David S Knopman, MD

  • 63815 Citations
  • 121 Scopus h-Index
1975 …2019
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Research Output 1975 2019

2019
4 Citations (Scopus)

18F-AV-1451 uptake differs between dementia with lewy bodies and posterior cortical atrophy

Nedelska, Z., Josephs, K. A., Graff-Radford, J., Przybelski, S. A., Lesnick, T. G., Boeve, B. F., Drubach, D. A., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V., Whitwell, J. L. & Kantarci, K. M., Jan 1 2019, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

Lewy Body Disease
Atrophy
Occipital Lobe
Lewy Bodies
Atlases
3 Citations (Scopus)

A blood-based signature of cerebrospinal fluid Aβ 1–42 status

Alzheimer’s Disease Metabolomics Consortium & Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 4163.

Research output: Contribution to journalArticle

Open Access
Cerebrospinal Fluid
Amyloid
Alzheimer Disease
Positron-Emission Tomography
Area Under Curve
1 Citation (Scopus)

A brief history of "Alzheimer disease": Multiple meanings separated by a common name

Knopman, D. S., Petersen, R. C. & Jack, C. R. J., May 28 2019, In : Neurology. 92, 22, p. 1053-1059 7 p.

Research output: Contribution to journalReview article

Names
Alzheimer Disease
Dementia
Neurofibrillary Tangles
Amyloid Plaques
2 Citations (Scopus)

A Comparison of Partial Volume Correction Techniques for Measuring Change in Serial Amyloid PET SUVR

Schwarz, C. G., Gunter, J. L., Lowe, V., Weigand, S., Vemuri, P. D., Senjem, M. L., Petersen, R. C., Knopman, D. S. & Jack, C. R. J., Jan 1 2019, In : Journal of Alzheimer's Disease. 67, 1, p. 181-195 15 p.

Research output: Contribution to journalArticle

Amyloid
Positron-Emission Tomography
Longitudinal Studies
Noise
Alzheimer Disease
Open Access
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Executive Function
Dementia
Clinical Trials

Association Between Critical Care Admissions and Cognitive Trajectories in Older Adults

Schulte, P., Warner, D. O., Martin, D. P., Deljou, A., Mielke, M. M., Knopman, D. S., Petersen, R. C., Weingarten, T. N., Warner, M., Rabinstein, A. A., Hanson, A. C., Schroeder, D. R. & Sprung, J., Aug 1 2019, In : Critical care medicine. 47, 8, p. 1116-1124 9 p.

Research output: Contribution to journalArticle

Delirium
Critical Care
Language
Electronic Health Records
Patient Admission

Association of Brain Magnetic Resonance Imaging Signs With Cognitive Outcomes in Persons With Nonimpaired Cognition and Mild Cognitive Impairment

Wu, A., Sharrett, A. R., Gottesman, R. F., Power, M. C., Mosley, T. H., Jack, C. R. J., Knopman, D. S., Windham, B. G., Gross, A. L. & Coresh, J., May 3 2019, In : JAMA network open. 2, 5, p. e193359

Research output: Contribution to journalArticle

Open Access
Cognition
Dementia
Magnetic Resonance Imaging
Brain
Alzheimer Disease
1 Citation (Scopus)

Association of midlife to late-life blood pressure patterns with incident dementia

Walker, K. A., Sharrett, A. R., Wu, A., Schneider, A. L. C., Albert, M., Lutsey, P. L., Bandeen-Roche, K., Coresh, J., Gross, A. L., Windham, B. G., Knopman, D. S., Power, M. C., Rawlings, A. M., Mosley, T. H. & Gottesman, R. F., Aug 13 2019, In : JAMA - Journal of the American Medical Association. 322, 6, p. 535-545 11 p.

Research output: Contribution to journalArticle

Dementia
Blood Pressure
Hypertension
Hypotension
Odds Ratio
Open Access
Apolipoprotein E4
Genotype
hard labor
Independent Living
manual labor
2 Citations (Scopus)
Amyloid
Dementia
Biomarkers
Positron-Emission Tomography
National Institute on Aging (U.S.)

