Debabrata Mukhopadhyay, PhD

  • 15555 Citations
  • 62 Scopus h-Index
1991 …2020

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2014

Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice

Wang, W., Qin, J. J., Voruganti, S., Wang, M. H., Sharma, H., Patil, S., Zhou, J., Wang, H., Mukhopadhyay, D., Buolamwini, J. K. & Zhang, R., Oct 1 2014, In : Gastroenterology. 147, 4, p. 893-902.e2

Research output: Contribution to journalArticle

41 Scopus citations

Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth

Pal, K., Pletnev, A. A., Dutta, S. K., Wang, E., Zhao, R., Baral, A., Yadav, V. K., Aggarwal, S., Krishnaswamy, S., Alkharfy, K. M., Chowdhury, S., Spaller, M. R. & Mukhopadhyay, D., Aug 14 2014, In : Molecular Cancer Therapeutics. 13, 10, p. 2264-2275 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Inhibition of gsk-3 induces differentiation and impaired glucose metabolism in renal cancer

Pal, K., Cao, Y., Gaisina, I. N., Bhattacharya, S., Dutta, S. K., Wang, E., Gunosewoyo, H., Kozikowski, A. P., Billadeau, D. D. & Mukhopadhyay, D., Feb 2014, In : Molecular cancer therapeutics. 13, 2, p. 285-296 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Non-metastatic 2 (NME2)-mediated suppression of lung cancer metastasis involves transcriptional regulation of key cell adhesion factor vinculin

Thakur, R. K., Yadav, V. K., Kumar, A., Singh, A., Pal, K., Hoeppner, L., Saha, D., Purohit, G., Basundra, R., Kar, A., Halder, R., Kumar, P., Baral, A., Kumar, M. J. M., Baldi, A., Vincenzi, B., Lorenzon, L., Banerjee, R., Kumar, P., Shridhar, V. & 2 others, Mukhopadhyay, D. & Chowdhury, S., Sep 12 2014, In : Nucleic acids research. 42, 18, p. 11589-11600 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Selective assembly of DNA-conjugated single-walled carbon nanotubes from the vascular secretome

Gong, X., Sharma, A. K., Strano, M. S. & Mukhopadhyay, D., Sep 23 2014, In : ACS Nano. 8, 9, p. 9126-9136 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Spatiotemporal intracellular nitric oxide signaling captured using internalized, near-infrared fluorescent carbon nanotube nanosensors

Ulissi, Z. W., Sen, F., Gong, X., Sen, S., Iverson, N., Boghossian, A. A., Godoy, L. C., Wogan, G. N., Mukhopadhyay, D. & Strano, M. S., Aug 13 2014, In : Nano Letters. 14, 8, p. 4887-4894 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

The role of Factor Inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme

Wang, E., Zhang, C., Polavaram, N., Liu, F., Wu, G., Schroeder, M. A., Lau, J. S., Mukhopadhyay, D., Jiang, S. W., O'Neill, B. P., Datta, K. & Li, J., Jan 23 2014, In : PloS one. 9, 1, e86102.

Research output: Contribution to journalArticle

19 Scopus citations

The role of Iex-1 in the pathogenesis of venous neointimal hyperplasia associated with hemodialysis arteriovenous fistula

Brahmbhatt, A., NievesTorres, E., Yang, B., Edwards, W. D., Chaudhury, P. R., Lee, M. K., Kong, H., Mukhopadhyay, D., Kumar, R. & Misra, S., Jul 18 2014, In : PloS one. 9, 7, e102542.

Research output: Contribution to journalArticle

13 Scopus citations

Vascular endothelial growth factor promotes fibrosis resolution and repair in mice

Yang, L., Kwon, J., Popov, Y., Gajdos, G. B., Ordog, T., Brekken, R. A., Mukhopadhyay, D., Schuppan, D., Bi, Y., Simonetto, D. & Shah, V. H., May 2014, In : Gastroenterology. 146, 5, p. 1339-1350.e1

Research output: Contribution to journalArticle

125 Scopus citations
2013

Antibody modified Bovine Serum Albumin microspheres for targeted delivery of anticancer agent Gemcitabine

