David S Knopman, MD

  • 65550 Citations
  • 122 Scopus h-Index
1975 …2019
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Research Output 1975 2019

2019
4 Citations (Scopus)
Lewy Body Disease
Atrophy
Occipital Lobe
Lewy Bodies
Atlases
3 Citations (Scopus)

A blood-based signature of cerebrospinal fluid Aβ 1–42 status

Alzheimer’s Disease Metabolomics Consortium & Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 4163.

Research output: Contribution to journalArticle

Open Access
Cerebrospinal Fluid
Amyloid
Alzheimer Disease
Positron-Emission Tomography
Area Under Curve
1 Citation (Scopus)

A brief history of "Alzheimer disease": Multiple meanings separated by a common name

Knopman, D. S., Petersen, R. C. & Jack, C. R. J., May 28 2019, In : Neurology. 92, 22, p. 1053-1059 7 p.

Research output: Contribution to journalReview article

Names
Alzheimer Disease
Dementia
Neurofibrillary Tangles
Amyloid Plaques
2 Citations (Scopus)

A Comparison of Partial Volume Correction Techniques for Measuring Change in Serial Amyloid PET SUVR

Schwarz, C., Gunter, J. L., Lowe, V., Weigand, S., Vemuri, P. D., Senjem, M. L., Petersen, R. C., Knopman, D. S. & Jack, C. R. J., Jan 1 2019, In : Journal of Alzheimer's Disease. 67, 1, p. 181-195 15 p.

Research output: Contribution to journalArticle

Amyloid
Positron-Emission Tomography
Longitudinal Studies
Noise
Alzheimer Disease

Amyloid, Vascular, and Resilience Pathways Associated with Cognitive Aging

Vemuri, P., Lesnick, T. G., Knopman, D. S., Przybelski, S. A., Reid, R. I., Mielke, M. M., Graff-Radford, J., Lowe, V. J., Machulda, M. M., Petersen, R. C. & Jack, C. R., Jan 1 2019, (Accepted/In press) In : Annals of neurology.

Research output: Contribution to journalArticle

Open Access
Amyloid
Blood Vessels
Health
Occupations
Diffusion Tensor Imaging

Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration

Bejanin, A., Murray, M. E., Martin, P., Botha, H., Tosakulwong, N., Schwarz, C. G., Senjem, M. L., Chételat, G., Kantarci, K., Jack, C. R., Boeve, B. F., Knopman, D. S., Petersen, R. C., Giannini, C., Parisi, J. E., Dickson, D. W., Whitwell, J. L. & Josephs, K. A., Nov 1 2019, In : Brain : a journal of neurology. 142, 11, p. 3621-3635 15 p.

Research output: Contribution to journalArticle

Temporal Lobe
Pathology
Alzheimer Disease
Brain
Frontotemporal Lobar Degeneration
Open Access
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Executive Function
Dementia
Clinical Trials

Association Between Critical Care Admissions and Cognitive Trajectories in Older Adults

Schulte, P., Warner, D. O., Martin, D. P., Deljou, A., Mielke, M. M., Knopman, D. S., Petersen, R. C., Weingarten, T. N., Warner, M., Rabinstein, A. A., Hanson, A. C., Schroeder, D. R. & Sprung, J., Aug 1 2019, In : Critical care medicine. 47, 8, p. 1116-1124 9 p.

Research output: Contribution to journalArticle

Delirium
Critical Care
Language
Electronic Health Records
Patient Admission
Open Access
Apolipoprotein E4
Entorhinal Cortex
Amyloidosis
Amyloid
Education

Association of Brain Magnetic Resonance Imaging Signs With Cognitive Outcomes in Persons With Nonimpaired Cognition and Mild Cognitive Impairment

Wu, A., Sharrett, A. R., Gottesman, R. F., Power, M. C., Mosley, T. H., Jack, C. R. J., Knopman, D. S., Windham, B. G., Gross, A. L. & Coresh, J., May 3 2019, In : JAMA network open. 2, 5, p. e193359

Research output: Contribution to journalArticle

Open Access
Cognition
Dementia
Magnetic Resonance Imaging
Brain
Alzheimer Disease
3 Citations (Scopus)

Association of midlife to late-life blood pressure patterns with incident dementia

Walker, K. A., Sharrett, A. R., Wu, A., Schneider, A. L. C., Albert, M., Lutsey, P. L., Bandeen-Roche, K., Coresh, J., Gross, A. L., Windham, B. G., Knopman, D. S., Power, M. C., Rawlings, A. M., Mosley, T. H. & Gottesman, R. F., Aug 13 2019, In : JAMA - Journal of the American Medical Association. 322, 6, p. 535-545 11 p.