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (Nature Communications, (2018), 9, 1, (2098), 10.1038/s41467-018-04362-x)

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-Ritchie, C., Liewald, D. C. M., Okely, J. A., Ahola-Olli, A. V., Barnes, C. L. K., Bertram, L., Bis, J. C., Burdick, K. E., Christoforou, A., DeRosse, P., Djurovic, S. & 202 others, Espeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., van der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, I., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S. C., Lill, C. M., Liu, T., Koini, M., London, E., Longstreth, W. T., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L. P., Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-Heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D. E., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Dan Rujescu, R., Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D. R., Weir, D. R., Wilson, J. F., Malhotra, A., McIntosh, A. M., Gale, C. R., Seshadri, S., Mosley, T. H., Bressler, J., Lencz, T. & Deary, I. J., Dec 1 2019, In : Nature communications. 10, 1, 2068.

Research output: Contribution to journalComment/debate

Open Access
document markup languages
HTML
Genetic Loci
loci
lists
2 Citations (Scopus)

Bad news and good news in AD, and how to reconcile them

Knopman, D. S., Jan 1 2019, (Accepted/In press) In : Nature Reviews Neurology.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Clinical Trials
Tauopathies
DNA-Binding Proteins
Atrophy
Brain
Amygdala

Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers

Chen, Q., Boeve, B. F., Tosakulwong, N., Lesnick, T., Brushaber, D., Dheel, C., Fields, J. A., Forsberg, L., Gavrilova, R. M., Gearhart, D., Haley, D., Gunter, J. L., Graff-Radford, J., Jones, D. T., Knopman, D. S., Graff Radford, N. R., Kraft, R., Lapid, M. I., Rademakers, R. V., Wszolek, Z. K. & 3 others, Rosen, H., Boxer, A. L. & Kantarci, K. M., Jan 1 2019, In : Journal of Neuroimaging.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Magnetic Resonance Spectroscopy
Mutation
Brain
Gyrus Cinguli
1 Citation (Scopus)

Central Arterial Stiffness Is Associated With Structural Brain Damage and Poorer Cognitive Performance: The ARIC Study

Palta, P., Sharrett, A. R., Wei, J., Meyer, M. L., Kucharska-Newton, A., Power, M. C., Deal, J. A., Jack, C. R. J., Knopman, D. S., Wright, J., Griswold, M., Tanaka, H., Mosley, T. H. & Heiss, G., Jan 22 2019, In : Journal of the American Heart Association. 8, 2, p. e011045

Research output: Contribution to journalArticle

Vascular Stiffness
Pulse Wave Analysis
Thigh
Brain
Blood Pressure
2 Citations (Scopus)

Cerebral microbleeds: Prevalence and relationship to amyloid burden

Graff-Radford, J., Botha, H., Rabinstein, A., Gunter, J. L., Przybelski, S. A., Lesnick, T., Huston, J. III., Flemming, K. D., Preboske, G. M., Senjem, M. L., Brown, R. D. J., Mielke, M. M., Roberts, R. O., Lowe, V., Knopman, D. S., Petersen, R. C., Kremers, W. K., Vemuri, P. D., Jack, C. R. J. & Kantarci, K. M., Jan 15 2019, In : Neurology. 92, 3, p. e253-e262

Research output: Contribution to journalArticle

Amyloid
Parietal Lobe
Logistic Models
Population
Hypertension

Chronic Systemic Inflammation Is Associated With Symptoms of Late-Life Depression: The ARIC Study

Sonsin-Diaz, N., Gottesman, R. F., Fracica, E., Walston, J., Windham, B. G., Knopman, D. S. & Walker, K. A., Jan 1 2019, In : American Journal of Geriatric Psychiatry.

Research output: Contribution to journalArticle

C-Reactive Protein
Depression
Inflammation
Epidemiologic Studies
Confidence Intervals

Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life

Rawlings, A. M., Sharrett, A. R., Mosley, T. H., Wong, D. F., Knopman, D. S. & Gottesman, R. F., Jan 1 2019, In : Journal of Alzheimer's Disease. 68, 2, p. 517-521 5 p.