Grinberg, O., Gedanken, A., Mukhopadhyay, D. & Patra, C. R., Mar 1 2013, In : Polymers for Advanced Technologies. 24, 3, p. 294-299 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence

Kottke, T., Boisgerault, N., Diaz, R. M., Donnelly, O., Rommelfanger-Konkol, D., Pulido, J., Thompson, J., Mukhopadhyay, D., Kaspar, R., Coffey, M., Pandha, H., Melcher, A., Harrington, K., Selby, P. & Vile, R., Dec 1 2013, In : Nature Medicine. 19, 12, p. 1625-1631 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Neuropilin-2 promotes extravasation and metastasis by interacting with endothelial α5 integrin

Cao, Y., Hoeppner, L. H., Bach, S., Guangqi, E., Guo, Y., Wang, E., Wu, J., Cowley, M. J., Chang, D. K., Waddell, N., Grimmond, S. M., Biankin, A. V., Daly, R. J., Zhang, X. & Mukhopadhyay, D., Jul 15 2013, In : Cancer research. 73, 14, p. 4579-4590 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cells in vivo

Sinha, S., Pal, K., Elkhanany, A., Dutta, S., Cao, Y., Mondal, G., Iyer, S., Somasundaram, V., Couch, F. J., Shridhar, V., Bhattacharya, R., Mukhopadhyay, D. & Srinivas, P., Mar 1 2013, In : International Journal of Cancer. 132, 5, p. 1201-1212 12 p.

Research output: Contribution to journalArticle

70 Scopus citations

Simvastatin reduces venous stenosis formation in a murine hemodialysis vascular access model

Janardhanan, R., Yang, B., Vohra, P., Roy, B., Withers, S., Bhattacharya, S., Mandrekar, J., Kong, H., Leof, E. B., Mukhopadhyay, D. & Misra, S., Aug 2013, In : Kidney international. 84, 2, p. 338-352 15 p.

Research output: Contribution to journalArticle

41 Scopus citations
2012

Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in β cells and mice

Aggarwal, G., Ramachandran, V., Javeed, N., Arumugam, T., Dutta, S., Klee, G. G., Klee, E. W., Smyrk, T. C., Bamlet, W., Han, J. J., Rumie Vittar, N. B., De Andrade, M., Mukhopadhyay, D., Petersen, G. M., Fernandez-Zapico, M. E., Logsdon, C. D. & Chari, S. T., Dec 2012, In : Gastroenterology. 143, 6, p. 1510-1517.e1

Research output: Contribution to journalArticle

95 Scopus citations

Chemically modified peptides targeting the PDZ domain of GIPC as a therapeutic approach for cancer

Patra, C. R., Rupasinghe, C. N., Dutta, S. K., Bhattacharya, S., Wang, E., Spaller, M. R. & Mukhopadhyay, D., Apr 20 2012, In : ACS Chemical Biology. 7, 4, p. 770-779 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

DNA conjugated SWCNTs enter endothelial cells via Rac1 mediated macropinocytosis

Bhattacharya, S., Roxbury, D., Gong, X., Mukhopadhyay, D. & Jagota, A., Apr 11 2012, In : Nano Letters. 12, 4, p. 1826-1830 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

Dopamine inhibits pulmonary edema through the VEGF-VEGFR2 axis in a murine model of acute lung injury

Vohra, P. K., Hoeppner, L. H., Sagar, G., Dutta, S. K., Misra, S., Hubmayr, R. D. & Mukhopadhyay, D., Jan 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 302, 2, p. 185-192 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Endogenous vascular endothelial growth factor-A (VEGF-A) maintains endothelial cell homeostasis by regulating VEGF receptor-2 transcription

E, G., Cao, Y., Bhattacharya, S., Dutta, S., Wang, E. & Mukhopadhyay, D., Jan 27 2012, In : Journal of Biological Chemistry. 287, 5, p. 3029-3041 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Nanomedicine: Pharmacological perspectives

Bhattacharya, S., Alkharfy, K. M., Janardhanan, R. & Mukhopadhyay, D., Jun 1 2012, In : Nanotechnology Reviews. 1, 3, p. 235-253 19 p.

