., Soker, S. & Mukhopadhyay, D., Dec 2004, In : Nano Letters. 4, 12, p. 2479-2481 3 p.

Research output: Contribution to journalArticle

heparins
Gold
Heparin
gold
Nanoparticles
87 Citations (Scopus)
Vascular Endothelial Growth Factor A
Neoplasms
Cell Line
Oxygen
RNA Stability
47 Citations (Scopus)

Protein Kinase C ζ Transactivates Hypoxia-Inducible Factor α by Promoting Its Association with p300 in Renal Cancer

Datta, K., Li, J., Bhattacharya, R., Gasparian, L., Wang, E. & Mukhopadhyay, D., Jan 15 2004, In : Cancer Research. 64, 2, p. 456-462 7 p.

Research output: Contribution to journalArticle

Kidney Neoplasms
Protein Kinase C
Renal Cell Carcinoma
Hypoxia-Inducible Factor 1
Asparagine
21 Citations (Scopus)

Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes

Datta, K., Li, J., Ananth Karumanchi, S., Wang, E., Rondeau, E. & Mukhopadhyay, D., Oct 2004, In : Kidney International. 66, 4, p. 1471-1478 8 p.

Research output: Contribution to journalArticle

Podocytes
Vascular Endothelial Growth Factor A
Kidney Glomerulus
Glomerular Filtration Barrier
Laminin Receptors
43 Citations (Scopus)

Role of Insulin Receptor Substrates and Protein Kinase C-ζ in Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Pancreatic Cancer Cells

Neid, M., Datta, K., Stephan, S., Khanna, I., Pal, S., Shaw, L., White, M. & Mukhopadhyay, D., Feb 6 2004, In : Journal of Biological Chemistry. 279, 6, p. 3941-3948 8 p.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Pancreatic Neoplasms
Protein Kinase C
Vascular Endothelial Growth Factor A
Cells
2003
59 Citations (Scopus)
Gq-G11 GTP-Binding Protein alpha Subunits
Vascular Endothelial Growth Factor Receptor-2
Phosphorylation
Vascular Endothelial Growth Factor A
Endothelial cells
161 Citations (Scopus)

Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration.

Wang, L., Zeng, H., Wang, P., Soker, S. & Mukhopadhyay, D., Dec 5 2003, In : The Journal of biological chemistry. 278, 49, p. 48848-48860 13 p.

Research output: Contribution to journalArticle

Neuropilin-1
Endothelial cells
Vascular Endothelial Growth Factor A
Cell Movement
Endothelial Cells
170 Citations (Scopus)

Proinflammatory functions of vascular endothelial growth factor in alloimmunity

Reinders, M. E. J., Sho, M., Izawa, A., Wang, P., Mukhopadhyay, D., Koss, K. E., Geehan, C. S., Luster, A. D., Sayegh, M. H. & Briscoe, D. M., Dec 2003, In : Journal of Clinical Investigation. 112, 11, p. 1655-1665 11 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Allografts
T-Lymphocytes
Endothelial Cells
Chemokines
58 Citations (Scopus)
IGF Type 1 Receptor
Vascular Endothelial Growth Factor A
Cells
Cell Line
Cell proliferation
2002
49 Citations (Scopus)
Monomeric GTP-Binding Proteins
Pertussis Toxin
Endothelial cells
Protein Subunits
Cell proliferation
6 Citations (Scopus)
Vascular Endothelial Growth Factors
Endothelial Growth Factors
Recombinant Fusion Proteins
Heterotrimeric GTP-Binding Proteins
Vascular Endothelial Growth Factor Receptor-2
96 Citations (Scopus)

KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA

Zeng, H., Zhao, D. & Mukhopadhyay, D., Nov 29 2002, In : Journal of Biological Chemistry. 277, 48, p. 46791-46798 8 p.

Research output: Contribution to journalArticle

Heterotrimeric GTP-Binding Proteins
Monomeric GTP-Binding Proteins
Endothelial cells
Vascular Endothelial Growth Factor A
Cell Movement
127 Citations (Scopus)

Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth

Takahashi, A., Kureishi, Y., Yang, J., Luo, Z., Guo, K., Mukhopadhyay, D., Ivashchenko, Y., Branellec, D. & Walsh, K., 2002, In : Molecular and Cellular Biology. 22, 13, p. 4803-4814 12 p.

Research output: Contribution to journalArticle

Hypertrophy
Blood Vessels
Vascular Endothelial Growth Factor A
Growth
Skeletal Muscle
2001
254 Citations (Scopus)

Cell surface glypicans are low-affinity endostatin receptors

Karumanchi, S. A., Jha, V., Ramchandran, R., Karihaloo, A., Tsiokas, L., Chan, B., Dhanabal, M., Hanai, J. I., Venkataraman, G., Shriver, Z., Keiser, N., Kalluri, R., Zeng, H., Mukhopadhyay, D., Chen, R. L., Lander, A. D., Hagihara, K., Yamaguchi, Y., Sasisekharan, R., Cantley, L. & 1 others, Sukhatme, V. P., Apr 2001, In : Molecular Cell. 7, 4, p. 811-822 12 p.