Research output: Contribution to journalArticle

Cognitive Reserve
Amyloid
Positron-Emission Tomography
Cognition
Dementia
1 Citation (Scopus)

Comparison of the Short Test of Mental Status and the Montreal Cognitive Assessment Across the Cognitive Spectrum

Townley, R. A., Syrjanen, J. A., Botha, H., Kremers, W. K., Aakre, J. A., Fields, J. A., Machulda, M. M., Graff-Radford, J., Savica, R., Jones, D. T., Knopman, D. S., Petersen, R. C. & Boeve, B. F., Jan 1 2019, In : Mayo Clinic proceedings.

Research output: Contribution to journalArticle

Intelligence Tests
Dementia
Alzheimer Disease
Referral and Consultation
Research
1 Citation (Scopus)

Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging

Krell-Roesch, J., Vassilaki, M., Mielke, M. M., Kremers, W. K., Lowe, V., Vemuri, P. D., Machulda, M. M., Christianson, T. J., Syrjanen, J. A., Stokin, G. B., Butler, L. M., Traber, M., Jack, C. R. J., Knopman, D. S., Roberts, R. O., Petersen, R. C. & Geda, Y. E., Dec 1 2019, In : Translational psychiatry. 9, 1, 123.

Research output: Contribution to journalArticle

Open Access
Neurobehavioral Manifestations
Amyloid
Equipment and Supplies
Anxiety
Cognitive Dysfunction

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

Lowe, V., Bruinsma, T. J., Wiste, H. J., Min, H. K., Weigand, S. D., Fang, P., Senjem, M. L., Therneau, T. M., Boeve, B. F., Josephs, K. A., Pandey, M., Murray, M. E., Kantarci, K. M., Jones, D. T., Vemuri, P. D., Graff-Radford, J., Schwarz, C. G., Machulda, M. M., Mielke, M. M., Roberts, R. O. & 3 others, Knopman, D. S., Petersen, R. C. & Jack, C. R. J., Jul 2 2019, In : Neurology. 93, 1, p. e29-e39

Research output: Contribution to journalArticle

Entorhinal Cortex
Temporal Lobe
Cognition
Amyloid
Brain
6 Citations (Scopus)

Entorhinal cortex tau, amyloid-β, cortical thickness and memory performance in non-demented subjects

Knopman, D. S., Lundt, E. S., Therneau, T. M., Vemuri, P. D., Lowe, V., Kantarci, K. M., Gunter, J. L., Senjem, M. L., Mielke, M. M., Machulda, M. M., Boeve, B. F., Jones, D. T., Graff-Radford, J., Albertson, S. M., Schwarz, C. G., Petersen, R. C. & Jack, C. R. J., Apr 1 2019, In : Brain : a journal of neurology. 142, 4, p. 1148-1160 13 p.

Research output: Contribution to journalArticle

Entorhinal Cortex
Amyloid
Biomarkers
Repression (Psychology)
Verbal Learning
Dementia
Lewy Body Disease
Alzheimer Disease
Frontotemporal Dementia