Research output: Contribution to journalArticle

11 Scopus citations

Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment

Yaqoob, U., Cao, S., Shergill, U., Jagavelu, K., Geng, Z., Yin, M., De Assuncao, T. M., Cao, Y., Szabolcs, A., Thorgeirsson, S., Schwartz, M., Yang, J. D., Ehman, R., Roberts, L., Mukhopadhyay, D. & Shah, V. H., Aug 15 2012, In : Cancer research. 72, 16, p. 4047-4059 13 p.

Research output: Contribution to journalArticle

80 Scopus citations

NHERF-2 maintains endothelial homeostasis

Bhattacharya, R., Wang, E., Dutta, S. K., Vohra, P. K., Guangqi, E., Prakash, Y. S. & Mukhopadhyay, D., May 17 2012, In : Blood. 119, 20, p. 4798-4806 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M. C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A. M., Wu, J., Chang, D. K., Cowley, M. J., Gardiner, B. B., Song, S., Harliwong, I., Idrisoglu, S., Nourse, C., Nourbakhsh, E., Manning, S., Wani, S. & 106 others, Gongora, M., Pajic, M., Scarlett, C. J., Gill, A. J., Pinho, A. V., Rooman, I., Anderson, M., Holmes, O., Leonard, C., Taylor, D., Wood, S., Xu, Q., Nones, K., Fink, J. L., Christ, A., Bruxner, T., Cloonan, N., Kolle, G., Newell, F., Pinese, M., Mead, R. S., Humphris, J. L., Kaplan, W., Jones, M. D., Colvin, E. K., Nagrial, A. M., Humphrey, E. S., Chou, A., Chin, V. T., Chantrill, L. A., Mawson, A., Samra, J. S., Kench, J. G., Lovell, J. A., Daly, R. J., Merrett, N. D., Toon, C., Epari, K., Nguyen, N. Q., Barbour, A., Zeps, N., Kakkar, N., Zhao, F., Wu, Y. Q., Wang, M., Muzny, D. M., Fisher, W. E., Brunicardi, F. C., Hodges, S. E., Reid, J. G., Drummond, J., Chang, K., Han, Y., Lewis, L. R., Dinh, H., Buhay, C. J., Beck, T., Timms, L., Sam, M., Begley, K., Brown, A., Pai, D., Panchal, A., Buchner, N., De Borja, R., Denroche, R. E., Yung, C. K., Serra, S., Onetto, N., Mukhopadhyay, D., Tsao, M. S., Shaw, P. A., Petersen, G. M., Gallinger, S., Hruban, R. H., Maitra, A., Iacobuzio-Donahue, C. A., Schulick, R. D., Wolfgang, C. L., Morgan, R. A., Lawlor, R. T., Capelli, P., Corbo, V., Scardoni, M., Tortora, G., Tempero, M. A., Mann, K. M., Jenkins, N. A., Perez-Mancera, P. A., Adams, D. J., Largaespada, D. A., Wessels, L. F. A., Rust, A. G., Stein, L. D., Tuveson, D. A., Copeland, N. G., Musgrove, E. A., Scarpa, A., Eshleman, J. R., Hudson, T. J., Sutherland, R. L., Wheeler, D. A., Pearson, J. V., McPherson, J. D., Gibbs, R. A. & Grimmond, S. M., Nov 15 2012, In : Nature. 491, 7424, p. 399-405 7 p.

Research output: Contribution to journalArticle

1128 Scopus citations

Revealing the role of phospholipase Cβ3 in the regulation of VEGF-induced vascular permeability

Hoeppner, L. H., Phoenix, K. N., Clark, K. J., Bhattacharya, R., Gong, X., Sciuto, T. E., Vohra, P., Suresh, S., Bhattacharya, S., Dvorak, A. M., Ekker, S. C., Dvorak, H. F., Claffey, K. P. & Mukhopadhyay, D., Sep 13 2012, In : Blood. 120, 11, p. 2167-2173 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Tissue factor pathway inhibitor blocks angiogenesis via its carboxyl terminus

Holroyd, E. W., Delacroix, S., Larsen, K., Harbuzariu, A., Psaltis, P. J., Wang, L., Pan, S., White, T. A., Witt, T. A., Kleppe, L. S., Mueske, C. S., Mukhopadhyay, D. & Simari, R. D., Mar 1 2012, In : Arteriosclerosis, thrombosis, and vascular biology. 32, 3, p. 704-711 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Vaccines targeting tumor blood vessel antigens promote CD8 + T cell-dependent tumor eradication or dormancy in HLA-A2 transgenic mice