Research output: Contribution to journalArticle

Glypicans
Endostatins
Endothelial Cells
Collagen Type XVIII
Angiogenic Proteins
165 Citations (Scopus)

Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma

Pal, S., Datta, K. & Mukhopadhyay, D., Sep 15 2001, In : Cancer Research. 61, 18, p. 6952-6957 6 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Breast Neoplasms
src-Family Kinases
Angiogenic Proteins
src Genes
65 Citations (Scopus)

Role of Protein Kinase Cζ in Ras-mediated Transcriptional Activation of Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression

Pal, S., Datta, K., Khosravi-Far, R. & Mukhopadhyay, D., Jan 26 2001, In : Journal of Biological Chemistry. 276, 4, p. 2395-2403 9 p.

Research output: Contribution to journalArticle

Protein Kinase C
Vascular Endothelial Growth Factor A
Transcriptional Activation
Chemical activation
Transcription
79 Citations (Scopus)

The 104-123 amino acid sequence of the β-domain of von Hippel-Lindau gene product is sufficient to inhibit renal tumor growth and invasion

Datta, K., Sundberg, C., Karumanchi, S. A. & Mukhopadhyay, D., Mar 1 2001, In : Cancer Research. 61, 5, p. 1768-1775 8 p.

Research output: Contribution to journalArticle

Amino Acid Sequence
Renal Cell Carcinoma
Kidney
Peptides
Growth
254 Citations (Scopus)

The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor

Basu, S., Nagy, J. A., Pal, S., Vasile, E., Eckelhoefer, I. A., Bliss, V. S., Manseau, E. J., Dasgupta, P. S., Dvorak, H. F. & Mukhopadhyay, D., May 2001, In : Nature Medicine. 7, 5, p. 569-574 6 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Neurotransmitter Agents
Dopamine
Vascular Endothelial Growth Factor Receptor
Dopamine D2 Receptors
124 Citations (Scopus)
Vascular Endothelial Growth Factor Receptor-2
Vascular Endothelial Growth Factor A
Endothelium
Tyrosine
Endothelial cells
241 Citations (Scopus)
Phosphatidylinositol 3-Kinase
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Endothelial cells
Cell proliferation
2000
2 Citations (Scopus)
Phorbol Esters
Glioblastoma
Protein Kinase C
Vascular Endothelial Growth Factor A
Protein Isoforms
74 Citations (Scopus)

Inhibition of insulin-like growth factor-I-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer

Datta, K., Nambudripad, R., Pal, S., Zhou, M., Cohen, H. T. & Mukhopadhyay, D., Jul 7 2000, In : Journal of Biological Chemistry. 275, 27, p. 20700-20706 7 p.

Research output: Contribution to journalArticle

Cell signaling
Kidney Neoplasms
Insulin-Like Growth Factor I
Tumors
Genes
165 Citations (Scopus)

Ligation of CD40 induces the expression of vascular endothelial growth factor by endothelial cells and monocytes and promotes angiogenesis in vivo

Melter, M., Reinders, M. E. J., Sho, M., Pal, S., Geehan, C., Denton, M. D., Mukhopadhyay, D. & Briscoe, D. M., Dec 1 2000, In : Blood. 96, 12, p. 3801-3808 8 p.

Research output: Contribution to journalArticle

Endothelial cells
Vascular Endothelial Growth Factor A
Ligation
CD40 Ligand
Monocytes
160 Citations (Scopus)

Oncogenes and tumor angiogenesis: The HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner

López-Ocejo, O., Viloria-Petit, A., Bequet-Romero, M., Mukhopadhyay, D., Rak, J. & Kerbel, R. S., Sep 21 2000, In : Oncogene. 19, 40, p. 4611-4620 10 p.

Research output: Contribution to journalArticle

Papillomaviridae
Oncogene Proteins
Oncogenes
Vascular Endothelial Growth Factor A
Genes
34 Citations (Scopus)

Retinoic acid selectively inhibits the vascular permeabilizing effect of VPF/VEGF, an early step in the angiogenic cascade

Pal, S., Iruela-Arispe, M. L., Harvey, V. S., Zeng, H., Nagy, J. A., Dvorak, H. F. & Mukhopadhyay, D., 2000, In : Microvascular Research. 60, 2, p. 112-120 9 p.

Research output: Contribution to journalArticle

Tretinoin
Vascular Endothelial Growth Factor A
Blood Vessels
Endothelial cells
Retinoids
1999
42 Citations (Scopus)

An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association

Cohen, H. T., Zhou, M., Welsh, A. M., Zarghamee, S., Scholz, H., Mukhopadhyay, D., Kishida, T., Zbar, B., Knebelmann, B. & Sukhatme, V. P., Dec 9 1999, In : Biochemical and Biophysical Research Communications. 266, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle

Metalloproteins
von Hippel-Lindau Disease
Zinc Fingers
Transcription
Renal Cell Carcinoma
83 Citations (Scopus)

Role of protein kinase C isoforms in phorbol ester-induced vascular endothelial growth factor expression in human glioblastoma cells

Shih, S. C., Mullen, A., Abrams, K., Mukhopadhyay, D. & Claffey, K. P., May 28 1999, In : Journal of Biological Chemistry. 274, 22, p. 15407-15414 8 p.