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Chauhan, G., Adams, H. H. H., Satizabal, C. L., Bis, J. C., Teumer, A., Sargurupremraj, M., Hofer, E., Trompet, S., Hilal, S., Smith, A. V., Jian, X., Malik, R., Traylor, M., Pulit, S. L., Amouyel, P., Mazoyer, B., Zhu, Y. C., Kaffashian, S., Schilling, S., Beecham, G. W. & 130 others, Montine, T. J., Schellenberg, G. D., Kjartansson, O., Guonason, V., Knopman, D. S., Griswold, M. E., Windham, B. G., Gottesman, R. F., Mosley, T. H., Schmidt, R., Saba, Y., Schmidt, H., Takeuchi, F., Yamaguchi, S., Nabika, T., Kato, N., Rajan, K. B., Aggarwal, N. T., De Jager, P. L., Evans, D. A., Psaty, B. M., Rotter, J. I., Rice, K., Lopez, O. L., Liao, J., Chen, C., Cheng, C. Y., Wong, T. Y., Ikram, M. K., Van Der Lee, J. S., Amin, N., Chouraki, V., DeStefano, A. L., Aparicio, H. J., Romero, J. R., Maillard, P., DeCarli, C., Wardlaw, J. M., Del Valdes Hernandez, M. C., Luciano, M., Liewald, D., Deary, I. J., Starr, J. M., Bastin, M. E., Maniega, S. M., Slagboom, P. E., Beekman, M., Deelen, J., Uh, H. W., Lemmens, R., Brodaty, H., Wright, M. J., Ames, D., Boncoraglio, G. B., Hopewell, J. C., Beecham, A. H., Blanton, S. H., Wright, C. B., Sacco, R. L., Wen, W., Thalamuthu, A., Armstrong, N. J., Chong, E., Schofield, P. R., Kwok, J. B., Van der Grond, J., Stott, D. J., Ford, I., Jukema, J. W., Vernooij, M. W., Hofman, A., Uitterlinden, A. G., Van der Lugt, A., Wittfeld, K., Grabe, H. J., Hosten, N., Von Sarnowski, B., Volker, U., Levi, C., Jimenez-Conde, J., Sharma, P., Sudlow, C. L. M., Rosand, J., Woo, D., Cole, J. W., Meschia, J. F., Slowik, A., Thijs, V., Lindgren, A., Melander, O., Grewal, R. P., Rundek, T., Rexrode, K., Rothwell, P. M., Arnett, D. K., Jern, C., Johnson, J. A., Benavente, O. R., Wasssertheil-Smoller, S., Lee, J. M., Wong, Q., Mitchell, B. D., Rich, S. S., McArdle, P. F., Geerlings, M. I., Van der Graaf, Y., De Bakker, P. I. W., Asselbergs, F. W., Srikanth, V., Thomson, R., McWhirter, R., Moran, C., Callisaya, M., Phan, T., Rutten-Jacobs, L. C. A., Bevan, S., Tzourio, C., Mather, K. A., Sachdev, P. S., Van Duijn, C. M., Worrall, B. B., Dichgans, M., Kittner, S. J., Markus, H. S., Ikram, M. A., Fornage, M., Launer, L. J., Seshadri, S., Longstreth, W. T. & Debette, S., Jan 29 2019, In : Neurology. 92, 5, p. E486-E503

Research output: Contribution to journalArticle

Open Access
Life Style
Brain
Population
Genome-Wide Association Study
Blood Pressure
4 Citations (Scopus)

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

Pottier, C., Ren, Y., Perkerson, R. B., Baker, M., Jenkins, G. D., Van Blitterswijk, M., DeJesus-Hernandez, M., van Rooij, J. G. J., Murray, M. E., Christopher, E., McDonnell, S. K., Fogarty, Z., Batzler, A., Tian, S., Vicente, C. T., Matchett, B., Karydas, A. M., Hsiung, G. Y. R., Seelaar, H., Mol, M. O. & 85 others, Finger, E. C., Graff, C., Öijerstedt, L., Neumann, M., Heutink, P., Synofzik, M., Wilke, C., Prudlo, J., Rizzu, P., Simon-Sanchez, J., Edbauer, D., Roeber, S., Diehl-Schmid, J., Evers, B. M., King, A., Mesulam, M. M., Weintraub, S., Geula, C., Bieniek, K. F., Petrucelli, L., Ahern, G. L., Reiman, E. M., Woodruff, B. K., Caselli, R. J., Huey, E. D., Farlow, M. R., Grafman, J., Mead, S., Grinberg, L. T., Spina, S., Grossman, M., Irwin, D. J., Lee, E. B., Suh, E. R., Snowden, J., Mann, D., Taner, N., Uitti, R. J., Wszolek, Z. K., Josephs, K. A., Parisi, J. E., Knopman, D. S., Petersen, R. C., Hodges, J. R., Piguet, O., Geier, E. G., Yokoyama, J. S., Rissman, R. A., Rogaeva, E., Keith, J., Zinman, L., Tartaglia, M. C., Cairns, N. J., Cruchaga, C., Ghetti, B., Kofler, J., Lopez, O. L., Beach, T. G., Arzberger, T., Herms, J., Honig, L. S., Vonsattel, J. P., Halliday, G. M., Kwok, J. B., White, C. L., Gearing, M., Glass, J., Rollinson, S., Pickering-Brown, S., Rohrer, J. D., Trojanowski, J. Q., Van Deerlin, V., Bigio, E. H., Troakes, C., Al-Sarraj, S., Asmann, Y., Miller, B. L., Graff Radford, N. R., Boeve, B. F., Seeley, W. W., Mackenzie, I. R. A., van Swieten, J. C., Dickson, D. W., Biernacka, J. M. & Rademakers, R. V., Jan 1 2019, In : Acta neuropathologica.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Genome
Genes
Mutation