Research output: Contribution to journalArticle

Dementia
Blood Pressure
Hypertension
Hypotension
Odds Ratio
Open Access
Apolipoprotein E4
Genotype
hard labor
Independent Living
manual labor

Association of white matter microstructural integrity with cognition and dementia

Power, M. C., Su, D., Wu, A., Reid, R. I., Jack, C. R., Knopman, D. S., Coresh, J., Huang, J., Kantarci, K., Sharrett, A. R., Gottesman, R. G., Griswold, M. E. & Mosley, T. H., Nov 2019, In : Neurobiology of aging. 83, p. 63-72 10 p.

Research output: Contribution to journalArticle

Cognition
Dementia
Anisotropy
Cognitive Dysfunction
White Matter
3 Citations (Scopus)
Amyloid
Dementia
Biomarkers
Positron-Emission Tomography
National Institute on Aging (U.S.)
1 Citation (Scopus)

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (Nature Communications, (2018), 9, 1, (2098), 10.1038/s41467-018-04362-x)

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-Ritchie, C., Liewald, D. C. M., Okely, J. A., Ahola-Olli, A. V., Barnes, C. L. K., Bertram, L., Bis, J. C., Burdick, K. E., Christoforou, A., DeRosse, P., Djurovic, S. & 202 others, Espeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., van der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, I., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S. C., Lill, C. M., Liu, T., Koini, M., London, E., Longstreth, W. T., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L. P., Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-Heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D. E., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Dan Rujescu, R., Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D. R., Weir, D. R., Wilson, J. F., Malhotra, A., McIntosh, A. M., Gale, C. R., Seshadri, S., Mosley, T. H., Bressler, J., Lencz, T. & Deary, I. J., Dec 1 2019, In : Nature communications. 10, 1, 2068.

Research output: Contribution to journalComment/debate

Open Access
document markup languages
HTML
Genetic Loci
loci
lists
Natural Language Processing
Life Style
Alzheimer Disease
Electronic Health Records
Dementia
3 Citations (Scopus)

Bad news and good news in AD, and how to reconcile them

Knopman, D. S., Jan 1 2019, (Accepted/In press) In : Nature Reviews Neurology.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Clinical Trials
1 Citation (Scopus)
Tauopathies
DNA-Binding Proteins
Atrophy
Brain
Amygdala

Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers

Chen, Q., Boeve, B. F., Tosakulwong, N., Lesnick, T., Brushaber, D., Dheel, C., Fields, J. A., Forsberg, L., Gavrilova, R. M., Gearhart, D., Haley, D., Gunter, J. L., Graff-Radford, J., Jones, D. T., Knopman, D. S., Graff Radford, N. R., Kraft, R., Lapid, M. I., Rademakers, R. V., Wszolek, Z. K. & 3 others, Rosen, H., Boxer, A. L. & Kantarci, K. M., Jan 1 2019, In : Journal of Neuroimaging.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Magnetic Resonance Spectroscopy
Mutation
Brain
Gyrus Cinguli
2 Citations (Scopus)

Central Arterial Stiffness Is Associated With Structural Brain Damage and Poorer Cognitive Performance: The ARIC Study

Palta, P., Sharrett, A. R., Wei, J., Meyer, M. L., Kucharska-Newton, A., Power, M. C., Deal, J. A., Jack, C. R. J., Knopman, D. S., Wright, J., Griswold, M., Tanaka, H., Mosley, T. H. & Heiss, G., Jan 22 2019, In : Journal of the American Heart Association. 8, 2, p. e011045

Research output: Contribution to journalArticle

Vascular Stiffness
Pulse Wave Analysis
Thigh
Brain
Blood Pressure
3 Citations (Scopus)

Cerebral microbleeds: Prevalence and relationship to amyloid burden

Graff-Radford, J., Botha, H., Rabinstein, A., Gunter, J. L., Przybelski, S. A., Lesnick, T., Huston, J., Flemming, K., Preboske, G. M., Senjem, M. L., Brown, R. D. J., Mielke, M. M., Roberts, R. O., Lowe, V., Knopman, D. S., Petersen, R. C., Kremers, W. K., Vemuri, P. D., Jack, C. R. J. & Kantarci, K. M., Jan 15 2019, In : Neurology. 92, 3, p. e253-e262

Research output: Contribution to journalArticle

Amyloid
Parietal Lobe
Logistic Models
Population
Hypertension
1 Citation (Scopus)

Chronic Systemic Inflammation Is Associated With Symptoms of Late-Life Depression: The ARIC Study

Sonsin-Diaz, N., Gottesman, R. F., Fracica, E., Walston, J., Windham, B. G., Knopman, D. S. & Walker, K. A., Jan 1 2019, In : American Journal of Geriatric Psychiatry.