Zhao, X., Bose, A., Komita, H., Taylor, J. L., Chi, N., Lowe, D. B., Okada, H., Cao, Y., Mukhopadhyay, D., Cohen, P. A. & Storkus, W. J., Feb 15 2012, In : Journal of Immunology. 188, 4, p. 1782-1788 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression

Cao, Y., E, G., Wang, E., Pal, K., Dutta, S. K., Bar-Sagi, D. & Mukhopadhyay, D., Aug 15 2012, In : Cancer research. 72, 16, p. 3912-3918 7 p.

Research output: Contribution to journalArticle

87 Scopus citations
2011

A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth

Fernandez-Zapico, M. E., Lomberk, G. A., Tsuji, S., DeMars, C. J., Bardsley, M. R., Lin, Y. H., Almada, L. L., Han, J. J., Mukhopadhyay, D., Ordog, T., Buttar, N. S. & Urrutia, R., Apr 15 2011, In : Biochemical Journal. 435, 2, p. 529-537 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

A lipid-modified estrogen derivative that treats breast cancer independent of estrogen receptor expression through simultaneous induction of autophagy and apoptosis

Sinha, S., Roy, S., Reddy, B. S., Pal, K., Sudhakar, G., Iyer, S., Dutta, S., Wang, E., Vohra, P. K., Roy, K. R., Reddanna, P., Mukhopadhyay, D. & Banerjee, R., Mar 2011, In : Molecular Cancer Research. 9, 3, p. 364-374 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
Open Access
18 Scopus citations

Designing nanoconjugates to effectively target pancreatic cancer cells in vitro and in vivo

Khan, J. A., Kudgus, R. A., Szabolcs, A., Dutta, S., Wang, E., Cao, S., Curran, G. L., Shah, V., Curley, S., Mukhopadhyay, D., Robertson, J. D., Bhattacharya, R. & Mukherjee, P., 2011, In : PloS one. 6, 6, e20347.

Research output: Contribution to journalArticle

45 Scopus citations

Effect of hyperglycemia on human monocyte activation

Nandy, D., Janardhanan, R., Mukhopadhyay, D. & Basu, A., Apr 2011, In : Journal of Investigative Medicine. 59, 4, p. 661-667 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Precise scheduling of chemotherapy primes VEGF-producing tumors for successful systemic oncolytic virotherapy

Kottke, T., Chester, J., Ilett, E., Thompson, J., Diaz, R., Coffey, M., Selby, P., Nuovo, G., Pulido, J., Mukhopadhyay, D., Pandha, H., Harrington, K., Melcher, A. & Vile, R., Oct 2011, In : Molecular Therapy. 19, 10, p. 1802-1812 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Reactive oxygen species driven angiogenesis by inorganic nanorods

Patra, C. R., Kim, J. H., Pramanik, K., D'Uscio, L. V., Patra, S., Pal, K., Ramchandran, R., Strano, M. S. & Mukhopadhyay, D., Nov 9 2011, In : Nano Letters. 11, 11, p. 4932-4938 7 p.

Research output: Contribution to journalArticle

51 Scopus citations

Regulation of vascular endothelial growth factor receptor 2 trafficking and angiogenesis by Golgi localized t-SNARE syntaxin 6

Manickam, V., Tiwari, A., Jung, J. J., Bhattacharya, R., Goel, A., Mukhopadhyay, D. & Choudhury, A., Jan 27 2011, In : Blood. 117, 4, p. 1425-1435 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Single-molecule detection of H2O2 mediating angiogenic redox signaling on fluorescent single-walled carbon nanotube array

Kim, J. H., Patra, C. R., Arkalgud, J. R., Boghossian, A. A., Zhang, J., Han, J. H., Reuel, N. F., Ahn, J. H., Mukhopadhyay, D. & Strano, M. S., Oct 25 2011, In : ACS Nano. 5, 10, p. 7848-7857 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Structure-activity study to develop cationic lipid-conjugated haloperidol derivatives as a new class of anticancer therapeutics

Pal, K., Pore, S., Sinha, S., Janardhanan, R., Mukhopadhyay, D. & Banerjee, R., Apr 14 2011, In : Journal of Medicinal Chemistry. 54, 7, p. 2378-2390 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: Implications for therapy

Ghosh, A. K., Secreto, C., Boysen, J., Sassoon, T., Shanafelt, T. D., Mukhopadhyay, D. & Kay, N. E., Feb 10 2011, In : Blood. 117, 6, p. 1928-1937 10 p.