High-Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change

Pokharel, Y., Mouhanna, F., Schneider, A. L. C., Rawlings, A. M., Knopman, D. S., Nambi, V., Virani, S. S., Hoogeveen, R. C., Alonso, A., Heiss, G., Coresh, J., Mosley, T., Gottesman, R., Selvin, E., Ballantyne, C. & Power, M. C., Jan 1 2019, (Accepted/In press) In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Natriuretic Peptides
Troponin T
Brain Natriuretic Peptide
Dementia
Verbal Learning
1 Citation (Scopus)

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

International Frontotemporal Dementia Genomics Consortium, Jan 1 2019, In : Nature Medicine. 25, 1, p. 152-164 13 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Dementia
Genes
MicroRNAs
Pharmaceutical Databases
2 Citations (Scopus)

Impaired lung function, lung disease, and risk of incident dementia

Lutsey, P. L., Chen, N., Mirabelli, M. C., Lakshminarayan, K., Knopman, D. S., Vossel, K. A., Gottesman, R. F., Mosley, T. H. & Alonso, A., Jan 1 2019, In : American journal of respiratory and critical care medicine. 199, 11, p. 1385-1396 12 p.

Research output: Contribution to journalArticle

Lung Diseases
Dementia
Lung
Obstructive Lung Diseases
Odds Ratio
1 Citation (Scopus)

Investigation of white matter PiB uptake as a marker of white matter integrity

Zeydan, B., Schwarz, C. G., Lowe, V., Reid, R. I., Przybelski, S. A., Lesnick, T. G., Kremers, W. K., Senjem, M. L., Gunter, J. L., Min, H. K., Vemuri, P. D., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Kantarci, O. H. & Kantarci, K. M., Apr 1 2019, In : Annals of Clinical and Translational Neurology. 6, 4, p. 678-688 11 p.

Research output: Contribution to journalArticle

Open Access
Cognition
White Matter
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Anisotropy
Language
Phosphatidylcholines
Neuroimaging
Cognition
Alzheimer Disease
Amyloid
4 Citations (Scopus)

Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials

Staffaroni, A. M., Ljubenkov, P. A., Kornak, J., Cobigo, Y., Datta, S., Marx, G., Walters, S. M., Chiang, K., Olney, N., Elahi, F. M., Knopman, D. S., Dickerson, B. C., Boeve, B. F., Gorno-Tempini, M. L., Spina, S., Grinberg, L. T., Seeley, W. W., Miller, B. L., Kramer, J. H., Boxer, A. L. & 1 others, Rosen, H. J., Feb 1 2019, In : Brain : a journal of neurology. 142, 2, p. 443-459 17 p.

Research output: Contribution to journalArticle

Multimodal Imaging
Frontotemporal Dementia
Clinical Trials
Sample Size
Diffusion Tensor Imaging
1 Citation (Scopus)

Longitudinal tau-PET uptake and atrophy in atypical Alzheimer's disease

Sintini, I., Martin, P. R., Graff-Radford, J., Senjem, M. L., Schwarz, C. G., Machulda, M. M., Spychalla, A. J., Drubach, D. A., Knopman, D. S., Petersen, R. C., Lowe, V., Jack, C. R. J., Josephs, K. A. & Whitwell, J. L., Jan 1 2019, In : NeuroImage: Clinical. 23, 101823.