Research output: Contribution to journalArticle

Phorbol Esters
Glioblastoma
Protein Kinase C
Vascular Endothelial Growth Factor A
Protein Isoforms
1998
155 Citations (Scopus)

Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C ζ

Pal, S., Claffey, K. P., Cohen, H. T. & Mukhopadhyay, D., Oct 9 1998, In : Journal of Biological Chemistry. 273, 41, p. 26277-26280 4 p.

Research output: Contribution to journalArticle

Transcription
Protein Kinase C
Vascular Endothelial Growth Factor A
Chemical activation
Renal Cell Carcinoma
38 Citations (Scopus)
Estrous Cycle
Vascular Endothelial Growth Factor A
Uterus
Proestrus
Estrus
23 Citations (Scopus)

Expression of fetal kidney growth factors in a kidney tumor line: Role of FGF2 in kidney development

Drummond, I. A., Mukhopadhyay, D. & Sukhatme, V. P., 1998, In : Experimental Nephrology. 6, 6, p. 522-533 12 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Fetal Development
Intercellular Signaling Peptides and Proteins
Kidney
Mitogens
25 Citations (Scopus)

High cell density induces vascular endothelial growth factor expression via protein tyrosine phosphorylation

Mukhopadhyay, D., Tsiokas, L. & Sukhatme, V. P., 1998, In : Gene Expression. 7, 1, p. 53-60 8 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Tyrosine
Cell Count
Phosphorylation
Messenger RNA
105 Citations (Scopus)

Modulation of voltage-dependent Ca2+ channels in rabbit colonic smooth muscle cells by c-Src and focal adhesion kinase

Hu, X. Q., Singh, N., Mukhopadhyay, D. & Akbarali, H. I., Feb 27 1998, In : Journal of Biological Chemistry. 273, 9, p. 5337-5342 6 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Smooth Muscle Myocytes
Muscle
Cells
Modulation
87 Citations (Scopus)

Vascular permeability factor/vascular endothelial growth factor-mediated signaling in mouse mesentery vascular endothelium

Mukhopadhyay, D., Nagy, J. A., Manseau, E. J. & Dvorak, H. F., Mar 15 1998, In : Cancer Research. 58, 6, p. 1278-1284 7 p.

Research output: Contribution to journalArticle

Mesentery
Vascular Endothelium
Vascular Endothelial Growth Factor A
Microvessels
Phosphorylation
1997
131 Citations (Scopus)
Renal Cell Carcinoma
Protein Kinase C
Vascular Endothelial Growth Factor A
Genes
Cells
294 Citations (Scopus)

The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity

Mukhopadhyay, D., Knebelmann, B., Cohen, H. T., Ananth, S. & Sukhatme, V. P., Sep 1997, In : Molecular and Cellular Biology. 17, 9, p. 5629-5639 11 p.

Research output: Contribution to journalArticle

Tumor Suppressor Genes
Vascular Endothelial Growth Factor A
Renal Cell Carcinoma
von Hippel-Lindau Disease
Cell Line
1996
25 Citations (Scopus)
Gene expression
Vascular Endothelial Growth Factor A
Gene Expression
Caffeine
Cromakalim
38 Citations (Scopus)

Tyrosine kinase-dependent modulation of calcium entry in rabbit colonic muscularis mucosae

Hatakeyama, N., Mukhopadhyay, D., Goyal, R. K. & Akbarali, H. I., Jun 1996, In : American Journal of Physiology - Cell Physiology. 270, 6 39-6

Research output: Contribution to journalArticle

Carbachol
Protein-Tyrosine Kinases
Mucous Membrane
Modulation
Genistein
1995
515 Citations (Scopus)

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

Mukhopadhyay, D., Tsiokas, L., Zhou, X. M., Foster, D., Brugge, J. S. & Sukhatme, V. P., 1995, In : Nature. 375, 6532, p. 577-581 5 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Protein-Tyrosine Kinases
Tyrosine
Angiogenic Proteins
Sinorhizobium meliloti
392 Citations (Scopus)

Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression

Mukhopadhyay, D., Tsiokas, L. & Sukhatme, V. P., 1995, In : Cancer Research. 55, 24, p. 6161-6165 5 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Gene Expression
src Genes
human VEGFA protein
Angiogenesis Inducing Agents
1994
2 Citations (Scopus)

3-Aminobenzamide delays rejoining of DNA strand breaks in γ-irradiated lymphocytes from patients with breast cancer and not cervical cancer

Mukhopadhyay, D., Anant, S. & Mukherji, S., 1994, In : Neoplasma. 41, 3, p. 151-157 7 p.

Research output: Contribution to journalArticle

DNA Breaks
Uterine Cervical Neoplasms
Lymphocytes
Breast Neoplasms
Poly(ADP-ribose) Polymerases
15 Citations (Scopus)
Organometallics
Operon
Mercury
Purification
Plasmids