David T Jones, MD

  • 3086 Citations
  • 27 Scopus h-Index
20112020
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Research Output 2011 2020

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2020

Trajectory of lobar atrophy in asymptomatic and symptomatic GRN mutation carriers: a longitudinal MRI study

Chen, Q., Boeve, B. F., Senjem, M., Tosakulwong, N., Lesnick, T., Brushaber, D., Dheel, C., Fields, J., Forsberg, L., Gavrilova, R., Gearhart, D., Graff-Radford, J., Graff-Radford, N., Jack, C. R., Jones, D., Knopman, D., Kremers, W. K., Lapid, M., Rademakers, R., Ramos, E. M. & 5 others, Syrjanen, J., Boxer, A. L., Rosen, H., Wszolek, Z. K. & Kantarci, K., Jan 1 2020, (Accepted/In press) In : Neurobiology of aging.

Research output: Contribution to journalArticle

Atrophy
Longitudinal Studies
Mutation
Temporal Lobe
Frontotemporal Lobar Degeneration
2019
Open Access
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Executive Function
Dementia
Clinical Trials
7 Citations (Scopus)
Amyloid
Dementia
Biomarkers
Positron-Emission Tomography
National Institute on Aging (U.S.)

Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers

Chen, Q., Boeve, B. F., Tosakulwong, N., Lesnick, T., Brushaber, D., Dheel, C., Fields, J. A., Forsberg, L., Gavrilova, R. M., Gearhart, D., Haley, D., Gunter, J. L., Graff-Radford, J., Jones, D. T., Knopman, D. S., Graff Radford, N. R., Kraft, R., Lapid, M. I., Rademakers, R. V., Wszolek, Z. K. & 3 others, Rosen, H., Boxer, A. L. & Kantarci, K. M., Jan 1 2019, In : Journal of Neuroimaging.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Magnetic Resonance Spectroscopy
Mutation
Brain
Gyrus Cinguli
1 Citation (Scopus)
Intelligence Tests
Dementia
Alzheimer Disease
Referral and Consultation
Research
1 Citation (Scopus)

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

Lowe, V. J., Bruinsma, T. J., Wiste, H. J., Min, H. K., Weigand, S. D., Fang, P., Senjem, M. L., Therneau, T. M., Boeve, B. F., Josephs, K. A., Pandey, M. K., Murray, M. E., Kantarci, K., Jones, D. T., Vemuri, P., Graff-Radford, J., Schwarz, C. G., Machulda, M. M., Mielke, M. M., Roberts, R. O. & 3 others, Knopman, D. S., Petersen, R. C. & Jack, C. R., Jul 2 2019, In : Neurology. 93, 1, p. e29-e39

Research output: Contribution to journalArticle

Entorhinal Cortex
Temporal Lobe
Cognition
Amyloid
Brain

CSF1R mutation presenting as dementia with Lewy bodies

Sharma, R., Graff-Radford, J., Rademakers, R. V., Boeve, B. F., Petersen, R. C. & Jones, D. T., Jan 1 2019, In : Neurocase.

Research output: Contribution to journalArticle

Lewy Body Disease
Mutation
Colony-Stimulating Factor Receptors
Leukoencephalopathies
Macrophage Colony-Stimulating Factor
Normal Pressure Hydrocephalus
Subarachnoid Space
Hydrocephalus
Atrophy
Autopsy
11 Citations (Scopus)
Entorhinal Cortex
Amyloid
Biomarkers
Repression (Psychology)
Verbal Learning
Dementia
Lewy Body Disease
Alzheimer Disease
Frontotemporal Dementia
1 Citation (Scopus)

Frontal lobe 1H MR spectroscopy in asymptomatic and symptomatic MAPT mutation carriers

Chen, Q., Boeve, B. F., Tosakulwong, N., Lesnick, T., Brushaber, D., Dheel, C., Fields, J. A., Forsberg, L., Gavrilova, R. M., Gearhart, D., Haley, D., Gunter, J. L., Graff-Radford, J., Jones, D. T., Knopman, D. S., Graff Radford, N. R., Kraft, R., Lapid, M. I., Rademakers, R. V., Syrjanen, J. & 4 others, Wszolek, Z. K., Rosen, H., Boxer, A. L. & Kantarci, K. M., Jan 1 2019, In : Neurology. 93, 8, p. E758-E765

Research output: Contribution to journalArticle

Microtubule-Associated Proteins
Frontal Lobe
Magnetic Resonance Spectroscopy
Creatine
Inositol
3 Citations (Scopus)

Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration

ARTFL/LEFFTDS consortium, Jan 1 2019, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Lobar Degeneration
Atrophy
Dementia
Logistic Models
Brain

Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 13845.