Research output: Contribution to journalArticle

C-Reactive Protein
Depression
Inflammation
Epidemiologic Studies
Confidence Intervals

Cognitive function after surgery with regional or general anesthesia: A population-based study

Sprung, J., Schulte, P., Knopman, D. S., Mielke, M. M., Petersen, R. C., Weingarten, T. N., Martin, D. P., Hanson, A. C., Schroeder, D. R. & Warner, D. O., Jan 1 2019, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Conduction Anesthesia
General Anesthesia
Cognition
Population
Anesthesia

Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life

Rawlings, A. M., Sharrett, A. R., Mosley, T. H., Wong, D. F., Knopman, D. S. & Gottesman, R. F., Jan 1 2019, In : Journal of Alzheimer's Disease. 68, 2, p. 517-521 5 p.

Research output: Contribution to journalArticle

Cognitive Reserve
Amyloid
Positron-Emission Tomography
Cognition
Dementia
1 Citation (Scopus)
Intelligence Tests
Dementia
Alzheimer Disease
Referral and Consultation
Research
2 Citations (Scopus)

Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging

Krell-Roesch, J., Vassilaki, M., Mielke, M. M., Kremers, W. K., Lowe, V., Vemuri, P. D., Machulda, M. M., Christianson, T. J., Syrjanen, J. A., Stokin, G. B., Butler, L. M., Traber, M., Jack, C. R. J., Knopman, D. S., Roberts, R. O., Petersen, R. C. & Geda, Y. E., Dec 1 2019, In : Translational psychiatry. 9, 1, 123.

Research output: Contribution to journalArticle

Open Access
Neurobehavioral Manifestations
Amyloid
Equipment and Supplies
Anxiety
Cognitive Dysfunction

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

Lowe, V. J., Bruinsma, T. J., Wiste, H. J., Min, H. K., Weigand, S. D., Fang, P., Senjem, M. L., Therneau, T. M., Boeve, B. F., Josephs, K. A., Pandey, M. K., Murray, M. E., Kantarci, K., Jones, D. T., Vemuri, P., Graff-Radford, J., Schwarz, C. G., Machulda, M. M., Mielke, M. M., Roberts, R. O. & 3 others, Knopman, D. S., Petersen, R. C. & Jack, C. R., Jul 2 2019, In : Neurology. 93, 1, p. e29-e39

Research output: Contribution to journalArticle

Entorhinal Cortex
Temporal Lobe
Cognition
Amyloid
Brain
Open Access
Sphingolipids
Ceramides
Cardiovascular Diseases
Hypertension
Cerebrovascular Disorders
8 Citations (Scopus)
Entorhinal Cortex
Amyloid
Biomarkers
Repression (Psychology)
Verbal Learning
Dementia
Lewy Body Disease
Alzheimer Disease
Frontotemporal Dementia

Exposure to surgery under general anaesthesia and brain magnetic resonance imaging changes in older adults

Sprung, J., Kruthiventi, S. C., Warner, D. O., Knopman, D. S., Petersen, R. C., Mielke, M. M., Jack, C. R., Graff-Radford, J., Martin, D. P., Hanson, A. C., Schroeder, D. R., Przybelski, S. A., Schulte, P. J., Weingarten, T. N. & Vemuri, P., Jan 1 2019, (Accepted/In press) In : British journal of anaesthesia.