Research output: Contribution to journalArticle

81 Scopus citations

Von Hippel-Lindau gene product directs cytokinesis: A new tumor suppressor function

Sinha, S., Mondal, G., Hwang, E. J., Han, D. W., Dutta, S. K., Iyer, S., Karumanchi, S. A., Kim, K. I., Couch, F. J. & Mukhopadhyay, D., Jul 1 2011, In : Journal of cell science. 124, 13, p. 2132-2142 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
2010

A core-shell nanomaterial with endogenous therapeutic and diagnostic functions

Patra, C. R., Jing, Y., Xu, Y. H., Bhattacharya, R., Mukhopadhyay, D., Glockner, J. F., Wang, J. P. & Mukherjee, P., Dec 1 2010, In : Cancer Nanotechnology. 1, 1-6, p. 13-18 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
17 Scopus citations

Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: Implications for disease progression

Ghosh, A. K., Secreto, C. R., Knox, T. R., Ding, W., Mukhopadhyay, D. & Kay, N. E., Mar 4 2010, In : Blood. 115, 9, p. 1755-1764 10 p.

Research output: Contribution to journalArticle

149 Scopus citations

Endothelial cell-specific chemotaxis receptor (ecscr) promotes angioblast migration during vasculogenesis and enhances VEGF receptor sensitivity

Verma, A., Bhattacharya, R., Remadevi, I., Li, K., Pramanik, K., Samant, G. V., Horswill, M., Chun, C. Z., Zhao, B., Wang, E., Miao, R. Q., Mukhopadhyay, D., Ramchandran, R. & Wilkinson, G. A., Jun 3 2010, In : Blood. 115, 22, p. 4614-4622 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
39 Scopus citations

Fabrication and characterization of an inorganic gold and silica nanoparticle mediated drug delivery system for nitric oxide.

Das, A., Mukherjee, P., Singla, S. K., Guturu, P., Frost, M. C., Mukhopadhyay, D., Shah, V. H. & Patra, C. R., Jul 30 2010, In : Nanotechnology. 21, 30, 1 p.

Research output: Contribution to journalArticle

34 Scopus citations
36 Scopus citations

Neuropilin-1 mediates divergent R-smad signaling and the myofibroblast phenotype

Cao, Y., Szabolcs, A., Dutta, S. K., Yaqoob, U., Jagavelu, K., Wang, L., Leof, E. B., Urrutia, R. A., Shah, V. H. & Mukhopadhyay, D., Oct 8 2010, In : Journal of Biological Chemistry. 285, 41, p. 31840-31848 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells

Cao, S., Yaqoob, U., Das, A., Shergill, U., Jagavelu, K., Huebert, R. C., Routray, C., Abdelmoneim, S., Vasdev, M., Leof, E., Charlton, M., Watts, R. J., Mukhopadhyay, D. & Shah, V. H., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2379-2394 16 p.

Research output: Contribution to journalArticle

103 Scopus citations

Pancreatic stellate cell models for transcriptional studies of desmoplasia-associated genes

Mathison, A., Liebl, A., Bharucha, J., Mukhopadhyay, D., Lomberk, G., Shah, V. & Urrutia, R., Oct 2010, In : Pancreatology. 10, 4, p. 505-516 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

RGS-GAIP-interacting protein controls breast cancer progression

Wang, L., Lau, J. S., Patra, C. R., Cao, Y., Bhattacharya, S., Dutta, S., Nandy, D., Wang, E., Rupasinghe, C. N., Vohra, P., Spaller, M. R. & Mukhopadhyay, D., Dec 2010, In : Molecular Cancer Research. 8, 12, p. 1591-1600 10 p.

Research output: Contribution to journalArticle

14 Scopus citations