Research output: Contribution to journalArticle

Open Access
Hippocampus
Alzheimer Disease
Biomarkers
Magnetic Resonance Imaging
Diffusion Magnetic Resonance Imaging
1 Citation (Scopus)

Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease

Lowe, V., Lundt, E. S., Albertson, S. M., Przybelski, S. A., Senjem, M. L., Parisi, J. E., Kantarci, K. M., Boeve, B. F., Jones, D. T., Knopman, D. S., Jack, C. R. J., Dickson, D. W., Petersen, R. C. & Murray, M. E., Jan 1 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Neuroimaging
Neurodegenerative Diseases
Amyloid Plaques
Alzheimer Disease
Autopsy
1 Citation (Scopus)

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Nature communications. 10, 1, 3310.

Research output: Contribution to journalArticle

Open Access
loci
Alzheimer Disease
Haplotypes
Endophenotypes
brain
1 Citation (Scopus)

Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy

Jo, H. J., Kenny-Jung, D. L., Balzekas, I., Benarroch, E. E., Jones, D. T., Brinkmann, B., Stead, S. M., Van Gompel, J., Welker, K. & Worrell, G. A., Jan 1 2019, (Accepted/In press) In : NeuroImage: Clinical. 101671.

Research output: Contribution to journalArticle

Thalamic Nuclei
Temporal Lobe Epilepsy
Seizures
Seeds
Pulvinar
11 Citations (Scopus)

Predicting Alzheimer’s disease progression using multi-modal deep learning approach

for Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 1952.

Research output: Contribution to journalArticle

Open Access
Disease Progression
Alzheimer Disease
Learning
Neuroimaging
Area Under Curve
3 Citations (Scopus)

Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

For the Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 2235.

Research output: Contribution to journalArticle

Open Access
Disease Progression
Alzheimer Disease
Demography
Complement C1
Prodromal Symptoms
11 Citations (Scopus)
National Institute on Aging (U.S.)
Alzheimer Disease
Amyloid
Research
Positron-Emission Tomography
1 Citation (Scopus)

Rates of lobar atrophy in asymptomatic MAPT mutation carriers

Chen, Q., Boeve, B. F., Senjem, M., Tosakulwong, N., Lesnick, T. G., Brushaber, D., Dheel, C., Fields, J., Forsberg, L., Gavrilova, R., Gearhart, D., Graff-Radford, J., Graff-Radford, N. R., Jack, C. R., Jones, D. T., Knopman, D. S., Kremers, W. K., Lapid, M., Rademakers, R., Syrjanen, J. & 4 others, Boxer, A. L., Rosen, H., Wszolek, Z. K. & Kantarci, K., Jan 1 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 338-346 9 p.

Research output: Contribution to journalArticle

Open Access
Microtubule-Associated Proteins
Atrophy
Temporal Lobe
Mutation
Parietal Lobe
4 Citations (Scopus)

Relationship between seizure frequency and functional abnormalities in limbic network of medial temporal lobe epilepsy

Jo, H. J., Kenney-Jung, D. L., Balzekas, I., Welker, K. M., Jones, D. T., Croarkin, P. E., Benarroch, E. E. & Worrell, G. A., Jan 1 2019, In : Frontiers in Neurology. 10, MAY, 488.

Research output: Contribution to journalArticle

Open Access
Temporal Lobe Epilepsy
Seizures
Gyrus Cinguli
Temporal Lobe
Hypothalamus

Tau-positron emission tomography correlates with neuropathology findings

Lowe, V. J., Lundt, E. S., Albertson, S. M., Min, H. K., Fang, P., Przybelski, S. A., Senjem, M. L., Schwarz, C. G., Kantarci, K., Boeve, B., Jones, D. T., Reichard, R. R., Tranovich, J. F., Hanna Al-Shaikh, F. S., Knopman, D. S., Jack, C. R., Dickson, D. W., Petersen, R. C. & Murray, M. E., Jan 1 2019, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Autopsy
Neuropathology
Alzheimer Disease
Tauopathies

Teaching Video NeuroImages: Foix-Chavany-Marie syndrome

Mantyh, W. G., Chandregowda, A., Fulgham, J. R., Flemming, K., Laughlin, R. S. & Jones, D. T., May 28 2019, In : Neurology. 92, 22, p. e2620-e2621

Research output: Contribution to journalArticle

Open Access
Teaching
Foix Chavany Marie syndrome
3 Citations (Scopus)

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

The Alzheimer’S Disease Neuroimaging Initiative (ADNI), Dec 1 2019, In : Nature communications. 10, 1, 1766.