Research output: Contribution to journalArticle

Open Access
Atrophy
Alzheimer Disease
Frontal Lobe
Occipital Lobe
Disease Progression
3 Citations (Scopus)

Lowering of amyloid-beta by β-secretase inhibitors - Some informative failures

Knopman, D. S., Apr 11 2019, In : New England Journal of Medicine. 380, 15, p. 1476-1478 3 p.

Research output: Contribution to journalReview article

Amyloid Precursor Protein Secretases
Amyloid

Neural correlates of domain-specific cognitive decline: The ARIC-NCS Study

Schneider, A. L. C., Senjem, M. L., Wu, A., Gross, A., Knopman, D. S., Gunter, J. L., Schwarz, C. G., Mosley, T. H., Gottesman, R. F., Sharrett, A. R. & Jack, C. R. J., Mar 5 2019, In : Neurology. 92, 10, p. e1051-e1063

Research output: Contribution to journalArticle

Atherosclerosis
Executive Function
Brain
Confidence Intervals
Language

Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease

Lowe, V., Lundt, E. S., Albertson, S. M., Przybelski, S. A., Senjem, M. L., Parisi, J. E., Kantarci, K. M., Boeve, B. F., Jones, D. T., Knopman, D. S., Jack, C. R. J., Dickson, D. W., Petersen, R. C. & Murray, M. E., Jan 1 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Neuroimaging
Neurodegenerative Diseases
Amyloid Plaques
Alzheimer Disease
Autopsy

Neuroimaging findings in midlife and risk of late-life dementia over 20 years of follow-up

West, N. A., Windham, B. G., Knopman, D. S., Shibata, D. K., Coker, L. H. & Mosley, T. H., Feb 26 2019, In : Neurology. 92, 9, p. e917-e923

Research output: Contribution to journalArticle

Neuroimaging
Dementia
Confidence Intervals
Diabetes Mellitus
International Classification of Diseases
Neuroimaging
Alzheimer Disease
Cognitive Dysfunction
ROC Curve
Cluster Analysis
1 Citation (Scopus)

Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains

Josephs, K. A., Murray, M. E., Tosakulwong, N., Weigand, S. D., Serie, A. M., Perkerson, R. B., Matchett, B. J., Jack, C. R. J., Knopman, D. S., Petersen, R. C., Parisi, J. E., Petrucelli, L., Baker, M., Rademakers, R. V., Whitwell, J. L. & Dickson, D. W., Jan 1 2019, (Accepted/In press) In : Acta Neuropathologica.

Research output: Contribution to journalArticle

Amygdala
Frontotemporal Lobar Degeneration
Brain
Neuroimaging
Hippocampus

Plasma and CSF neurofilament light: Relation to longitudinal neuroimaging and cognitive measures

Mielke, M. M., Syrjanen, J. A., Blennow, K., Zetterberg, H., Vemuri, P., Skoog, I., Machulda, M. M., Kremers, W. K., Knopman, D. S., Jack, C., Petersen, R. C. & Kern, S., Jul 16 2019, In : Neurology. 93, 3, p. E252-E260

Research output: Contribution to journalArticle

Open Access
Intermediate Filaments
Neuroimaging
Light
Amyloid
Cognition
Open Access
arteriosclerosis
Sphingomyelins
metabolites
Magnetic resonance
Metabolites
2 Citations (Scopus)

Predicting Alzheimer’s disease progression using multi-modal deep learning approach

for Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 1952.

Research output: Contribution to journalArticle

Open Access
Disease Progression
Alzheimer Disease
Learning
Neuroimaging
Area Under Curve
1 Citation (Scopus)

Predicting Progression to Mild Cognitive Impairment

Petersen, R. C., Lundt, E. S., Therneau, T. M., Weigand, S. D., Knopman, D. S., Mielke, M. M., Roberts, R. O., Lowe, V., Machulda, M. M., Kremers, W. K., Geda, Y. E. & Jack, C. R. J., Jan 1 2019, In : Annals of Neurology. 85, 1, p. 155-160 6 p.