Research output: Contribution to journalArticle

General Anesthesia
Magnetic Resonance Imaging
Brain
Alzheimer Disease
Confidence Intervals

Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers

Dickson, D. W., Baker, M. C., Jackson, J. L., Dejesus-Hernandez, M., Finch, N. C. A., Tian, S., Heckman, M. G., Pottier, C., Gendron, T. F., Murray, M. E., Ren, Y., Reddy, J. S., Graff-Radford, N. R., Boeve, B. F., Petersen, R. C., Knopman, D. S., Josephs, K. A., Petrucelli, L., Oskarsson, B., Sheppard, J. W. & 3 others, Asmann, Y. W., Rademakers, R. & Van Blitterswijk, M., Oct 8 2019, In : Acta Neuropathologica Communications. 7, 1, 150.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Lobar Degeneration
Motor Neuron Disease
Monomeric GTP-Binding Proteins
Dipeptides
GTP Phosphohydrolase Activators
1 Citation (Scopus)

Frontal lobe 1H MR spectroscopy in asymptomatic and symptomatic MAPT mutation carriers

Chen, Q., Boeve, B. F., Tosakulwong, N., Lesnick, T., Brushaber, D., Dheel, C., Fields, J. A., Forsberg, L., Gavrilova, R. M., Gearhart, D., Haley, D., Gunter, J. L., Graff-Radford, J., Jones, D. T., Knopman, D. S., Graff Radford, N. R., Kraft, R., Lapid, M. I., Rademakers, R. V., Syrjanen, J. & 4 others, Wszolek, Z. K., Rosen, H., Boxer, A. L. & Kantarci, K. M., Jan 1 2019, In : Neurology. 93, 8, p. E758-E765

Research output: Contribution to journalArticle

Microtubule-Associated Proteins
Frontal Lobe
Magnetic Resonance Spectroscopy
Creatine
Inositol
1 Citation (Scopus)

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Chauhan, G., Adams, H. H. H., Satizabal, C. L., Bis, J. C., Teumer, A., Sargurupremraj, M., Hofer, E., Trompet, S., Hilal, S., Smith, A. V., Jian, X., Malik, R., Traylor, M., Pulit, S. L., Amouyel, P., Mazoyer, B., Zhu, Y. C., Kaffashian, S., Schilling, S., Beecham, G. W. & 130 others, Montine, T. J., Schellenberg, G. D., Kjartansson, O., Guonason, V., Knopman, D. S., Griswold, M. E., Windham, B. G., Gottesman, R. F., Mosley, T. H., Schmidt, R., Saba, Y., Schmidt, H., Takeuchi, F., Yamaguchi, S., Nabika, T., Kato, N., Rajan, K. B., Aggarwal, N. T., De Jager, P. L., Evans, D. A., Psaty, B. M., Rotter, J. I., Rice, K., Lopez, O. L., Liao, J., Chen, C., Cheng, C. Y., Wong, T. Y., Ikram, M. K., Van Der Lee, J. S., Amin, N., Chouraki, V., DeStefano, A. L., Aparicio, H. J., Romero, J. R., Maillard, P., DeCarli, C., Wardlaw, J. M., Del Valdes Hernandez, M. C., Luciano, M., Liewald, D., Deary, I. J., Starr, J. M., Bastin, M. E., Maniega, S. M., Slagboom, P. E., Beekman, M., Deelen, J., Uh, H. W., Lemmens, R., Brodaty, H., Wright, M. J., Ames, D., Boncoraglio, G. B., Hopewell, J. C., Beecham, A. H., Blanton, S. H., Wright, C. B., Sacco, R. L., Wen, W., Thalamuthu, A., Armstrong, N. J., Chong, E., Schofield, P. R., Kwok, J. B., Van der Grond, J., Stott, D. J., Ford, I., Jukema, J. W., Vernooij, M. W., Hofman, A., Uitterlinden, A. G., Van der Lugt, A., Wittfeld, K., Grabe, H. J., Hosten, N., Von Sarnowski, B., Volker, U., Levi, C., Jimenez-Conde, J., Sharma, P., Sudlow, C. L. M., Rosand, J., Woo, D., Cole, J. W., Meschia, J. F., Slowik, A., Thijs, V., Lindgren, A., Melander, O., Grewal, R. P., Rundek, T., Rexrode, K., Rothwell, P. M., Arnett, D. K., Jern, C., Johnson, J. A., Benavente, O. R., Wasssertheil-Smoller, S., Lee, J. M., Wong, Q., Mitchell, B. D., Rich, S. S., McArdle, P. F., Geerlings, M. I., Van der Graaf, Y., De Bakker, P. I. W., Asselbergs, F. W., Srikanth, V., Thomson, R., McWhirter, R., Moran, C., Callisaya, M., Phan, T., Rutten-Jacobs, L. C. A., Bevan, S., Tzourio, C., Mather, K. A., Sachdev, P. S., Van Duijn, C. M., Worrall, B. B., Dichgans, M., Kittner, S. J., Markus, H. S., Ikram, M. A., Fornage, M., Launer, L. J., Seshadri, S., Longstreth, W. T. & Debette, S., Jan 29 2019, In : Neurology. 92, 5, p. E486-E503

Research output: Contribution to journalArticle

Open Access
Life Style
Brain
Population
Genome-Wide Association Study
Blood Pressure

Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia

International FTD-Genomics Consortium (IFGC), Dec 1 2019, In : Scientific reports. 9, 1, 10854.