Research output: Contribution to journalArticle

Open Access
integrators
polymorphism
nucleotides
Polymorphism
genes
2 Citations (Scopus)
Open Access
Amyloid
Alzheimer Disease
Tauopathies
Lewy Body Disease
Amyloidosis
2 Citations (Scopus)

The influence of β-amyloid on [ 18 F]AV-1451 in semantic variant of primary progressive aphasia

Whitwell, J. L., Martin, P. R., Duffy, J. R., Clark, H., Machulda, M. M., Schwarz, C., Weigand, S. D., Sintini, I., Senjem, M. L., Taner, N., Botha, H., Utianski, R., Graff-Radford, J., Jones, D. T., Boeve, B. F., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Josephs, K. A., Feb 12 2019, In : Neurology. 92, 7, p. e710-e722

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Semantics
Amyloid
Alzheimer Disease
Temporal Lobe
1 Citation (Scopus)

The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology

LEFFTDS Consortium, Jan 1 2019, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Dementia
tau Proteins
Chromosomes, Human, Pair 9

Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers

LEFFTDS Consortium, Nov 2019, In : Neurobiology of aging. 83, p. 54-62 9 p.

Research output: Contribution to journalArticle

Microtubule-Associated Proteins
Mutation
Diffusion Tensor Imaging
Anisotropy
Disease Progression

Transient epileptic amnesia: A treatable cause of spells associated with persistent cognitive symptoms

Ramanan, V. K., Morris, K. A., Graff-Radford, J., Jones, D. T., Burkholder, D. B., Britton, J. W., Josephs, K. A., Boeve, B. F. & Savica, R., Jan 1 2019, In : Frontiers in Neurology. 10, AUG, 939.

Research output: Contribution to journalArticle

Open Access
Neurobehavioral Manifestations
Amnesia
Electroencephalography
Behavioral Symptoms
Seizures
2 Citations (Scopus)

Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium

ARTFL/LEFFTDS consortium, Jan 1 2019, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Dementia
Language
Personality
Primary Progressive Nonfluent Aphasia
2018
18 Citations (Scopus)

[18F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease

Whitwell, J. L., Graff-Radford, J., Tosakulwong, N., Weigand, S. D., Machulda, M. M., Senjem, M. L., Schwarz, C., Spychalla, A. J., Jones, D. T., Drubach, D., Knopman, D. S., Boeve, B. F., Taner, N., Petersen, R. C., Lowe, V., Jack, C. R. J. & Josephs, K. A., Feb 1 2018, In : Annals of Neurology. 83, 2, p. 248-257 10 p.

Research output: Contribution to journalArticle

Cluster Analysis
Alzheimer Disease
Apolipoprotein E4
Entorhinal Cortex
Neocortex
17 Citations (Scopus)

[18F]AV-1451 tau-PET and primary progressive aphasia

Josephs, K. A., Martin, P. R., Botha, H., Schwarz, C., Duffy, J. R., Clark, H., Machulda, M. M., Graff-Radford, J., Weigand, S. D., Senjem, M. L., Utianski, R., Drubach, D., Boeve, B. F., Jones, D. T., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Whitwell, J. L., Jan 1 2018, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Semantics
Principal Component Analysis
7 Citations (Scopus)

18F-FDG PET-CT pattern in idiopathic normal pressure hydrocephalus

Townley, R. A., Botha, H., Graff-Radford, J., Boeve, B. F., Petersen, R. C., Senjem, M. L., Knopman, D. S., Lowe, V., Jack, C. R. J. & Jones, D. T., Jan 1 2018, In : NeuroImage: Clinical. 18, p. 897-902 6 p.

Research output: Contribution to journalArticle

Normal Pressure Hydrocephalus
Fluorodeoxyglucose F18
Dementia
Alzheimer Disease
Frontotemporal Dementia

Amyloid- and tau-PET imaging in a familial prion kindred

Jones, D. T., Townley, R. A., Graff-Radford, J., Botha, H., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Boeve, B. F., Dec 1 2018, In : Neurology: Genetics. 4, 6, e290.

Research output: Contribution to journalArticle

Prions
Amyloid
Alzheimer Disease
Neurobiology
Amyloid Plaques
2 Citations (Scopus)
Subarachnoid Space
Hydrocephalus
Cerebrospinal Fluid
ROC Curve
Normal Pressure Hydrocephalus
1 Citation (Scopus)

Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

For the Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2018, In : Scientific Reports. 8, 1, 13807.

Research output: Contribution to journalArticle

Alzheimer Disease
Metabolic Networks and Pathways
Brain
Fluorodeoxyglucose F18
Occipital Lobe
3 Citations (Scopus)
Lewy Body Disease
Single-Photon Emission-Computed Tomography
Dementia
Corpus Striatum
Putamen
3 Citations (Scopus)

Disrupted functional connectivity in primary progressive apraxia of speech

Botha, H., Utianski, R., Whitwell, J. L., Duffy, J. R., Clark, H., Strand, E. A., Machulda, M. M., Tosakulwong, N., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Josephs, K. A. & Jones, D. T., Jan 1 2018, In : NeuroImage: Clinical. 18, p. 617-629 13 p.