Research output: Contribution to journalArticle

Biomarkers
Amyloid
Cognitive Dysfunction
Alzheimer Disease
Population

Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

For the Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 2235.

Research output: Contribution to journalArticle

Open Access
Disease Progression
Alzheimer Disease
Demography
Complement C1
Prodromal Symptoms
1 Citation (Scopus)
National Institute on Aging (U.S.)
Alzheimer Disease
Amyloid
Research
Positron-Emission Tomography

Progressive agrammatic aphasia without apraxia of speech as a distinct syndrome

Tetzloff, K. A., Duffy, J. R., Clark, H., Utianski, R., Strand, E. A., Machulda, M. M., Botha, H., Martin, P. R., Schwarz, C., Senjem, M. L., Reid, R. I., Gunter, J. L., Spychalla, A. J., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V., Josephs, K. A. & Whitwell, J. L., Aug 1 2019, In : Brain : a journal of neurology. 142, 8, p. 2466-2482 17 p.

Research output: Contribution to journalArticle

Apraxias
Aphasia
Positron-Emission Tomography
Broca Aphasia
Parkinsonian Disorders

Quantity and quality of mental activities and the risk of incident mild cognitive impairment

Krell-Roesch, J., Syrjanen, J. A., Vassilaki, M., Machulda, M. M., Mielke, M. M., Knopman, D. S., Kremers, W. K., Petersen, R. C. & Geda, Y. E., Aug 6 2019, In : Neurology. 93, 6, p. e548-e558

Research output: Contribution to journalArticle

Open Access
Independent Living
Cognitive Dysfunction
Reading
Cohort Studies
Prospective Studies

Rates of lobar atrophy in asymptomatic MAPT mutation carriers

Chen, Q., Boeve, B. F., Senjem, M., Tosakulwong, N., Lesnick, T. G., Brushaber, D., Dheel, C., Fields, J. A., Forsberg, L., Gavrilova, R. M., Gearhart, D., Graff-Radford, J., Graff Radford, N. R., Jack, C. R. J., Jones, D. T., Knopman, D. S., Kremers, W. K., Lapid, M. I., Rademakers, R. V., Syrjanen, J. & 4 others, Boxer, A. L., Rosen, H., Wszolek, Z. K. & Kantarci, K. M., Jan 1 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 338-346 9 p.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Dementia
Microtubule-Associated Proteins
Atrophy
Temporal Lobe
Mutation
9 Citations (Scopus)

Sensitivity and Specificity of Diagnostic Criteria for Progressive Supranuclear Palsy

Ali, F., Martin, P. R., Botha, H., Ahlskog, J. E., Bower, J. H., Masumoto, J. Y., Maraganore, D., Hassan, A., Eggers, S. D., Boeve, B. F., Knopman, D. S., Drubach, D., Petersen, R. C., Dunkley, E. D., Van Gerpen, J. A., Uitti, R., Whitwell, J. L., Dickson, D. W. & Josephs, K. A., Jan 1 2019, In : Movement Disorders.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Sensitivity and Specificity
Phenotype
Parkinsonian Disorders
Neurodegenerative Diseases
1 Citation (Scopus)

Severity dependent distribution of impairments in PSP and CBS: Interactive visualizations

The AL-108-231 Study Group, The PROPSPERA investigators, 4RNTI-1authors & Tau Restoration on PSP (TAUROS) Investigators, Mar 1 2019, In : Parkinsonism and Related Disorders. 60, p. 138-145 8 p.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Clinical Trials
Extremities
Tauopathies
Therapeutic Uses
3 Citations (Scopus)

Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study

Walker, K. A., Gottesman, R. F., Wu, A., Knopman, D. S., Gross, A. L., Mosley, T. H., Selvin, E. & Windham, B. G., Mar 12 2019, In : Neurology. 92, 11, p. e1256-e1267

Research output: Contribution to journalArticle

Inflammation
C-Reactive Protein
Biomarkers
Confidence Intervals
Executive Function