Research output: Contribution to journalArticle

Open Access
Primary Progressive Aphasia
Gene Regulatory Networks
Semantics
Cell Death
RNA
6 Citations (Scopus)

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

Pottier, C., Ren, Y., Perkerson, R. B., Baker, M., Jenkins, G. D., Van Blitterswijk, M., DeJesus-Hernandez, M., van Rooij, J. G. J., Murray, M. E., Christopher, E., McDonnell, S. K., Fogarty, Z., Batzler, A., Tian, S., Vicente, C. T., Matchett, B., Karydas, A. M., Hsiung, G. Y. R., Seelaar, H., Mol, M. O. & 85 others, Finger, E. C., Graff, C., Öijerstedt, L., Neumann, M., Heutink, P., Synofzik, M., Wilke, C., Prudlo, J., Rizzu, P., Simon-Sanchez, J., Edbauer, D., Roeber, S., Diehl-Schmid, J., Evers, B. M., King, A., Mesulam, M. M., Weintraub, S., Geula, C., Bieniek, K. F., Petrucelli, L., Ahern, G. L., Reiman, E. M., Woodruff, B. K., Caselli, R. J., Huey, E. D., Farlow, M. R., Grafman, J., Mead, S., Grinberg, L. T., Spina, S., Grossman, M., Irwin, D. J., Lee, E. B., Suh, E. R., Snowden, J., Mann, D., Taner, N., Uitti, R. J., Wszolek, Z. K., Josephs, K. A., Parisi, J. E., Knopman, D. S., Petersen, R. C., Hodges, J. R., Piguet, O., Geier, E. G., Yokoyama, J. S., Rissman, R. A., Rogaeva, E., Keith, J., Zinman, L., Tartaglia, M. C., Cairns, N. J., Cruchaga, C., Ghetti, B., Kofler, J., Lopez, O. L., Beach, T. G., Arzberger, T., Herms, J., Honig, L. S., Vonsattel, J. P., Halliday, G. M., Kwok, J. B., White, C. L., Gearing, M., Glass, J., Rollinson, S., Pickering-Brown, S., Rohrer, J. D., Trojanowski, J. Q., Van Deerlin, V., Bigio, E. H., Troakes, C., Al-Sarraj, S., Asmann, Y., Miller, B. L., Graff Radford, N. R., Boeve, B. F., Seeley, W. W., Mackenzie, I. R. A., van Swieten, J. C., Dickson, D. W., Biernacka, J. M. & Rademakers, R. V., Jan 1 2019, In : Acta neuropathologica.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Genome
Genes
Mutation

Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways

Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2019, In : Scientific reports. 9, 1, 14498.

Research output: Contribution to journalArticle

Open Access
Genome-Wide Association Study
Neurogenesis
Genes
Parahippocampal Gyrus
Dentate Gyrus
1 Citation (Scopus)

High-Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change

Pokharel, Y., Mouhanna, F., Schneider, A. L. C., Rawlings, A. M., Knopman, D. S., Nambi, V., Virani, S. S., Hoogeveen, R. C., Alonso, A., Heiss, G., Coresh, J., Mosley, T., Gottesman, R., Selvin, E., Ballantyne, C. & Power, M. C., Jan 1 2019, (Accepted/In press) In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Natriuretic Peptides
Troponin T
Brain Natriuretic Peptide
Verbal Learning
Survivors

Identification of anonymous MRI research participants with face-recognition software

Schwarz, C. G., Kremers, W. K., Therneau, T. M., Sharp, R. R., Gunter, J. L., Vemuri, P., Arani, A., Spychalla, A. J., Kantarci, K., Knopman, D. S., Petersen, R. C. & Jack, C. R., Oct 24 2019, In : New England Journal of Medicine. 381, 17, NEJMc1908881.