Research output: Contribution to journalArticle

Apraxias
Motor Cortex
Language
Short-Term Memory
Speech Disorders
3 Citations (Scopus)
Temporal Lobe
Alzheimer Disease
Brain
Neurofibrillary Tangles
Tomography
10 Citations (Scopus)

FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis

Botha, H., Mantyh, W. G., Murray, M. E., Knopman, D. S., Przybelski, S. A., Wiste, H. J., Graff-Radford, J., Josephs, K. A., Schwarz, C., Kremers, W. K., Boeve, B. F., Petersen, R. C., Machulda, M. M., Parisi, J. E., Dickson, D. W., Lowe, V., Jack, C. R. J. & Jones, D. T., Apr 1 2018, In : Brain. 141, 4, p. 1201-1217 17 p.

Research output: Contribution to journalArticle

Sclerosis
Dementia
Autopsy
Amyloid
Fluorodeoxyglucose F18
1 Citation (Scopus)
Cerebral Infarction
Population
Magnetic Resonance Imaging
Diffusion Tensor Imaging
Incidental Findings
4 Citations (Scopus)

Identification and functional characterization of novel mutations including frameshift mutation in exon 4 of CSF1R in patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia

Miura, T., Mezaki, N., Konno, T., Iwasaki, A., Hara, N., Miura, M., Funayama, M., Unai, Y., Tashiro, Y., Okita, K., Kihara, T., Ito, N., Kanatsuka, Y., Jones, D. T., Hara, N., Ishiguro, T., Tokutake, T., Kasuga, K., Nozaki, H., Dickson, D. W. & 3 others, Onodera, O., Wszolek, Z. K. & Ikeuchi, T., Jan 1 2018, (Accepted/In press) In : Journal of Neurology.

Research output: Contribution to journalArticle

Leukoencephalopathies
Frameshift Mutation
Neuroglia
Exons
Mutation
15 Citations (Scopus)
Amyloid
Positron-Emission Tomography
Atrophy
Alzheimer Disease
Neuroimaging
13 Citations (Scopus)
Microtubule-Associated Proteins
Protein Isoforms
Mutation
Exons
Alzheimer Disease
8 Citations (Scopus)

Joint associations of β-amyloidosis and cortical thickness with cognition

Knopman, D. S., Lundt, E. S., Therneau, T. M., Vemuri, P. D., Lowe, V., Kantarci, K. M., Gunter, J. L., Senjem, M. L., Mielke, M. M., Machulda, M. M., Roberts, R. O., Boeve, B. F., Jones, D. T., Petersen, R. C. & Jack, C. R. J., May 1 2018, In : Neurobiology of Aging. 65, p. 121-131 11 p.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Cognition
Positron-Emission Tomography
Alzheimer Disease
48 Citations (Scopus)

Longitudinal tau PET in ageing and Alzheimer's disease

Jack, C. R. J., Wiste, H. J., Schwarz, C., Lowe, V., Senjem, M. L., Vemuri, P. D., Weigand, S. D., Therneau, T. M., Knopman, D. S., Gunter, J. L., Jones, D. T., Graff-Radford, J., Kantarci, K. M., Roberts, R. O., Mielke, M. M., Machulda, M. M. & Petersen, R. C., May 1 2018, In : Brain. 141, 5, p. 1517-1528 12 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Sample Size
Brain
Outcome Assessment (Health Care)
5 Citations (Scopus)
Lewy Body Disease
Perfusion
Glucose
Occipital Lobe
Parietal Lobe
5 Citations (Scopus)

Tau-negative amnestic dementia masquerading as Alzheimer disease dementia

Botha, H., Mantyh, W. G., Graff-Radford, J., Machulda, M. M., Przybelski, S. A., Wiste, H. J., Senjem, M. L., Parisi, J. E., Petersen, R. C., Murray, M. E., Boeve, B. F., Lowe, V., Knopman, D. S., Jack, C. R. J. & Jones, D. T., Mar 13 2018, In : Neurology. 90, 11, p. e940-e946

Research output: Contribution to journalArticle

Dementia
Alzheimer Disease
Amyloid
Biomarkers
Accidental Falls
17 Citations (Scopus)

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

The Genetic FTD Initiative (GENFI) & The Alzheimer’S Disease Neuroimaging Initiative (ADNI), Dec 1 2018, In : Nature Communications. 9, 1, 4273.

Research output: Contribution to journalArticle

Neurodegenerative diseases
inference
Neurodegenerative Diseases
Aptitude
Genotype
52 Citations (Scopus)
Alzheimer Disease
Amyloid
Brain
Tauopathies
Neurofibrillary Tangles