Research output: Contribution to journalLetter

Software
Research
Facial Recognition
1 Citation (Scopus)

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

International Frontotemporal Dementia Genomics Consortium, Jan 1 2019, In : Nature Medicine. 25, 1, p. 152-164 13 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Dementia
Genes
MicroRNAs
Pharmaceutical Databases
2 Citations (Scopus)

Impaired lung function, lung disease, and risk of incident dementia

Lutsey, P. L., Chen, N., Mirabelli, M. C., Lakshminarayan, K., Knopman, D. S., Vossel, K. A., Gottesman, R. F., Mosley, T. H. & Alonso, A., Jan 1 2019, In : American journal of respiratory and critical care medicine. 199, 11, p. 1385-1396 12 p.

Research output: Contribution to journalArticle

Lung Diseases
Dementia
Lung
Obstructive Lung Diseases
Odds Ratio

Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration

ARTFL/LEFFTDS consortium, Jan 1 2019, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Atrophy
Dementia
Magnetic Resonance Imaging

Informant-based hearing difficulties and the risk for mild cognitive impairment and dementia

Vassilaki, M., Aakre, J. A., Knopman, D. S., Kremers, W. K., Mielke, M. M., Geda, Y. E., Machulda, M. M., Al Fakir, R., Undavalli, C., Roberts, R. O. & Petersen, R. C., Nov 1 2019, In : Age and Ageing. 48, 6, p. 888-894 7 p.

Research output: Contribution to journalArticle

Hearing
Dementia
Cohort Studies
Sex Education
Cognitive Dysfunction
1 Citation (Scopus)

Investigation of white matter PiB uptake as a marker of white matter integrity

Zeydan, B., Schwarz, C., Lowe, V., Reid, R. I., Przybelski, S. A., Lesnick, T. G., Kremers, W. K., Senjem, M. L., Gunter, J. L., Min, H. K., Vemuri, P. D., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Kantarci, O. H. & Kantarci, K. M., Apr 1 2019, In : Annals of Clinical and Translational Neurology. 6, 4, p. 678-688 11 p.

Research output: Contribution to journalArticle

Open Access
Cognition
White Matter
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Anisotropy
Language
Phosphatidylcholines
Neuroimaging
Cognition
Alzheimer Disease
Amyloid
5 Citations (Scopus)

Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials

Staffaroni, A. M., Ljubenkov, P. A., Kornak, J., Cobigo, Y., Datta, S., Marx, G., Walters, S. M., Chiang, K., Olney, N., Elahi, F. M., Knopman, D. S., Dickerson, B. C., Boeve, B. F., Gorno-Tempini, M. L., Spina, S., Grinberg, L. T., Seeley, W. W., Miller, B. L., Kramer, J. H., Boxer, A. L. & 1 others, Rosen, H. J., Feb 1 2019, In : Brain : a journal of neurology. 142, 2, p. 443-459 17 p.

Research output: Contribution to journalArticle

Multimodal Imaging
Frontotemporal Dementia
Clinical Trials
Sample Size
Diffusion Tensor Imaging
1 Citation (Scopus)

Longitudinal tau-PET uptake and atrophy in atypical Alzheimer's disease

Sintini, I., Martin, P. R., Graff-Radford, J., Senjem, M. L., Schwarz, C., Machulda, M. M., Spychalla, A. J., Drubach, D., Knopman, D. S., Petersen, R. C., Lowe, V., Jack, C. R. J., Josephs, K. A. & Whitwell, J. L., Jan 1 2019, In : NeuroImage: Clinical. 23, 101823.

Research output: Contribution to journalArticle

Open Access
Atrophy
Alzheimer Disease
Frontal Lobe
Occipital Lobe
Disease Progression
5 Citations (Scopus)

Lowering of amyloid-beta by β-secretase inhibitors - Some informative failures

Knopman, D. S., Apr 11 2019, In : New England Journal of Medicine. 380, 15, p. 1476-1478 3 p.

Research output: Contribution to journalReview article

Amyloid Precursor Protein Secretases
Amyloid

Midlife smaller and larger infarctions, white matter hyperintensities, and 20-year cognitive decline

Gwen Windham, B., Griswold, M. E., Wilkening, S. R., Su, D., Tingle, J., Coker, L. H., Knopman, D. S., Gottesman, R. F., Shibata, D. & Mosley, T. H., Sep 17 2019, In : Annals of internal medicine. 171, 6, p. 389-396 8 p.

Research output: Contribution to journalArticle

Infarction
Stroke
Cognitive Dysfunction
White Matter

Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 13845.

Research output: Contribution to journalArticle

Open Access
Hippocampus
Alzheimer Disease
Biomarkers
Magnetic Resonance Imaging
Diffusion Magnetic Resonance Imaging